eLife

Latest preprint reviews

1. Menopause, Brain Anatomy, Cognition and Alzheimer’s Disease

   This article has 7 authors:

   1. Manuela Costantino
   2. Grace Pigeau
   3. Olivier Parent
   4. Justine Ziolkowski
   5. Gabriel A. Devenyi
   6. Nicole J. Gervais
   7. M. Mallar Chakravarty

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents useful findings from a large sample of participants from the UK Biobank on the relationship between menopause (including status, type, and age of onset), cognition, neuroanatomical measures derived from magnetic resonance imaging, and Alzheimer's disease. The strength of evidence is incomplete, and the study would benefit from clearer methodological descriptions, more careful consideration of potential confounds, and better theoretical integration with prior work in the field. This paper will be of interest to people working in the fields of cognitive neuroscience, endocrinology, and dementia.

   Reviewed by eLife

2. Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination

   This article has 21 authors:

   1. Amber R Philp
   2. Carolina R Reyes
   3. Josselyne Mansilla
   4. Amar Sharma
   5. Chao Zhao
   6. Carlos Valenzuela-Krugmann
   7. Khalil S Rawji
   8. Ginez A Gonzalez Martinez
   9. Penelope Dimas
   10. Bryan Hinrichsen
   11. César Ulloa-Leal
   12. Amie K Waller
   13. Diana M Bessa de Sousa
   14. Maite A Castro
   15. Ludwig Aigner
   16. Pamela Ehrenfeld
   17. Maria Elena Silva
   18. Ilias Kazanis
   19. Cedric Ghevaert
   20. Robin JM Franklin
   21. Francisco J Rivera

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study aims to understand how the regulation of oligodendrocyte progenitor cell (OPC) remyelination and function contributes to the treatment of multiple sclerosis. The authors provide convincing evidence for the platelets mediating OPC differentiation and remyelination. This work will be of interest to several disciplines.

   Reviewed by eLife

3. Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

   This article has 12 authors:

   1. Linda H Kim
   2. Adam P Lognon
   3. Sandeep Sharma
   4. Michelle A Tran
   5. Cecilia Badenhorst
   6. Taylor Chomiak
   7. Stephanie Tam
   8. Claire McPherson
   9. Todd E Stang
   10. Shane EA Eaton
   11. Zelma HT Kiss
   12. Patrick J Whelan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reveals the pro-locomotor effects of activating a deep brain region containing diverse range of neurons in both healthy and Parkinson's disease mouse models. While the findings are solid, mechanistic insights remain limited due to the small sample size. This research is relevant to motor control researchers and offers clinical perspectives.

   Reviewed by eLife

4. The magnitude and time course of pre-saccadic foveal prediction depend on the conspicuity of the saccade target

   This article has 2 authors:

   1. Lisa M Kroell
   2. Martin Rolfs

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports important findings about pre-saccadic foveal prediction and the extent to which it is influenced by the visibility of the saccade target relative to its background. The research methodology and results make a convincing case that foveal congruency effects develop when salient local contrast variations at the saccade target location can be used to direct the eye movement. This work should be of broad interest to visual neuroscientists, as well as those interested in understanding perception in the context of eye movements and in modeling visually guided actions.

   Reviewed by eLife

5. Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies

   This article has 6 authors:

   1. Mathieu C Husser
   2. Nhat P Pham
   3. Chris Law
   4. Flavia RB Araujo
   5. Vincent JJ Martin
   6. Alisa Piekny

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, the authors develop a strategy for fluorophore-tagging endogenous proteins in human induced pluripotent stem cells (iPSCs) using a split mNeonGreen approach, and they conclude that the system will be appropriate for performing live imaging studies of highly dynamic cellular processes such as cytokinesis in iPSCs. Experimentally, the methods are solid, and the data presented support the authors' conclusions. Overall, these methodologies should be useful to a wide audience of cell biologists who want to study protein localization and dynamics at endogenous levels in iPSCs.

   Reviewed by eLife

6. Foveated metamers of the early visual system

   This article has 4 authors:

   1. William F. Broderick
   2. Gizem Rufo
   3. Jonathan Winawer
   4. Eero P. Simoncelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable insights into how researchers can use perceptual metamers to formally explore the limits of visual representations at different processing stages. While the study is overall convincing in terms of approach and results, issues were identified with respect to novelty, sample size, incomplete psychophysical methodology, and better motivation of the models tested.

   Reviewed by eLife

7. Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

   This article has 4 authors:

   1. Yu-Feng Xie
   2. Jane Yang
   3. Stéphanie Ratté
   4. Steven A Prescott

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides an unprecedented understanding of the roles of different combinations of NaV channel isoforms in nociceptors' excitability, with relevance for the design of better strategies targeting NaV channels to treat pain. Although the experimental combination of electrophysiological, modeling, imaging, molecular biology, and behavioral data is convincing and supports the major claims of the work, some results remain inconclusive and need to be strengthened by further evidence. The work may be of broad interest to scientists working on pain, drug development, neuronal excitability, and ion channels.

   Reviewed by eLife

8. β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head

   This article has 14 authors:

   1. Chenjie Xia
   2. Huihui Xu
   3. Liang Fang
   4. Jiali Chen
   5. Wenhua Yuan
   6. Danqing Fu
   7. Xucheng Wang
   8. Bangjian He
   9. Luwei Xiao
   10. Chengliang Wu
   11. Peijian Tong
   12. Di Chen
   13. Pinger Wang
   14. Hongting Jin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on the mechanism of glucocorticoid-induced osteonecrosis of the femoral head. The data were collected and analyzed using solid, validated methodology and can be used as a starting point for functional studies of development of glucocorticoid-induced osteonecrosis. This paper would be of interest to cell biologists and biophysicists working on potential pharmacological treatments for glucocorticoid-induced osteonecrosis.

   Reviewed by eLife

9. RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia

   This article has 10 authors:

   1. Xiaozhuo Yu
   2. Wen Zhou
   3. Xiaodong Chen
   4. Shunyu He
   5. Mengting Qin
   6. Meng Yuan
   7. Yang Wang
   8. Woodvine Otieno Odhiambo
   9. Yinsha Miao
   10. Yanhong Ji

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using a set of animal models, this valuable paper shows tumor suppressive function of the non-core regions of RAG1/2 recombinases. The conclusions are supported by solid evidence.

   Reviewed by eLife

10. Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    This article has 13 authors:

    1. Zijing Wang
    2. Bihan Xia
    3. Shaochong Qi
    4. Xian Zhang
    5. Xiaoshuang Zhang
    6. Yan Li
    7. Huimin Wang
    8. Miao Zhang
    9. Ziyi Zhao
    10. David Kerr
    11. Li Yang
    12. Shijie Cai
    13. Jilin Yang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The findings of this valuable manuscript advance our understanding of the significance of Bestrophin isoform 4 (BEST4) in suppressing colorectal cancer (CRC) progression. The authors used appropriate and validated methodology, such as the knockout of BEST4 using CRISPR/Cas9 in CRC cells, to provide a solid foundation for elucidating the potential link between BEST4 and CRC progression.

    Reviewed by eLife