eLife

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1. Learned response dynamics reflect stimulus timing and encode temporal expectation violations in superficial layers of mouse V1

   This article has 3 authors:

   1. Scott G Knudstrup
   2. Catalina Martinez
   3. Jeffrey P Gavornik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents useful results that extend our understanding of how the visual cortex encodes temporal structure, providing new information about sequence representations in the upper layers of the visual cortex. The evidence for prediction errors is solid, however, support for other claims regarding sparsification and simplification of activity following training is incomplete. The main concerns pertain to the confounds associated with restricted ordering within blocks that does not allow for separate plasticity mechanisms operating on different time scales.

   Reviewed by eLife

2. Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia

   This article has 10 authors:

   1. Maria Ardaya
   2. Marie-Catherine Tiveron
   3. Harold Cremer
   4. Esther Rubio-López
   5. Abraham Martín
   6. Benjamin Dehay
   7. Fernando Pérez-Cerdá
   8. Carlos Matute
   9. Federico N Soria
   10. Fabio Cavaliere

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors show that a middle carotid artery occlusion (MCAO) hypoxia lesion leads to hyaluronan-mediated chemoattraction to the lesion penumbra of Thbs-4-expressing astrocytes of the sub-ventricular zone (SVZ). These findings are valuable because they shed light on the function of astrocytes from the adult SVZ in pathological states like brain ischemic injury. The results are convincing, as they rely on a comprehensive analysis of experimental data.

   Reviewed by eLife

3. Indistinguishable network dynamics can emerge from unalike plasticity rules

   This article has 5 authors:

   1. Poornima Ramesh
   2. Basile Confavreux
   3. Pedro J. Gonçalves
   4. Tim P. Vogels
   5. Jakob H. Macke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents a valuable data-driven method to extract the "true" synaptic plasticity rule (or learning rule) operating in a neural circuit from empirical measurements of neural activity. The approach aims to train a generative adversarial network (GAN) to match neural activity measurements in terms of statistics, learning them from the data, rather than being pre-determined by the experimenter. The main conclusion is that the extracted learning rules are not unique, but rather degenerate, meaning that multiple plasticity rules can produce the same neural activity. Although the paper presents a thorough investigation using one learning rule as a case study (the Oja rule), the evidence that the results can be inferred beyond the specific numerical experiments presented in the paper is incomplete.

   Reviewed by eLife

4. Wound-Induced Syncytia Outpace Mononucleate Neighbors during Drosophila Wound Repair

   This article has 6 authors:

   1. James S. White
   2. Jasmine J. Su
   3. Elizabeth M. Ruark
   4. Junmin Hua
   5. M. Shane Hutson
   6. Andrea Page-McCaw

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work addresses an important biological question: what is the cellular basis of wound healing? Using the Drosophila pupal notum as a model, the paper provides an elegant, thorough, descriptive characterisation of syncytia-driven wound closure using state-of-the-art confocal live imaging of the pupal notum. The authors meticulously characterize the cell-cell fusion events during wound healing, but without any mechanisms to inhibit cell fusion, it is incomplete, since it remains unclear whether cell fusion is required or not for speeding wound healing and/ or increasing the level of actin resources at the leading edge.

   Reviewed by eLife

5. PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

   This article has 10 authors:

   1. Gang Liu
   2. Yunxuan Hou
   3. Xin Jin
   4. Yixue Zhang
   5. Chaoyue Sun
   6. Chengquan Huang
   7. Yujie Ren
   8. Jianmin Gao
   9. Xiuli Wang
   10. Xiumei Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work significantly advances our understanding of how FOG1 nuclear localization is regulated during erythropoiesis and megakaryopoiesis, including the role of EPO and MPL/TPO signaling in this process. The authors provide compelling evidence using both K562 and CD34+ cells that heat shock cognate B (HSCB) can promote the proteasomal degradation of TACC3 to regulate the nuclear localization of FOG1, and that this function is independent of its role in iron-sulfur cluster (ISC) biogenesis. Together these data will be of interest to the fields of hematopoiesis and cell biology.

   Reviewed by eLife

6. Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice

   This article has 8 authors:

   1. Eleni CR Hackwell
   2. Sharon R Ladyman
   3. Jenny Clarkson
   4. H James McQuillan
   5. Ulrich Boehm
   6. Allan E Herbison
   7. Rosemary SE Brown
   8. David R Grattan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work advances our understanding of the mechanisms underlying lactation-induced infertility. Compelling evidence supports the notion that prolactin inhibits kisspeptin activity and LH pulsatile release and that loss of this signal results in an early reestablishment of fertility during lactation. This work will be of interest to endocrinologists and reproductive biologists.

   Reviewed by eLife

7. TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

   This article has 13 authors:

   1. Jing Wang
   2. Yingying Yin
   3. Lei Yang
   4. Junchao Qin
   5. Zixiang Wang
   6. Chunhong Qiu
   7. Yuan Gao
   8. Gang Lu
   9. Fei Gao
   10. Zi-Jiang Chen
   11. Xiyu Zhang
   12. Hongbin Liu
   13. Zhaojian Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports an important discovery highlighting the essential role of the putative ion channel, TMC7, in acrosome formation during sperm development and thus male fertility. The evidence for the requirement of TMC7 in acrosome biogenesis and sperm function is convincing, although its function as an ion channel remains to be further determined. Overall, this work will be of great interest to developmental biologists and ion channel physiologists alike.

   Reviewed by eLife

8. Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

   This article has 9 authors:

   1. Katsuyuki Nishi
   2. Taro Sakamaki
   3. Akiomi Nagasaka
   4. Kevin Shuolong Kao
   5. Kay Sadaoka
   6. Masahide Asano
   7. Nobuyuki Yamamoto
   8. Akifumi Takaori-Kondo
   9. Masanori Miyanishi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides valuable insights into the heterogeneity of hematopoietic stem cells and age-associated myeloid-biased hematopoiesis. While several aspects of the study are intriguing and merit further investigation, the current results remain incomplete and additional data are necessary to substantiate the conclusions. Some of the methods and data analyses partially support the claims.

   Reviewed by eLife, preLights

9. Ciliary length regulation by intraflagellar transport in zebrafish

   This article has 5 authors:

   1. Yi Sun
   2. Zhe Chen
   3. Minjun Jin
   4. Haibo Xie
   5. Chengtian Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript represents a valuable conceptual and technical contribution to our understanding of ciliogenesis and intraflagellar transport in vertebrates. Through a series of solid and technically superb live imaging experiments to directly visualize intraflagellar transport in various zebrafish ciliated tissues, the authors unveil the surprising breadth of intraflagellar transport speed among differing organs and link this to cell type-specific differences in cilia length and intraflagellar transport train size. This work will be of broad interest to researchers in numerous fields, including development, cell biology, and imaging.

   Reviewed by eLife

10. Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

    This article has 11 authors:

    1. Jianwei Li
    2. Yutong He
    3. Xin Xu
    4. Martin Alcorlo
    5. Jian Shi
    6. Souvik Naskar
    7. Nicholas S Briggs
    8. David I Roper
    9. Juan A Hermoso
    10. Lok-To Sham
    11. Min Luo

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is a potentially useful study that provides solid, yet confirmatory structural findings about the complex (FtsEX) that controls peptidoglycan remodeling during bacterial cell division. The authors capitalize on the fact that ATP binding stabilizes the FtsEX complex allowing structural characterization for this system. A model is then developed to explain ATP regulation but there is a gap between the model presented here and in vivo data reported previously.

    Reviewed by eLife