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  1. Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

    This article has 7 authors:
    1. Houfang Zhang
    2. Wenhan Guo
    3. Wang Xu
    4. Anbang Li
    5. Lijun Jiang
    6. Lin Li
    7. Yunhui Peng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study explores the impact of pH changes and cancer mutations on nucleosome interactions and higher-order chromatin structures. The evidence supporting the main conclusions is solid, based on rigorous computational methods, including pKa prediction, electrostatic force calculation, and molecular dynamics simulations. The findings provide insights into how protonation states and cancer-associated mutations affect nucleosome electrostatics and chromatin organization, making this work of broad interest to chromatin biologists, cancer researchers, and computational biophysicists.

    Reviewed by eLife

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