eLife

Latest preprint reviews

1. A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides

   This article has 15 authors:

   1. Malik Zohaib Ali
   2. Taru S Dutt
   3. Amy MacNeill
   4. Amanda Walz
   5. Camron Pearce
   6. Ha Lam
   7. Jamie S Philp
   8. Johnathan Patterson
   9. Marcela Henao-Tamayo
   10. Richard Lee
   11. Jiuyu Liu
   12. Gregory T Robertson
   13. Anthony J Hickey
   14. Bernd Meibohm
   15. Mercedes Gonzalez Juarrero

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this useful study, the authors report the efficacy, hematological effects, and inflammatory response of the BPaL regimen (containing bedaquiline, pretomanid, and linezolid) compared to a variation in which Linezolid is replaced with the preclinical development candidate spectinamide 1599, administered by inhalation in tuberculosis-infected mice. The authors provide convincing evidence that supports the replacement of Linezolid in the current standard of care for drug-resistant tuberculosis. The work will be of interest to those studying tuberculosis treatment regimens.

   Reviewed by eLife

2. Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

   This article has 11 authors:

   1. Wenjing Liu
   2. Shujin Li
   3. Mu Yang
   4. Jie Ma
   5. Lu Liu
   6. Ping Fei
   7. Qianchun Xiang
   8. Lulin Huang
   9. Peiquan Zhao
   10. Zhenglin Yang
   11. Xianjun Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study explores the role of calcyphosine-like (CAPSL) in Familial Exudative Vitreoretinopathy (FEVR) via the MYC pathway, offering valuable insights into disease mechanisms that are supported by a solid, multi-pronged approach. The manuscript, which presents the phenotype of an interesting new mouse model, provides convincing evidence that CAPSL variants cause disease.

   Reviewed by eLife

3. Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoids

   This article has 13 authors:

   1. Wei Jie Wong
   2. Yi Wen Zhu
   3. Hai Ting Wang
   4. Jia Wen Qian
   5. Ziyi Li
   6. Song Li
   7. Zhao Yuan Liu
   8. Wei Guo
   9. Shuang Yan Zhang
   10. Bing Su
   11. Fang Ping He
   12. Kang Wang
   13. Florent Ginhoux

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on the mechanisms underlying a rare brain disease using an organoid system. In this revised version, there are remaining reviewers' comments that are not yet addressed and as such, while the data presented are solid, the evidence supporting some of the claims is deemed incomplete. The work will be of interest to neuroscientists and clinicians aiming to understand and combat similar neurodegenerative disorders.

   Reviewed by eLife

4. Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

   This article has 6 authors:

   1. Yuqi Cai
   2. Zhirong Zhao
   3. Mingyue Shi
   4. Mingfang Zheng
   5. Ling Gong
   6. Miao He

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study the authors revisited the question of the embryonic origin of telencephalic oligodendrocytes using some new and powerful genetic tools. There is convincing evidence to support previous suggestions of a predominantly cortical origin of oligodendrocytes in the cerebral cortex, however the new studies suggest that LGE/CGE-derived oligodendrocytes make a modest contribution in some areas, while MGE/POA-derived oligodendrocytes make a small but enduring contribution. The findings are valuable and should be of interest to developmental and myelin biologists.

   Reviewed by eLife

5. Chemokine expression profile of an innate granuloma

   This article has 5 authors:

   1. Megan E Amason
   2. Cole J Beatty
   3. Carissa K Harvest
   4. Daniel R Saban
   5. Edward A Miao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances the understanding of granuloma formation by identifying a key chemokine receptors in containing infection by a specific species of bacteria. The evidence supporting this is solid, providing a spatial transcriptomic dataset spanning granuloma formation and resolution by a specific species of bacteria. The work should be of interest to microbiologists and immunologists.

   Reviewed by eLife

6. LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

   This article has 22 authors:

   1. Giulia Tombesi
   2. Shiva Kompella
   3. Giulia Favetta
   4. Chuyu Chen
   5. Marta Ornaghi
   6. Yibo Zhao
   7. Ester Morosin
   8. Martina Sevegnani
   9. Adriano Lama
   10. Antonella Marte
   11. Ilaria Battisti
   12. Lucia Iannotta
   13. Nicoletta Plotegher
   14. Laura Civiero
   15. Franco Onofri
   16. Britta J Eickholt
   17. Giovanni Piccoli
   18. Giorgio Arrigoni
   19. Dayne Beccano-Kelly
   20. Claudia Manzoni
   21. Loukia Parisiadou
   22. Elisa Greggio

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work begins to understand how BDNF regulates the phosphorylation and activity of LRRK2. The overall strength of evidence has been assessed as compelling, though some claims are only partially supported. The work will be of interest for those that might pursue specific LRRK2 interactions and mutational effects on these pathways as the work continues to develop.

   Reviewed by eLife

7. Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

   This article has 8 authors:

   1. Katrina Bartas
   2. Pieter Derdeyn
   3. Guilian Tian
   4. Jose J Vasquez
   5. Ghalia Azouz
   6. Cindy M Yamamoto
   7. May Hui
   8. Kevin T Beier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study by Bartas and colleagues examined how patterns of monosynaptic input to specific cell types in the ventral tegmental area are altered by drugs of abuse. The authors applied a dimensionality reduction approach (principal component analysis) and showed that various drugs of abuse, and somewhat surprisingly the anesthesia alone (ketamine/xylasin), caused changes in the distribution of inputs labeled by the transsynaptic rabies virus. The evidence supporting the conclusions is overall convincing and provides foundational information, as well as a cautionary note on the interpretation of rabies virus-based tracing experiments.

   Reviewed by eLife

8. Identification of an early subset of cerebellar nuclei neurons in mice

   This article has 8 authors:

   1. Maryam Rahimi-Balaei
   2. Shayan Amiri
   3. Thomas Lamonerie
   4. Sih-Rong Wu
   5. Huda Y Zoghbi
   6. G Giacomo Consalez
   7. Daniel Goldowitz
   8. Hassan Marzban

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors are interested in the developmental origin of the neurons of the cerebellar nuclei. In this study, they identify a population of neurons with a specific complement of markers that originate in a distinct location from where cerebellar nuclear precursor cells have been thought to originate that show distinct developmental properties. The discovery of a new germinal zone giving rise to a new population of neurons is an exciting finding, and it enriches our understanding of cerebellar development. The important claims, better explained in the current version, are well supported by solid evidence with the authors using a wide range of technical approaches, including transgenic mice that allow them to disentangle the influence of distinct developmental organizers

   Reviewed by eLife

9. Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

   This article has 7 authors:

   1. Felix Michaud
   2. Ruggiero Francavilla
   3. Dimitry Topolnik
   4. Parisa Iloun
   5. Suhel Tamboli
   6. Frederic Calon
   7. Lisa Topolnik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study describes fundamental findings related to early disruptions in disinhibitory modulation exerted by VIP+ interneurons, in CA1 in a transgenic model of Alzheimer's disease pathology. The authors provide a compelling analysis at the cellular, synaptic, network, and behavioral levels on how these changes correlate and might be related to behavioral impairments during these early stages of AD pathology.

   Reviewed by eLife

10. Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species

    This article has 16 authors:

    1. Hans Martin Kjer
    2. Mariam Andersson
    3. Yi He
    4. Alexandra Pacureanu
    5. Alessandro Daducci
    6. Marco Pizzolato
    7. Tim Salditt
    8. Anna-Lena Robisch
    9. Marina Eckermann
    10. Mareike Töpperwien
    11. Anders Bjorholm Dahl
    12. Maria Louise Elkjær
    13. Zsolt Illes
    14. Maurice Ptito
    15. Vedrana Andersen Dahl
    16. Tim B Dyrby

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study presents new observations on white matter organisation at the micron scale, using a combination of synchrotron imaging and diffusion MRI across two species. Notably, the authors provide solid evidence for the fasciculation of axons within major fibre bundles into laminar structures, though these structures are not consistently observed across modalities or species. The study will be of general interest to neuroanatomists and those interested in white matter imaging.

    Reviewed by eLife