eLife

Latest preprint reviews

1. N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation

   This article has 6 authors:

   1. Valentin Babosha
   2. Natalia Klimenko
   3. Anastasia Revel-Muroz
   4. Evgeniya Tikhonova
   5. Pavel Georgiev
   6. Oksana Maksimenko

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a potentially valuable contribution, reporting a deletion analysis of the MSL1 gene to assess how different parts of the protein product interact with the MSL2 protein and roX RNA to affect the association of the MSL complex with the male X chromosome of Drosophila. However, the framework that the MSL complex mediates dosage compensation is outdated and has flaws, and the evidence is currently considered inadequate to support the claims. Because there are many ways to alter viability, sex-specific viability is insufficient to make claims regarding dosage compensation.

   Reviewed by eLife

2. Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions

   This article has 16 authors:

   1. Xingfeng Shao
   2. Qinyang Shou
   3. Kimberly Felix
   4. Brandon Ojogho
   5. Xuejuan Jiang
   6. Brian T Gold
   7. Megan M Herting
   8. Eric L Goldwaser
   9. Peter Kochunov
   10. Elliot Hong
   11. Ioannis Pappas
   12. Meredith Braskie
   13. Hosung Kim
   14. Steven Cen
   15. Kay Jann
   16. Danny JJ Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding that the blood-brain barrier functionality changes with age and differs between males and females. The analysis is solid, comprising a large and racially diverse dataset, and utilizes a contrast-agent-free MRI method. Since limited work has been done in the MRI field on the blood-brain barrier using this method, this study is of great interest to neuroimaging researchers and clinicians.

   Reviewed by eLife

3. Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

   This article has 31 authors:

   1. Richard C Centore
   2. Luis MM Soares
   3. Salih Topal
   4. Rishi G Vaswani
   5. Kana Ichikawa
   6. Zhifang Li
   7. Hong Fan
   8. Jeremy W Setser
   9. David L Lahr
   10. Laura E Zawadzke
   11. Xueying Chen
   12. Kimberly D Barnash
   13. Jordana Muwanguzi
   14. Neville Anthony
   15. Gabriel J Sandoval
   16. Katharine Feldman
   17. GiNell Elliott
   18. Ammar Adam
   19. David Huang
   20. Yunji Davenport
   21. Shawn Schiller
   22. Kevin J Wilson
   23. Johannes Voigt
   24. Lan Xu
   25. Martin Hentemann
   26. David S Millan
   27. Ho Man Chan
   28. Carl P Decicco
   29. Ryan G Kruger
   30. Gromoslaw A Smolen
   31. Steven F Bellon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study constitutes a fundamental advance for the uveal melanoma research field that might be exploited to target this deadly cancer and more generally for targeting transcriptional dependency in cancers. This work substantially advances our understanding of pharmacological inhibition of SWI/SNF as a therapeutic approach for cancer. The study is well written and provides compelling evidence, including comprehensive datasets, compound screens, gene expression analysis, epigenetics, as well as animal studies.

   Reviewed by eLife

4. RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

   This article has 19 authors:

   1. Alejandro Rosell
   2. Agata Adelajda Krygowska
   3. Marta Alcón Pérez
   4. Cristina Cuesta
   5. Mathieu-Benoit Voisin
   6. Juan de Paz
   7. Héctor Sanz-Fraile
   8. Vinothini Rajeeve
   9. Ana Carreras-González
   10. Alberto Berral-González
   11. Ottilie Swinyard
   12. Enrique Gabandé-Rodríguez
   13. Julian Downward
   14. Jordi Alcaraz
   15. Juan Anguita
   16. Carmen García-Macías
   17. Javier De Las Rivas
   18. Pedro R Cutillas
   19. Esther Castellano Sanchez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study investigates the impact of disrupting the interaction of RAS with the PI3K subunit p110α in macrophage function in vitro and inflammatory responses in vivo. Solid data overall supports a role for RAS-p110α signalling in regulating macrophage activity and so inflammation, however for many of the readouts presented the magnitude of the phenotype is not particularly pronounced. Further analysis would be required to substantiate the claims that RAS-p110α signalling plays a key role in macrophage function. Of note, the molecular mechanisms of how exactly p110α regulates the functions in macrophages have not yet been established.

   Reviewed by eLife

5. Automated workflow for the cell cycle analysis of (non-)adherent cells using a machine learning approach

   This article has 12 authors:

   1. Kourosh Hayatigolkhatmi
   2. Chiara Soriani
   3. Emanuel Soda
   4. Elena Ceccacci
   5. Oualid El Menna
   6. Sebastiano Peri
   7. Ivan Negrelli
   8. Giacomo Bertolini
   9. Gian Martino Franchi
   10. Roberta Carbone
   11. Saverio Minucci
   12. Simona Rodighiero

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents a valuable automated method to track individual mammalian cells as they progress through the cell cycle using the FUCCI system. The authors have developed a technique for analyzing cells that grow in suspension and used their method to look at different tumor cell lines that grow in suspension and determine the effect of drugs that directly affect the cell cycle. They show solid evidence that the method can be applied to both adherent and non-adherent cell lines. This paper will be of interest to cell biologists investigating cell cycle effects.

   Reviewed by eLife

6. The T cell receptor β chain repertoire of tumor infiltrating lymphocytes improves neoantigen prediction and prioritization

   This article has 18 authors:

   1. Thi Mong Quynh Pham
   2. Thanh Nhan Nguyen
   3. Bui Que Tran Nguyen
   4. Thi Phuong Diem Tran
   5. Nguyen My Diem Pham
   6. Hoang Thien Phuc Nguyen
   7. Thi Kim Cuong Ho
   8. Dinh Viet Linh Nguyen
   9. Huu Thinh Nguyen
   10. Duc Huy Tran
   11. Thanh Sang Tran
   12. Truong Vinh Ngoc Pham
   13. Minh Triet Le
   14. Thi Tuong Vy Nguyen
   15. Minh-Duy Phan
   16. Hoa Giang
   17. Hoai-Nghia Nguyen
   18. Le Son Tran

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents a potentially valuable approach by combining two measurements (pHLA binding and pHLA-TCR binding) to improve predictions of which mutations in colorectal cancer are likely to be presented to and recognised by the immune system. While this approach is promising, the evidence supporting the primary claim remains somewhat incomplete. The experimental validation of the computational predictions with actual immune responses is still limited, despite the increase in sample size from 4 to 8 in this revision.

   Reviewed by eLife

7. Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity

   This article has 2 authors:

   1. Toshitake Asabuki
   2. Claudia Clopath

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that investigates how neural networks can learn to stochastically replay presented sequences of activity according to learned transition probabilities. The authors use error-based excitatory plasticity to minimize the difference between internally predicted activity and stimulus-driven activity, and inhibitory plasticity to maintain E-I balance. The approach is solid but the choice of learning rules and parameters is not always always justified, with some unclear aspects to the formal derivation.

   Reviewed by eLife

8. GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health

   This article has 13 authors:

   1. Dianyuan Zhao
   2. Ziwei Huang
   3. Xiaoyu Li
   4. Huan Wang
   5. Qingwei Hou
   6. Yuyao Wang
   7. Fang Yan
   8. Wenting Yang
   9. Di Liu
   10. Shaoqiong Yi
   11. Chunguang Han
   12. Yanan Hao
   13. Li Tang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study delineates the cellular contributions of BMP signaling in liver development and function. The findings are convincing, and the study employs state-of-the-art molecular, genetic, and cellular approaches to demonstrate that hepatic stellate cells play a central role in liver health by mediating cell-to-cell crosstalk via the production of specific BMP proteins. This study will be of interest to scientists interested in developmental biology and organ physiology.

   Reviewed by eLife

9. Hybrid immunity from severe acute respiratory syndrome coronavirus 2 infection and vaccination in Canadian adults: A cohort study

   This article has 22 authors:

   1. Patrick E Brown
   2. Sze Hang Fu
   3. Leslie Newcombe
   4. Xuyang Tang
   5. Nico Nagelkerke
   6. H Chaim Birnboim
   7. Aiyush Bansal
   8. Karen Colwill
   9. Geneviève Mailhot
   10. Melanie Delgado-Brand
   11. Tulunay Tursun
   12. Freda Qi
   13. Anne-Claude Gingras
   14. Arthur S Slutsky
   15. Maria D Pasic
   16. Jeffrey Companion
   17. Isaac I Bogoch
   18. Ed Morawski
   19. Teresa Lam
   20. Angus Reid
   21. Prabhat Jha
   22. Ab-C Study Collaborators

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study assessed antibody levels, which are indicative of protection, resulting from both COVID-19 vaccination and natural infection in a representative sample of the Canadian population. The work provides solid evidence that Individuals who received a booster vaccination and had a prior infection had the highest antibody levels, particularly when either the vaccination or natural infection had occurred within the past six months. These findings are of fundamental importance in supporting the value of booster vaccination in populations vulnerable to severe COVID-19.

   Reviewed by eLife

10. Obox4 promotes zygotic genome activation upon loss of Dux

    This article has 13 authors:

    1. Youjia Guo
    2. Tomohiro Kitano
    3. Kimiko Inoue
    4. Kensaku Murano
    5. Michiko Hirose
    6. Ten D Li
    7. Akihiko Sakashita
    8. Hirotsugu Ishizu
    9. Narumi Ogonuki
    10. Shogo Matoba
    11. Masayuki Sato
    12. Atsuo Ogura
    13. Haruhiko Siomi

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents an important finding that Obox4 and Dux act redundantly in regulating zygotic genome activation in mice. The evidence supporting the claims of the authors is solid. The work will be of interest to researchers interested in early embryo development and epigenetic reprogramming.

    Reviewed by eLife