eLife

Latest preprint reviews

1. Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

   This article has 8 authors:

   1. Raji E Joseph
   2. Thomas E Wales
   3. Sandrine Jayne
   4. Robert G Britton
   5. D Bruce Fulton
   6. John R Engen
   7. Martin JS Dyer
   8. Amy H Andreotti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript reports on an important comparison of a range of approved clinical inhibitors for BTK used for the treatment of chronic lymphocytic leukemia (CLL). The authors provide compelling evidence for their claims, using a combination of HDX-MS and NMR spectroscopy. The novelty is that this study also seeks to evaluate resistance mutation bias. The manuscript will be of high interest to scientists working on protein drug interactions.

   Reviewed by eLife

2. Ligand response of guanidine-IV riboswitch at single-molecule level

   This article has 3 authors:

   1. Lingzhi Gao
   2. Dian Chen
   3. Yu Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on the ligand- and ion-dependent structural dynamics of a transcriptional riboswitch. The single-molecule data presented are solid and prompts intriguing hypotheses and models, which will undoubtedly stimulate future structural analyses. These findings are of considerable interest to biochemists and biophysicists engaged in the study of RNA structure and riboswitch mechanisms.

   Reviewed by eLife

3. Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

   This article has 15 authors:

   1. Jörn Lötsch
   2. Khayal Gasimli
   3. Sebastian Malkusch
   4. Lisa Hahnefeld
   5. Carlo Angioni
   6. Yannick Schreiber
   7. Sandra Trautmann
   8. Saskia Wedel
   9. Dominique Thomas
   10. Nerea Ferreiros Bouzas
   11. Christian H Brandts
   12. Benjamin Schnappauf
   13. Christine Solbach
   14. Gerd Geisslinger
   15. Marco Sisignano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Sisigano et al. report findings about the role of sphingolipids using lipidomics with machine learning in paclitaxel-induced peripheral neuropathy and preliminary translation of the impact of SA1P in cultured neuronal cells. This study presents a valuable finding on the increased activity of two well-studied signal transduction pathways in a subtype of breast cancer. The significance is limited by incomplete evidence which can be addressed in larger clinical cohorts in the future and with more robust biological validation approaches.

   Reviewed by eLife

4. Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition

   This article has 8 authors:

   1. Anastasiia Lozovska
   2. Ana Casaca
   3. Ana Novoa
   4. Ying-Yi Kuo
   5. Arnon D Jurberg
   6. Gabriel G Martins
   7. Anna-Katerina Hadjantonakis
   8. Moises Mallo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Morphological characteristics and phenotypes of mutations in key developmental genes suggest that head, trunk, and tail development are regulated by discernible modules. Gdf11 signalling plays a crucial role in orchestrating the transition from trunk to tail tissues in vertebrate embryos. This important study presents convincing evidence that Tgfbr1 acts upstream of Isl1 (a pivotal effector of Gdf11 signalling) and regulates blood vessels, the lateral plate mesoderm, and the endoderm associated with the trunk-to-tail transition. Together with the previous studies, this work identifies a key signal that acts as the pivot of the trunk-to-tail transition.

   Reviewed by eLife

5. ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

   This article has 17 authors:

   1. Jordina Rincon-Torroella
   2. Marco Dal Molin
   3. Brian Mog
   4. Gyuri Han
   5. Evangeline Watson
   6. Nicolas Wyhs
   7. Shun Ishiyama
   8. Taha Ahmedna
   9. Il Minn
   10. Nilofer Azad
   11. Chetan Bettegowda
   12. Nickolas Papadopoulos
   13. Kenneth W Kinzler
   14. Shibin Zhou
   15. Bert Vogelstein
   16. Kathleen Gabrielson
   17. Surojit Sur

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding and developed ME3BP-7 as a novel microencapsulated formulation of 3BP, which specifically targets MCT1-overexpressing PDAC cells. It demonstrates its specificity and efficacy in vitro and in PDAC mouse models, with significant anti-tumor effects and improved serum stability. Overall, the evidence supporting the authors' claims is solid.

   Reviewed by eLife

6. Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

   This article has 12 authors:

   1. Adrián Merino-Salomón
   2. Jonathan Scheneider
   3. Leon Babl
   4. Jan-Hagen Krohn
   5. Marta Sobrinos-Sanguino
   6. Tillman Schaefer
   7. Juan Ramon Luque-Ortega
   8. Carlos Alfonso
   9. Mercedes Jiménez
   10. Marion Jasnin
   11. Petra Schwille
   12. German Rivas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The formation of the Z-ring at the time of bacterial cell division interests researchers working towards understanding cell division across all domains of life. The manuscript by Jasnin et al reports the cryoET structure of toroid assembly formation of FtsZ filaments driven by ZapD as the cross linker. The findings are important and have the potential to open a new dimension in the field, and the evidence to support these exciting claims is solid.

   Reviewed by eLife

7. Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket

   This article has 2 authors:

   1. Yi Zeng
   2. Jonathan P. Staley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that demonstrates that RNA intermediates arising from improper splicing are exported out of the nucleus via the canonical mRNA export machinery and the nuclear pore basket. The authors provide convincing evidence that the role of the nuclear basket rather than retaining the transcripts is stimulating their export, putting into question the current model of the role of the basket. The conclusions are in line with recent studies in mammalian cells that suggest that the basket's role in mRNA export and quality control has to be revised.

   Reviewed by eLife

8. Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

   This article has 20 authors:

   1. Jeongkyung Lee
   2. Ruya Liu
   3. Byung S. Kim
   4. Yiqun Zhang
   5. Feng Li
   6. Rajaganapti Jagannathan
   7. Ping Yang
   8. Vinny Negi
   9. Joseph Danvers
   10. Eliana Melissa Perez-Garcia
   11. Pradip K. Saha
   12. Omaima Sabek
   13. Chad J. Creighton
   14. Cristian Coarfa
   15. Mark O. Huising
   16. Hung-Ping Shih
   17. Rita Bottino
   18. Ke Ma
   19. Mousumi Moulik
   20. Vijay K. Yechoor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The Hippo signaling pathway plays a crucial role in controlling organ size, cell proliferation, and apoptosis, though its role in endocrine pancreas development has remained unclear. In this useful work, the authors study the function of the Tead1 transcription factor, a Hippo effector, specifically in pancreatic beta cells. They provide solid evidence, using multiple different conditional knockout models to reveal Tead1's regulatory functions in insulin secretion and beta cell proliferation. However, deeper exploration of their data and incorporating findings from existing literature on this topic would provide a clearer understanding of Tead1's role in β-cell function, within or beyond the Hippo pathway.

   Reviewed by eLife

9. The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

   This article has 9 authors:

   1. Roger Huerlimann
   2. Natacha Roux
   3. Ken Maeda
   4. Polina Pilieva
   5. Saori Miura
   6. Hsiao-chian Chen
   7. Michael Izumiyama
   8. Vincent Laudet
   9. Timothy Ravasi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work provides valuable genomic resources to address the endocrine control of a life cycle transition in the Malabar grouper fish. The revised manuscript is more solid and the resources and experimental data help to build up a meaningful biological understanding of thyroid signaling in grouper fish.

   Reviewed by eLife

10. Bidirectional fear modulation by discrete anterior insular circuits in male mice

    This article has 4 authors:

    1. Sanggeon Park
    2. Yeowool Huh
    3. Jeansok J Kim
    4. Jeiwon Cho

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This work provides a valuable characterization of neural activity in the anterior insular cortex during fear. Using behavior, single unit recording, and optogenetic control of neural activity, the paper provides convincing data on the role of anterior insular circuits in bidirectionally controlling fear. The study is a great starting point on the path to testing hypotheses about bidirectional control of behavior via neural activity in anatomically defined output populations.

    Reviewed by eLife