eLife

Latest preprint reviews

1. Linking root-associated fungal and bacterial functions to root economics

   This article has 13 authors:

   1. Ran Wu
   2. Xiaoyue Zeng
   3. M. Luke McCormack
   4. Christopher W. Fernandez
   5. Yin Yang
   6. Hui Guo
   7. Meijie Xi
   8. Yu Liu
   9. Xiangbin Qi
   10. Shuang Liang
   11. Thomas E. Juenger
   12. Roger T. Koide
   13. Weile Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of the below-ground resource acquisition strategies of diverse tree species, integrating the roles of both roots and their associated microbes. The support for the conclusions is incomplete owing to the uncertainties or shortcomings associated with the design and statistical analyses. Regardless of these technical issues, this study can be of broad interest for plant and microbial ecologists.

   Reviewed by eLife

2. A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein

   This article has 8 authors:

   1. Markéta Častorálová
   2. Jakub Sýs
   3. Jan Prchal
   4. Anna Pavlů
   5. Lucie Prokopová
   6. Zina Briki
   7. Martin Hubálek
   8. Tomas Ruml

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of how the viral protease in a D-type retrovirus is activated and in particular how the exposure of the myristoyl group is required for processing of the Gag matrix precursor. The supporting evidence is convincing, but the work would benefit from additional data in support of the claims. This manuscript is of interest to retrovirologists and structural biologists.

   Reviewed by eLife

3. Ingestible pills reveal gastric correlates of emotions

   This article has 4 authors:

   1. Giuseppina Porciello
   2. Alessandro Monti
   3. Maria Serena Panasiti
   4. Salvatore Maria Aglioti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study used a novel method to relate gastric acidity to subjective ratings of emotions induced by video clips. The findings are solid but could be strengthened by additional analyses and/or visualization. The findings have broad implications for the field of emotion research and opens new avenues of research for understanding psychosomatic disorders.

   Reviewed by eLife

4. Disruption of awake sharp-wave ripples does not affect memorization of locations in repeated-acquisition spatial memory tasks

   This article has 2 authors:

   1. Lies Deceuninck
   2. Fabian Kloosterman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents the lack of effect of closed-loop SWR disruption in guiding behavior and remembering the recent past in short-term memory tasks in rats. These negative results may have important theoretical and practical implications in the field of memory and learning. However, while SWR detection methods are carefully validated, the strength of evidence is incomplete and some additional controls are required.

   Reviewed by eLife

5. Experience transforms crossmodal object representations in the anterior temporal lobes

   This article has 7 authors:

   1. Aedan Yue Li
   2. Natalia Ladyka-Wojcik
   3. Heba Qazilbash
   4. Ali Golestani
   5. Dirk B Walther
   6. Chris B Martin
   7. Morgan D Barense

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The fMRI study is important because it investigates fundamental questions about the neural basis of multimodal binding using an innovative multi-day learning approach. The results provide solid evidence for learning-related changes in the anterior temporal lobe, however, the interpretation of these changes is not straightforward, and the study does not (yet) provide direct evidence for an integrative code. This paper is of potential interest to a broad audience of neuroscientists.

   Reviewed by eLife

6. The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

   This article has 25 authors:

   1. Thomas Morgan Li
   2. Victoria Zyulina
   3. Ethan S Seltzer
   4. Marija Dacic
   5. Yurii Chinenov
   6. Andrea R Daamen
   7. Keila R Veiga
   8. Noa Schwartz
   9. David J Oliver
   10. Pamela Cabahug-Zuckerman
   11. Jose Lora
   12. Yong Liu
   13. William D Shipman
   14. William G Ambler
   15. Sarah F Taber
   16. Karen B Onel
   17. Jonathan H Zippin
   18. Mehdi Rashighi
   19. James G Krueger
   20. Niroshana Anandasabapathy
   21. Inez Rogatsky
   22. Ali Jabbari
   23. Carl P Blobel
   24. Peter E Lipsky
   25. Theresa T Lu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful assessment of the possible role of type I interferons in inhibiting Adam17 protease/sheddase activity and their correlation with decreased Langerhans Cells signature in lesional and nonlesional CLE and murine models as cause of photosensitive lupus. The data were collected and analyzed using a solid methodology. This work will be of interest to scientists interested in photosensitivity in the setting of lupus.

   Reviewed by eLife

7. Coenzyme-protein interactions since early life

   This article has 5 authors:

   1. Alma Carolina Sanchez Rocha
   2. Mikhail Makarov
   3. Lukáš Pravda
   4. Marian Novotný
   5. Klára Hlouchová

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable examination of the prevalence of interactions between amino acids from different periods of Earth's history and coenzymes. While the premise of this work is well founded and the analysis is solid, with more data, the interpretation could change. This manuscript would be of interest to evolutionary biologists and biophysicists.

   Reviewed by eLife

8. Molecular identification of wide-field amacrine cells in mouse retina that encode stimulus orientation

   This article has 13 authors:

   1. Silvia J. Park
   2. Wanyu Lei
   3. John Pisano
   4. Andrea Orpia
   5. Jacqueline Minehart
   6. Joseph Pottackal
   7. Christin Hanke-Gogokhia
   8. Thomas E. Zapadka
   9. Cheryl Clarkson-Paredes
   10. Anastas Popratiloff
   11. Sarah E. Ross
   12. Joshua H. Singer
   13. Jonathan B. Demb

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Amacrine cells are a heterogeneous and understudied set of retinal interneurons. This study presents valuable new insights into the structure, function, and circuit connectivity of a particular subset of wide field amacrine cells (WACs). The authors use an impressive set of techniques to study structural and functional properties of these cells and to establish their postsynaptic circuit partners. Evidence for the central conclusions is solid, although some of the most interesting results could be pursued more completely.

   Reviewed by eLife

9. The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

   This article has 8 authors:

   1. Liam C Hunt
   2. Kudzai Nyamkondiwa
   3. Anna Stephan
   4. Jianqin Jiao
   5. Kanisha Kavdia
   6. Vishwajeeth Pagala
   7. Junmin Peng
   8. Fabio Demontis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study presents findings on the role of the ubiquitin-conjugating enzyme UBE2D/eff in maintaining proteostasis during aging. The evidence supporting the conclusions is solid, although one reviewer had concerns about the readout for protein aggregation and the loss-of-function studies. In the future, mechanistic insights explaining the impact of UBE2D/eff deficiency on the accumulation of poly-ubiquitinated proteins and in shortening lifespan would be interesting. The present study is of broad interest to cell biologists working in aging and age-related diseases.

   Reviewed by eLife

10. Speech-induced suppression and vocal feedback sensitivity in human cortex

    This article has 7 authors:

    1. Muge Ozker
    2. Leyao Yu
    3. Patricia Dugan
    4. Werner Doyle
    5. Daniel Friedman
    6. Orrin Devinsky
    7. Adeen Flinker

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The manuscript describes human intracranial neural recordings in the auditory cortex during speech production, showing that the effects of delayed auditory feedback correlate with the degree of underlying speech-induced suppression. This is an important finding, as previous work has suggested that speech suppression and feedback sensitivity often do not co-localize and may be distinct processes, in contrast with findings in non-human primates where there is a strong correlation. The strength of the evidence is convincing, with appropriate experimental methods, data, and analysis.

    Reviewed by eLife