eLife

Latest preprint reviews

1. GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex

   This article has 12 authors:

   1. Yuan Gao
   2. Yong-Chun Cai
   3. Dong-Yu Liu
   4. Juan Yu
   5. Jue Wang
   6. Ming Li
   7. Bin Xu
   8. Tengfei Wang
   9. Gang Chen
   10. Georg Northoff
   11. Ruiliang Bai
   12. Xue Mei Song

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study adopts a comprehensive approach: functional connectivity, biochemistry, and psychophysics to reveal a holistic understanding of the relationship between GABA-ergic inhibition in the human MT+ region and visuo-spatial intelligence. The evidence supporting the conclusion is convincing. The result advances our understanding of how the human MT+ is assemble into complex cognition as an intellectual hub, and will be of interest to researchers in psychology, cognitive science, and neuroscience.

   Reviewed by eLife

2. Cortical beta oscillations map to shared brain networks modulated by dopamine

   This article has 8 authors:

   1. Meera Chikermane
   2. Liz Weerdmeester
   3. Nanditha Rajamani
   4. Richard M Köhler
   5. Timon Merk
   6. Jojo Vanhoecke
   7. Andreas Horn
   8. Wolf Julian Neumann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study poses an important step forward in understanding the brain-network embedding of beta oscillations. The study advances our circuit-level understanding of the pathophysiology associated with dopaminergic alterations in psychiatric or neurological disorders. The study provides compelling evidence that beta oscillations across the neocortex and basal ganglia map onto shared functional and structural networks that show significant positive correlations with dopamine receptors.

   Reviewed by eLife

3. Inverted encoding of neural responses to audiovisual stimuli reveals super-additive multisensory enhancement

   This article has 4 authors:

   1. Zak Buhmann
   2. Amanda K Robinson
   3. Jason B Mattingley
   4. Reuben Rideaux

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Despite the well-established facilitatory effects of multisensory integration on behavioural measures, standard neuroimaging approaches have yet to reliably and precisely identify the corresponding neural correlates. In this valuable paper, Buhmann et al. leverage EEG decoding methods, moving beyond traditional univariate analyses, to capture these correlates. They present solid evidence that this approach can effectively estimate multisensory integration in humans across a broad range of contexts.

   Reviewed by eLife

4. A microglia clonal inflammatory disorder in Alzheimer’s disease

   This article has 26 authors:

   1. Rocio Vicario
   2. Stamatina Fragkogianni
   3. Leslie Weber
   4. Tomi Lazarov
   5. Yang Hu
   6. Samantha Y Hayashi
   7. Barbara Craddock
   8. Nicholas D Socci
   9. Araitz Alberdi
   10. Ann Baako
   11. Oyku Ay
   12. Masato Ogishi
   13. Estibaliz Lopez-Rodrigo
   14. Rajya Kappagantula
   15. Agnes Viale
   16. Christine A Iacobuzio-Donahue
   17. Ting Zhou
   18. Richard M Ransohoff
   19. Richard Chesworth
   20. Netherlands Brain Bank
   21. Omar Abdel-Wahab
   22. Bertrand Boisson
   23. Olivier Elemento
   24. Jean-Laurent Casanova
   25. W Todd Miller
   26. Frédéric Geissmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study enhances our understanding of how somatic variants in microglia might influence the onset and progression of neurodegenerative diseases such as Alzheimer's. The evidence supporting the conclusions is compelling, with the authors employing a multi-faceted approach to identify an enrichment of potentially pathogenic somatic mutations in Alzheimer's disease microglia. This research will be of significant interest to those investigating somatic mutations, Alzheimer's disease, microglial biology and cell signalling pathways.

   Reviewed by eLife

5. Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices

   This article has 6 authors:

   1. Yanqi Liu
   2. Pol Bech
   3. Keita Tamura
   4. Lucas T Délez
   5. Sylvain Crochet
   6. Carl CH Petersen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study offers a valuable description of the layer-and sublayer specific outputs of the somatosensory cortex based on compelling evidence obtained with modern tools for the analysis of brain connectivity, together with functional validation of the connectivity using optogenetic approaches in vivo. Beyond bridging together, in one dataset, the results of disparate studies, this effort brings new insights on layer specific outputs, and on differences between primary and secondary somatosensory areas. This study will be of interest to neuroanatomists and neurophysiologists.

   Reviewed by eLife

6. Frequency-specific cortico-subcortical interaction in continuous speaking and listening

   This article has 5 authors:

   1. Omid Abbasi
   2. Nadine Steingräber
   3. Nikos Chalas
   4. Daniel S Kluger
   5. Joachim Gross

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Abbasi and colleagues use Granger causality to explore the cortico-subcortical dynamics during speaking and listening. They find valuable evidence for bi-directional connectivity in distinct frequency bands as a function of behaviour, but currently offer incomplete support for the validity of their analyses and the predictive coding interpretation of their results.

   Reviewed by eLife

7. Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

   This article has 13 authors:

   1. Hsiao-Fen Han
   2. Shao-Fu Nien
   3. Hang-Shiang Jiang
   4. Jui-Ching Wu
   5. Chia-Yi Chiang
   6. Man-Tzu Li
   7. Leng-Jie Huang
   8. Sufeng Chiang
   9. Lien-Chieh Lin
   10. Yi-Ting Chuang
   11. Yu-Ho Lin
   12. Chao-Wen Wang
   13. Yi-Chun Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This a useful study that reports a genetic regulatory network that accounts for altered lipid metabolism in response to two different bacterial diets of C. elegans. The proposed mechanism, linking vitamin B12, S-adenosyl methionine (SAM), phosphatidylcholine (PC), and neutral lipid levels, is solid but has been previously demonstrated by other studies using similar assays. The evidence to support a new layer of regulation, via the production of phospho-choline by ASM-3/acid sphingomyelinase, requires further substantiation.

   Reviewed by eLife

8. Effort drives saccade selection

   This article has 6 authors:

   1. Damian Koevoet
   2. Laura Van Zantwijk
   3. Marnix Naber
   4. Sebastiaan Mathôt
   5. Stefan van der Stigchel
   6. Christoph Strauch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important findings on the nature of eye movement choices by human subjects. The study uses a novel approach and provides relatively clear and convincing results of the relationship between pupil size and saccade production. The results should be of interest to a broad audience interested in sensorimotor integration and sensory-guided decision-making.

   Reviewed by eLife

9. Engineered migrasomes provide a robust and thermally stable vaccination platform

   This article has 11 authors:

   1. Dongju Wang
   2. Haifang Wang
   3. Wei Wan
   4. Zihui Zhu
   5. Takami Sho
   6. Yi Zheng
   7. Xing Zhang
   8. Longyu Dou
   9. Qiang Ding
   10. Li Yu
   11. Zhihua Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study, from the group that pioneered migrasome, describes a novel vaccine platform of engineered migrasomes that behave like natural migrasomes. Importantly, this platform has the potential to overcome obstacles associated with cold chain issues for vaccines such as mRNA. In the revised version, the authors have addressed previous concerns and the results from additional experiments provide compelling evidence that features methods, data, and analyses more rigorous than the current state-of-the-art. Although the findings are important with practical implications for the vaccine technology, results from additional experiments would make this an outstanding study.

   Reviewed by eLife

10. Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone

    This article has 7 authors:

    1. Yan-Xue Li
    2. Xin-Le Kang
    3. Yan-Li Li
    4. Xiao-Pei Wang
    5. Qiao Yan
    6. Jin-Xing Wang
    7. Xiao-Fan Zhao

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this important study, Li and others identified cell membrane receptors for juvenile hormone (JH), a terpenoid hormone in insects that regulates their development and reproduction. While intracellular receptors for JH are well characterized, membrane receptors for JH have remained elusive for many years. The authors provide convincing evidence indicating that two receptor tyrosine kinases (RTKs), CAD96CA and FGFR1, modulate the genomic effects of JH by phosphorylating the intracellular receptors in the cotton bollworm, Helicoverpa armigera. Although differential functions of the two RTKs and potential effects of the other endogenous ligands of these RTKs on JH signaling remain unclear, this study lays a foundation for future studies.

    Reviewed by eLife