eLife

Latest preprint reviews

1. PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

   This article has 8 authors:

   1. Pengbo Chen
   2. Bo Li
   3. Zeyu Lu
   4. Qingyin Xu
   5. Huoliang Zheng
   6. Shengdan Jiang
   7. Leisheng Jiang
   8. Xinfeng Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, the authors aimed to identify and characterize intrinsic factors that govern the aging process of bone marrow mesenchymal stromal cells (BMSCs), which are believed to be related to osteoporosis. The authors conclude that PCBP2 is an intrinsic aging factor, the decrease of its expression during aging results in cell proliferation activity decrease and cell senescence. The study provides convincing evidence in support of its conclusions.

   Reviewed by eLife

2. Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange

   This article has 3 authors:

   1. Ameya Harmalkar
   2. Sergey Lyskov
   3. Jeffrey J Gray

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors report how a previously published method, ReplicaDock, can be used to improve predictions from AlphaFold-multimer (AFm) for protein docking studies. The level of improvement is modest for cases where AFm is successful; for cases where AFm is not as successful, the improvement is more significant, although the accuracy of prediction is also notably lower. The evidence for the ReplicaDock approach being more predictive than AFm is particularly convincing for the antibody-antigen test case. Overall, the study makes a valuable contribution by combining data- and physics-driven approaches.

   Reviewed by eLife

3. CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

   This article has 2 authors:

   1. Ryo Kariyazono
   2. Takashi Osanai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors provide solid data on a functional investigation of potential nucleoid-associated proteins and the modulation of chromosomal conformation in a model cyanobacterium. These valuable findings will be of interest to the chromosome and microbiology fields. Additional analysis and the tempering of conclusions has helped to improve the work, although further refinement remains possible.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2303.14159v5

5. Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

   This article has 3 authors:

   1. Moneeza A Agha
   2. Sandeep Kishore
   3. David L McLean

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this fundamental study, authors present compelling evidence for the diversity in cellular and synaptic properties of one class of spinal interneurons and tie it to their differentiated role in locomotor pattern generation. The findings reported here will be of broad interest to neuroscientists in general and to motor systems scientists in particular.

   Reviewed by eLife

6. Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

   This article has 10 authors:

   1. Phillip A Erice
   2. Xinyan Huang
   3. Matthew J Seasock
   4. Matthew J Robertson
   5. Hui-Ying Tung
   6. Melissa A Perez-Negron
   7. Shivani L Lotlikar
   8. David B Corry
   9. Farrah Kheradmand
   10. Antony Rodriguez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study indicates a significant role for individual let-7 miRNA clusters in regulating generation of Tc17 CD8 cells and emphysema severity in a mouse model. The authors provide convincing evidence for let-7-mediated repression of the transcription factor RORgt and consequent modulation of IL-17-producing CD8 T cells, with correlated data from human emphysema material, though some of the effective let-7 clusters remain to be tested for the ability to modulate disease. The findings, which substantially advance the understanding of roles that let-7 miRNA clusters play in modulating both T cell responses and emphysematous lung disease, will be of interest to T cell and lung disease researchers.

   Reviewed by eLife

7. Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity

   This article has 5 authors:

   1. Charles-francois V Latchoumane
   2. Joon-Hyuk Lee
   3. Seong-Wook Kim
   4. Jinhyun Kim
   5. Hee-Sup Shin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the relationship between neuronal dynamics in the thalamus and brain state modulation. The claims that a specific channel is a critical player in the regulation of brain-states and ethanol-resistance in mice are supported by convincing evidence. The work will be of interest to systems neuroscientists interested in brain dynamics and behavioural states.

   Reviewed by eLife

8. Driver lines for studying associative learning in Drosophila

   This article has 12 authors:

   1. Yichun Shuai
   2. Megan Sammons
   3. Gabriella R Sterne
   4. Karen L Hibbard
   5. He Yang
   6. Ching-Po Yang
   7. Claire Managan
   8. Igor Siwanowicz
   9. Tzumin Lee
   10. Gerald M Rubin
   11. Glenn C Turner
   12. Yoshinori Aso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important collection of over 800 new cell type-specific driver lines will be an invaluable resource for researchers studying associative learning in Drosophila. Thoroughly characterized and well documented, this collection will permit researchers to selectively target neurons that deliver information to, or receive it from, the memory center of the fly brain called the Mushroom Body. Given the wealth of new drivers and the genetic access they provide to over 300 cell types, this compelling work will be of interest not only to researchers studying the mechanisms of associative learning but more generally to those dissecting sensorimotor circuits in the fly nervous system.

   Reviewed by eLife

9. Future movement plans interact in sequential arm movements

   This article has 7 authors:

   1. Mehrdad Kashefi
   2. Sasha Reschechtko
   3. Giacomo Ariani
   4. Mahdiyar Shahbazi
   5. Alice Tan
   6. Jörn Diedrichsen
   7. J Andrew Pruszynski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important set of results illuminating how movement sequences are planned. Using several different behavioural manipulations and analysis methods, the authors present compelling evidence that multiple future movements are planned simultaneously with execution, and that these future movement plans influence each other. The work will be of great interest to those studying motor control.

   Reviewed by eLife

10. A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

    This article has 8 authors:

    1. Tommaso Amico
    2. Samuel Toluwanimi Dada
    3. Andrea Lazzari
    4. Michaela Brezinova
    5. Antonio Trovato
    6. Michele Vendruscolo
    7. Monika Fuxreiter
    8. Amos Maritan

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      In this valuable study, the authors analyze droplet size distributions of multiple protein condensates and their fit to a scaling ansatz, highlighting that they exhibit features of first- and second-order phase transitions. The experimental evidence is solid, and it prompts further research into the nature of the link between percolation and phase separation.

    Reviewed by eLife