eLife

Latest preprint reviews

1. Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

   This article has 12 authors:

   1. Adrián Merino-Salomón
   2. Jonathan Schneider
   3. Leon Babl
   4. Jan-Hagen Krohn
   5. Marta Sobrinos-Sanguino
   6. Tillman Schäfer
   7. Juan Ramon Luque-Ortega
   8. Carlos Alfonso
   9. Mercedes Jiménez
   10. Marion Jasnin
   11. Petra Schwille
   12. Germán Rivas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The formation of the Z-ring at the time of bacterial cell division interests researchers working towards understanding cell division across all domains of life. The manuscript by Jasnin et al reports the cryoET structure of toroid assembly formation of FtsZ filaments driven by ZapD as the cross linker. The findings are important and have the potential to open a new dimension in the field, and the evidence to support these exciting claims is solid.

   Reviewed by eLife

2. Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket

   This article has 2 authors:

   1. Yi Zeng
   2. Jonathan P. Staley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that demonstrates that RNA intermediates arising from improper splicing are exported out of the nucleus via the canonical mRNA export machinery and the nuclear pore basket. The authors provide convincing evidence that the role of the nuclear basket rather than retaining the transcripts is stimulating their export, putting into question the current model of the role of the basket. The conclusions are in line with recent studies in mammalian cells that suggest that the basket's role in mRNA export and quality control has to be revised.

   Reviewed by eLife

3. Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

   This article has 20 authors:

   1. Jeongkyung Lee
   2. Ruya Liu
   3. Byung S. Kim
   4. Yiqun Zhang
   5. Feng Li
   6. Rajaganapti Jagannathan
   7. Ping Yang
   8. Vinny Negi
   9. Joseph Danvers
   10. Eliana Melissa Perez-Garcia
   11. Pradip K. Saha
   12. Omaima Sabek
   13. Chad J. Creighton
   14. Cristian Coarfa
   15. Mark O. Huising
   16. Hung-Ping Shih
   17. Rita Bottino
   18. Ke Ma
   19. Mousumi Moulik
   20. Vijay K. Yechoor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The Hippo signaling pathway plays a crucial role in controlling organ size, cell proliferation, and apoptosis, though its role in endocrine pancreas development has remained unclear. In this useful work, the authors study the function of the Tead1 transcription factor, a Hippo effector, specifically in pancreatic beta cells. They provide solid evidence, using multiple different conditional knockout models to reveal Tead1's regulatory functions in insulin secretion and beta cell proliferation. However, deeper exploration of their data and incorporating findings from existing literature on this topic would provide a clearer understanding of Tead1's role in β-cell function, within or beyond the Hippo pathway.

   Reviewed by eLife

4. The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

   This article has 9 authors:

   1. Roger Huerlimann
   2. Natacha Roux
   3. Ken Maeda
   4. Polina Pilieva
   5. Saori Miura
   6. Hsiao-chian Chen
   7. Michael Izumiyama
   8. Vincent Laudet
   9. Timothy Ravasi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work provides valuable genomic resources to address the endocrine control of a life cycle transition in the Malabar grouper fish. The revised manuscript is more solid and the resources and experimental data help to build up a meaningful biological understanding of thyroid signaling in grouper fish.

   Reviewed by eLife

5. Bidirectional fear modulation by discrete anterior insular circuits in male mice

   This article has 4 authors:

   1. Sanggeon Park
   2. Yeowool Huh
   3. Jeansok J Kim
   4. Jeiwon Cho

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work provides a valuable characterization of neural activity in the anterior insular cortex during fear. Using behavior, single unit recording, and optogenetic control of neural activity, the paper provides convincing data on the role of anterior insular circuits in bidirectionally controlling fear. The study is a great starting point on the path to testing hypotheses about bidirectional control of behavior via neural activity in anatomically defined output populations.

   Reviewed by eLife

6. Distinct effects of phyllosphere and rhizosphere microbes on invader Ageratina adenophora during its early life stages

   This article has 7 authors:

   1. Zhao-Ying Zeng
   2. Jun-Rong Huang
   3. Zi-Qing Liu
   4. Ai-Ling Yang
   5. Yu-Xuan Li
   6. Yong-Lan Wang
   7. Han-Bo Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study investigates plant-microbe interactions for an invasive plant, Ageratina adenophora. The findings are valuable in advancing our understanding of how leaf and soil microbes separately affect its performance, with solid experimental evidence revealing the importance of litter microbes in shaping A. adenophora populations. The work will be of interest to invasion biologists.

   Reviewed by eLife

7. Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood

   This article has 14 authors:

   1. Chiara Bulgarelli
   2. Anna Blasi
   3. Samantha McCann
   4. Bosiljka Milosavljevic
   5. Giulia Ghillia
   6. Ebrima Mbye
   7. Ebou Touray
   8. Tijan Fadera
   9. Lena Acolatse
   10. Sophie E Moore
   11. Sarah Lloyd-Fox
   12. Clare E Elwell
   13. Adam T Eggebrecht
   14. the BRIGHT Study Team

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study details changes in the brain functional connectivity in a longitudinal cohort of Gambian children assessed outside a lab setup with functional near-infrared spectroscopy (fNIRS) from age 5 to 24 months, in relation to early physical growth and cognitive flexibility capacities at preschool age. While evidence supporting conclusions on the evolution of brain connectivity are solid, the statistical power was insufficient to perform proper analyses of longitudinal data and link the connectivity trajectories with early adverse conditions such as undernutrition and later cognitive development. This study will be of significant interest to neuroscientists, psychologists and neuroimaging researchers working on infant development in relation to environmental factors.

   Reviewed by eLife

8. Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

   This article has 8 authors:

   1. Ryosuke Isotani
   2. Masaki Igarashi
   3. Masaomi Miura
   4. Kyoko Naruse
   5. Satoshi Kuranami
   6. Manami Katoh
   7. Seitaro Nomura
   8. Toshimasa Yamauchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the claims of the authors is solid. This research will be of interest to medical biologists specializing in intestinal tumors.

   Reviewed by eLife

9. Transforming descending input into motor output: An analysis of the Drosophila Male Adult Nerve Cord connectome

   This article has 16 authors:

   1. Han SJ Cheong
   2. Katharina Eichler
   3. Tomke Stürner
   4. Samuel K Asinof
   5. Andrew S Champion
   6. Elizabeth C Marin
   7. Tess B Oram
   8. Marissa Sumathipala
   9. Lalanti Venkatasubramanian
   10. Shigehiro Namiki
   11. Igor Siwanowicz
   12. Marta Costa
   13. Stuart Berg
   14. Janelia FlyEM Project Team
   15. Gregory SXE Jefferis
   16. Gwyneth M Card

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper describes the structure and connectivity of brain neurons that send descending connections to motor neurons and muscle in the fruit fly nerve cord, using a synapse-resolution connectome. This important work provides a wealth of hypotheses and predictions for future experimentation and modelling. Using state-of-the-art methods, the authors provide solid evidence for their conclusions.

   Reviewed by eLife

10. Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability

    This article has 6 authors:

    1. Ludovica Labruna
    2. Christina Merrick
    3. Angel V Peterchev
    4. Ben Inglis
    5. Richard B Ivry
    6. Daniel Sheltraw

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study introduces and evaluates the efficacy of a novel form of non-invasive brain stimulation in humans: kilohertz transcranial magnetic perturbation (kTMP). The evidence provided for the ability of kTMP to increase cortical excitability with minimal sensation is compelling, with two separate replication experiments. Although exploratory in nature, this work represents new avenues for non-invasive brain stimulation research that has potential long-term appeal for both clinical and research applications. This paper will be of significant interest to neuroscientists interested in brain stimulation.

    Reviewed by eLife