eLife reviews preprints in the life sciences and medicine.

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  1. Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource

    1. Hugo Caffaratti
    2. Ben Slater
    3. Nour Shaheen
    4. Ariane Rhone
    5. Ryan Calmus
    6. Michael Kritikos
    7. Sukhbinder Kumar
    8. Brian Dlouhy
    9. Hiroyuki Oya
    10. Tim Griffiths
    11. Aaron D Boes
    12. Nicholas Trapp
    13. Marcus Kaiser
    14. Jérôme Sallet
    15. Matthew I Banks
    16. Matthew A Howard
    17. Mario Zanaty
    18. Christopher I Petkov

    • Curated by eLife

      eLife Assessment

      This paper is an important overview of the currently published literature on low-intensity focused ultrasound stimulation (TUS) in humans, providing a meta-analysis of this literature that explores which stimulation parameters might predict the directionality of the physiological stimulation effects. The overall synthesis is convincing. The database proposed by the paper has the potential to become a key community resource if carefully curated and developed.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  2. Multiple and subject-specific roles of uncertainty in reward-guided decision-making

    1. Alexander Paunov
    2. Maëva L’Hôtellier
    3. Dalin Guo
    4. Zoe He
    5. Angela Yu
    6. Florent Meyniel

    • Curated by eLife

      eLife Assessment

      The findings of this study are valuable, as they address a critical methodological gap in decision-making research by demonstrating how heuristic strategies can confound interpretations of uncertainty-driven behaviour and provide a clearer framework for distinguishing between uncertainty-seeking and heuristic-driven exploration. While the evidence is solid, with strong methodological rigour in task design and computational modelling, some claims, such as the stability of uncertainty parameters and correlations with psychopathology measures, require refinement. Overall, the data broadly support the study's claims, but interpretational ambiguities limit the impact of certain findings.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo

    1. Siân Wilson
    2. Daan Christiaens
    3. Hyukjin Yun
    4. Alena Uus
    5. Lucilio Cordero-Grande
    6. Vyacheslav Karolis
    7. Anthony Price
    8. Maria Deprez
    9. Jacques-Donald Tournier
    10. Mary Rutherford
    11. Ellen Grant
    12. Joseph V Hajnal
    13. A David Edwards
    14. Tomoki Arichi
    15. Jonathan O’Muircheartaigh
    16. Kiho Im

    • Curated by eLife

      eLife Assessment

      This study presents a valuable study of early brain development using advanced MRI methods. In particular, the study investigates the relationship between the maturation of diffusion MRI tissue properties and suggests that they may precede and guide the emergence of brain folding patterns. The data is solid, however, the evidence supporting the precedence of tissue changes over brain folding appears incomplete.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  6. Integrating microscopy and transcriptomics from individual uncultured eukaryotic plankton

    1. Catherine Gatt
    2. Yike Xie
    3. Kanu Wahi
    4. Emma MV Johansson
    5. Fabio Zanini

    • Curated by eLife

      eLife Assessment

      This valuable research contributes to our understanding of marine plankton diversity and gene expression by employing robust methodologies for sample collection and analysis. However, it lacks a comprehensive comparison with existing single-cell transcriptomics techniques in microbial ecology, and some terminology requires clarification for consistency with field standards. The downstream data analysis therefore provides only incomplete support for the claims made by the authors.

    Reviewed by eLife, Arcadia Science

    9 evaluationsAppears in 2 listsLatest version Latest activity

  8. It’s the Sound, not the Pulse: Peripheral Magnetic Stimulation Reduces Central Sensitization through Auditory Modulatory Effects

    1. Spencer S Abssy
    2. Natalie R Osborne
    3. Evgeny E Osokin
    4. Rossi Tomin
    5. Liat Honigman
    6. James S Khan
    7. Nathaniel W De Vera
    8. Andrew Furman
    9. Ali Mazaheri
    10. David A Seminowicz
    11. Massieh Moayedi

    • Curated by eLife

      eLife Assessment

      Abssy et al. carried out a study to test the effects of repetitive peripheral magnetic stimulation (rPMS) on pain perception in an experimental pain model and concluded that the analgesic properties of rPMS could be largely attributed to its auditory component rather than peripheral nerve stimulation per se. While the study presents valuable data on the modulation of pain perception in response to the stimulation paradigms that were tested, several issues in the experimental design and interpretation of results render the evidence incomplete to support their main claims, which should therefore be revised. In that case, these results could be of interest to pain clinicians and researchers.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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