Latest preprint reviews

  1. LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-β Signaling Suppression

    This article has 12 authors:
    1. Kai Xu
    2. Xiaoyue Pan
    3. Hui Lian
    4. Yaxuan Wang
    5. Ruyan Wan
    6. Zhongzheng Li
    7. Xin Pan
    8. Yajun Li
    9. Juntang Yang
    10. Ivan Rosas
    11. Lan Wang
    12. Guoying Yu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable manuscript, the authors propose that the lysosomal protein LAPTM4B plays a role in suppressing the TGF-β/SMAD signaling pathway and suggest that enhancing LAPTM4B function could be a potential therapeutic strategy for alleviating bleomycin-induced lung fibrosis. The findings will be of interest to the lung disease field, and the data presented to support the authors' conclusions is solid. However, it remains unclear whether the suppressive effect of LAPTM4b on idiopathic pulmonary fibrosis is mediated by Nedd4l.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. HIV integrase compacts viral DNA into biphasic condensates

    This article has 14 authors:
    1. Pauline J Kolbeck
    2. Marjolein de Jager
    3. Margherita Gallano
    4. Tine Brouns
    5. Ben Bekaert
    6. Wout Frederickx
    7. Sebastian F Konrad
    8. Siska Van Belle
    9. Frauke Christ
    10. Steven De Feyter
    11. Zeger Debyser
    12. Laura Filion
    13. Jan Lipfert
    14. Willem Vanderlinden
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript by Kolbeck and co-workers is an important contribution to understanding the physical mechanism that controls a key step in the retroviral infectious cycle. The authors employ a wide range of experimental techniques, complemented with Montecarlo simulations, that result in convincing evidence of compaction of HIV DNA by the viral integrase. This manuscript would benefit from in-depth discussion and analysis of the biophysical implications of the results.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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