eLife

Latest preprint reviews

1. A split-GAL4 driver line resource for Drosophila neuron types

   This article has 84 authors:

   1. Geoffrey W Meissner
   2. Allison Vannan
   3. Jennifer Jeter
   4. Kari Close
   5. Gina M DePasquale
   6. Zachary Dorman
   7. Kaitlyn Forster
   8. Jaye Anne Beringer
   9. Theresa Gibney
   10. Joanna H Hausenfluck
   11. Yisheng He
   12. Kristin Henderson
   13. Lauren Johnson
   14. Rebecca M Johnston
   15. Gudrun Ihrke
   16. Nirmala A Iyer
   17. Rachel Lazarus
   18. Kelley Lee
   19. Hsing-Hsi Li
   20. Hua-Peng Liaw
   21. Brian Melton
   22. Scott Miller
   23. Reeham Motaher
   24. Alexandra Novak
   25. Omotara Ogundeyi
   26. Alyson Petruncio
   27. Jacquelyn Price
   28. Sophia Protopapas
   29. Susana Tae
   30. Jennifer Taylor
   31. Rebecca Vorimo
   32. Brianna Yarbrough
   33. Kevin Xiankun Zeng
   34. Christopher T Zugates
   35. Heather Dionne
   36. Claire Angstadt
   37. Kelly Ashley
   38. Amanda Cavallaro
   39. Tam Dang
   40. Guillermo A Gonzalez
   41. Karen L Hibbard
   42. Cuizhen Huang
   43. Jui-Chun Kao
   44. Todd Laverty
   45. Monti Mercer
   46. Brenda Perez
   47. Scarlett Rose Pitts
   48. Danielle Ruiz
   49. Viruthika Vallanadu
   50. Grace Zhiyu Zheng
   51. Cristian Goina
   52. Hideo Otsuna
   53. Konrad Rokicki
   54. Robert R Svirskas
   55. Han SJ Cheong
   56. Michael-John Dolan
   57. Erica Ehrhardt
   58. Kai Feng
   59. Basel EI Galfi
   60. Jens Goldammer
   61. Stephen J Huston
   62. Nan Hu
   63. Masayoshi Ito
   64. Claire McKellar
   65. Ryo Minegishi
   66. Shigehiro Namiki
   67. Aljoscha Nern
   68. Catherine E Schretter
   69. Gabriella R Sterne
   70. Lalanti Venkatasubramanian
   71. Kaiyu Wang
   72. Tanya Wolff
   73. Ming Wu
   74. Reed George
   75. Oz Malkesman
   76. Yoshinori Aso
   77. Gwyneth M Card
   78. Barry J Dickson
   79. Wyatt Korff
   80. Kei Ito
   81. James W Truman
   82. Marta Zlatic
   83. Gerald M Rubin
   84. FlyLight Project Team

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a resource for researchers using Drosophila to study neural circuits, in the form of a collection of split-Gal4 lines with an online search engine, which will facilitate the mapping of neuronal circuits. The evidence is convincing to demonstrate the utility of these new tools, and of the search engine, for understanding expression patterns in adults and larvae, and differences between the sexes. These resources will be of broad interest to Drosophila researchers in the field of neurobiology.

   Reviewed by eLife

2. Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

   This article has 7 authors:

   1. Suguru Takagi
   2. Shiina Takano
   3. Tomohiro Kubo
   4. Yusaku Hashimoto
   5. Shu Morise
   6. Xiangsunze Zeng
   7. Akinao Nose

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Takagi and colleagues is an important contribution to the question of how homologous neuronal circuits might be wired differently to elicit specific behaviours. The authors combine genetic, neuroanatomical, and behavioral data to provide convincing evidence that Dfz2/DWnt4 signaling controls the innervation pattern of wave command neurons in the fly larva, and thereby behavioral locomotion program selection.

   Reviewed by eLife

3. Untangling stability and gain modulation in cortical circuits with multiple interneuron classes

   This article has 4 authors:

   1. Hannah Bos
   2. Christoph Miehl
   3. Anne-Marie Michelle Oswald
   4. Brent Doiron

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper explores how diverse forms of inhibition impact firing rates in models for cortical circuits. In particular, the paper studies how the network operating point affects the balance of direct inhibition from SOM inhibitory neurons to pyramidal cells, and disinhibition from SOM inhibitory input to PV inhibitory neurons. This is an important issue as these two inhibitory pathways have largely been studied in isolation. A combination of analytical calculations and direct numerical simulations provides convincing evidence that the interplay of these inhibitory circuits can separately control network gain and stability.

   Reviewed by eLife

4. T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells

   This article has 8 authors:

   1. Josep Garnica
   2. Patricia Sole
   3. Jun Yamanouchi
   4. Joel Moro
   5. Debajyoti Mondal
   6. Cesar Fandos
   7. Pau Serra
   8. Pere Santamaria

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important information on pre-existing epigenetic modification in T cell plasticity. The evidence supporting the conclusions is compelling, supported by comprehensive transcriptional and epigenetic analyses. The work will be of interest to immunologists and colleagues studying transcriptional regulation.

   Reviewed by eLife

5. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2209.08066v5

6. Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

   This article has 5 authors:

   1. Igor Kondrychyn
   2. Liqun He
   3. Haymar Wint
   4. Christer Betsholtz
   5. Li-Kun Phng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study convincingly shows that aquaporin-mediated cell migration plays a key role in blood vessel formation during zebrafish development. In particular, the paper implicates hydrostatic pressure and water flow as mechanisms controlling endothelial cell migration during angiogenic sprouting. This fundamental study is highly novel and significantly advances our understanding of cell migration during morphogenesis. As such, this work will be of great interest to developmental and cell biologists working on organogenesis, angiogenesis, and cell migration.

   Reviewed by eLife

7. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2311.00616

8. The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

   This article has 9 authors:

   1. Roger Huerlimann
   2. Natacha Roux
   3. Ken Maeda
   4. Polina Pilieva
   5. Saori Miura
   6. Hsiao-chian Chen
   7. Michael Izumiyama
   8. Vincent Laudet
   9. Timothy Ravasi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work provides valuable genomic resources to address the endocrine control of a life cycle transition in the Malabar grouper fish. The revised manuscript is more solid and the resources and experimental data help to build up a meaningful biological understanding of thyroid signaling in grouper fish.

   Reviewed by eLife

9. Impact of maximal overexpression of a non-toxic protein on yeast cell physiology

   This article has 4 authors:

   1. Yuri Fujita
   2. Shotaro Namba
   3. Yoshiaki Kamada
   4. Hisao Moriya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This convincing study advances our understanding of the physiological consequences of the strong overexpression of non-toxic proteins in baker's yeast. The findings suggest that a massive protein burden results in nitrogen starvation and a shift in metabolism likely regulated via the TORC1 pathway, as well as defects in ribosome biogenesis in the nucleolus. The study presents findings and tools that are important for the cell biology and protein homeostasis fields.

   Reviewed by eLife

10. Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity

    This article has 8 authors:

    1. Jingbo Kan
    2. Adrian Morales-Amador
    3. Yozen Hernandez
    4. Melinda A Ternei
    5. Christophe Lemetre
    6. Logan W Maclntyre
    7. Nicolas Biais
    8. Sean F Brady

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Kan et al. report the discovery of a Bacillus amyloliquifaciens strain that kills Nerisseria gonorrhoeae via oxydifficidin which targets ribosomal proteins. Resistance occurred via mutation in the DedA flippase to influence oxydifficidin uptake. The overall mechanism of action is well described making this an important study with implications for combating clinical antibiotic resistance. The evidence presented is convincing due to rigour employed in the methodological approach. The authors should consider performing a more comprehensive genetic analyses of DedA and RpIL in this clinically relevant strain. This work will be of broad interest to microbiologists and synthetic biologists.

    Reviewed by eLife