eLife

Latest preprint reviews

1. Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex

   This article has 24 authors:

   1. Jittoku Ihara
   2. Yibin Huang
   3. Yoichi Takami
   4. Yoichi Nozato
   5. Toshimasa Takahashi
   6. Akemi Kakino
   7. Cheng Wang
   8. Ziwei Wang
   9. Yu Guo
   10. Weidong Liu
   11. Nanxiang Yin
   12. Ryoichi Ohara
   13. Taku Fujimoto
   14. Shino Yoshida
   15. Kazuhiro Hongyo
   16. Hiroshi Koriyama
   17. Hiroshi Akasaka
   18. Hikari Takeshita
   19. Shinsuke Sakai
   20. Kazunori Inoue
   21. Yoshitaka Isaka
   22. Hiromi Rakugi
   23. Tatsuya Sawamura
   24. Koichi Yamamoto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides useful in vitro evidence to support a mechanism whereby dyslipidemia could accelerate renal functional decline through the activation of the AT1R/LOX1 complex by oxLDL and AngII. As such, it improves the knowledge regarding the complex interplay between dyslipidemia and renal disease and provides a solid basis for the discovery of novel therapeutic strategies for patients with lipid disorders. The methods, data, and analyses partly support the presented findings, although the observed variability and need for further in vivo validation require additional research in this key area.

   Reviewed by eLife

2. Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

   This article has 13 authors:

   1. Xiexiang Shao
   2. Xingzuan Lin
   3. Hao Zhou
   4. Minghui Wang
   5. Lili Han
   6. Xin Fu
   7. Sheng Li
   8. Siyuan Zhu
   9. Shenao Zhou
   10. Wenjun Yang
   11. Jianhua Wang
   12. Zhanghua Li
   13. Ping Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors demonstrate the valuable discovery that human CD29+/CD56+ myogenic progenitors can differentiate into tendon through the TGFβ pathway, addressing mouse and human interspecies differences in regard to the potential of muscle stem cells. The in vivo transplantation experiments provide convincing evidence for the conclusion, as human CD29+/CD56+ myogenic progenitors contribute to tendon regeneration, resulting in functional recovery in mouse model. The authors' approach can be used for the development of cell therapy for tendon-injured patients.

   Reviewed by eLife

3. Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs

   This article has 15 authors:

   1. Shuo Chao
   2. Jun Lu
   3. Li-Jun Li
   4. Hong-Yan Guo
   5. Kuipeng Xu
   6. Ning Wang
   7. Shu-Xian Zhao
   8. Xiao-Wen Jin
   9. Shao-Ge Wang
   10. Shen Yin
   11. Wei Shen
   12. Ming-Hui Zhao
   13. Gui-An Huang
   14. Qing-Yuan Sun
   15. Zhao-Jia Ge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports important findings on the impact of maternal obesity on offspring metabolism. It presents solid evidence that maternal obesity induces genomic methylation alterations in oocytes, which can be partly transmitted to F2 in females, and that melatonin is involved in regulating the hyper-methylation of high fat diet oocytes by increasing the expression of DNMTs via the cAMP/PKA/CREB pathway. This study would be of interest to biologists in the fields of epigenetics and metabolism.

   Reviewed by eLife

4. Decoding the physics of observed actions in the human brain

   This article has 2 authors:

   1. Moritz F Wurm
   2. Doruk Yiğit Erigüç

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In an important fMRI study with an elegant experimental design and rigorous cross-decoding analyses, this work shows a convincing dissociation between two parietal regions in visually processing actions. Specifically, aIPL is found to be sensitive to the causal effects of observed actions, while SPL is sensitive to the patterns of body motion involved in those actions. The work will be of broad interest to cognitive neuroscientists, particularly vision and action researchers.

   Reviewed by eLife

5. Muscarinic receptors mediate motivation via preparatory neural activity in humans

   This article has 6 authors:

   1. John P Grogan
   2. Matthias Raemaekers
   3. Maaike MH van Swieten
   4. Alexander L Green
   5. Martin J Gillies
   6. Sanjay G Manohar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors have reported an important study in which they use a double-blind design to explore pharmacological manipulations in the context of a behavioral task. While the sample size is small, the use of varied methodology, including electrophysiology, behavior, and pharmacology, makes this manuscript particularly notable. Overall, the findings are solid and motivate future explanations into the relationships between acetylcholine and motivation.

   Reviewed by eLife

6. Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations

   This article has 10 authors:

   1. Bin Zheng
   2. Meimei Duan
   3. Yifen Huang
   4. Shangchen Wang
   5. Jun Qiu
   6. Zhuojian Lu
   7. Lichao Liu
   8. Guojin Tang
   9. Lin Cheng
   10. Peng Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents important findings regarding the interaction of the monkeypox virus (MPXV) attachment H3 protein with the cellular receptor heparan sulfate and the use of this information to develop antivirals potentially effective against all orthopoxviruses. Using a combination of state-of-the art computational and wet experiments the authors present convincing evidence to sustain their claims. These results will interest those working on basic orthopoxviruses biology and antiviral development.

   Reviewed by eLife

7. Stimulus-specificity of surround-induced responses in primary visual cortex

   This article has 8 authors:

   1. Nisa Cuevas
   2. Boris Sotomayor-Gómez
   3. Athanasia Tzanou
   4. Irene Onorato
   5. Brian Rummell
   6. Cem Uran
   7. Ana Broggini
   8. Martin Vinck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the selectivity of neuronal responses in the neocortex and thalamus to visual stimuli presented far outside their receptive fields. The study shows convincing evidence for a long-latency surround-induced response in primary visual cortex that is absent in the dorsal lateral geniculate nucleus and does not depend strongly on the visual characteristics of the surround stimulus. The paper should be of interest to neurophysiologists interested in vision and contextual modulations.

   Reviewed by eLife

8. The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

   This article has 14 authors:

   1. Weiwei Qi
   2. Yanlan Long
   3. Ziming Li
   4. Zhen Zhao
   5. Jinhui Shi
   6. Wanting Xie
   7. Laijian Wang
   8. Yandan Tan
   9. Ti Zhou
   10. Minting Liang
   11. Ping Jiang
   12. Bin Jiang
   13. Xia Yang
   14. Guoquan Gao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identified a molecular mechanism linking diabetes to AD risk and the data presented are convincing. The authors investigated the role of kallistatin in metabolic abnormalities associated with AD and identified that Kallistatin is a key player that mediates Aβ accumulation and tau hyperphosphorylation in AD. This manuscript provides novel insights into the pathogenesis of AD, indicating that the hypolipidemic drug fenofibrate attenuates AD-like pathology in Kallistatin transgenic mice.

   Reviewed by eLife

9. Growth consequences of the inhomogeneous organization of the bacterial cytoplasm

   This article has 4 authors:

   1. Johan H van Heerden
   2. Alicia Berkvens
   3. Daan H de Groot
   4. Frank J Bruggeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study examines E. coli growth and division, suggesting that inhomogeneous organization of ribosomes in the cytoplasm results in cell size-dependent growth rate perturbations. The work is conceptually appealing, but incomplete due to shortcomings in the experiments and modeling.

   Reviewed by eLife

10. Adaptive chunking improves effective working memory capacity in a prefrontal cortex and basal ganglia circuit

    This article has 2 authors:

    1. Aneri Soni
    2. Michael J Frank

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important work proposes a neural network model of interactions between the prefrontal cortex and basal ganglia to implement adaptive resource allocation in working memory, where the gating strategies for storage are adjusted by reinforcement learning. Numerical simulations provide convincing evidence for the superiority of the model in improving effective capacity, optimizing resource management, and reducing error rates, as well as for its human-like performance. This work will be of broad interest to computational and cognitive neuroscientists, and may also interest machine-learning researchers who seek to develop brain-inspired machine-learning algorithms for memory.

    Reviewed by eLife