eLife

Latest preprint reviews

1. An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

   This article has 4 authors:

   1. Shang Geng
   2. Xing Lv
   3. Weiwei Zheng
   4. Tianjun Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows that in teleost fish, the RIG-I-like protein MDA5 can compensate for the absence of RIG-I by detecting 5'-triphosphorylated RNA. A fish virus containing such RNA can nevertheless evade MDA5 detection through a mechanism involving m6A methylation-induced silencing. The conclusions, which are supported by solid data, advance our understanding of antiviral immunity and virus-host conflicts in vertebrates.

   Reviewed by eLife

2. Modulation of biophysical properties of nucleocapsid protein in the mutant spectrum of SARS-CoV-2

   This article has 8 authors:

   1. Ai Nguyen
   2. Huaying Zhao
   3. Dulguun Myagmarsuren
   4. Sanjana Srinivasan
   5. Di Wu
   6. Jiji Chen
   7. Grzegorz Piszczek
   8. Peter Schuck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript provides new insights into the biophysics of the SARS-CoV-2 nucleocapsid. The evidence, which relies on a convincing combination of genetic and biophysical data, nicely supports the conclusions.

   Reviewed by eLife

3. Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

   This article has 10 authors:

   1. Qiong He
   2. Miao-Miao Zhao
   3. Ming-Jia Li
   4. Xiao-Ya Li
   5. Jian-Min Jin
   6. Ying-Mei Feng
   7. Li Zhang
   8. Wei Jin Huang
   9. Fangyuan Yang
   10. Jin-Kui Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of why diabetes is a risk factor for more severe Covid-19 disease. The authors offer convincing evidence that cathepsin L is more active in diabetic individuals because of the presence of high glucose, where the main mechanism is increased cathepsin L maturation. This study should be of interest to researchers in diabetes, virology and immunology.

   Reviewed by eLife

4. PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

   This article has 17 authors:

   1. Marcel Proske
   2. Robert Janowski
   3. Sabrina Bacher
   4. Hyun-Seo Kang
   5. Thomas Monecke
   6. Tony Koehler
   7. Saskia Hutten
   8. Jana Tretter
   9. Anna Crois
   10. Lena Molitor
   11. Alejandro Varela-Rial
   12. Roberto Fino
   13. Elisa Donati
   14. Gianni De Fabritiis
   15. Dorothee Dormann
   16. Michael Sattler
   17. Dierk Niessing

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study addresses the mechanisms by which mutations in the PURA protein, a regulator of gene transcription and mRNA transport and translation, cause the neurodevelopmental PURA syndrome. Based on convincing evidence from structural biology, molecular dynamics simulation, biochemical, and cell biological analyses, the authors show that the PURA structure is very dynamic, rendering it generally sensitive to structure-altering mutations that affect its folding, DNA-unwinding activity, RNA binding, dimerization, and partitioning into processing bodies. These findings are of substantial importance to cell biology, neurogenetics, and neurology alike, because they provide first insights into how very diverse PURA mutations can cause similar and penetrant molecular, cellular, and clinical defects.

   Reviewed by eLife

5. Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

   This article has 8 authors:

   1. Tristan Gicquel
   2. Fabio Marchiano
   3. Gabriela Reyes-Castellanos
   4. Stephane Audebert
   5. Luc Camoin
   6. Bianca H Habermann
   7. Benoit Giannesini
   8. Alice Carrier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study uses a mouse model of pancreatic cancer to examine mitochondrial mass and structure in atrophying muscle along with aspects of mitochondrial metabolism in the same tissue. Most relevant are the solid transcriptomics and proteomics approaches to map out related changes in gene expression networks in muscle during cancer cachexia.

   Reviewed by eLife

6. Self-inhibiting percolation and viral spreading in epithelial tissue

   This article has 3 authors:

   1. Xiaochan Xu
   2. Bjarke Frost Nielsen
   3. Kim Sneppen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a cellular automaton model to study the dynamics of virus-induced signalling and innate host defense against viruses such as SARS-CoV-2 in epithelial tissue. The simulations and data analysis are convincing and represent a valuable contribution that would be of interest to researchers studying the dynamics of viral propagation.

   Reviewed by eLife

7. TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

   This article has 10 authors:

   1. Maojin Tian
   2. Le Yang
   3. Ziqian Zhao
   4. Jigang Li
   5. Lianqing Wang
   6. Qingqing Yin
   7. Wei Hu
   8. Yunwei Lou
   9. Jianxin Du
   10. Peiqing Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates the molecular mechanisms underpinning how the tumor necrosis factor alpha-induced protein (TIPE) regulates aerobic glycolysis to promote tumor growth in melanoma. Convincing data using multiple independent approaches provides new insights into the molecular mechanisms underpinning aerobic glycolysis in melanoma cells. The work will be of interest to biomedical researchers working in cancer and metabolism.

   Reviewed by eLife

8. FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

   This article has 8 authors:

   1. Yuki Kaneda
   2. Haruhiko Miyata
   3. Zoulan Xu
   4. Keisuke Shimada
   5. Maki Kamoshita
   6. Tatsuya Nakagawa
   7. Chihiro Emori
   8. Masahito Ikawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports that FBXO24 is essential for the normal formation and function of the sperm flagellum, motility, and male fertility in mice. The evidence supporting the direct role of this protein in preventing RNP granule formation in the sperm flagellum is compelling. This work will be of interest to biomedical researchers who work on testicular biology and male fertility.

   Reviewed by eLife

9. A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

   This article has 18 authors:

   1. Swati Jain
   2. Gherman Uritskiy
   3. Marthandan Mahalingam
   4. Himanshu Batra
   5. Subhash Chand
   6. Hung V Trinh
   7. Charles Beck
   8. Woong-Hee Shin
   9. Wadad Alsalmi
   10. Gustavo Kijak
   11. Leigh A Eller
   12. Jerome Kim
   13. Daisuke Kihara
   14. Sodsai Tovanabutra
   15. Guido Ferrari
   16. Merlin L Robb
   17. Mangala Rao
   18. Venigalla B Rao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a detailed evaluation of how HIV evades nascent immune pressure from people living with HIV followed nearly immediately after infection. There is convincing evidence that H173 mutations in the V2 loop was a key determinant of selection pressure and escape. These data are congruent with protection in the RV144 clinical trial, the only trial that showed protection from infection. Overall, this study is an important contribution to the field.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.48550/arxiv.2301.00759v3