eLife

Latest preprint reviews

1. Distinct effects of phyllosphere and rhizosphere microbes on invader Ageratina adenophora during its early life stages

   This article has 7 authors:

   1. Zhao-Ying Zeng
   2. Jun-Rong Huang
   3. Zi-Qing Liu
   4. Ai-Ling Yang
   5. Yu-Xuan Li
   6. Yong-Lan Wang
   7. Han-Bo Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study investigates plant-microbe interactions for an invasive plant, Ageratina adenophora. The findings are valuable in advancing our understanding of how leaf and soil microbes separately affect its performance, with solid experimental evidence revealing the importance of litter microbes in shaping A. adenophora populations. The work will be of interest to invasion biologists.

   Reviewed by eLife

2. Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood

   This article has 14 authors:

   1. Chiara Bulgarelli
   2. Anna Blasi
   3. Samantha McCann
   4. Bosiljka Milosavljevic
   5. Giulia Ghillia
   6. Ebrima Mbye
   7. Ebou Touray
   8. Tijan Fadera
   9. Lena Acolatse
   10. Sophie E Moore
   11. Sarah Lloyd-Fox
   12. Clare E Elwell
   13. Adam T Eggebrecht
   14. the BRIGHT Study Team

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study details changes in the brain functional connectivity in a longitudinal cohort of Gambian children assessed outside a lab setup with functional near-infrared spectroscopy (fNIRS) from age 5 to 24 months, in relation to early physical growth and cognitive flexibility capacities at preschool age. While evidence supporting conclusions on the evolution of brain connectivity are solid, the statistical power was insufficient to perform proper analyses of longitudinal data and link the connectivity trajectories with early adverse conditions such as undernutrition and later cognitive development. This study will be of significant interest to neuroscientists, psychologists and neuroimaging researchers working on infant development in relation to environmental factors.

   Reviewed by eLife

3. Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

   This article has 8 authors:

   1. Ryosuke Isotani
   2. Masaki Igarashi
   3. Masaomi Miura
   4. Kyoko Naruse
   5. Satoshi Kuranami
   6. Manami Katoh
   7. Seitaro Nomura
   8. Toshimasa Yamauchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the claims of the authors is solid. This research will be of interest to medical biologists specializing in intestinal tumors.

   Reviewed by eLife

4. Transforming descending input into motor output: An analysis of the Drosophila Male Adult Nerve Cord connectome

   This article has 16 authors:

   1. Han SJ Cheong
   2. Katharina Eichler
   3. Tomke Stürner
   4. Samuel K Asinof
   5. Andrew S Champion
   6. Elizabeth C Marin
   7. Tess B Oram
   8. Marissa Sumathipala
   9. Lalanti Venkatasubramanian
   10. Shigehiro Namiki
   11. Igor Siwanowicz
   12. Marta Costa
   13. Stuart Berg
   14. Janelia FlyEM Project Team
   15. Gregory SXE Jefferis
   16. Gwyneth M Card

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper describes the structure and connectivity of brain neurons that send descending connections to motor neurons and muscle in the fruit fly nerve cord, using a synapse-resolution connectome. This important work provides a wealth of hypotheses and predictions for future experimentation and modelling. Using state-of-the-art methods, the authors provide solid evidence for their conclusions.

   Reviewed by eLife

5. Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability

   This article has 6 authors:

   1. Ludovica Labruna
   2. Christina Merrick
   3. Angel V Peterchev
   4. Ben Inglis
   5. Richard B Ivry
   6. Daniel Sheltraw

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study introduces and evaluates the efficacy of a novel form of non-invasive brain stimulation in humans: kilohertz transcranial magnetic perturbation (kTMP). The evidence provided for the ability of kTMP to increase cortical excitability with minimal sensation is compelling, with two separate replication experiments. Although exploratory in nature, this work represents new avenues for non-invasive brain stimulation research that has potential long-term appeal for both clinical and research applications. This paper will be of significant interest to neuroscientists interested in brain stimulation.

   Reviewed by eLife

6. Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision making

   This article has 5 authors:

   1. Miguel Barretto García
   2. Marcus Grueschow
   3. Marius Moisa
   4. Rafael Polania
   5. Christian C. Ruff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combined fMRI, TMS and computational modelling of behaviour to investigate the functional role of the left superior frontal sulcus (SFS) in both perceptual and value-based decisions. Based on sophisticated analyses, the results provide solid evidence that downregulating left SFS activity through TMS selectively alters perceptual decision accuracy but does not influence value-based decisions. The work will be of interest to cognitive neuroscientists investigating the neural correlates of decision-making and may have implications for computational psychiatry.

   Reviewed by eLife

7. Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

   This article has 14 authors:

   1. Camille Dantzer
   2. Justine Vaché
   3. Aude Brunel
   4. Isabelle Mahouche
   5. Anne-Aurélie Raymond
   6. Jean-William Dupuy
   7. Melina Petrel
   8. Paulette Bioulac-Sage
   9. David Perrais
   10. Nathalie Dugot-Senant
   11. Mireille Verdier
   12. Barbara Bessette
   13. Clotilde Billottet
   14. Violaine Moreau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Hepatocellular carcinoma (HCC) is a particularly aggressive form of cancer, with an increasing number of treatment options approved for use in patients over the past decade. However, the biology of HCC and identifiable therapeutic targets have not been as clear, even in the era of molecular oncology. Likewise, the cellular biology of HCC, including the role of intercellular communication, has not been well elucidated. In this compelling study, Dantzer et al. provide fundamental insight into the role of beta-catenin on intercellular communication occurring via extracellular vesicles, with implications for immune evasion in a cancer increasingly being treated using immuno-oncologic agents.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2303.17893v2

9. Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

   This article has 7 authors:

   1. Yue Sun
   2. Jingwei Li
   3. Jiadai Huang
   4. Shumin Li
   5. Youyue Li
   6. Beifang Lu
   7. Xin Deng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work advances our understanding of transcriptional regulation of virulence and metabolic pathways in plant pathogenic bacteria. Solid evidence for the claims is provided by computational analysis of newly generated data on the genome-wide binding of 170 transcription factors to their target genes, together with experimental validation of the biological functions of some of these transcription factors. The findings and resources from this study will be valuable to researchers in the fields of systems biology, bacteriology, and plant-microbe interactions.

   Reviewed by eLife

10. Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

    This article has 6 authors:

    1. Kara Schmidlin
    2. Sam Apodaca
    3. Daphne Newell
    4. Alexander Sastokas
    5. Grant Kinsler
    6. Kerry Geiler-Samerotte

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study provides valuable new insights into the trade-offs associated with the evolution of drug resistance in the yeast S. cerevisiae, based on a solid approach to evolving and phenotyping hundreds of independent strains. The authors identify distinct phenotypic clusters, defined by their growth across defined conditions, which suggest that tradeoffs are diverse but at the same time could be limited to a few classes according to the underlying resistance mechanisms. The methodologies used align with the current state-of-the-art, and the data and analysis are solid as they broadly support the claims, with only a few minor weaknesses remaining after revision. This work will interest molecular biologists working on the evolution of new phenotypes and microbiologists studying multi-drug therapy.

    Reviewed by eLife