eLife

Latest preprint reviews

1. Tonotopy is not preserved in a descending stage of auditory cortex

   This article has 14 authors:

   1. Miaoqing Gu
   2. Shanshan Liang
   3. Jiahui Zhu
   4. Ruijie Li
   5. Ke Liu
   6. Xuanyue Wang
   7. Frank W Ohl
   8. Yun Zhang
   9. Xiang Liao
   10. Chunqing Zhang
   11. Hongbo Jia
   12. Yi Zhou
   13. Jianxiong Zhang
   14. Xiaowei Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This revised manuscript presents an important characterization of mouse auditory cortex receptive field organization, utilizing two-photon imaging of specific subpopulations. They demonstrate a degradation of tonotopic organization from the input to the output neurons. The strength of the evidence is convincing.

   Reviewed by eLife

2. Cryo-EM structure of the bicarbonate receptor GPR30

   This article has 7 authors:

   1. Shota Kaneda
   2. Airi Jo-Watanabe
   3. Hiroaki Akasaka
   4. Hidetaka S Oshima
   5. Takehiko Yokomizo
   6. Wataru Shihoya
   7. Osamu Nureki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study resolves a cryo-EM structure of the GPCR, human GPR30, which responds to bicarbonate and regulates cellular responses to pH and ion homeostasis. Understanding the ligand and the mechanism of activation is important to the field of receptor signaling and potentially facilitates drug development targeting this receptor. Structures and functional assays provide solid evidence for a potential bicarbonate binding site.

   Reviewed by eLife

3. Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

   This article has 23 authors:

   1. Peng Xie
   2. Xu Jiang
   3. Jingjing He
   4. Qingyun Pan
   5. Xianfa Yang
   6. Yanying Zheng
   7. Zhuanzhuan Che
   8. Wenli Fan
   9. Chen Wu
   10. Weiheng Zheng
   11. Shuhan Si
   12. Kun Gao
   13. Shiqi Zhu
   14. Ke Fang
   15. Haitong Fang
   16. Yi Yang
   17. Tao P Zhong
   18. Zhongzhou Yang
   19. Ke Wei
   20. Wei Xie
   21. Naihe Jing
   22. Zhuojuan Luo
   23. Chengqi Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides new single-cell multi-omics datasets that may be useful in the study of early cardiac lineages. However, the authors' conclusions regarding the mutual regulation of key regulators for cardiac specification and new cardiac lineage trajectories are inadequately supported by persuasive analysis and do not align with prior published studies. If revised to address the serious caveats adequately, the findings may be of interest to researchers in the field of cardiac development and congenital heart disease.

   Reviewed by eLife

4. Interdependence between SEB-3 receptor and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans

   This article has 3 authors:

   1. Kathleen T Quach
   2. Gillian A Hughes
   3. Sreekanth H Chalasani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on predator threat detection in C. elegans and the role of neuropeptide systems in defensive behavioral strategies. The evidence supporting the conclusions is solid, although additional analyses and control experiments would strengthen the claims of the study. Overall, the work is of interest to the C. elegans community as well as neuroethologists and ecologists studying predator-prey interactions.

   Reviewed by eLife

5. Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

   This article has 5 authors:

   1. Katherine R Cording
   2. Emilie M Tu
   3. Hongli Wang
   4. Alexander HCW Agopyan-Miu
   5. Helen S Bateup

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important and well-executed study describes how deleting the autism spectrum disorder risk gene CNTNAP2 in mice increases dorsolateral striatal projection neuron excitability and promotes repetitive behaviors and cognitive inflexibility. The evidence supporting this claim is convincing. The study provides a potential cellular explanation for the repetitive and inflexible behavior in Cntnap2 knockout mice and CNTNAP2 disorder in humans, which would interest both basic and translational neuroscientists.

   Reviewed by eLife

6. Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

   This article has 12 authors:

   1. Mohsen Khosravi-Maharlooei
   2. Andrea Vecchione
   3. Nichole Danzl
   4. Hao Wei Li
   5. Grace Nauman
   6. Rachel Madley
   7. Elizabeth Waffarn
   8. Robert Winchester
   9. Amanda Ruiz
   10. Xiaolan Ding
   11. Georgia Fousteri
   12. Megan Sykes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study utilizes humanized mice, in which human immune cells are introduced into immune-deficient mice, to provide convincing evidence that two helper CD4 T-cell subsets, T-follicular helper (Tfh) and T-peripheral helper (Tph) cells, are able to drive both autoantibody production and induction of autoimmunity. The work will be of broad interest to medical scientists engaged in deciphering how human immune cells mediate immune responses and contribute to the development of autoimmune diseases.

   Reviewed by eLife

7. Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

   This article has 4 authors:

   1. Veronika Koren
   2. Simone Blanco Malerba
   3. Tilo Schwalger
   4. Stefano Panzeri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers a valuable treatment of how the population of excitatory and inhibitory neurons integrates principles of energy efficiency in their coding strategies. The convincing analysis provides a comprehensive characterisation of the model, highlighting the structured connectivity between excitatory and inhibitory neurons. The role of the many free parameters are discussed and studied in depth.

   Reviewed by eLife

8. Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)

   This article has 5 authors:

   1. Bikash Adhikari
   2. Katharina Schneider
   3. Mathias Diebold
   4. Christoph Sotriffer
   5. Elmar Wolf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study describes a valuable new technology in the field of targeted protein degradation that allows identification of E3-ubiquitin ligases that target a protein of interest. The presented data are convincing, however, additional work will be needed to optimize for high-throughput evaluation. This technology will therefore serve the community in the initial stages of developing targeted protein degraders.

   Reviewed by eLife

9. Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish

   This article has 14 authors:

   1. Evan Lloyd
   2. Fanning Xia
   3. Kinsley Moore
   4. Carolina Zertuche Mery
   5. Aakriti Rastogi
   6. Robert A Kozol
   7. Olga Kenzor
   8. Wesley Warren
   9. Lior Appelbaum
   10. Rachel L Moran
   11. Chongbei Zhao
   12. Erik R Duboue
   13. Nicolas Rohner
   14. Alex C Keene

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Lloyd et al. used an evolutionary comparative approach to study DNA damage repair associated with low sleep duration in Astyanax mexicanus, highlighting how the cavefish population has evolved a reduced DNA damage response. The results presented here have important implications. Their results are generally solid however, the evidence suggesting that sleep differences are linked to DNA damage response is missing and this hypothesis remains to be fully tested.

   Reviewed by eLife

10. Detecting directed motion and confinement in single-particle trajectories using hidden variables

    This article has 9 authors:

    1. François Simon
    2. Guillaume Ramadier
    3. Inès Fonquernie
    4. Janka Zsok
    5. Sergiy Patskovsky
    6. Michel Meunier
    7. Caroline Boudoux
    8. Elisa Dultz
    9. Lucien E Weiss

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this valuable contribution, the authors present a novel and versatile probabilistic tool for classifying tracking behaviors and understanding parameters for different types of single-particle motion. The software package will be broadly applicable to single-particle tracking studies. The methodology has been convincingly tested by computational comparisons and experimental data, although the mathematical foundation for the hypothesis testing method can be further strengthened.

    Reviewed by eLife