eLife

Latest preprint reviews

1. A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice

   This article has 1 author:

   1. Zheng Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a valuable strategy for treating mouse cutaneous squamous cell carcinoma (mCSCC) with serum derived from mCSCC-exposed mice. The exploration of serum-derived antibodies as a potential therapy for curing cancer is particularly promising but the study provides incomplete evidence for specific effects of mCSCC-binding serum antibodies. This study will be of interest to scientists seeking a novel immunotherapeutic strategy in cancer therapy.

   Reviewed by eLife

2. Associative plasticity of granule cell inputs to cerebellar Purkinje cells

   This article has 2 authors:

   1. Rossella Conti
   2. Céline Auger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on an unresolved question of cerebellar physiology: Do synapses between Purkinje cells and granule cells, made by the ascending part of the granule cells' axon, have different properties than those made by parallel fibers? The authors conducted patch-clamp recordings on rat cerebellar slices and found a new type of plasticity in the synapses of the ascending part of granule cell axons. The experiments are well-designed with appropriate controls, and the study provides solid evidence for the new form of cerebellar synaptic plasticity.

   Reviewed by eLife

3. Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury

   This article has 10 authors:

   1. Qing Zhao
   2. Yanjing Zhu
   3. Yilong Ren
   4. Lijuan Zhao
   5. Jingwei Zhao
   6. Shuai Yin
   7. Haofei Ni
   8. Rongrong Zhu
   9. Liming Cheng
   10. Ning Xie

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrated that ablation of astrocytes in the lumbar spinal cord not only reduced neuropathic pain but also caused microglia activation. The findings presented add considerable value to the current understanding of the role of astrocyte elimination in neuropathic pain, offering convincing evidence that supports existing hypotheses and insights into the interactions between astrocytes and microglial cells, likely through IFN-mediated mechanisms

   Reviewed by eLife

4. Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution

   This article has 15 authors:

   1. Felix Lankester
   2. Tito J Kibona
   3. Kathryn J Allan
   4. William de Glanville
   5. Joram J Buza
   6. Frank Katzer
   7. Jo E Halliday
   8. Blandina T Mmbaga
   9. Nick Wheelhouse
   10. Elisabeth A Innes
   11. Kate M Thomas
   12. Obed M Nyasebwa
   13. Emanuel Swai
   14. John R Claxton
   15. Sarah Cleaveland

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports the use of a surveillance approach in identifying emerging diseases, monitoring disease trends, and informing evidence-based interventions in the control and prevention of livestock abortions, as it relates to their public health implications. The data support the convincing finding that abortion incidence is higher during the dry season, and occurs more in cross-bred and exotic livestock breeds. Aetiological and epidemiological data can be generated through established protocols for sample collection and laboratory diagnosis. These findings are of potential interest to the fields of veterinary medicine, public health, and epidemiology.

   Reviewed by eLife

5. Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

   This article has 9 authors:

   1. Weihua Wang
   2. Junqiao Xing
   3. Xiqi Zhang
   4. Hongni Liu
   5. Xingyu Liu
   6. Haochen Jiang
   7. Cheng Xu
   8. Xue Zhao
   9. Zhangfeng Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents data suggesting the critical roles of two ancient proteins, XAP5 and XAP5L, in regulating the transcriptional program of ciliogenesis during mouse spermatogenesis. The supporting data are solid, and this work will be of interest to biomedical researchers studying ciliogenesis and reproduction.

   Reviewed by eLife

6. N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation

   This article has 6 authors:

   1. Valentin Babosha
   2. Natalia Klimenko
   3. Anastasia Revel-Muroz
   4. Evgeniya Tikhonova
   5. Pavel Georgiev
   6. Oksana Maksimenko

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a potentially valuable contribution, reporting a deletion analysis of the MSL1 gene to assess how different parts of the protein product interact with the MSL2 protein and roX RNA to affect the association of the MSL complex with the male X chromosome of Drosophila. However, the framework that the MSL complex mediates dosage compensation is outdated and has flaws, and the evidence is currently considered inadequate to support the claims. Because there are many ways to alter viability, sex-specific viability is insufficient to make claims regarding dosage compensation.

   Reviewed by eLife

7. Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions

   This article has 16 authors:

   1. Xingfeng Shao
   2. Qinyang Shou
   3. Kimberly Felix
   4. Brandon Ojogho
   5. Xuejuan Jiang
   6. Brian T Gold
   7. Megan M Herting
   8. Eric L Goldwaser
   9. Peter Kochunov
   10. Elliot Hong
   11. Ioannis Pappas
   12. Meredith Braskie
   13. Hosung Kim
   14. Steven Cen
   15. Kay Jann
   16. Danny JJ Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding that the blood-brain barrier functionality changes with age and differs between males and females. The analysis is solid, comprising a large and racially diverse dataset, and utilizes a contrast-agent-free MRI method. Since limited work has been done in the MRI field on the blood-brain barrier using this method, this study is of great interest to neuroimaging researchers and clinicians.

   Reviewed by eLife

8. Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

   This article has 31 authors:

   1. Richard C Centore
   2. Luis MM Soares
   3. Salih Topal
   4. Rishi G Vaswani
   5. Kana Ichikawa
   6. Zhifang Li
   7. Hong Fan
   8. Jeremy W Setser
   9. David L Lahr
   10. Laura E Zawadzke
   11. Xueying Chen
   12. Kimberly D Barnash
   13. Jordana Muwanguzi
   14. Neville Anthony
   15. Gabriel J Sandoval
   16. Katharine Feldman
   17. GiNell Elliott
   18. Ammar Adam
   19. David Huang
   20. Yunji Davenport
   21. Shawn Schiller
   22. Kevin J Wilson
   23. Johannes Voigt
   24. Lan Xu
   25. Martin Hentemann
   26. David S Millan
   27. Ho Man Chan
   28. Carl P Decicco
   29. Ryan G Kruger
   30. Gromoslaw A Smolen
   31. Steven F Bellon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study constitutes a fundamental advance for the uveal melanoma research field that might be exploited to target this deadly cancer and, more generally, for targeting transcriptional dependency in cancers. This work substantially advances our understanding of pharmacological inhibition of SWI/SNF as a therapeutic approach for cancer. The study is well written and provides compelling evidence, including comprehensive datasets, compound screens, gene expression analysis, epigenetics, as well as animal studies.

   Reviewed by eLife

9. RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

   This article has 19 authors:

   1. Alejandro Rosell
   2. Agata Adelajda Krygowska
   3. Marta Alcón Pérez
   4. Cristina Cuesta
   5. Mathieu-Benoit Voisin
   6. Juan de Paz
   7. Héctor Sanz-Fraile
   8. Vinothini Rajeeve
   9. Ana Carreras-González
   10. Alberto Berral-González
   11. Ottilie Swinyard
   12. Enrique Gabandé-Rodríguez
   13. Julian Downward
   14. Jordi Alcaraz
   15. Juan Anguita
   16. Carmen García-Macías
   17. Javier De Las Rivas
   18. Pedro R Cutillas
   19. Esther Castellano Sanchez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study investigates the impact of disrupting the interaction of RAS with the PI3K subunit p110α in macrophage function in vitro and inflammatory responses in vivo. Solid data overall supports a role for RAS-p110α signalling in regulating macrophage activity and so inflammation, however for many of the readouts presented the magnitude of the phenotype is not particularly pronounced. Further analysis would be required to substantiate the claims that RAS-p110α signalling plays a key role in macrophage function. Of note, the molecular mechanisms of how exactly p110α regulates the functions in macrophages have not yet been established.

   Reviewed by eLife

10. Automated workflow for the cell cycle analysis of (non-)adherent cells using a machine learning approach

    This article has 12 authors:

    1. Kourosh Hayatigolkhatmi
    2. Chiara Soriani
    3. Emanuel Soda
    4. Elena Ceccacci
    5. Oualid El Menna
    6. Sebastiano Peri
    7. Ivan Negrelli
    8. Giacomo Bertolini
    9. Gian Martino Franchi
    10. Roberta Carbone
    11. Saverio Minucci
    12. Simona Rodighiero

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper presents a valuable automated method to track individual mammalian cells as they progress through the cell cycle using the FUCCI system. The authors have developed a technique for analyzing cells that grow in suspension and used their method to look at different tumor cell lines that grow in suspension and determine the effect of drugs that directly affect the cell cycle. They show solid evidence that the method can be applied to both adherent and non-adherent cell lines. This paper will be of interest to cell biologists investigating cell cycle effects.

    Reviewed by eLife