eLife reviews preprints in the life sciences and medicine.

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  1. Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

    1. Amrita Rai
    2. Petra Janning
    3. Ingrid R Vetter
    4. Roger S Goody

    • Curated by eLife

      eLife Assessment

      This fundamental study addresses the regulation of the MICAL-family of actin regulators by Rab GTPases, which play a key role in directing membrane trafficking within cells. The compelling evidence explains how Rab8 family members bind at two sites to allosterically regulate MICAL1, and relieve an auto-inhibited state unable to bind actin. This study lays the basis for further progress in understanding membrane trafficking and cytoskeleton dynamics in eukaryotic cells.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice

    1. Puqiao Lian
    2. Artemiy Kovynev
    3. Lei Wang
    4. Amanda CM Pronk
    5. Aswin Verhoeven
    6. Martin Giera
    7. Suzan Thijssen
    8. Borja Martínez Téllez
    9. Sander Kooijman
    10. Patrick CN Rensen
    11. Harro Timmerman
    12. Harry J Wichers
    13. Paul AJ Henricks
    14. Gert Folkerts
    15. Milena Schönke
    16. Saskia Braber

    • Curated by eLife

      eLife Assessment

      This valuable study examines how different exercise training intensities affect intestinal barrier function and gut microbiota composition over a 6-week period in mice. The evidence supporting the main claims about exercise-induced intestinal injury and microbiota changes is solid, featuring comprehensive histological analysis, molecular characterization, and metabolomic profiling, though key mechanistic insights and causal relationships remain to be established. The findings have practical implications for understanding exercise-induced gastrointestinal stress, particularly the observation that daily moderate exercise may be more damaging to intestinal integrity than vigorous exercise with rest days. Additional experimental validation would strengthen these conclusions.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Inhibition on neutrophil extracellular traps by oligomeric procyanidins alleviate chemotherapy-induced chronic kidney injury via gut-kidney axis

    1. Yaqi Luan
    2. Weiwei He
    3. Kunmao Jiang
    4. Shenghui Qiu
    5. Lan Jin
    6. Xinrui Mao
    7. Ying Huang
    8. Wentao Liu
    9. Jingyuan Cao
    10. Lai Jin
    11. Rong Wang

    • Curated by eLife

      eLife Assessment

      This important study provides evidence for the role of neutrophil extracellular traps in chronic kidney damage (CKD) induced by chemotherapy and suggests a therapeutic approach to mitigate the kidney pathology caused by the NETs. The study utilizes a sound murine in vivo model of CKD with low-dose administration cisplatin and a genetic model for impairment of NET formation by deletion of the enzyme Pad4. In its current form, the study was seen as incomplete as there is not yet formal demonstration of NET production by neutrophils in the model of CKD used. Additionally, the accuracy and clarity of data presentation could be improved.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity
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