eLife

Latest preprint reviews

1. Genetic stability of Mycobacterium smegmatis under the stress of first-line antitubercular agents

   This article has 6 authors:

   1. Dániel Molnár
   2. Éva Viola Surányi
   3. Tamás Trombitás
   4. Dóra Füzesi
   5. Rita Hirmondó
   6. Judit Toth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study reports on the impact of antibiotic pressure on the genomic stability of the mc2155 strain of Mycobacterium smegmatis, a model for Mycobacterium tuberculosis. The findings of the study indicate that exposure to antibiotics did not lead to the development of new adaptive mutations in controlled laboratory environments, challenging the notion that antibiotic resistance arises from drug-induced microevolution. The genomic analysis provides detailed insights into the stability of M. smegmatis following exposure to standard TB treatment antibiotics, and the evidence suggesting that antibiotic pressure does not contribute to the emergence of new adaptive mutations is solid.

   Reviewed by eLife

2. High-density sampling reveals volume growth in human tumours

   This article has 6 authors:

   1. Arman Angaji
   2. Michel Owusu
   3. Christoph Velling
   4. Nicola Dick
   5. Donate Weghorn
   6. Johannes Berg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The article uses a cell-based model to investigate how mutations and cells spread throughout a tumour. The paper uses published data and the proposed model to understand how growth and death mechanisms lead to the observed data. This work provides an important insight into the early stages of tumour development. From the work provided here, the results are convincing, using a thorough analysis.

   Reviewed by eLife

3. Connecting Chromatin Structures to Gene Regulation Using Dynamic Polymer Simulations

   This article has 6 authors:

   1. Yi Fu
   2. Tianxiao Zhao
   3. Finnegan Clark
   4. Sofia Nomikou
   5. Aristotelis Tsirigos
   6. Timothée Lionnet

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable optimization algorithm to identify polymer models that best fit population-averaged chromosome contact data that will be of interest to physicists and biologists working on chromatin organization. The conclusions are supported by solid evidence.

   Reviewed by eLife

4. Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

   This article has 8 authors:

   1. Adriana K Alexander
   2. Karina F Rodriguez
   3. Yu-Ying Chen
   4. Ciro Amato
   5. Martin A Estermann
   6. Barbara Nicol
   7. Xin Xu
   8. Humphrey HC Yao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, which will be of interest to developmental and reproductive biologists, as well as andrologists, are supported by convincing data.

   Reviewed by eLife

5. Hosts manipulate lifestyle switch and pathogenicity heterogeneity of opportunistic pathogens in the single-cell resolution

   This article has 14 authors:

   1. Ziguang Wang
   2. Shuai Li
   3. Sheng Zhang
   4. Tianyu Zhang
   5. Yujie Wu
   6. Anqi Liu
   7. Kui Wang
   8. Xiaowen Ji
   9. Haiqun Cao
   10. Yinglao Zhang
   11. Eng King Tan
   12. Yongcheng Wang
   13. Yirong Wang
   14. Wei Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The fundamental findings of this work substantially advance our understanding of the impact of the host on its gut microbes. The authors provided compelling evidence at single-cell resolution that the host can drive heterogeneity in the populations of gut microbes with significant consequences for the host physiology.

   Reviewed by eLife

6. Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

   This article has 9 authors:

   1. Emily Delgouffe
   2. Samuel Madureira Silva
   3. Frédéric Chalmel
   4. Wilfried Cools
   5. Camille Raets
   6. Kelly Tilleman
   7. Guy T'Sjoen
   8. Yoni Baert
   9. Ellen Goossens

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents new knowledge of the spermatogonial stem cell (SSC) niche in trans women after gender-affirming hormone therapy (GAHT). The evidence supporting the claims is convincing. The work will be of interest to researchers and clinicians working in the field of reproductive medicine and andrology.

   Reviewed by eLife

7. Spatially targeted inhibitory rhythms differentially affect neuronal integration

   This article has 4 authors:

   1. Drew B. Headley
   2. Benjamin Latimer
   3. Adin Aberbach
   4. Satish S. Nair

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study assesses through simulations how several known features of local cortical circuits - interneuron subtypes, their specific targeting of dendritic compartments, and certain brain rhythms - together affect the integration of synaptic inputs by a pyramidal cell into a spiking output signal. Employing several carefully considered simulation setups they convincingly demonstrate that beta rhythms are best suited to modulate and control dendritic Ca-spikes while gamma rhythms affect their coupling to somatic spiking, or how basal inputs are directly integrated into somatic spikes. However, the baseline setup may be idealized for the generation of the events in question and it would be beneficial if the similarity to the in-vivo activity regime was demonstrated further. The results will be relevant for neuroscientists studying local circuits or developing more abstract theories at the systems level.

   Reviewed by eLife

8. Task-dependent coarticulation of movement sequences

   This article has 2 authors:

   1. Hari Teja Kalidindi
   2. Frederic Crevecoeur

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper presents convincing evidence that changing the constraint of how long to stop at an intermediate target significantly influences the degree of coarticulation of two sequential reaching movements, as well as their response to mechanical perturbations. Using an optimal-control framework, the authors offer a normative explanation of how both co-articulated and separated sequential movement can be understood as an optimal solution to the task requirements.

   Reviewed by eLife

9. Targeting plasmid-encoded proteins that contain immunoglobulin-like domains to combat antimicrobial resistance

   This article has 12 authors:

   1. Alejandro Prieto
   2. Luïsa Miró
   3. Yago Margolles
   4. Manuel Bernabeu
   5. David Salguero
   6. Susana Merino
   7. Joan Tomas
   8. Juan Alberto Corbera
   9. Anna Perez-Bosque
   10. Mario Huttener
   11. Luis Ángel Fernández
   12. Antonio Juarez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important and novel study addresses the challenge of antimicrobial resistance by targeting plasmid proteins that interfere with plasmid transfer as a strategy to limit the spread of antibiotic-resistance genes. The evidence presented and the integration of two approaches to tackle antimicrobial resistance is convincing. This work will interest those working on plasmid transfer and antimicrobial resistance.

   Reviewed by eLife

10. Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

    This article has 10 authors:

    1. Jacob D. Bowman
    2. Neide Silva
    3. Erik Schüftan
    4. Joana M. Almeida
    5. Rion Brattig-Correia
    6. Raquel A. Oliveira
    7. Frank Tüttelmann
    8. David Enard
    9. Paulo Navarro-Costa
    10. Vincent J. Lynch

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important work reports that genome-wide patterns of relaxed purifying selection on genes involved in male fertility may represent a response to the reduced sperm competition in the gorillas' mating system. However, the evidence supporting the conclusion is incomplete and needs to be strengthened. This work will be of interest to researchers working on evolution and reproductive biology.

    Reviewed by eLife