eLife

Latest preprint reviews

1. Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

   This article has 21 authors:

   1. Carolyn M Jablonowski
   2. Waise Quarni
   3. Shivendra Singh
   4. Haiyan Tan
   5. Dhanushka Hewa Bostanthirige
   6. Hongjian Jin
   7. Jie Fang
   8. Ti-Cheng Chang
   9. David Finkelstein
   10. Ji-Hoon Cho
   11. Dongli Hu
   12. Vishwajeeth Pagala
   13. Sadie Miki Sakurada
   14. Shondra M Pruett-Miller
   15. Ruoning Wang
   16. Andrew Murphy
   17. Kevin Freeman
   18. Junmin Peng
   19. Andrew M Davidoff
   20. Gang Wu
   21. Jun Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports on key characteristics of MYC-driven cancers: dysregulated pre-mRNA splicing and altered metabolism, with the data being overall solid. The manuscript should be of broad interest to cancer biologists due to its therapeutic implications.

   Reviewed by eLife

2. Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

   This article has 15 authors:

   1. Preksha Gaur
   2. Yesheswini Rajendran
   3. Bhagyashree Srivastava
   4. Manasvini Markandey
   5. Vered Fishbain-Yoskovitz
   6. Gayatree Mohapatra
   7. Aamir Suhail
   8. Shikha Chaudhary
   9. Shaifali Tyagi
   10. Subhash Chandra Yadav
   11. Amit Kumar Pandey
   12. Yifat Merbl
   13. Avinash Bajaj
   14. Vineet Ahuja
   15. Chittur Srikanth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study for understanding the pathogenesis of ulcerative colitis. It convincingly demonstrates reduced levels of the vesicular trafficking protein Rab7 in ulcerative colitis and Crohn's disease, leading to altered levels of calcium-activated chloride channel regulator 1 (CLCA1) and subsequent mucin dysregulation, highlighting Rab7's significance in gut homeostasis maintenance. The manuscript advances the field as it provides insights into a novel regulatory pathway implicated in ulcerative colitis, potentially paving the way for the development of targeted therapeutic interventions.

   Reviewed by eLife

3. Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase

   This article has 11 authors:

   1. Manon Boulet
   2. Guerric Gilbert
   3. Yoan Renaud
   4. Martina Schmidt-Dengler
   5. Emilie Plantié
   6. Romane Bertrand
   7. Xinsheng Nan
   8. Tomasz Jurkowski
   9. Mark Helm
   10. Laurence Vandel
   11. Lucas Waltzer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study investigates the presence of DNA adenine methylation (6mA) and the associated function of TET enzyme, a DNA methylation mark eraser, in Drosophila. The study presents valuable findings on the scarcity of 6mA in the Drosophila genome and challenges previous findings regarding the role of TET in 6mA modification. The evidence supporting the claims is solid, and the paper has the potential to stimulate re-evaluations of the significance and regulatory mechanisms of 6mA DNA modifications in Drosophila.

   Reviewed by eLife

4. Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

   This article has 6 authors:

   1. F Javier DeHaro-Arbona
   2. Charalambos Roussos
   3. Sarah Baloul
   4. Jonathan Townson
   5. María J Gómez Lamarca
   6. Sarah Bray

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study advances our understanding of how Notch signaling activates transcription by analyzing dynamics of the Mastermind transcriptional co-activator and its role in the activation complex. The evidence is compelling and based on state of the art methods with precise quantitative measurements.

   Reviewed by eLife

5. Human receptive endometrial organoid for deciphering the implantation window

   This article has 15 authors:

   1. Yu Zhang
   2. Rusong Zhao
   3. Chaoyan Yang
   4. Jinzhu Song
   5. Peishu Liu
   6. Yan Li
   7. Boyang Liu
   8. Tao Li
   9. Changjian Yin
   10. Minghui Lu
   11. Zhenzhen Hou
   12. Chuanxin Zhang
   13. Zi-Jiang Chen
   14. Keliang Wu
   15. Han Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable development of endometrial organoid culture methodology that mimics the window of implantation. Functional validation to demonstrate its robustness is lacking; therefore, the study is considered incomplete. The data may be interesting to embryologists and investigators working on reproductive biology and medicine.

   Reviewed by eLife

6. Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

   This article has 19 authors:

   1. Michael J Currie
   2. James S Davies
   3. Mariafrancesca Scalise
   4. Ashutosh Gulati
   5. Joshua D Wright
   6. Michael C Newton-Vesty
   7. Gayan S Abeysekera
   8. Ramaswamy Subramanian
   9. Weixiao Y Wahlgren
   10. Rosmarie Friemann
   11. Jane R Allison
   12. Peter D Mace
   13. Michael DW Griffin
   14. Borries Demeler
   15. Soichi Wakatsuki
   16. David Drew
   17. Cesare Indiveri
   18. Renwick CJ Dobson
   19. Rachel A North

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The current manuscript presents a cryo-EM structure of a tripartite ATP-independent periplasmic (TRAP) transporter that contributes to Haemophilus influenzae virulence. Convincing biophysical and cryo-EM experiments yield a valuable molecular model, but the functional importance of some of the molecular features identified remains to be demonstrated.

   Reviewed by eLife

7. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2212.00741v2

8. Cryo-EM structure of the CBC-ALYREF complex

   This article has 6 authors:

   1. Bradley P Clarke
   2. Alexia E Angelos
   3. Menghan Mei
   4. Pate S Hill
   5. Yihu Xie
   6. Yi Ren

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports the cryo-electron microscopy structure of a multi-protein complex that recognizes the 5'-end cap of mRNAs and plays a critical role in mRNA export. The structural and biochemical analyses in this study provide convincing evidence to support the major claims of the authors, with the inclusion of more functional characterizations in cell-based systems having corroborated the claims further and and thus strengthening the study. This paper would be of interest to structural biologists and RNA biologists working on mRNA metabolism.

   Reviewed by eLife

9. A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

   This article has 7 authors:

   1. Amy Tresenrider
   2. Marcus Hooper
   3. Levi Todd
   4. Faith Kierney
   5. Nicolai A Blasdel
   6. Cole Trapnell
   7. Thomas A Reh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript used the sci-Plex system for screening compounds to improve the Ascl1-induced reprogramming from Müller glia to bipolar neurons in vitro, followed by in vivo characterization of two promising compounds in mice. The findings are valuable for future studies to develop cell replacement strategies for treatment of retinal degeneration. The strength of evidence is solid, featuring a scalable drug screening design, albeit with limited mechanistic insights.

   Reviewed by eLife

10. Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex

    This article has 5 authors:

    1. Sara Ibañez
    2. Nilapratim Sengupta
    3. Jennifer I Luebke
    4. Klaus Wimmer
    5. Christina M Weaver

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This manuscript reports a valuable computational study of the effects of axon de-myelination and re-myelination on action potential speed and propagation failure. The manuscript presents solid evidence for the effects of de- and re-myelination in different models of working memory, with potential implications in disorders such as multiple sclerosis. The exposition of the manuscript is targeted for researchers interested in biophysical models of cognitive deficits.

    Reviewed by eLife