eLife

Latest preprint reviews

1. Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

   This article has 25 authors:

   1. Maiko Kawasaki
   2. Katsushige Kawasaki
   3. Finsa Tisna Sari
   4. Takehisa Kudo
   5. Jun Nihara
   6. Madoka Kitamura
   7. Takahiro Nagai
   8. Vanessa Utama
   9. Yoko Ishida
   10. Fumiya Meguro
   11. Alex Kesuma
   12. Akira Fujita
   13. Takayuki Nishimura
   14. Yuan Kogure
   15. Satoshi Maruyama
   16. Jun-ichi Tanuma
   17. Yoshito Kakihara
   18. Takeyasu Maeda
   19. Sarah Ghafoor
   20. Roman H Khonsari
   21. Pierre Corre
   22. Paul T Sharpe
   23. Martyn Cobourne
   24. Brunella Franco
   25. Atsushi Ohazama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The investigation of the functional significance of the X-linked ciliary protein OFD1 gene in regulating the fate of cranial neural crest-derived cells (CNCCs) and its potential effect on myogenic progenitors during tongue development is interesting because the Ofd1 conditional knockout mouse model has a very striking phenotype and nicely mimics the phenotype in humans. It is a valuable model to understand human disease. This study will require additional experiments to support their conclusions.

   Reviewed by eLife

2. Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

   This article has 20 authors:

   1. Carolin Gerke
   2. Liane Bauersfeld
   3. Ivo Schirmeister
   4. Chiara Noemi-Marie Mireisz
   5. Valerie Oberhardt
   6. Lea Mery
   7. Di Wu
   8. Christopher Sebastian Jürges
   9. Robbert M Spaapen
   10. Claudio Mussolino
   11. Vu Thuy Khanh Le-Trilling
   12. Mirko Trilling
   13. Lars Dölken
   14. Wolfgang Paster
   15. Florian Erhard
   16. Maike Hofmann
   17. Andreas Schlosser
   18. Hartmut Hengel
   19. Frank Momburg
   20. Anne Halenius

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful finding on a virally encoded immune-evasin which differentially inhibits antigen presentation by cellular protein complexes called Major histocompatibility complex (MHC) class I, thereby diminishing the activation of cytotoxic T cells. The evidence supporting the claims of the authors is solid, although the addition of more mechanistic insights would strengthen the study. The work will be of interest to virologists and immunologists working on the adaptive immune response to herpesviral infection. Some conclusions would require additional experimental support.

   Reviewed by eLife

3. Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

   This article has 15 authors:

   1. Lan Pang
   2. Gangqi Fang
   3. Zhiguo Liu
   4. Zhi Dong
   5. Jiani Chen
   6. Ting Feng
   7. Qichao Zhang
   8. Yifeng Sheng
   9. Yueqi Lu
   10. Ying Wang
   11. Yixiang Zhang
   12. Guiyun Li
   13. Xuexin Chen
   14. Shuai Zhan
   15. Jianhua Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper presents valuable insights into the success of the parasitoid Trichopria drosophilae on Drosophila suzukii, elucidating the importance of both molecular adaptations, such as specialized venom proteins and unique cell types, ecological strategies, including tolerance of intraspecific competition and avoidance of interspecific competition. Through convincing methodological approaches, the authors demonstrate how these adaptations optimize nutrient uptake and enhance parasitic success, highlighting the intricate coordination between molecular and ecological factors in driving parasitization success.

   Reviewed by eLife

4. Regional response to light illuminance across the human hypothalamus

   This article has 16 authors:

   1. Islay Campbell
   2. Roya Sharifpour
   3. Jose Fermin Balda Aizpurua
   4. Elise Beckers
   5. Ilenia Paparella
   6. Alexandre Berger
   7. Ekaterina Koshmanova
   8. Nasrin Mortazavi
   9. John Read
   10. Mikhail Zubkov
   11. Puneet Talwar
   12. Fabienne Collette
   13. Siya Sherif
   14. Christophe Phillips
   15. Laurent Lamalle
   16. Gilles Vandewalle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work describes the complex interplay between light exposure, hypothalamic activity, and cognitive function. The evidence supporting the conclusion is compelling with potential therapeutic applications of light modulation. The work will be of broad interest to basic and clinical neuroscientists.

   Reviewed by eLife

5. SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress

   This article has 4 authors:

   1. Rezwana Karim
   2. Wendi Teng
   3. Cameron D Behram
   4. Hening Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study describes a role for acetylation in controlling the stability of acetyl-CoA synthetase 2, which converts acetate to acetyl-CoA for de novo lipid synthesis. While many aspects of the study are solid, some evidence supporting these findings is incomplete. Including direct demonstration of target deacetylation by sirtuin 2, revisiting statistical analyses, and confirming generalizability to adipocyte cell lines would further strengthen the study. This work will be of interest to researchers studying lipid metabolism and related diseases.

   Reviewed by eLife

6. The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

   This article has 3 authors:

   1. Elise S Bruguera
   2. Jacob P Mahoney
   3. William I Weis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a fundamental study that addresses the key question of how the tetraspanin Tspan12 functions biochemically as a co-receptor for Norrin to initiate β-catenin signaling. The strength of the work lies in the rigorous and compelling binding analyses involving various purified receptors, co-receptors, and ligands, as well as molecular modeling by AlphaFold that was subsequently validated by an extensive series of mutagenesis experiments. The study advances the field by providing a novel mechanism of co-receptor function and shedding new light on how signaling specificity is achieved in the complex Wnt/Norrin signaling system.

   Reviewed by eLife

7. Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization

   This article has 10 authors:

   1. Dena Goldblatt
   2. Basak Rosti
   3. Kyla Rose Hamling
   4. Paige Leary
   5. Harsh Panchal
   6. Marlyn Li
   7. Hannah Gelnaw
   8. Stephanie Huang
   9. Cheryl Quainoo
   10. David Schoppik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study asks whether motor neurons within the vestibulo-ocular circuit of zebrafish are required to determine the identity, connectivity, and function of upstream premotor neurons. They provide compelling and comprehensive genetic, anatomical and behavioral evidence that the answer is, "No!". This work will be of general interest to developmental neurobiologists and will motivate future studies of whether motor neurons are dispensable for assembly of other sensorimotor neural circuits.

   Reviewed by eLife

8. Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

   This article has 10 authors:

   1. Han V Han
   2. Richard Efem
   3. Barbara Rosati
   4. Kevin Lu
   5. Sara Maimouni
   6. Ya-Ping Jiang
   7. Valeria Montoya
   8. Ando Van Der Velden
   9. Wei-Xing Zong
   10. Richard Z Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The significance of the findings is valuable, with implications for immunotherapy design in pancreatic ductal adenocarcinoma. The evidence was considered incomplete and partially supportive of the major claims.

   Reviewed by eLife

9. RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

   This article has 10 authors:

   1. Yang Liu
   2. Yi Jiang
   3. Peng Qiu
   4. Tie Ma
   5. Yang Bai
   6. Jiawen Bu
   7. Yueting Hu
   8. Ming Jin
   9. Tong Zhu
   10. Xi Gu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper first demonstrated that RGS10 was identified as a biomarker to evaluate the prognosis of breast cancer. To prevent the loss of RGS10 theoretically provide a new strategy for the treatment of breast cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples and an animal model would have strengthened the study. The work will be of interest to clinicians working on breast cancer.

   Reviewed by eLife

10. Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

    This article has 11 authors:

    1. Danielle Algranati
    2. Roni Oren
    3. Bareket Dassa
    4. Liat Fellus-Alyagor
    5. Alexander Plotnikov
    6. Haim Barr
    7. Alon Harmelin
    8. Nir London
    9. Guy Ron
    10. Noa Furth
    11. Efrat Shema

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This work contributes to the study of H3-K27M mutated pediatric gliomas. It convincingly demonstrates that the concomitant targeting of histone deacetylases (HDACs) and the transcription factor MYC results in a notable reduction in cell viability and tumor growth. This reduction is linked to the suppression of critical oncogenic pathways, particularly mTOR signaling, emphasizing the role of these pathways in the disease's pathogenesis. The current version of the manuscript is important because it unveils a vulnerability from dual targeting HDACs and MYC in the context of pediatric gliomas. This work will be of interest to cancer epigenetics and therapeutics research, with a focus on the neuro-oncology field.

    Reviewed by eLife