eLife

Latest preprint reviews

1. A ventral hippocampal-lateral septum pathway regulates social novelty preference

   This article has 6 authors:

   1. Maha Rashid
   2. Sarah Thomas
   3. Jennifer Isaac
   4. Sonia Corbett Karkare
   5. Hannah Klein
   6. Malavika Murugan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript uses circuit mapping, chemogenetics, and optogenetics to demonstrate a novel hippocampal lateral septal circuit that regulates social novelty behaviours and shows that downstream of the hippocampal septal circuit, septal projections to the ventral tegmental area are necessary for general novelty discrimination. The strength of the evidence supporting the claims is convincing but would be strengthened by the inclusion of additional functional assays. The work will be of interest to systems and behavioural neuroscientists who are interested in the brain mechanisms of social behaviours.

   Reviewed by eLife

2. Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons

   This article has 5 authors:

   1. Jingjing Liu
   2. Yuedong Wang
   3. Xian Liu
   4. Junhai Han
   5. Yao Tian

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides insights into the mechanism of axonal directional changes, utilizing the pacemaker neurons of the circadian clock, the sLNVs, as a model system. The data were collected and analysed using solid methodology, resulting in valuable data on the interplay of signalling pathways and the growth of the axon. The study holds potential interest for neurobiologists focusing on axonal growth and development.

   Reviewed by eLife

3. Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species

   This article has 7 authors:

   1. Guoling Tang
   2. Yaning Han
   3. Xing Sun
   4. Ruonan Zhang
   5. Ming-Hu Han
   6. Quanying Liu
   7. Pengfei Wei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study introduces a deep learning-based algorithm that tracks animal postures with reduced drift by incorporating transformers for more robust keypoint detection. The efficacy of this new algorithm for single-animal pose estimation was demonstrated through comparisons with two popular algorithms. The strength of evidence is solid but would benefit from consideration of issues in multi-animal tracking. This work will be of interest to those interested in animal behavior tracking.

   Reviewed by eLife

4. Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging

   This article has 11 authors:

   1. Laxmi Rathor
   2. Shayla Curry
   3. Youngyong Park
   4. Taylor McElroy
   5. Briana Robles
   6. Yi Sheng
   7. Wei-Wen Chen
   8. Kisuk Min
   9. Rui Xiao
   10. Myon Hee Lee
   11. Sung Min Han

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study interrogates cell non-autonomous signaling between GABAergic neurons and somatic tissues in the nematode C. elegans. The authors report that mitochondrial stress in only GABAergic neurons extends lifespan and improves healthspan, phenotypes that are dependent on the transcription factor daf-16/FOXO3a. However, while the findings may be valuable to furthering our understanding of neuronal control of aging and health, the current evidence is incomplete and additional experiments are needed to support their claims.

   Reviewed by eLife

5. A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

   This article has 8 authors:

   1. Fan Zhang
   2. Annie Lee
   3. Anna V Freitas
   4. Jake T Herb
   5. Zong-Heng Wang
   6. Snigdha Gupta
   7. Zhe Chen
   8. Hong Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study's findings substantially advance our understanding of an important aspect of mitochondrial metabolism. The data are compelling and the study is well executed. The work is relevant to all who are interested in the biogenesis of mitochondria.

   Reviewed by eLife

6. Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

   This article has 8 authors:

   1. Giuseppe Deganutti
   2. Ludovico Pipito
   3. Roxana Maria Rujan
   4. Tal Weizmann
   5. Peter Griffin
   6. Antonella Ciancetta
   7. Stefano Moro
   8. Christopher Arthur Reynolds

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study describes an improved adaptive sampling approach, multiple-walker Supervised Molecular Dynamics (mwSuMD), and its application to G protein-coupled receptors (GPCRs), which are the most abundant membrane proteins and key targets for drug discovery. The manuscript provides solid evidence that the mwSuMD approach can assist in the sampling of complex binding processes, leading to useful findings for GPCR activity, including resolution of interactions not seen experimentally. The method has the potential to have broad applicability in structural biology and pharmacology.

   Reviewed by eLife

7. An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli

   This article has 6 authors:

   1. Irina Kalita
   2. Ira Alexandra Iosub
   3. Lorna McLaren
   4. Louise Goossens
   5. Sander Granneman
   6. Meriem El Karoui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Combining experimental and computation approaches, this manuscript provides convincing evidence for a post-transcriptional mechanism that provides robust control over the protein expression level of RecB in E. coli. In addition to uncovering how DNA damage drives higher levels of RecB protein, this work also reveals important tenets for how broader mechanisms that suppress noise and underlie responsive tuning of protein levels can be achieved.

   Reviewed by eLife

8. LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

   This article has 23 authors:

   1. Xianghong Xie
   2. Mingyue Gao
   3. Wei Zhao
   4. Chunmei Li
   5. Weihong Zhang
   6. Jiahui Yang
   7. Yinliang Zhang
   8. Enhui Chen
   9. Yanfang Guo
   10. Zeyu Guo
   11. Minglong Zhang
   12. Ebenezeri Erasto Ngowi
   13. Heping Wang
   14. Xiaoman Wang
   15. Yinghan Zhu
   16. Yiting Wang
   17. Xiaolu Li
   18. Hong Yao
   19. Li Yan
   20. Fude Fang
   21. Meixia Li
   22. Aijun Qiao
   23. Xiaojun Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful evidence substantiating a role for long noncoding RNAs in liver metabolism and organismal physiology. Using murine knockout and knock-in models, the authors invoke a previously unidentified role for the lncRNA Snhg3 in fatty liver. The revised manuscript has improved and most studies are backed by solid evidence but the study was found to be incomplete and will require future studies to substantiate some of the claims.

   Reviewed by eLife

9. Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

   This article has 17 authors:

   1. Morgane Djebar
   2. Isabelle Anselme
   3. Guillaume Pezeron
   4. Pierre-Luc Bardet
   5. Yasmine Cantaut-Belarif
   6. Alexis Eschstruth
   7. Diego López-Santos
   8. Hélène Le Ribeuz
   9. Arnim Jenett
   10. Hanane Khoury
   11. Joelle Veziers
   12. Caroline Parmentier
   13. Aurélie Hirschler
   14. Christine Carapito
   15. Ruxandra Bachmann-Gagescu
   16. Sylvie Schneider-Maunoury
   17. Christine Vesque

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study analyzes the role of rpgrip1l encoding a ciliary transition zone component in the development of neuroinflammation and scoliotic phenotypes in zebrafish. Through proteomic and experimental validation in vivo, the authors demonstrated increased Annexin A2 expression and astrogliosis in the brains of scoliosis fish. Anti-inflammatory drug treatment restored normal spine development in these mutant fish, thus providing additional convincing evidence for the role of neuroinflammation in the development of scoliosis in zebrafish.

   Reviewed by eLife

10. Clearance of protein aggregates during cell division

    This article has 7 authors:

    1. Shoukang Du
    2. Yuhan Wang
    3. Bowen Chen
    4. Shuangshuang Xie
    5. Kuan Yoow Chan
    6. David C Hay
    7. Ting Gang Chew

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      How misfolded proteins are segregated and cleared is a significant question in cell biology, since clearance of these aggregates can protect against pathologies that may otherwise arise. The authors discover a cell cycle stage-dependent clearing mechanism that involves the ER chaperone BiP, the proteosome, and CDK inactivation, but is curiously independent of the anaphase promoting complex (APC). These are valuable and interesting new observations, and the evidence supporting these claims is solid.

    Reviewed by eLife