eLife

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1. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2402.07252v2

2. Binding of LncDACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility

   This article has 21 authors:

   1. Genlong Xue
   2. Jiming Yang
   3. Yang Zhang
   4. Ying Yang
   5. Ruixin Zhang
   6. Desheng Li
   7. Tao Tian
   8. Jialiang Li
   9. Xiaofang Zhang
   10. Changzhu Li
   11. Xingda Li
   12. Jiqin Yang
   13. Kewei Shen
   14. Yang Guo
   15. Xuening Liu
   16. Guohui Yang
   17. Lina Xuan
   18. Hongli Shan
   19. Yanjie Lu
   20. Yang Baofeng
   21. Zhenwei Pan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important contribution to cardiac arrhythmia research by demonstrating long noncoding RNA Dachshund homolog 1 (lncDACH1) tunes sodium channel functional expression and affects cardiac action potential conduction and rhythms. The evidence supporting the major claims are convincing. The work will be of broad interest to cell biologists and cardiac electrophysiologists.

   Reviewed by eLife

3. Feeding rates in sessile versus motile ciliates are hydrodynamically equivalent

   This article has 4 authors:

   1. Jingyi Liu
   2. Yi Man
   3. John H Costello
   4. Eva Kanso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper addresses the role of fluid flows in nutrient uptake by microorganisms propelled by the action of cilia or flagella. Using a range of mathematical models for the flows created by such appendages, the authors provide convincing evidence that the two strategies of swimming and sessile motion can be competitive. These results will have significant implications for our understanding of the evolution of multicellularity in its various forms.

   Reviewed by eLife

4. Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

   This article has 8 authors:

   1. Ning Song
   2. Hang Gao
   3. Jianhao Li
   4. Yi Liu
   5. Mingze Wang
   6. Zhiming Ma
   7. Naisheng Zhang
   8. Wenlong Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study showing that age-related gut microbiota modulate uric acid metabolism through the NLRP3 inflammasome pathway and thereby regulate susceptibility to age-related gout. Several experimental approaches (mechanistic insights) and methods (data quality) remain incomplete. This paper should be of interest to researchers working on gout and microbiota.

   Reviewed by eLife

5. SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

   This article has 19 authors:

   1. Kira Breunig
   2. Xuifen Lei
   3. Mauro Montalbano
   4. Gabriela DA Guardia
   5. Shiva Ostadrahimi
   6. Victoria Alers
   7. Adam Kosti
   8. Jennifer Chiou
   9. Nicole Klein
   10. Corina Vinarov
   11. Lily Wang
   12. Mujia Li
   13. Weidan Song
   14. W Lee Kraus
   15. David S Libich
   16. Stefano Tiziani
   17. Susan T Weintraub
   18. Pedro AF Galante
   19. Luiz O Penalva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports valuable insights into the interactome of the RNA-binding protein SERBP1 and possible links through PARylation to diverse processes, including splicing, cell division, and ribosome biogenesis. The diversity of processes SERBP1 may regulate means this work would be of very broad interest to the cell biology community. The proteomics data are solid, but the functional connection to downstream processes and the link to Alzheimer's disease, while compelling, still require further examination. These latter data currently rely on a very limited set of experiments and patient samples with questionable quality of preservation and methodology.

   Reviewed by eLife

6. Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions

   This article has 7 authors:

   1. Katarzyna Tutak
   2. Izabela Broniarek
   3. Andrzej Zielezinski
   4. Daria Niewiadomska
   5. Tomasz Skrzypczak
   6. Anna Baud
   7. Krzysztof Sobczak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, Tutak and colleagues set out to identify factors that mediate Repeat Associated Non-AUG (RAN) translation of CGG repeats in the FMR1 mRNA which are implicated in toxic protein accumulation that underpins ensuing neurological pathologies. The authors provide solid evidence that RPS26 may be implicated in mediating the RAN translation of FMR1 mRNA. This article should be of broad interest to researchers in the variety of disciplines including post-transcriptional regulation of gene expression and neurobiology.

   Reviewed by eLife

7. Observing one-divalent-metal-ion-dependent and histidine-promoted His-Me family I-PpoI nuclease catalysis in crystallo

   This article has 3 authors:

   1. Caleb Chang
   2. Grace Zhou
   3. Yang Gao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Chang et al. have investigated the catalytic mechanism of I-PpoI nuclease, a one-metal-ion dependent nuclease, by time-resolved X-ray crystallography using soaking of crystals with metal ions under different pH conditions. This convincing study revealed that I-PpoI catalyzes the reaction process through a single divalent cation. The study uncovers important details of the roles of the metal ion and the active site histidine in catalysis.

   Reviewed by eLife

8. Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella

   This article has 3 authors:

   1. Liam P. Hallada
   2. Abbas Shirinifard
   3. David J Solecki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents a valuable finding in advancing our understanding of the cellular and molecular mechanisms that regulate the switching of the migration mode from parallel to radial in cerebellar granule cell development. The evidence supporting the claims of the authors is solid and supports the main conclusion; the highlight was the imaging system's visualization of the cell-recognition event associated with neuronal migration, which established a new standard for the field. This study would be of interest to cell biologists and neurodevelopmental biologists working on cell-cell interaction and neuronal migration.

   Reviewed by eLife

9. The neural dynamics of positive and negative expectations of pain

   This article has 3 authors:

   1. Christoph Arne Wittkamp
   2. Maren-Isabel Wolf
   3. Michael Rose

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Wittkamp et al. investigated the spatiotemporal dynamics of expectation of pain using an original fMRI-EEG approach. The methods are solid and the evidence for a substantially different neural representation between the anticipatory and the actual pain period is convincing. These important findings are discussed within a general framework that encompasses their research questions, hypotheses, and analysis of results. Although the choice of conditions and their influence on the results might accept different interpretations, the manuscript is strong and contributes beneficial insights to the field.

   Reviewed by eLife

10. Systematic evaluation of multifactorial causal associations for Alzheimer’s disease and an interactive platform MRAD developed based on Mendelian randomization analysis

    This article has 6 authors:

    1. Tianyu Zhao
    2. Hui Li
    3. Meishuang Zhang
    4. Yang Xu
    5. Ming Zhang
    6. Li Chen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study introduces the MRAD database, an advancement in Alzheimer's disease research that provides a powerful tool for evaluating risk and protective factors through Mendelian randomization analysis. The evidence supporting the database's utility is solid, with findings backed by robust data, though addressing methodological concerns and ensuring more rigorous validation of associations would further strengthen its impact. This resource represents a significant leap forward in the field, offering unprecedented opportunities for researchers and clinicians to uncover key insights into Alzheimer's etiology, potentially revolutionizing how Alzheimer's research is approached and accelerating the discovery of new prevention strategies and treatments.

    Reviewed by eLife