Latest preprint reviews

1. Gasdermin D-Mediated Neutrophil Pyroptosis drives Inflammation in Psoriasis

   This article has 8 authors:

   1. Jian Liu
   2. YuYing Jiang
   3. ZiYue Diao
   4. DanDan Chen
   5. RuiYuan Xia
   6. BingWei Wang
   7. Shuo Yang
   8. ZhiQiang Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a potentially interesting study regarding the role of gasdesmin D in experimental psoriasis. The study contains useful data from murine models of skin inflammation, however the main claims (on neutrophil pyroptosis) are incompletely supported in its current form and require additional experimental support to justify the conclusions made.

   Reviewed by eLife

2. Human Brain Ancestral Barcodes

   This article has 1 author:

   1. Darryl Shibata

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable conceptual approach that cell lineage can be determined using methylation data. However, the evidence supporting the claims of the author is currently inadequate. If the author could carry out some additional experiments as well as explore alternative explanations for the current data, this approach could be of broad interest to neuroscientists and developmental biologists.

   Reviewed by eLife

3. AgRP1 modulates breeding season-dependent feeding behavior in female medaka

   This article has 9 authors:

   1. Yurika Tagui
   2. Shingo Takeda
   3. Hiroyo Waida
   4. Shoichi Kitahara
   5. Tomoki Kimura
   6. Shinji Kanda
   7. Yoshitaka Oka
   8. Yu Hayashi
   9. Chie Umatani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides important new insight into the mechanisms underlying seasonal physiology, using medaka fish as a functional genetic model that naturally exhibits photoperiodic responses. The authors provide a range of data that implicate agrp1 in feeding regulation in response to photoperiod and reproductive status. This paper provides solid evidence connecting the effects of long and short photoperiods on the food intake of female medaka fish and egg production. It will be of relevance for biologists interested in understanding the molecular and cellular underpinnings of environmental effects on animal biology.

   Reviewed by eLife

4. The value of initiating a pursuit in temporal decision-making

   This article has 4 authors:

   1. Elissa Sutlief
   2. Charlie Walters
   3. Tanya Marton
   4. Marshall G Hussain Shuler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper undertakes a valuable theoretical treatment of the potential role of foraging-related concepts in several forms of intertemporal choice. While the computational evidence and methodologies employed are novel, some issues with clarity and generality result in incomplete support for the paper's claims.

   Reviewed by eLife

5. β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury

   This article has 11 authors:

   1. Renaud Prével
   2. Erwan Pernet
   3. Kim A Tran
   4. Abderrahmane Sadek
   5. Mina Sadeghi
   6. Elizabeth Lapshina
   7. Leonardo Jurado
   8. Arnold S Kristof
   9. Mohieddine Moumni
   10. Jérémie Poschmann
   11. Maziar Divangahi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of maladaptive innate immune training. The experimental evidence supporting the conclusions is convincing with only a few clarifications required. The work will be of high interest to both researchers in the trained immunity field and clinician scientists.

   Reviewed by eLife

6. Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

   This article has 4 authors:

   1. Bhanu Shrestha
   2. Jiun Sang
   3. Suman Rimal
   4. Youngseok Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful contribution to our understanding of taste perception. The idea that specific receptors function in the pharynx to mediate responses to carboxylic acids is interesting, although the expression analysis is incomplete. Reviewers also have a number of other suggestions for improvement, including the request that authors provide more details about the methodology used. In general, the claims are supported by solid evidence and add to a growing body of literature on this topic.

   Reviewed by eLife, preLights

7. Structure of human PIEZO1 and its slow inactivating channelopathy mutants

   This article has 7 authors:

   1. Yuanyue Shan
   2. Xinyi Guo
   3. Mengmeng Zhang
   4. Meiyu Chen
   5. Ying Li
   6. Mingfeng Zhang
   7. Duanqing Pei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful revised manuscript that shows a set of data including the first cryo-EM structures of human PIEZO1 as well as structures of disease-related mutants in complex with the regulatory subunit MDFIC, which generate different inactivation phenotypes. The molecular basis of PIEZO channel inactivation is of great interest due to its association with several pathologies. This manuscript provides some structural insights that may help to ultimately build a molecular picture of PIEZO channel inactivation. While the structures are of use and clear conformational differences can be seen in the presence of the auxiliary subunit MDFIC, the strength of the evidence supporting the conclusions of the paper, especially the proposed role for pore lipids in inactivation, is incomplete.

   Reviewed by eLife

8. Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

   This article has 5 authors:

   1. Hans Kirschner
   2. Hanna M Molla
   3. Matthew R Nassar
   4. Harriet de Wit
   5. Markus Ullsperger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports on the effects of a single dose of methamphetamine vs placebo on a probabilistic reversal learning task with different levels of noise, in a large group of young healthy volunteers. The paper is well written and the methods are rigorous. The findings are valuable and have theoretical or practical implications for a subfield. The strength of the evidence is solid, with the methods, data, and analyses broadly supporting the claims with only minor weaknesses.

   Reviewed by eLife

9. Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

   This article has 15 authors:

   1. Zhengming Tian
   2. Feiyang Jin
   3. Zirui Xu
   4. Yakun Gu
   5. Mengyuan Guo
   6. Yuning Li
   7. Qianqian Shao
   8. Yingxia Liu
   9. Hanjiang Luo
   10. Yue Wang
   11. Suyu Zhang
   12. Chenlu Yang
   13. Xin Liu
   14. Xunming Ji
   15. Jia Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable paper seeks to determine the role of endogenous CNS hemoglobin in protecting mitochondrial homeostasis in hypoxia. There is merit in the work, although it remains incomplete as there is a question as to the validity of the hypoxia model as relevant to CNS-specific ischemia/hypoxia that should be considered. In particular, a whole-body hypoxia model may liberate exosomes from other hypoxic organs, which should be addressed by the authors. Overall, this work has the potential to be of broad interest to the neuroscience and hypoxia communities.

   Reviewed by eLife

10. The replication principle revisited: a shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates

    This article has 17 authors:

    1. Gianpaolo Antonio Basile
    2. Augusto Ielo
    3. Lilla Bonanno
    4. Antonio Cerasa
    5. Giuseppe Santoro
    6. Demetrio Milardi
    7. Giuseppe Pio Anastasi
    8. Ambra Torre
    9. Sergio Baldari
    10. Riccardo Laudicella
    11. Michele Gaeta
    12. Marina Quartu
    13. Maria Pina Serra
    14. Marcello Trucas
    15. Angelo Quartarone
    16. Manojkumar Saranathan
    17. Alberto Cacciola

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents a useful characterisation of the topographical organisation of the human pulvinar, an associative thalamic subregion crucial for visual perception and attention. The evidence supporting the conclusions is solid given the multimodal validation and replication across datasets, although even higher-resolution imaging data would have strengthened the study. The manuscript would also be strengthened by clarifying how the work extends previous assessments of thalamic connectivity and expanding the results with a more digested interpretation of the findings and validation of the segmentation quality. With these components strengthened, the work would be of interest to neuroscientists, neurologists, and neuropsychiatrists working on pulvinar functioning in health and disease.

    Reviewed by eLife