eLife reviews preprints in the life sciences and medicine.

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  1. Cognitive control networks in human and macaque

    1. Valentina Mione
    2. Freja Holm Prins
    3. Moataz Assem
    4. Urs Schüffelgen
    5. Søren Kyllingsbæk
    6. Mark Buckley
    7. Daniel J Mitchell
    8. John Duncan

    • Curated by eLife

      eLife Assessment

      This study presents a valuable contribution to comparative cognitive neuroscience by directly mapping functional homologues of the human multiple-demand network in macaques using a matched spatial maze task. However, the evidence is incomplete due to methodological asymmetries in task design and preprocessing parameters that warrant careful consideration. The work will be of interest to researchers studying the evolution of cognitive control and cross-species neuroimaging.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. Fragile polyQ assemblies cause Golgipathy in Huntington’s disease

    1. Lixiang Ma
    2. Xinyu Chen
    3. Yang Liu
    4. Lijun Dai
    5. Fangzhou Ye
    6. Weiqi Yang
    7. Hada Buhe
    8. Jixin Ma
    9. Chenyun Song
    10. Li Li
    11. Dandan Fan
    12. Fanxun Chen
    13. Haoman Chen
    14. Jianwei Shuai
    15. Jianzhong Su
    16. Hexige Saiyin

    • Curated by eLife

      eLife Assessment

      In this study, the authors propose a role for the Huntingtin protein in the organization of the Golgi apparatus and examine the effect of polyQ aggregates at the Golgi. The observations are interesting and potentially important for the field; however, the key claim that polyQ HTT functionally disrupts the Golgi (Golgipathy) is incompletely supported by the data.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Synaptotagmin isoforms differentially regulate glutamate and GABA release in the lateral habenula

    1. Dustin N White
    2. J Keenan Kushner
    3. Kelly E Winther
    4. Dillon J McGovern
    5. Tamara Basta
    6. Zoe R Donaldson
    7. Charles A Hoeffer
    8. David H Root
    9. Michael HB Stowell

    • Curated by eLife

      eLife Assessment

      This paper addresses a key question regarding the molecular mechanisms underlying GABA and glutamate release from co-releasing neurons projecting from the entopeduncular nucleus (EPN) to the lateral habenula (LHb) in mice. The authors conclude that the two neurotransmitters are released from separate vesicle pools and rely on distinct molecular machinery; these conclusions contrast with previous functional studies at the same synapse, suggesting that GABA and glutamate are co-packaged within the same vesicles. The study employs useful electrophysiological and imaging approaches, however, a key limitation is the use of Cre lines that also label a purely glutamatergic EPN population projecting to the LHb. This inadequate methodology complicates the interpretation of the data and weakens the central conclusions regarding neurotransmitter co-release mechanisms.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  6. Head before heart: cognitive empathy emerges before affective empathy in the developing brain

    1. Chiara Bulgarelli
    2. Paola Pinti
    3. Tessel Bazelmans
    4. Antonia Hamilton
    5. Emily J Jones

    • Curated by eLife

      eLife Assessment

      The authors have presented a study which addresses a recognised gap in the literature, the emergence of the neural correlates of cognitive and affective empathy in children; they introduce a task for measuring both positive and negative empathy in a relatively large group of children aged 3-5. The task was combined with functional near-infrared spectroscopy to examine brain regions involved in the task. The findings are interpreted as providing evidence for the earlier emergence of cognitive than affective empathy. The study represents a valuable contribution to understanding the development of cognitive function, but in its current form, the strength of support for the conclusion is incomplete due to limited support for the comparison to the adult literature and a need to more clearly justify the pre-selected brain regions, their links to empathy and the justification of the hypotheses.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  8. The Par complex regulates apical-basal cell polarity through modulation of FAK signaling homeostasis

    1. Meiai He
    2. Lining Liang
    3. Yulu Wang
    4. Yongyu Chen
    5. Hao Sun
    6. Lin Guo
    7. Changpeng Li
    8. Jingcai He
    9. Yanhua Wu
    10. Shiyu Chen
    11. Tingting Yang
    12. Fei Meng
    13. Qiwen Ren
    14. Linna Dong
    15. Lin Liu
    16. Qianqian Zou
    17. Tianya Zhang
    18. Xinyue Hou
    19. Qing Guo
    20. Dajing Qin
    21. Hui Zheng

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding that the Par polarity complex, but not Crumbs or Scrib, regulates morphological remodeling during the naive-to-primed transition of pluripotent stem cells, with later effects on differentiation and neural tube organoid lumen formation. The evidence is incomplete, as the developmental significance of the PAR KO phenotype requires clearer framing and deeper characterization, and the proposed signaling pathway is currently presented more strongly than the data support. The work will be of interest to developmental and stem cell biologists studying polarity, pluripotent-state transitions, epithelialization, and lumen formation.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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