eLife

Latest preprint reviews

1. RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals

   This article has 4 authors:

   1. Rinako Miyano
   2. Hirokazu Sakamoto
   3. Kenzo Hirose
   4. Takeshi Sakaba

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Miyano et al. study the impact of RIM-BP2 deletion at mossy fiber synapses, using direct electrophysiological recordings from mossy terminals and STED super-resolution microscopy. The paper addresses an important question in the field of synaptic transmission and provides compelling evidence demonstrating reduced calcium channel abundance in mossy terminals upon RIM-BP2 removal.

   Reviewed by eLife

2. osl-dynamics, a toolbox for modeling fast dynamic brain activity

   This article has 7 authors:

   1. Chetan Gohil
   2. Rukuang Huang
   3. Evan Roberts
   4. Mats WJ van Es
   5. Andrew J Quinn
   6. Diego Vidaurre
   7. Mark W Woolrich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present a comprehensive set of tools to compactly characterize the time-frequency interactions across a network. The utility of the toolbox is compelling and demonstrated through a series of exemplar brain imaging datasets. This fundamental work adds to the repertoire of techniques that can be used to study high-dimensional data.

   Reviewed by eLife

3. Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

   This article has 9 authors:

   1. Natalia E Ketaren
   2. Fred D Mast
   3. Peter C Fridy
   4. Jean Paul Olivier
   5. Tanmoy Sanyal
   6. Andrej Sali
   7. Brian T Chait
   8. Michael P Rout
   9. John D Aitchison

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important insights on the impact of SARS-CoV-2 variants on the binding and neutralization of a small library of nanobodies. The authors should be applauded for their comprehensive in vitro and in silico analyses of nanobody targeting of SARS-CoV-2 variants. The evidence supporting the claims of the authors is now convincing. This work will be of great interest to researchers in the fields of antibody/nanobody engineering and SARS-CoV-2 therapeutics.

   Reviewed by eLife

4. Neural interactions in the human frontal cortex dissociate reward and punishment learning

   This article has 7 authors:

   1. Etienne Combrisson
   2. Ruggero Basanisi
   3. Maelle CM Gueguen
   4. Sylvain Rheims
   5. Philippe Kahane
   6. Julien Bastin
   7. Andrea Brovelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important information-theoretic re-analysis of human intracranial recordings during reward and punishment learning. It provides convincing evidence that reward and punishment learning is represented in overlapping regions of the brain while relying on specific inter-regional interactions. This preprint will be interesting to researchers in systems and cognitive neuroscience.

   Reviewed by eLife

5. Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

   This article has 8 authors:

   1. Louis Richevaux
   2. Dongkyun Lim
   3. Mérie Nassar
   4. Léa Dias Rodrigues
   5. Constanze Mauthe
   6. Ivan Cohen
   7. Nathalie Sol-Foulon
   8. Desdemona Fricker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Richevaux and colleagues conducted a valuable study that investigated the integration of thalamic and retrosplenial inputs in the dorsal presubiculum, an essential hippocampal region involved in spatial navigation and memory. Through ex vivo optogenetic electrophysiological experiments, they discovered that many presubicular pyramidal cells receive convergent inputs from both the anterior thalamus and the retrosplenial cortex. These solid findings provide a potential cellular mechanism for anchoring the brain's internal compass to external landmarks, shedding light on how the brain integrates spatial information with an animal's sense of its position in space.

   Reviewed by eLife

6. Assembly of neuron- and radial glial-cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons

   This article has 9 authors:

   1. Ayumu Mubuchi
   2. Mina Takechi
   3. Shunsuke Nishio
   4. Tsukasa Matsuda
   5. Yoshifumi Itoh
   6. Chihiro Sato
   7. Ken Kitajima
   8. Hiroshi Kitagawa
   9. Shinji Miyata

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The solid study addresses the role of extracellular matrix (ECM) in neuronal migration. The authors showed that the interaction between the ternary complex formed by tenascin-C, the chondroitin sulfate proteoglycan neurocan, and hyaluronic acid is important for the multipolar to bipolar transition in the intermediate zone (IZ) of the developing cortex

   Reviewed by eLife

7. Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy

   This article has 8 authors:

   1. Sang-Hyeon Hann
   2. Seon-Yong Kim
   3. Ye Lynne Kim
   4. Young-Woo Jo
   5. Jong-Seol Kang
   6. Hyerim Park
   7. Se-Young Choi
   8. Young-Yun Kong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work by Hann et al. advances our understanding of the role of the survival motor neuron (SMN) protein in coordinating pathogenesis of the spinal muscular atrophy (SMA). The authors addressed many concerns raised by the reviewers, providing convincing evidence in terms of skeletal analyses not being able to satisfactorily elucidate SMN regulation of bone development.

   Reviewed by eLife

8. The larva and adult of Helicoverpa armigera use differential gustatory receptors to sense sucrose

   This article has 8 authors:

   1. Shuai-Shuai Zhang
   2. Pei-Chao Wang
   3. Chao Ning
   4. Ke Yang
   5. Guo-Cheng Li
   6. Lin-Lin Cao
   7. Ling-Qiao Huang
   8. Chen-Zhu Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies the gustatory receptors for sugar sensing in the larval and adult forms of the cotton bollworm, which is responsible for the destruction of many food crops world-wide. The authors find that the larval and adult forms utilise different receptors to sense sugars. The data are convincing and will be of interest neuroscientists working in sensory coding of sugars and to the pest management field.

   Reviewed by eLife

9. Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China

   This article has 16 authors:

   1. Wenhui Zhang
   2. Yan Wang
   3. Min Qu
   4. Haoqing Shi
   5. Xin Lu
   6. Qingsong Yang
   7. Fang Liu
   8. Tao Wang
   9. Ziwei Wang
   10. Bijun Lian
   11. Ling Chen
   12. Xiaoyi Yin
   13. Yongwei Yu
   14. Jing Li
   15. Xu Gao
   16. Zhuan Liao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable report on the first warm autopsy case of a metastatic prostate cancer patient and the follow-up genomic and epigenomic analysis. The evidence supporting the claims of the authors is solid, although inclusion of more discussion of the study limitation and elaboration of mechanistic link for TP53, CDK12, and CDKN1B mutations would have strengthened the study. The work will be of interest to medical biologists working on prostate cancer.

   Reviewed by eLife

10. Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation

    This article has 8 authors:

    1. Thi Thom Mac
    2. Teddy Fauquier
    3. Nicolas Jullien
    4. Pauline Romanet
    5. Heather Etchevers
    6. Anne Barlier
    7. Frederic Castinetti
    8. Thierry Brue

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study examines the effects of NFKB2 mutations on pituitary gland development through hypothalamic-pituitary organoids. The evidence supporting the main conclusions is solid, although analysis of additional clones to exclude inter-clone variability would strengthen the conclusions. This is a revised study, but insight into the mechanism of action of NFKB2 during pituitary development is incomplete. This work will be of interest to endocrinologists and biologists working on pituitary gland development and disease.

    Reviewed by eLife