eLife

Latest preprint reviews

1. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2209.08066v5

2. Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

   This article has 5 authors:

   1. Igor Kondrychyn
   2. Liqun He
   3. Haymar Wint
   4. Christer Betsholtz
   5. Li-Kun Phng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study convincingly shows that aquaporin-mediated cell migration plays a key role in blood vessel formation during zebrafish development. In particular, the paper implicates hydrostatic pressure and water flow as mechanisms controlling endothelial cell migration during angiogenic sprouting. This fundamental study is highly novel and significantly advances our understanding of cell migration during morphogenesis. As such, this work will be of great interest to developmental and cell biologists working on organogenesis, angiogenesis, and cell migration.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2311.00616

4. The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

   This article has 9 authors:

   1. Roger Huerlimann
   2. Natacha Roux
   3. Ken Maeda
   4. Polina Pilieva
   5. Saori Miura
   6. Hsiao-chian Chen
   7. Michael Izumiyama
   8. Vincent Laudet
   9. Timothy Ravasi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work provides valuable genomic resources to address the endocrine control of a life cycle transition in the Malabar grouper fish. The revised manuscript is more solid and the resources and experimental data help to build up a meaningful biological understanding of thyroid signaling in grouper fish.

   Reviewed by eLife

5. Impact of maximal overexpression of a non-toxic protein on yeast cell physiology

   This article has 4 authors:

   1. Yuri Fujita
   2. Shotaro Namba
   3. Yoshiaki Kamada
   4. Hisao Moriya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This convincing study advances our understanding of the physiological consequences of the strong overexpression of non-toxic proteins in baker's yeast. The findings suggest that a massive protein burden results in nitrogen starvation and a shift in metabolism likely regulated via the TORC1 pathway, as well as defects in ribosome biogenesis in the nucleolus. The study presents findings and tools that are important for the cell biology and protein homeostasis fields.

   Reviewed by eLife

6. Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity

   This article has 8 authors:

   1. Jingbo Kan
   2. Adrian Morales-Amador
   3. Yozen Hernandez
   4. Melinda A Ternei
   5. Christophe Lemetre
   6. Logan W Maclntyre
   7. Nicolas Biais
   8. Sean F Brady

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Kan et al. report the discovery of a Bacillus amyloliquifaciens strain that kills Nerisseria gonorrhoeae via oxydifficidin which targets ribosomal proteins. Resistance occurred via mutation in the DedA flippase to influence oxydifficidin uptake. The overall mechanism of action is well described making this an important study with implications for combating clinical antibiotic resistance. The evidence presented is convincing due to rigour employed in the methodological approach. The authors should consider performing a more comprehensive genetic analyses of DedA and RpIL in this clinically relevant strain. This work will be of broad interest to microbiologists and synthetic biologists.

   Reviewed by eLife

7. Tonotopy is not preserved in a descending stage of auditory cortex

   This article has 14 authors:

   1. Miaoqing Gu
   2. Shanshan Liang
   3. Jiahui Zhu
   4. Ruijie Li
   5. Ke Liu
   6. Xuanyue Wang
   7. Frank W Ohl
   8. Yun Zhang
   9. Xiang Liao
   10. Chunqing Zhang
   11. Hongbo Jia
   12. Yi Zhou
   13. Jianxiong Zhang
   14. Xiaowei Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This revised manuscript presents an important characterization of mouse auditory cortex receptive field organization, utilizing two-photon imaging of specific subpopulations. They demonstrate a degradation of tonotopic organization from the input to the output neurons. The strength of the evidence is convincing.

   Reviewed by eLife

8. Cryo-EM structure of the bicarbonate receptor GPR30

   This article has 7 authors:

   1. Shota Kaneda
   2. Airi Jo-Watanabe
   3. Hiroaki Akasaka
   4. Hidetaka S Oshima
   5. Takehiko Yokomizo
   6. Wataru Shihoya
   7. Osamu Nureki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study resolves a cryo-EM structure of the GPCR, human GPR30, which responds to bicarbonate and regulates cellular responses to pH and ion homeostasis. Understanding the ligand and the mechanism of activation is important to the field of receptor signaling and potentially facilitates drug development targeting this receptor. Structures and functional assays provide solid evidence for a potential bicarbonate binding site.

   Reviewed by eLife

9. Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

   This article has 23 authors:

   1. Peng Xie
   2. Xu Jiang
   3. Jingjing He
   4. Qingyun Pan
   5. Xianfa Yang
   6. Yanying Zheng
   7. Zhuanzhuan Che
   8. Wenli Fan
   9. Chen Wu
   10. Weiheng Zheng
   11. Shuhan Si
   12. Kun Gao
   13. Shiqi Zhu
   14. Ke Fang
   15. Haitong Fang
   16. Yi Yang
   17. Tao P Zhong
   18. Zhongzhou Yang
   19. Ke Wei
   20. Wei Xie
   21. Naihe Jing
   22. Zhuojuan Luo
   23. Chengqi Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides new single-cell multi-omics datasets that may be useful in the study of early cardiac lineages. However, the authors' conclusions regarding the mutual regulation of key regulators for cardiac specification and new cardiac lineage trajectories are inadequately supported by persuasive analysis and do not align with prior published studies. If revised to address the serious caveats adequately, the findings may be of interest to researchers in the field of cardiac development and congenital heart disease.

   Reviewed by eLife

10. Interdependence between SEB-3 receptor and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans

    This article has 3 authors:

    1. Kathleen T Quach
    2. Gillian A Hughes
    3. Sreekanth H Chalasani

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on predator threat detection in C. elegans and the role of neuropeptide systems in defensive behavioral strategies. The evidence supporting the conclusions is solid, although additional analyses and control experiments would strengthen the claims of the study. Overall, the work is of interest to the C. elegans community as well as neuroethologists and ecologists studying predator-prey interactions.

    Reviewed by eLife