eLife

Latest preprint reviews

1. Acquisition of auditory discrimination mediated by different processes through two distinct circuits linked to the lateral striatum

   This article has 13 authors:

   1. Susumu Setogawa
   2. Takashi Okauchi
   3. Di Hu
   4. Yasuhiro Wada
   5. Keigo Hikishima
   6. Hirotaka Onoe
   7. Kayo Nishizawa
   8. Nobuyuki Sakayori
   9. Hiroyuki Miyawaki
   10. Takuma Kitanishi
   11. Kenji Mizuseki
   12. Yilong Cui
   13. Kazuto Kobayashi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important understanding of the contribution of different striatal subregions, the anterior Dorsal Lateral Striatum (aDLS) and the posterior Ventrolateral Striatum (pVLS), to auditory discrimination learning. The authors have included robust behavior combined with multiple observational and perturbation techniques. The data provided are convincing of the relevance of task-related activity in these two subregions during learning.

   Reviewed by eLife

2. Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)

   This article has 43 authors:

   1. Michael W Reimann
   2. Sirio Bolaños-Puchet
   3. Jean-Denis Courcol
   4. Daniela Egas Santander
   5. Alexis Arnaudon
   6. Benoît Coste
   7. Fabien Delalondre
   8. Thomas Delemontex
   9. Adrien Devresse
   10. Hugo Dictus
   11. Alexander Dietz
   12. András Ecker
   13. Cyrille Favreau
   14. Gianluca Ficarelli
   15. Mike Gevaert
   16. Joni Herttuainen
   17. James B Isbister
   18. Lida Kanari
   19. Daniel Keller
   20. James King
   21. Pramod Kumbhar
   22. Samuel Lapere
   23. Jãnis Lazovskis
   24. Huanxiang Lu
   25. Nicolas Ninin
   26. Fernando Pereira
   27. Judit Planas
   28. Christoph Pokorny
   29. Juan Luis Riquelme
   30. Armando Romani
   31. Ying Shi
   32. Jason P Smith
   33. Vishal Sood
   34. Mohit Srivastava
   35. Werner Van Geit
   36. Liesbeth Vanherpe
   37. Matthias Wolf
   38. Ran Levi
   39. Kathryn Hess
   40. Felix Schürmann
   41. Eilif B Muller
   42. Henry Markram
   43. Srikanth Ramaswamy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports a detailed model of juvenile rat somatosensory cortex, consisting of 4.2 million morphologically and biophysically detailed neuron models, arranged in space and connected according to diverse experimental data - a valuable tool for the field. The construction of the model is based on a methodology with solid supporting evidence. It should be noted that, by necessity, such a large-scale model development involves many assumptions, interpolations, and decisions that could have compounding downstream effects on further analyses that may be difficult to disambiguate.

   Reviewed by eLife

3. Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain

   This article has 5 authors:

   1. Yue Li
   2. Qinyao Sun
   3. Shunli Zhu
   4. Congying Chu
   5. Jiaojian Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study compared the brain development trajectories of humans and macaque monkeys to quantify different evolutionary effects of convergent and divergent neural pathways between the two species. The cross-species evidence is solid, based on brain age prediction models that were carefully developed by using public MRI datasets of both humans and macaque monkeys. The findings will be of interest to neuroscientists, developmental biologists, and evolutionary biologists.

   Reviewed by eLife

4. Multimodal neural correlates of childhood psychopathology

   This article has 10 authors:

   1. Jessica Royer
   2. Valeria Kebets
   3. Camille Piguet
   4. Jianzhong Chen
   5. Leon Qi Rong Ooi
   6. Matthias Kirschner
   7. Vanessa Siffredi
   8. Bratislav Misic
   9. BT Thomas Yeo
   10. Boris C Bernhardt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study explores and delineates multivariate mappings between brain structure and functional measures with latent dimensions of psychopathology. This work provides solid evidence for the existence of such mappings and charts the relationship between different neurobiological measures and distinct dimensions of psychopathology. This work will be of broad interest within the neuroscience field.

   Reviewed by eLife

5. A rapid phylogeny-based method for accurate community profiling of large-scale metabarcoding datasets

   This article has 2 authors:

   1. Lenore Pipes
   2. Rasmus Nielsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This potentially important work presents a tool for performing phylogenetic taxonomic classification of DNA sequences. In terms of methodology, the work is compelling. The authors perform a benchmark experiment against current state-of-the-art tools using real and simulated datasets to demonstrate where the novel tool stands in the context of existing methods. However, the experimentation is still incomplete. It would benefit from a more thorough exploration of existing methods as well as data sets that better represent real-world use cases.

   Reviewed by eLife

6. The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

   This article has 12 authors:

   1. Artem N Bonchuk
   2. Konstantin I Balagurov
   3. Rozbeh Baradaran
   4. Konstantin M Boyko
   5. Nikolai N Sluchanko
   6. Anastasia M Khrustaleva
   7. Anna D Burtseva
   8. Olga V Arkova
   9. Karina K Khalisova
   10. Vladimir O Popov
   11. Andreas Naschberger
   12. Pavel G Georgiev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work offers an experimental structural characterization of the Tramtrack-like BTB/POZ domains in insects, revealing that these domains form stable hexameric assemblies. The structural evidence is convincing, and validated by fold prediction and evolutionary pathway analyses. This paper would be of interest to structural and evolutionary biologists.

   Reviewed by eLife

7. CCL28 modulates neutrophil responses during infection with mucosal pathogens

   This article has 21 authors:

   1. Gregory T Walker
   2. Araceli Perez-Lopez
   3. Steven Silva
   4. Michael H Lee
   5. Elisabet Bjånes
   6. Nicholas Dillon
   7. Stephanie L Brandt
   8. Romana R Gerner
   9. Karine Melchior
   10. Grant J Norton
   11. Felix A Argueta
   12. Frenchesca Dela Pena
   13. Lauren Park
   14. Victor A Sosa-Hernandez
   15. Rodrigo Cervantes-Diaz
   16. Sandra Romero-Ramirez
   17. Monica Cartelle Gestal
   18. Jose L Maravillas-Montero
   19. Sean-Paul Nuccio
   20. Victor Nizet
   21. Manuela Raffatellu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, Perez-Lopez and colleagues examine an important function of the chemokine CCL28 in mucosal host defenses against the gut bacterial pathogen Salmonella Typhimurium and lung pathogen Acinetobacter baumanii. They find that CCL28-CCR3 axis regulates neutrophil recruitment and function, and promotes bacterial clearance in one infectious context but exacerbates disease against the other pathogen. Therefore, CCL28 plays a critical role in mucosal immunity and neutrophil biology that differentially affects host defenses against pathogens.

   Reviewed by eLife

8. Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics

   This article has 6 authors:

   1. Hui Li
   2. Jun Yang
   3. Su-fang Kuang
   4. Huan-zhe Fu
   5. Hui-yin Lin
   6. Bo Peng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study explored the influence of magnesium on phenotypic antibiotic resistance in two strains of Vibrios: V. alginolyticus ATCC33787 and V. parahaemolyticus VP01. This research is fundamental for revealing the phenotypic antibiotic resistance mechanism utilized by the specified model bacteria in elevated levels of magnesium. The study produced convincing evidence indicating that in high concentrations of magnesium, the efficacy of selected antibiotics was diminished due to decreased biosynthesis of unsaturated fatty acids and PE, along with an increase in the biosynthesis of PG.

   Reviewed by eLife

9. Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

   This article has 13 authors:

   1. Zewei Zhao
   2. Longyun Hu
   3. Bigui Song
   4. Tao Jiang
   5. Qian Wu
   6. Jiejing Lin
   7. Xiaoxiao Li
   8. Yi Cai
   9. Jin Li
   10. Bingxiu Qian
   11. Siqi Liu
   12. Jilu Lang
   13. Zhonghan Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study highlights adhesion G-protein-coupled receptor A3 (ADGRA3) as a potential target for activating adaptive thermogenesis in both white and brown adipose tissue. This finding offers valuable insights for researchers in the field of adipose tissue biology and metabolism. The authors have presented additional evidence to address the reviewers' comments, including experiments conducted on primary stromal vascular fractions from adipose tissues. However, the revised manuscript fails to address several reviewer concerns, such as the measurement of whole-body energy expenditure through indirect calorimetry and the assessment of food intake. Furthermore, the nanoparticle-mediated knockdown of Adgra3 did not adequately address the tissue selectivity of ADGRA in mice. As a result, the primary claims of the study are only partially supported by the available data, leading to the conclusion that the research is deemed incomplete.

   Reviewed by eLife

10. Direct and indirect salt effects on homotypic phase separation

    This article has 3 authors:

    1. Matt MacAinsh
    2. Souvik Dey
    3. Huan-Xiang Zhou

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this potentially important study, the authors conducted atomistic simulations to probe the salt-dependent phase separation of the low-complexity domain of hnRN-PA1 (A1-LCD). The authors have identified both direct and indirect mechanisms of salt modulation, provided explanations for four distinct classes of salt dependence, and proposed a model for predicting protein properties from amino acid composition. There is a range of opinions regarding the strength of evidence, with some considering the evidence as incomplete due to the limitations in the length and statistical errors of the computationally intense atomistic MD simulations.

    Reviewed by eLife