eLife

Latest preprint reviews

1. Structure transfer and consolidation in visual implicit learning

   This article has 2 authors:

   1. Dominik Garber
   2. József Fiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigates the conditions under which abstract knowledge transfers to new learning. It presents convincing evidence across a number of behavioral experiments that when explicit awareness of learned statistical structure is present, knowledge can transfer immediately, but that otherwise similar transfer requires sleep-dependent consolidation. The valuable results provide new constraints on theories of transfer learning and consolidation.

   Reviewed by eLife

2. A pair of dopaminergic neurons DAN-c1 mediate Drosophila larval aversive olfactory learning through D2-like receptors

   This article has 5 authors:

   1. Cheng Qi
   2. Cheng Qian
   3. Emma Steijvers
   4. Robert A Colvin
   5. Daewoo Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the role of dopamine receptor D2R in dopaminergic neurons DAN-c1 and mushroom body neurons (Y201-GAL4 pattern) on aversive and appetitive conditioning. The evidence supporting the claims of the authors is solid in the context of their behavioural paradigm. Controls using a reciprocal training protocol would have broadened the scope of their conclusions. The work will be of interest to researchers studying the role of dopamine during learning and memory.

   Reviewed by eLife

3. Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms

   This article has 8 authors:

   1. Martin Breyton
   2. Jan Fousek
   3. Giovanni Rabuffo
   4. Pierpaolo Sorrentino
   5. Lionel Kusch
   6. Marcello Massimini
   7. Spase Petkoski
   8. Viktor Jirsa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examined the complexity of emergent dynamics of large-scale neural network models after perturbation (perturbational complexity index, PCI) and used it as a measurement of consciousness to account for previous recordings of humans at various anesthetized levels. The evidence supporting the conclusion is convincing and constitutes a unified framework for different observations related to consciousness. There are many fields that would be interested in this study, including cognitive neuroscience, psychology, complex systems, neural networks, and neural dynamics.

   Reviewed by eLife

4. A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

   This article has 20 authors:

   1. Lotfi Ferhat
   2. Rabia Soussi
   3. Maxime Masse
   4. Grigorios Kyriatzis
   5. Stéphane Girard
   6. Fanny Gassiot
   7. Nicolas Gaudin
   8. Mathieu Laurencin
   9. Anne Bernard
   10. Angélique Bôle
   11. Géraldine Ferracci
   12. Maria Smirnova
   13. François Roman
   14. Vincent Dive
   15. Salvatore Cisternino
   16. Jamal Temsamani
   17. Marion David
   18. Pascaline Lécorché
   19. Guillaume Jacquot
   20. Michel Khrestchatisky

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors developed a method to allow a hypothermic agent, neurotensin, to cross the blood-brain barrier so it could potentially protect the brain from seizures and the adverse effects of seizures. The work is important because it is known that cooling the brain can protect it but developing a therapeutic approach based on that knowledge has not been done. The paper is well presented and the data are convincing.

   Reviewed by eLife

5. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2310.02257v3

6. Different treatment durations of loperamide in preventing pyrotinib-induced diarrhea: A randomized, parallel-group sub-study of the phase II PHAEDRA trial

   This article has 22 authors:

   1. Changjun Wang
   2. Yan Lin
   3. Ying Xu
   4. Feng Mao
   5. Jinghong Guan
   6. Xuejing Wang
   7. Yanna Zhang
   8. Xiaohui Zhang
   9. Songjie Shen
   10. Ying Zhong
   11. Bo Pan
   12. Li Peng
   13. Xin Huang
   14. Xi Cao
   15. Ru Yao
   16. Xintong Zhou
   17. Zecheng He
   18. Yuhan Liu
   19. Jie Lang
   20. Chenggang Li
   21. Yidong Zhou
   22. Qiang Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful finding for the prevention of diarrhea with loperamide in patients with early HER2-positive breast cancer treated with nab-paclitaxel in combination with pyrotinib. The evidence supporting the claims of the authors is somewhat incomplete. The enrollment of patients as a control group who have not received prophylactic treatment for diarrhea would have strengthened the study, and the addition of double-blinding for the assessment of treatment may be necessary. The work will be of interest to scientists working in the field of clinical breast cancer treatment.

   Reviewed by eLife

7. Spatial localization of hippocampal replay requires dopamine signaling

   This article has 2 authors:

   1. Matthew R Kleinman
   2. David J Foster

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides a valuable contribution to our understanding of the neurobiological mechanisms underlying spatial memory and learning, suggesting that dopamine plays a pivotal role in linking reward context and novelty to memory consolidation processes. The evidence presented to support the main conclusions is solid, although reviewers felt that the strength of evidence could have been further strengthened by more rigorous histological verification of the experimental conditions and the complexity of the experimental manipulations, increased sample sizes, and a more consistent approach to experimental dosing and timing, which will be crucial for confirming the reproducibility and reliability of the observed effects.

   Reviewed by eLife

8. fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

   This article has 9 authors:

   1. Angela M Tuckowski
   2. Safa Beydoun
   3. Elizabeth S Kitto
   4. Ajay Bhat
   5. Marshall B Howington
   6. Aditya Sridhar
   7. Mira Bhandari
   8. Kelly Chambers
   9. Scott F Leiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study offers convincing evidence that fmo-4 plays essential roles in established lifespan interventions and downstream of its paralog fmo-2. The work is of substantial benefit for our understanding of this enzyme family, underscoring their importance in longevity and stress resistance. The study also suggests a connection between fmo-4 and dysregulation of calcium signalling, with conclusions and interpretations based on solid genetic methodology and evidence.

   Reviewed by eLife

9. Heparan sulphate binding controls in vivo half-life of the HpARI protein family

   This article has 9 authors:

   1. Florent Colomb
   2. Abhishek Jamwal
   3. Adefunke Ogunkanbi
   4. Tania Frangova
   5. Alice R Savage
   6. Sarah Kelly
   7. Gavin J Wright
   8. Matthew K Higgins
   9. Henry J McSorley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses in vitro and in vivo methods to identify HpARI proteins from H. polygyrus as modulators of the host immune system. The data from comprehensive approaches for investigating differential roles of HpARI proteins are convincing. This paper is relevant to those who investigate host-pathogen interactions at the systems and molecular levels.

   Reviewed by eLife

10. Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

    This article has 7 authors:

    1. Lili Karashchuk
    2. Jing Shuang Li
    3. Grant M Chou
    4. Sarah Walling-Bell
    5. Steven L Brunton
    6. John C Tuthill
    7. Bingni W Brunton

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study presents a computational model that simulates walking motions in Drosophila and suggests that, if sensorimotor delays in the neural circuitry were any longer, the system would be easily destabilized by external perturbations. The hierarchical control model is sensible and the evidence supporting the conclusions convincing. The modular model, which has many interacting components with varying degrees of biological realism, will serve as a well-grounded starting point for future studies that incorporate richer or more complete empirical data.

    Reviewed by eLife