Latest preprint reviews

  1. Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    This article has 23 authors:
    1. Elizabeth C Marin
    2. Billy J Morris
    3. Tomke Stürner
    4. Andrew S Champion
    5. Dominik Krzeminski
    6. Griffin Badalamente
    7. Marina Gkantia
    8. Christopher R Dunne
    9. Katharina Eichler
    10. Shin-ya Takemura
    11. Imaan FM Tamimi
    12. Siqi Fang
    13. Sung Soo Moon
    14. Han SJ Cheong
    15. Feng Li
    16. Philipp Schlegel
    17. Sebastian E Ahnert
    18. Stuart Berg
    19. Janelia FlyEM Project Team
    20. Gwyneth M Card
    21. Marta Costa
    22. David Shepherd
    23. Gregory SXE Jefferis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study provides a near-comprehensive anatomical description and annotation of neurons in a male Drosophila ventral nerve cord, based on large-scale circuit reconstruction from electron microscopy. This connectome resource will be of substantial interest to neuroscientists interested in sensorimotor control, neural development, and analysis of brain connectivity. However, although the evidence is extensive and compelling, the presentation of results in this very large manuscript lacks clarity and concision.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

    This article has 15 authors:
    1. Viviane Kremling
    2. Sven Falke
    3. Yaiza Fernández-García
    4. Christiane Ehrt
    5. Antonia Kiene
    6. Bjarne Klopprogge
    7. Emilie Scheer
    8. Fabian Barthels
    9. Philipp Middendorf
    10. Sebastian Kühn
    11. Stephan Günther
    12. Matthias Rarey
    13. Henry N Chapman
    14. Dominik Oberthür
    15. Janina Sprenger
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study describes the crystallographic screening of a number of small molecules against a viral enzyme critical for the 5' capping of SARS-CoV-2 RNA and viral replication. While the high-quality crystal structures and complementary biophysical assays in this study provide solid evidence to support the major claims regarding how these small molecule compounds bind to the viral enzyme, the mismatch between the antiviral activity and binding to the viral enzyme of several small molecule compounds could have been more thoroughly investigated or discussed. This paper would be of interest to the fields of coronavirus biology, structural biology, and drug discovery.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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