eLife

Latest preprint reviews

1. Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

   This article has 8 authors:

   1. Jiayao Zhang
   2. Juan Li
   3. Jiehong Huang
   4. Xuerui Xiang
   5. Ruoyu Li
   6. Yun Zhai
   7. Shuxian Lin
   8. Weicai Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript presents valuable findings of bone remodeling under chronic unpredictable mild stress (CUMS). This is an interesting work on mental stress on bone health and osteoporosis, and the authors offer solid evidence of decreased bone mass mediated by miR-335-3p/Fos signaling in osteoclasts that are involved in the induction of bone loss caused by CUMS. This revised version provided new data that improved the quality of the manuscript and addressed the reviewers' concerns.

   Reviewed by eLife

2. Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

   This article has 5 authors:

   1. Denise M Poltavski
   2. Alexander T Cunha
   3. Jaime Tan
   4. Henry M Sucov
   5. Takako Makita

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into our understanding of the development of the enteric nervous system. The authors use genetically engineered mice to study the behavior of stem cells in organizing the enteric nervous system and the secreted signals that regulate these cells. The study rests on a degree of incomplete evidence since the characterization of some of the mouse resources is not complete in the current version.

   Reviewed by eLife

3. The full-length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice

   This article has 14 authors:

   1. Yan Huang
   2. Nina Bucevic
   3. Carmen Coves
   4. Natalia Felipe-Medina
   5. Marina Marcet-Ortega
   6. Nikoleta Nikou
   7. Cristina Madrid-Sandín
   8. Maria López-Panadés
   9. Carolina Buza
   10. Neus Ferrer Miralles
   11. Antoni Iborra
   12. Anna Pujol
   13. Alberto M Pendás
   14. Ignasi Roig

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable information on a novel gene that regulates meiotic progression in both male and female meiosis. The evidence supporting the conclusions of the authors is solid. This study will be of interest to developmental and reproductive biologists.

   Reviewed by eLife

4. Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies

   This article has 15 authors:

   1. Sami Fawaz
   2. Severine Marti
   3. Melody Dufossee
   4. Yann Pucheu
   5. Astrid Gaufroy
   6. Jean Broitman
   7. Audrey Bidet
   8. Aicha Soumare
   9. Gaëlle Munsch
   10. Christophe Tzourio
   11. Stephanie Debette
   12. David-Alexandre Trégouët
   13. Chloe James
   14. Olivier Mansier
   15. Thierry Couffinhal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this small study involving patients with a history of myocardial infarction, Fawaz et al. found no significant contribution of clonal hematopoiesis and mosaic loss of the Y chromosome to the incidence of myocardial infarction and atherosclerosis. Although the evidence provided by the study is incomplete due to its small sample size, the findings are valuable for guiding future larger studies that will further investigate this significant and controversial subject.

   Reviewed by eLife

5. A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

   This article has 11 authors:

   1. Paolo Petazzi
   2. Telma Ventura
   3. Francesca Paola Luongo
   4. Heather McClafferty
   5. Alisha May
   6. Helen Alice Taylor
   7. Michael J Shipston
   8. Nicola Romanò
   9. Lesley M Forrester
   10. Pablo Menendez
   11. Antonella Fidanza

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents useful findings to inform and improve the in vitro differentiation of hematopoietic progenitor cells from human induced pluripotent stem cells. Relying on a well-characterised technical approach, the data analysis is overall solid and reasonably supports the main conclusions.

   Reviewed by eLife

6. Neural representations of predicted events: Evidence from time-resolved EEG decoding

   This article has 3 authors:

   1. Ai-Su Li
   2. Jan Theeuwes
   3. Dirk van Moorselaar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study investigates how a predicted - but not presented - stimulus within a sequence is represented in the brain using time-resolved EEG decoding. The results demonstrate that when the predicted stimulus is omitted, it is still represented at the expected space and time, although at present they provide only incomplete support given some alternative explanations. The findings will have implications for researchers across domains who are interested in learning and perception.

   Reviewed by eLife

7. The NeuroML ecosystem for standardized multi-scale modeling in neuroscience

   This article has 11 authors:

   1. Ankur Sinha
   2. Padraig Gleeson
   3. Bóris Marin
   4. Salvador Dura-Bernal
   5. Sotirios Panagiotou
   6. Sharon Crook
   7. Matteo Cantarelli
   8. Robert C Cannon
   9. Andrew P Davison
   10. Harsha Gurnani
   11. Robin Angus Silver

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work presents a consolidated overview of the NeuroML2 open community standard and provides convincing evidence for its central role within a broader software ecosystem for the development of neuronal models that are open, shareable, reproducible, and interoperable. A major strength of the work is the continued development over more than two decades to establish, maintain, and adapt this standard to meet the evolving needs of the field. This work is of broad interest to the sub-cellular, cellular, computational, and systems neuroscience communities undertaking studies involving theory, modeling, and simulation.

   Reviewed by eLife

8. Energetic demands regulate sleep-wake rhythm circuit development

   This article has 5 authors:

   1. Amy R Poe
   2. Lucy Zhu
   3. Si Hao Tang
   4. Ella Valencia
   5. Matthew S Kayser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings as it shows that sleep rhythm formation and memory capabilities depend on a balanced and rich diet in fly larvae. The evidence supporting the claims of the authors is convincing with rigorous behavioral assays and state-of-the-art genetic manipulations. The work will be of interest to researchers working on sleep and memory.

   Reviewed by eLife

9. A septo-hypothalamic-medullary circuit directs stress-induced analgesia

   This article has 4 authors:

   1. Devanshi Piyush Shah
   2. Pallavi Raj Sharma
   3. Rachit Agarwal
   4. Arnab Barik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work explores the modulation of pain by intense stress. The authors employed a series of cutting-edge techniques and provided convincing evidence suggesting that the dorsal lateral septum-> lateral hypothalamus-> rostral ventromedial medulla circuit is responsible for mediating stress-induced analgesia. This work will be of interest to neuroscientists interested in the neural circuits of behavior, and scientists interested in stress or pain.

   Reviewed by eLife

10. Axon arrival times and physical occupancy establish visual projection neuron integration on developing dendrites in the Drosophila optic glomeruli

    This article has 11 authors:

    1. Brennan W. McFarland
    2. HyoJong Jang
    3. Natalie Smolin
    4. Bryce W. Hina
    5. Michael J. Parisi
    6. Kristen C. Davis
    7. Timothy J. Mosca
    8. Tanja A. Godenschwege
    9. Aljoscha Nern
    10. Yerbol Z. Kurmangaliyev
    11. Catherine R. von Reyn

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study establishes a two distinct feature-encoding visual projection neurons in Drosophila as a model for the development of synaptic specificity. The comprehensive description of connectivity development in this system is valuable to a more general understanding of principles that underlie neural circuit development. The high-quality supporting evidence is convincing.

    Reviewed by eLife