eLife

Latest preprint reviews

1. Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development

   This article has 13 authors:

   1. Pénélope Tignard
   2. Karen Pottin
   3. Audrey Geeverding
   4. Mohamed Doulazmi
   5. Mélody Cabrera
   6. Coralie Fouquet
   7. Mathilde Liffran
   8. Jonathan Fouchard
   9. Marion Rosello
   10. Shahad Albadri
   11. Filippo Del Bene
   12. Alain Trembleau
   13. Marie Anne Breau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes the function of Laminin y1-dependent basement membranes in development of the olfactory placode, including morphogenesis of the placode, boundary formation, and olfactory axonal pathfinding. The study uses elegant live imaging approaches and extensive quantitative analyses, combined with detailed mutant analyses to provide a compelling description of the role of Laminin in olfactory placode development. In addition to the contributions this study makes to understanding olfactory placode development, it will also be of broader interest to individuals studying extracellular matrix regulation of tissue morphogenesis, and neural development including neuronal pathfinding.

   Reviewed by eLife

2. Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

   This article has 6 authors:

   1. Rajan M Thomas
   2. Matthew C Pahl
   3. Liqing Wang
   4. Struan FA Grant
   5. Wayne W Hancock
   6. Andrew D Wells

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This comprehensive study provides valuable information on the cooperation of Ikaros with Foxp3 to establish and regulate a major portion of the epigenome and transcriptome of T-regulatory cells. While the data are compelling, the evidence that these features are solely intrinsic, independent of the micro-environment, could be strengthened.

   Reviewed by eLife

3. Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

   This article has 8 authors:

   1. Angel D'Oliviera
   2. Xuhang Dai
   3. Saba Mottaghinia
   4. Sophie Olson
   5. Evan P Geissler
   6. Lucie Etienne
   7. Yingkai Zhang
   8. Jeffrey S Mugridge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides important structural insights into the recognition and degradation of the host tRNA methyltransferase TRMT1 by SARS-CoV-2 protease nsp5 (Mpro). The data provide compelling support for the main conclusions of the authors. These results will be of interest to researchers studying structures, substrate recognition and specificity of viral proteases and their action on cellular targets.

   Reviewed by eLife

4. A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

   This article has 14 authors:

   1. Pattama Wiriyasermkul
   2. Satomi Moriyama
   3. Masataka Suzuki
   4. Pornparn Kongpracha
   5. Nodoka Nakamae
   6. Saki Takeshita
   7. Yoko Tanaka
   8. Akina Matsuda
   9. Masaki Miyasaka
   10. Kenji Hamase
   11. Tomonori Kimura
   12. Masashi Mita
   13. Jumpei Sasabe
   14. Shushi Nagamori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study shows compelling evidence that the less common D-serine stereoisomer is transported in the kidney by the neutral amino acid transporter ASCT2 and that it is a non-canonical substrate for sodium-coupled monocarboxylate transporter SMCTs. With a multi-hierarchical approach, this important study further shows that Ischemia-Reperfusion Injury in the kidney causes a specific increment in renal reabsorption carried out, in part, by ASCT2.

   Reviewed by eLife

5. Neural substrates of cold nociception in Drosophila larva

   This article has 3 authors:

   1. Atit A Patel
   2. Albert Cardona
   3. Daniel N Cox

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates neural circuits mediating motor responses to cold in Drosophila larvae. Using a combination of behavioral analysis, genetic manipulations, EM connectomics, and reporters of calcium activity, the authors provide solid evidence that specific sensory and central neurons are required for cold-induced body contraction. This paper may be of interest to neuroscientists interested in how nervous systems sense and respond to cold.

   Reviewed by eLife

6. Cyclic muscle contractions reinforce the actomyosin motors and mediate the full elongation of C. elegans embryo

   This article has 2 authors:

   1. Anna Dai
   2. Martine Ben Amar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using continuum theory of elastic solids the authors present evidence that periodic muscle contraction leads to elongation of C. elegans embryos by storing elastic energy that is subsequently released by extending the embryo's long axis. This important finding could apply to other developmental processes and be exploited in soft robotics. The presented evidence is convincing on the phenomenological level adopted in the work. How bending energy is converted into elongation on a more microscopic level remains to be worked out.

   Reviewed by eLife

7. Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

   This article has 4 authors:

   1. Alyssa D Huff
   2. Marlusa Karlen-Amarante
   3. Luiz M Oliveira
   4. Jan-Marino Ramirez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study represents a follow-up of previous papers by Huff et al. (2023) in which the authors further investigate a specific medullary region named the Postinspiratory Complex (PiCo) involved in the control of swallow behaviour and its coordination with breathing. In the present work, they tested the impact of chronic intermittent hypoxia on the swallow motor pattern evoked by optogenetic stimulation of the same medullary area in transgenic mice. These solid results indicate that in chronic intermittent hypoxia-exposed mice PiCo stimulation triggers atypical swallow motor patterns. The experimental procedures are rigorous and technically remarkable. The work will be of interest in the field of respiratory physiology and pathophysiology since a disruption of swallowing and possibly discoordination with breathing may be involved in diseases characterized by the presence of hypoxic conditions such as obstructive sleep apnea.

   Reviewed by eLife

8. Distractor effects in decision making are related to the individual’s style of integrating choice attributes

   This article has 4 authors:

   1. Jing Jun Wong
   2. Alessandro Bongioanni
   3. Matthew FS Rushworth
   4. Bolton KH Chau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a valuable demonstration that distractor effects in multi-attribute decision-making correlate with the form of attribute integration (additive vs. multiplicative). The evidence supporting the conclusions is convincing, but there are questions about how to interpret the findings. The manuscript will be interesting to decision-making researchers in neuroscience, psychology, and related fields.

   Reviewed by eLife

9. Reconfigurations of cortical manifold structure during reward-based motor learning

   This article has 10 authors:

   1. Qasem Nick
   2. Daniel J Gale
   3. Corson Areshenkoff
   4. Anouk De Brouwer
   5. Joseph Nashed
   6. Jeffrey Wammes
   7. Tianyao Zhu
   8. Randy Flanagan
   9. Jonny Smallwood
   10. Jason Gallivan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study uses convincing state-of-the-art neuroimaging analyses to characterise whole-brain networks during reward-based motor learning. This work motivates future research to dissociate why the observed changes in neural connectivity occur and how they support reward-based motor learning. The study is highly relevant for researchers at the intersection of decision-making and sensorimotor learning.

   Reviewed by eLife

10. Modulation of alpha oscillations by attention is predicted by hemispheric asymmetry of subcortical regions

    This article has 5 authors:

    1. Tara Ghafari
    2. Cecilia Mazzetti
    3. Kelly Garner
    4. Tjerk Gutteling
    5. Ole Jensen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study by Ghafari et al. tackles a question relevant for the field of attention as it connects structural differences in subcortical regions with oscillatory modulations during attention allocation. Using a combination of Magnetoencephalography (MEG) and magnetic resonance imaging (MRI) data in human subjects, the valuable results show that inter-individual differences in the lateralisation of alpha oscillations are explained by asymmetry of subcortical brain regions. The strength of evidence is deemed convincing in line with current state-of-the-art.

    Reviewed by eLife