eLife

Latest preprint reviews

1. Speech and music recruit frequency-specific distributed and overlapping cortical networks

   This article has 5 authors:

   1. Noémie te Rietmolen
   2. Manuel R Mercier
   3. Agnès Trébuchon
   4. Benjamin Morillon
   5. Daniele Schön

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable intracranial findings on how two types of natural auditory stimuli - speech and music - are processed in the human brain, and demonstrates that speech and music largely share network-level brain activities, thus challenging the domain-specific processing view. The evidence supporting the claims of the authors is solid. The work will be of broad interest to speech and music researchers as well as cognitive scientists in general.

   Reviewed by eLife

2. Hemispheric divergence of interoceptive processing across psychiatric disorders

   This article has 5 authors:

   1. Emily M Adamic
   2. Adam R Teed
   3. Jason Avery
   4. Feliberto de la Cruz
   5. Sahib Khalsa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides compelling evidence for dysgranular insular involvement in top-down and bottom-up interoceptive processing by building on previous evidence using state-of-the-art methods. Its translational application in ADE patients corroborates the assumption that the mid-insula may indeed be a locus of 'interoceptive disruption' in psychiatric disorders, which underscores the study's high relevance for both body-brain as well as clinical research.

   Reviewed by eLife

3. Plastic vasomotion entrainment

   This article has 4 authors:

   1. Daichi Sasaki
   2. Ken Imai
   3. Yoko Ikoma
   4. Ko Matsui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents important results indicating a plastic enhancement in the vasomotion response of pial cortical arterioles to external stimulation in awake mice using a wide range of external visual stimulation paradigms. The evidence for this interesting effect, with broad potential applications, is solid. These results are relevant for scientists and clinicians interested in the regulation of blood flow in the brain.

   Reviewed by eLife

4. Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression

   This article has 6 authors:

   1. Zulong Chen
   2. Xin Wang
   3. Xinlei Gao
   4. Nina Arslanovic
   5. Kaifu Chen
   6. Jessica K Tyler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work describes a compelling analysis of DNA damage-induced changes in nascent RNA transcripts, and a genome-wide screening effort to identify the responsible proteins. A significant discovery is the inability of arrested cells to undergo DNA damage-induced gene silencing, which, is attributed to an inability to mediate ATM-induced transcriptional repression. This work will be of general interest to the DNA damage, repair, and transcription fields, with a potential impact on the cancer field.

   Reviewed by eLife

5. A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

   This article has 4 authors:

   1. Swagata Bose
   2. Satya Ranjan Sahu
   3. Abinash Dutta
   4. Narottam Acharya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful strategy in which the authors devised a simple method to attenuate Candida albicans and deliver a live whole-cell vaccine in a mouse model of systemic candidiasis. The reviewers are not convinced about the completeness of the study: the strength of the evidence is incomplete and could be augmented with additional experiments to more fully characterize vaccine efficacy and host immune responses.

   Reviewed by eLife

6. Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

   This article has 6 authors:

   1. Guo Yu
   2. Shaoyang Zhang
   3. Ana Romo
   4. Soma Biswas
   5. Baojie Li
   6. Jing Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is partly useful as it corroborates what is already known about the elevated proliferation capacity of mid lobular hepatocytes in liver regeneration. Lineage tracing and scRNAseq studies are powerful for the investigation of such heterogeneous hepatocyte proliferation capacity. Nevertheless, based on experimental limitations, incomplete method description and inadequate data analyses the presented data are insufficient to support the proposed conclusions of a mesenchymal-hepatocyte hybrid population in the murine liver.

   Reviewed by eLife

7. Neural evidence of functional compensation for fluid intelligence in healthy ageing

   This article has 5 authors:

   1. Ethan Knights
   2. Richard N Henson
   3. Alexa Morcom
   4. Daniel J Mitchell
   5. Kamen A Tsvetanov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important advancement of knowledge by showing neural functional compensation in the brains of healthy older adults completing a fluid-intelligence task. Validated whole-brain voxel-wide analyses and multivariate Bayesian approaches provide compelling evidence that supports the claims of the authors. The work delivers methods for quantifying reserve and compensation in future studies and will be of interest to researchers in the field of the neuroscience of healthy aging.

   Reviewed by eLife

8. Mechanism of barotaxis in marine zooplankton

   This article has 3 authors:

   1. Luis Alberto Bezares Calderón
   2. Réza Shahidi
   3. Gáspár Jékely

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study addresses the question of how certain zooplankton achieve barotaxis, directed locomotion in response to changes in hydraulic pressure. The authors provide compelling evidence that the response involves ciliary photoreceptors interacting with motoneurons. This work should be of broad interest to scientists working on mechanosensation, cilia, locomotion, and photoreceptors.

   Reviewed by eLife

9. Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

   This article has 42 authors:

   1. Megan M Sperry
   2. Berenice Charrez
   3. Haleh Fotowat
   4. Erica Gardner
   5. Kanoelani Pilobello
   6. Zohreh Izadifar
   7. Tiffany Lin
   8. Abigail Kuelker
   9. Sahith Kaki
   10. Michael Lewandowski
   11. Shanda Lightbown
   12. Ramses Martinez
   13. Susan Marquez
   14. Joel Moore
   15. Maria Plaza-Oliver
   16. Adama M Sesay
   17. Kostyantyn Shcherbina
   18. Katherine Sheehan
   19. Takako Takeda
   20. Daniela Del Campo
   21. Kristina Andrijauskaite
   22. Exal Cisneros
   23. Riley Lopez
   24. Isabella Cano
   25. Zachary Maxwell
   26. Israel Jessop
   27. Rafa Veraza
   28. Leon Bunegin
   29. Thomas J Percival
   30. Jaclyn Yracheta
   31. Jorge J Pena
   32. Diandra M Wood
   33. Zachary T Homas
   34. Cody J Hinshaw
   35. Jennifer Cox-Hinshaw
   36. Olivia G Parry
   37. Justin J Sleeter
   38. Erik K Weitzel
   39. Michael Levin
   40. Michael Super
   41. Richard Novak
   42. Donald E Ingber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Pharmacological induction of physiological slowing combined with organ perfusion systems could provide a novel therapeutic strategy for tissue and organ preservation. Using a Xenopus model, the authors provide important findings on a use of drug to slow down metabolism for the purpose of organ preservation. The authors provide compelling evidence that SNC80 can rapidly and reversibly slow biochemical and metabolic activities while preserving cell and tissue viability. This approach may be beneficial for transplantation, trauma management, and improving organ survival in remote and low-resource settings

   Reviewed by eLife

10. Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3

    This article has 11 authors:

    1. Nicholas J Hathaway
    2. Isaac E Kim
    3. Neeva WernsmanYoung
    4. Sin Ting Hui
    5. Rebecca Crudale
    6. Emily Y Liang
    7. Christian P Nixon
    8. David Giesbrecht
    9. Jonathan J Juliano
    10. Jonathan B Parr
    11. Jeffrey A Bailey

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This work provides important insight into the mechanisms of hrp2 and particularly hrp3 deletion generation. The generation of additional long-read data alongside a new analysis of 19,000 public short-read sequenced genomes makes this the most detailed investigation currently available on this topic, which has high public health importance and also basic biological interest. The revised version of the manuscript provides convincing evidence for the proposed mechanisms.

    Reviewed by eLife