Latest preprint reviews

  1. PD-1 negatively regulates helper T cell differentiation into Th2

    This article has 9 authors:
    1. Masaki Tajima
    2. Naoko Ikuta
    3. Yuka Nakajima
    4. Kensuke Suzuki
    5. Yosuke Tokumaru
    6. Peng Li
    7. Hiroshi Kiyonari
    8. Tasuku Honjo
    9. Akio Ohta
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for the treatment of allergies. However, whereas the series of well-designed experiments using OVA-specific CD4 T cells from DO.11.10 mice and the use of an allergy model generated compelling data, the study is still incomplete since it shows gaps in the rationale for the experimental protocols, contradictory data regarding IFN-gamma and IL-4 production, and the lack of in vivo experiments on Th2 differentiation to further support the main hypothesis. Nonetheless, the reported data would be of interest to immunologists working on T cell differentiation and allergy.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Low-dimensional olfactory signatures of fruit ripening and fermentation

    This article has 6 authors:
    1. Yuansheng Zhou
    2. Thomas F O’Connell
    3. Majid Ghaninia
    4. Brian H Smith
    5. Elizabeth J Hong
    6. Tatyana O Sharpee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study presents results for the theory of odor coding in hyperbolic spaces by revealing spiral trajectories in the dynamics of odors during natural, ethologically relevant processes such as ripening. In the current manuscript, the strength of the evidence is solid and would be strengthened by answering several technical points raised by reviewers.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

    This article has 13 authors:
    1. Nicole Foxworth
    2. Julie Wells
    3. Sara Ocaña-Lopez
    4. Sandrine Muller
    5. Pooja Bhayani
    6. James Denegre
    7. Kristina Palmer
    8. Wendy Memishian
    9. Teresa McGee
    10. Steven A Murray
    11. Patricia K Donahoe
    12. Carol J Bult
    13. Maria Loscertales
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important piece of work that sheds light on our understanding of early lung development. There is solid evidence that there is a key new role for Svep1, which may be acting via FGF9. A more precise understanding of the interactions between Svep1 and FGF9, with a possibility of other ECM factors, would add value.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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