eLife

Latest preprint reviews

1. Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in C. elegans

   This article has 11 authors:

   1. Sarah J Benbow
   2. Aleen D Saxton
   3. Misa Baum
   4. Rikki L Uhrich
   5. Jade G Stair
   6. Kelly Keene
   7. Chloe Dahleen
   8. Linda Wordeman
   9. Nicole F Liachko
   10. Rebecca L Kow
   11. Brian C Kraemer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using a genetic screen in C. elegans, Benbow et al., identify mutations in alpha-tubulin genes that suppress Tau-induced neurodegenerative phenotypes. The results provide solid support the authors' claim that the tubulin mutants protect against neurodegeneration without altering tau aggregation and hyperphosphorylation. While precise mechanisms of protection by tubulin mutants remain to be established, the results are valuable for understanding the underlying cellular mechanisms of Tauopathies and for the development of therapeutic interventions.

   Reviewed by eLife

2. Hippocampal neuronal and astrocytic responses to noradrenaline and natural arousal

   This article has 7 authors:

   1. Sian N Duss
   2. Maria Wilhelm
   3. Alina-Mariuca Marinescu
   4. Runzhong Zhang
   5. Fritjof Helmchen
   6. Johannes Bohacek
   7. Peter Rupprecht

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work uses a sophisticated combination of neuromodulator imaging, optogenetics, and two-photon calcium imaging to examine how locus coeruleus-mediated norepinephrine signaling influences distinct hippocampal cell types. The evidence is solid and provides novel insights into cell type-specific responses to norepinephrine release. However, the conclusions would be strengthened by a more thorough analysis of the differences between locomotion-associated activity and optogenetic stimulation of the locus coeruleus.

   Reviewed by eLife

3. Reduction of complex dynamic touch information to a single stable perceptual feature

   This article has 7 authors:

   1. Naghmeh Zamani
   2. Benjamin Stephens-Fripp
   3. Chase Tymms
   4. Sonny Chan
   5. Roham Pardakhtim
   6. Heather Culbertson
   7. Jess Hartcher-O’Brien

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding that perception of a material's properties and hardness during brief touches can be altered using only vibrotactile feedback. The user studies show that vibration energy can influence judgements of material hardness, but the evidence is incomplete to support the broader claim made by the authors that spectral energy is the dominant feature governing hardness perception.

   Reviewed by eLife

4. Transcriptional profiling of extraocular motor neurons reveals sim1a as a candidate strabismus-related gene

   This article has 9 authors:

   1. Emily Gershowitz
   2. Kyla Rose Hamling
   3. Başak Rosti
   4. Hannah Gelnaw
   5. Grace Xiang
   6. Cheryl Quainoo
   7. Dena Goldblatt
   8. Paige Leary
   9. David Schoppik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study adds important data on the transcriptional identity of the motor neurons innervating eye muscles in larval zebrafish, and shows how disruption to a specific gene, sim1a, impairs the movements of the eye. The evidence supporting the claims is convincing, with bulk and single-cell RNA sequencing as well as functional testing of the vestibulo-ocular reflex. This work will be of interest to developmental biologists and eye movement specialists.

   Reviewed by eLife

5. Dopamine ramps as a normative consequence of dual-process control

   This article has 2 authors:

   1. Luke Priestley
   2. Thomas Akam

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study developed a novel theory to account for various aspects of dopamine signals, particularly dopamine ramps. The authors propose that dopamine reward prediction error (RPE) signals are generated by a dual-process learning system in which values inferred by a model-based system enter the RPE asymmetrically into the update target but not the prediction. The results are well-presented and convincing, and make a contribution that is of importance to the field. This work will be of interest to those studying dopamine specifically or brain learning computations and systems more broadly.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.64898/2025.12.18.694444

7. Hierarchical priors enable neural prediction of perceived biological motion

   This article has 3 authors:

   1. Ingmar EJ de Vries
   2. Floris P de Lange
   3. Moritz F Wurm

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, de Vries and colleagues aim to determine how the perception of biological motion is organized at the neural level, specifically testing whether this process rests on hierarchical predictive processing by extending a methodological framework that the authors previously published. The evidence is solid for the empirical claim that neural representations of body motion systematically lead the stimulus in time, with simulations validating the regression approach and consistent effects on both peak magnitude and peak latency. Support for the stronger theoretical interpretation that these signatures specifically reflect active hierarchical predictive inference requires further substantiation, since the design and analysis do not distinguish such inference from cached associative retrieval or from nonlinear temporal integration of slowly varying features.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.08.27.672681

9. Ecological diversification in rapidly evolving populations

   This article has 2 authors:

   1. Daniel PGH Wong
   2. Benjamin H Good

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important theoretical contribution, the authors study the evolution of large microbial populations competing for resources in the challenging and relevant regime of overlapping ecological and evolutionary timescales. The modeling approach is overall convincing, anlthough its presentation would benefit from clarifications, e.g. on assumptions and approximations. The results will be of broad interest to researchers in evolutionary biology, ecology and microbiology.

   Reviewed by eLife

10. Proteolytic remodeling by Yme1 enables mitochondrial-derived compartment formation

    This article has 4 authors:

    1. Sai Sangeetha Balasubramaniam
    2. Amy E Curtis
    3. Jonathan R Friedman
    4. Adam L Hughes

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study demonstrates that the inner membrane protease YME1 contributes to the formation of mitochondrial-derived compartments in yeast through the modulation of both the lipid transporter UPS2 and the MICOS complex. The evidence supporting this model is solid, although this manuscript could be improved by providing additional evidence supporting the independent roles for UPS2 and MICOS regulation in this process. This work will be of interest to cell biologists, biochemists, and geneticists interested in understanding the molecular basis of mitochondrial regulation and function.

    Reviewed by eLife