eLife

Latest preprint reviews

1. Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making

   This article has 5 authors:

   1. Miguel Barretto-Garcia
   2. Marcus Grueschow
   3. Marius Moisa
   4. Rafael Polania
   5. Christian C Ruff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important paper, Garcia et al seek to determine whether the superior frontal sulcus (SFS), an area previously implicated in evidence accumulation for perceptual decisions, plays a causal role in perceptual and/or value-based decisions. Through a combination of careful paradigm design, computational modelling, transcranial magnetic stimulation and fMRI analyses, the authors provide convincing evidence that the SFS supports perceptual but not value-based decisions and that its disruption leads to a lowering of decision boundaries.

   Reviewed by eLife

2. Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

   This article has 14 authors:

   1. Camille Dantzer
   2. Justine Vaché
   3. Aude Brunel
   4. Isabelle Mahouche
   5. Anne-Aurélie Raymond
   6. Jean-William Dupuy
   7. Melina Petrel
   8. Paulette Bioulac-Sage
   9. David Perrais
   10. Nathalie Dugot-Senant
   11. Mireille Verdier
   12. Barbara Bessette
   13. Clotilde Billottet
   14. Violaine Moreau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Hepatocellular carcinoma (HCC) is a particularly aggressive form of cancer, with an increasing number of treatment options approved for use in patients over the past decade. However, the biology of HCC and identifiable therapeutic targets have not been as clear, even in the era of molecular oncology. Likewise, the cellular biology of HCC, including the role of intercellular communication, has not been well elucidated. In this compelling study, Dantzer et al. provide fundamental insight into the role of beta-catenin on intercellular communication occurring via extracellular vesicles, with implications for immune evasion in a cancer increasingly being treated using immuno-oncologic agents.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2303.17893v2

4. Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

   This article has 7 authors:

   1. Yue Sun
   2. Jingwei Li
   3. Jiadai Huang
   4. Shumin Li
   5. Youyue Li
   6. Beifang Lu
   7. Xin Deng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work advances our understanding of transcriptional regulation of virulence and metabolic pathways in plant pathogenic bacteria. Solid evidence for the claims is provided by computational analysis of newly generated data on the genome-wide binding of 170 transcription factors to their target genes, together with experimental validation of the biological functions of some of these transcription factors. The findings and resources from this study will be valuable to researchers in the fields of systems biology, bacteriology, and plant-microbe interactions.

   Reviewed by eLife

5. Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

   This article has 6 authors:

   1. Kara Schmidlin
   2. Sam Apodaca
   3. Daphne Newell
   4. Alexander Sastokas
   5. Grant Kinsler
   6. Kerry Geiler-Samerotte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable new insights into the trade-offs associated with the evolution of drug resistance in the yeast S. cerevisiae, based on a solid approach to evolving and phenotyping hundreds of independent strains. The authors identify distinct phenotypic clusters, defined by their growth across defined conditions, which suggest that tradeoffs are diverse but at the same time could be limited to a few classes according to the underlying resistance mechanisms. The methodologies used align with the current state-of-the-art, and the data and analysis are solid as they broadly support the claims, with only a few minor weaknesses remaining after revision. This work will interest molecular biologists working on the evolution of new phenotypes and microbiologists studying multi-drug therapy.

   Reviewed by eLife

6. The recombination landscape of introgression in yeast

   This article has 3 authors:

   1. Enrique J. Schwarzkopf
   2. Nathan Brandt
   3. Caiti Smukowski Heil

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study aims to analyse the effect of polymorphism on meiotic recombination in subspecies of Saccharomyces. The detection of reciprocal and non-reciprocal events is based on sequencing the haploid products of meiosis, and frequencies are compared between strains having introgressed genomic segments and strains lacking such segments. Unfortunately, the method used are inadequate for quantifying the non-reciprocal events.

   Reviewed by eLife

7. Identifying images in the biology literature that are problematic for people with a color-vision deficiency

   This article has 4 authors:

   1. Harlan P Stevens
   2. Carly V Winegar
   3. Arwen F Oakley
   4. Stephen R Piccolo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors manually assessed randomly selected images published in eLife between 2012 and 2022 to determine whether they were accessible for readers with deuteranopia, the most common form of color vision deficiency. They then developed an automated tool designed to classify figures and images as either "friendly" or "unfriendly" for people with deuteranopia. Such a tool could be used by journals or researchers to monitor the accessibility of figures and images, and the evidence for its utility was solid: it performed well for eLife articles, but performance was weaker for a broader dataset of PubMed articles, which were not included in the training data. The authors also provide code that readers can download and run to test their own images, and this may be of most use for testing the tool, as there are already several free, user-friendly recoloring programs that allow users to see how images would look to a person with different forms of color vision deficiency. Automated classifications are of most use for assessing many images, when the user does not have the time or resources to assess each image individually.

   Reviewed by eLife

8. Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis

   This article has 22 authors:

   1. Vivian C Salgueiro-Toledo
   2. Jorge Bertol
   3. Claude Gutierrez
   4. Jose L Serrano-Mestre
   5. Noelia Ferrer-Luzon
   6. Lucia Vázquez-Iniesta
   7. Ainhoa Palacios
   8. Laia Pasquina-Lemonche
   9. Akbar Espaillat
   10. Laura Lerma
   11. Brian Weinrick
   12. Jose L Lavin
   13. Felix Elortza
   14. Mikel Azkargorta
   15. Alicia Prieto
   16. Pilar Buendía-Nacarino
   17. Jose L Luque-García
   18. Olivier Neyrolles
   19. Felipe Cava
   20. Jamie K Hobbs
   21. Joaquín Sanz
   22. Rafael Prados-Rosales

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors investigate the biogenesis of extracellular vesicles in mycobacteria and provide several observations to link VirR with vesiculogenesis, peptidoglycan metabolism, lipid metabolism, and cell wall permeability. The authors have done a commendable job of comprehensively examining the phenotypes associated with the VirR mutant using various techniques. The evidence presented in the revised manuscript is convincing and creates several avenues for further research.

   Reviewed by eLife

9. Machine Learning Based Modelling of Human and Insect Olfaction Screens Millions of compounds to Identify Pleasant Smelling Insect Repellents

   This article has 5 authors:

   1. Joel Kowalewski
   2. Sean M. Boyle
   3. Ryan Arvidson
   4. Jadrian Ejercito
   5. Anandasankar Ray

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study uses a chemoinformatics pipeline to identify a list of candidate mosquito repellants that may be pleasant to smell and safe for humans. The computational methodology is solid, but insufficiently benchmarked against other leading models. At the high concentrations tested, there may also be off-target effects of the repellents on the mosquitoes that are not considered. This paper may be of interest to specialists interested in the discovery of new mosquito repellents.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.48550/arxiv.2307.07654v2