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  1. Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8+ T cell pathogenicity in non-obese diabetic mice

    This article has 5 authors:
    1. Chia-Lo Ho
    2. Li-Tzu Yeh
    3. Yu-Wen Liu
    4. Jia-Ling Dong
    5. Huey-Kang Sytwu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study addresses T cell receptor activation during autoreactive T cell development and how the strength of T cell receptor engagement in naïve cells can predispose T cells to develop into effector/memory T cells. The authors lead with solid results that are largely consistent with data in the field suggesting that, in comparison to their counterparts with relatively lower basal self-reactivity, naive CD5hi CD8 T cells in non-obese diabetic (NOD) mice are poised for activation. They propose that diabetogenic T cells are preferentially found among the naive CD5hi CD8 T cell population. While the evidence does not fully support all the authors' conclusions, the data provide a foundation that sets up future studies.

    Reviewed by eLife

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