eLife

Latest preprint reviews

1. MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

   This article has 24 authors:

   1. Linsey Peters
   2. Leonida Rakateli
   3. Rosanna Huchzermeier
   4. Andrea Bonnin-Marquez
   5. Sanne L Maas
   6. Cheng Lin
   7. Alexander Jans
   8. Yana Geng
   9. Alan Gorter
   10. Marion Gijbels
   11. Sander Rensen
   12. Peter Olinga
   13. Tim Hendrikx
   14. Marcin Krawczyk
   15. Malvina Brisbois
   16. Joachim Jankowski
   17. Kiril Bidzhekov
   18. Christian Weber
   19. Erik AL Biessen
   20. Ronit Shiri-Sverdlov
   21. Tom Houben
   22. Yvonne Döring
   23. Matthias Bartneck
   24. Emiel van der Vorst

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable insights into the involvement of miR-26b in the progression of metabolic dysfunction-associated steatohepatitis (MASH). The delivery of microRNA-containing nanoparticles to reduce MASH severity has practical implications as a therapeutic strategy. The authors use two sets of transgenic mouse models, conducted kinase activity profiling of mouse liver samples, and supplemented their findings with additional experiments on human liver and plasma, providing solid support for their findings.

   Reviewed by eLife

2. IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

   This article has 12 authors:

   1. Mengjia Li
   2. Hengchao Zhang
   3. Xiuyun Wu
   4. Mengqi Yu
   5. Qianqian Yang
   6. Lei Sun
   7. Wei Li
   8. Zhongxing Jiang
   9. Fumin Xue
   10. Ting Wang
   11. Xiuli An
   12. Lixiang Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study by Li et al. presents important findings on the metabolism-independent role of nuclear IDH1 in chromatin regulation during erythropoiesis. The authors provide convincing evidence that IDH1 deficiency disrupts H3K79 methylation and nuclear architecture, contributing to dyserythropoiesis. Their findings offer invaluable mechanistic insights with potential therapeutic implications for erythroid disorders and hematologic malignancies.

   Reviewed by eLife

3. Alleviating cell-free DNA sequencing biases with optimal transport

   This article has 10 authors:

   1. Antoine Passemiers
   2. Tatjana Jatsenko
   3. Adriaan Vanderstichele
   4. Pieter Busschaert
   5. An Coosemans
   6. Dirk Timmerman
   7. Diether Lambrechts
   8. Daniele Raimondi
   9. Joris Robert Vermeesch
   10. Yves Moreau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful computational data preprocessing methodology for de-biasing/denoising high-throughput genomic signals using optimal transport techniques. The evidence supporting the claims of the authors is, however, in parts incomplete, with a partially insufficient experimental setup for validation. The method needs to be be compared with other algorithms, using datasets that demonstrate broad applicability of the algorithm presented. The work could be of interest to scientists in the field of computational genomics.

   Reviewed by eLife

4. A multiscale model of striatum microcircuit dynamics

   This article has 4 authors:

   1. Federico Tesler
   2. Alexander Kozlov
   3. Sten Grillner
   4. Alain Destexhe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is potentially valuable, however currently its findings are incomplete, in that the paper's promise to deliver multiscale models that further our understanding of striatal function remains largely unfulfilled. A major weakness is that the findings are not integrated well within the rich landscape of existing striatal network modeling literature. Another major weakness is that the model is explored only in overly simplified scenarios and with limited comparison to data.

   Reviewed by eLife

5. Individual recognition in a jumping spider (Phidippus regius)

   This article has 2 authors:

   1. Christoph D Dahl
   2. Yaling Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable examination of the social discrimination abilities of a jumping spider, Phippidus regius, based on visual cues. Behavioral essays yielded solid evidence that these spiders discriminate between familiar and unfamiliar individuals on the basis of visual cues, however the experimental support for individual recognition and long-term memory is incomplete. While the results supply evidence of discrimination, additional experiments would be needed to verify the evidence of individual recognition.

   Reviewed by eLife

6. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2404.07102v3

7. Multidimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition

   This article has 23 authors:

   1. Ming-Qiang Wang
   2. Shi-Kun Guo
   3. Peng-Fei Guo
   4. Juan-Juan Yang
   5. Guo-Ai Chen
   6. Douglas Chesters
   7. Michael C Orr
   8. Ze-Qing Niu
   9. Michael Staab
   10. Jing-Ting Chen
   11. Yi Li
   12. Qing-Song Zhou
   13. Felix Fornoff
   14. Xiaoyu Shi
   15. Shan Li
   16. Massimo Martini
   17. Alexandra-Maria Klein
   18. Andreas Schuldt
   19. Xiaojuan Liu
   20. Keping Ma
   21. Helge Bruelheide
   22. Arong Luo
   23. Chao-Dong Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study uses a massive and long-term experimental data set to provide solid evidence on how tree diversity affects host-parasitoid communities of insects in forests. The work will be of interest to ecologists working on biodiversity conservation, community ecology, and food webs.

   Reviewed by eLife

8. Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis

   This article has 22 authors:

   1. Ben Higgins
   2. Ioannis Simitsidellis
   3. Xiaozhong Zheng
   4. Frances Collins
   5. Natalie ZM Homer
   6. Scott G Denham
   7. Joanna P Simpson
   8. Mike Millar
   9. Lyndsey Boswell
   10. Hee Y Lee
   11. Yeon G Kim
   12. Kyung H Park
   13. Larry C Park
   14. Patrick J Sweeney
   15. Gerard Feraille
   16. Alessandro Taddei
   17. David Chagras
   18. Thierry Alvarez
   19. Scott P Webster
   20. Andrew Horne
   21. Philippa TK Saunders
   22. Damian J Mole

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study holds importance within the focused scope of endometriosis treatment, providing initial evidence of a potential new therapeutic target. The strength of the evidence is solid, as the methods, data, and analyses support the authors' conclusions regarding the specific aims. The study provides promising preliminary evidence of KMO implication in endometriosis, but it falls short of establishing a strong rationale for proposing KNS898 as a treatment for endometriosis given the limitations in evidence and mechanistic insights.

   Reviewed by eLife

9. Passive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses

   This article has 13 authors:

   1. Rebecca D Tarvin
   2. Jeffrey L Coleman
   3. David A Donoso
   4. Mileidy Betancourth-Cundar
   5. Karem López-Hervas
   6. Kimberly S Gleason
   7. J Ryan Sanders
   8. Jacqueline M Smith
   9. Santiago R Ron
   10. Juan C Santos
   11. Brian E Sedio
   12. David C Cannatella
   13. Richard W Fitch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study is important, with the potential to greatly impact future research on the evolution of chemical defense mechanisms in animals. The authors present compelling evidence for the presence of low quantities of alkaloids in amphibians previously thought to lack these toxins. They then integrate these findings with existing literature to propose a four-phase scenario for the evolution of chemical defense in alkaloid-containing poison frogs, emphasizing the role of passive accumulation mechanisms.

   Reviewed by eLife

10. Template switching during DNA replication is a prevalent source of adaptive gene amplification

    This article has 10 authors:

    1. Julie N Chuong
    2. Nadav Ben Nun
    3. Ina Suresh
    4. Julia Cano Matthews
    5. Titir De
    6. Grace Avecilla
    7. Farah Abdul-Rahman
    8. Nathan Brandt
    9. Yoav Ram
    10. David Gresham

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides important new insights into the contributions of local DNA features to the complex molecular mechanisms and dynamics of copy number variation (CNV) formation during adaptive evolution. While limited to a single CNV of interest, the study is well-designed and carefully controlled, presenting compelling evidence that supports the conclusions. This work will be of general interest to those studying genome architecture and evolution from yeast biologists to cancer researchers.

    Reviewed by eLife