eLife

Latest preprint reviews

1. First evidence for the evolution of host manipulation by tumors during the long-term vertical transmission of tumor cells in Hydra oligactis

   This article has 12 authors:

   1. Justine Boutry
   2. Océane Rieu
   3. Lena Guimard
   4. Jordan Meliani
   5. Aurora M Nedelcu
   6. Sophie Tissot
   7. Nikita Stepanskyy
   8. Beata Ujvari
   9. Rodrigo Hamede
   10. Antoine M Dujon
   11. Jácint Tökölyi
   12. Fréderic Thomas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This interesting study explores whether tumor cells can manipulate their Hydra hosts, and includes important findings on the consequences for the fitness of the host Hydra. The evidence supporting these findings is convincing. The work will be of broad interest to many fields including development biology, evolutionary biology and tumor biology.

   Reviewed by eLife

2. Neural Trajectories of Conceptually Related Events

   This article has 5 authors:

   1. Matthew Schafer
   2. Philip Kamilar-Britt
   3. Vyoma Sahani
   4. Keren Bachi
   5. Daniela Schiller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript investigates the extremely interesting and important claim that the human hippocampus represents interactions with multiple social interaction partners on two relatively abstract social dimensions - and that this ability correlates with the social network size of the participant. This research potentially demonstrates the intricate role of the hippocampus in navigating our social world. While most of the results are solid, the paper requires some further clarification.

   Reviewed by eLife

3. Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

   This article has 11 authors:

   1. Ole Bæk
   2. Tik Muk
   3. Ziyuan Wu
   4. Yongxin Ye
   5. Bekzod Khakimov
   6. Alessandra Maria Casano
   7. Bagirath Gangadharan
   8. Ivan Bilic
   9. Anders Brunse
   10. Per Torp Sangild
   11. Duc Ninh Nguyen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study follows up on previous work suggesting that lower glucose concentrations are protective from sepsis but put the patient at risk for hypoglycemia. In this paper, the authors identify that a slightly higher dose of glucose is still protective but no longer puts the patients at risk for hypoglycemia. The study is important, supported by convincing data, and will be of interest to a broad audience.

   Reviewed by eLife

4. Developmental stage shapes the realized energy landscape for a flight specialist

   This article has 14 authors:

   1. Elham Nourani
   2. Louise Faure
   3. Hester Brønnvik
   4. Martina Scacco
   5. Enrico Bassi
   6. Wolfgang Fiedler
   7. Martin U Grüebler
   8. Julia S Hatzl
   9. David Jenny
   10. Andrea Roverselli
   11. Petra Sumasgutner
   12. Matthias Tschumi
   13. Martin Wikelski
   14. Kamran Safi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study substantially advances our understanding of energy landscapes and their link to animal ontogeny. The evidence supporting the conclusions is compelling, with high-throughput telemetry data and advanced track segmentation methods used to develop and map energy landscapes. The work will be of broad interest to animal ecologists.

   Reviewed by eLife

5. Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking

   This article has 19 authors:

   1. Caitlin S. Mitchell
   2. Aida Mohammadkhani
   3. Elizabeth E. Manning
   4. Erin J. Campbell
   5. Simon D Fisher
   6. Jiann W. Yeoh
   7. Amy J. Pearl
   8. Nicholas J. Burton
   9. Min Qiao
   10. Jacqueline A. Iredale
   11. Jaideep S. Bains
   12. Gavan P. McNally
   13. Zane A. Andrews
   14. Brett A. Graham
   15. Thomas E. Scammell
   16. Bradford B. Lowell
   17. Dong Kong
   18. Stephanie L. Borgland
   19. Christopher V. Dayas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important and timely study that advances our understanding of the role of lateral hypothalamic orexin/hypocretin neurons in appetitive approach and consummatory behaviors. Specifically, using fiber photometry, the authors provide solid and convincing evidence that orexin neurons are primarily active during approach and not consummatory behavior, in a manner that is dependent on metabolic state. Further, using optogenetics and cell type-specific electrophysiology, they show that inputs from the ventral pallidum and lateral nucleus accumbens shell to orexin/hypocretin neurons in the lateral hypothalamus are predominantly inhibitory.

   Reviewed by eLife

6. Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway

   This article has 14 authors:

   1. Yongli Qin
   2. Jumpei Shirakawa
   3. Cheng Xu
   4. Ruge Chen
   5. Xu Yang
   6. Courtney Ng
   7. Shinichi Nakano
   8. Mahmoud Elguindy
   9. Zhonghao Deng
   10. Kannanganattu V Prasanth
   11. Moritz F Eissmann
   12. Shinichi Nakagawa
   13. William M Ricci
   14. Baohong Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important and convincing dataset shedding new light on a role for Malat1 in osteoblast physiology. The work is of value to areas other than the bone field because it supports a role and mechanism for beta-catenin that is novel and unusual. The findings are significant in that they support the presence of another anabolic pathway in bone that can be productively targeted for therapeutic goals. Revisions further improved the paper and addressed the reviewers' concerns.

   Reviewed by eLife

7. Dynamic basis of lipopolysaccharide export by LptB2FGC

   This article has 4 authors:

   1. Marina Dajka
   2. Tobias Rath
   3. Nina Morgner
   4. Benesh Joseph

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides an important advance in the molecular understanding of the lipopolysaccharide export mechanism and machinery in bacteria. By using advanced spectroscopy approaches, the experiments provide convincing biophysical support for the dynamic behavior of the multisubunit Lpt transport system. This work has implications for understanding bacterial cell envelope biogenesis and developing drugs that target Gram negative pathogens.

   Reviewed by eLife

8. A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

   This article has 8 authors:

   1. Rachel Pudlowski
   2. Lingyi Xu
   3. Ljiljana Milenkovic
   4. Chandan Kumar
   5. Katherine Hemsworth
   6. Zayd Aqrabawi
   7. Tim Stearns
   8. Jennifer T Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Pudlowski et al. shows that a previously-identified protein complex, composed of delta- and epsilon-tubulin together with TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell cycle. This is an important study that advances our understanding of centriole biogenesis and structure and is supported by convincing evidence based on knockout cell lines, immunoprecipitation, and ultrastructure expansion microscopy. The work is of interest to cell biologists, in particular researchers with interest in centrosome biology.

   Reviewed by eLife

9. The emergence and evolution of gene expression in genome regions replete with regulatory motifs

   This article has 3 authors:

   1. Timothy Fuqua
   2. Yiqiao Sun
   3. Andreas Wagner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study explores the relationship between the sequence of prokaryotic promoter elements and their activity using mutagenesis to generate thousands of mutant sequences. The evidence supporting these findings is convincing. This work will appeal to those interested in bacterial genetics, genome evolution, and gene regulation.

   Reviewed by eLife

10. VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300

    This article has 13 authors:

    1. Susu Guo
    2. Xiaodi Hu
    3. Jennifer L Cotton
    4. Lifang Ma
    5. Qi Li
    6. Jiangtao Cui
    7. Yongjie Wang
    8. Ritesh P Thakare
    9. Zhipeng Tao
    10. Y Tony Ip
    11. Xu Wu
    12. Jiayi Wang
    13. Junhao Mao

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is a valuable study describing how rhabdomyosarcoma fusion-oncogenes, VGLL2-NCOA2 and TEAD1-NCOA2, function at the genomic, transcriptional, and proteomic levels in multiple systems. The experimental data is convincing, supporting a model in which these fusion-oncogenes leverage TEAD transcriptional signatures independent of YAP/TAZ. This work offers new mechanistic insights into oncogenic gene fusion events and reveals potential therapeutic strategies for the treatment of rhabdomyosarcomas.

    Reviewed by eLife