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  1. Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

    This article has 8 authors:
    1. Iuliia Ferling
    2. Steffen Pfalzgraf
    3. Lea Moutounet
    4. Lanhui Qiu
    5. Yumeng Li
    6. Yuhuan Zhou
    7. Sergio Grinstein
    8. Spencer A Freeman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this study, Ferling and colleagues provide convincing evidence demonstrating that myeloid cells exert distinct, cargo-dependent responses during and after phagocytosis. These important findings establish previously unrecognized insights into the function(s) of myeloid cells in immunosurveillance and are thus likely to be broadly impactful across the spectrum of biomedical disciplines including immunology and cell biology. Notwithstanding these clear strengths of the article, some minor issues were noted pertinent to the relative opaqueness of the mechanisms underpinning context-specific RhoA activation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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