eLife

Latest preprint reviews

1. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2301.12812v5

2. Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits

   This article has 6 authors:

   1. Yaroslav Molkov
   2. Anke Borgmann
   3. Hidehiko Koizumi
   4. Noriyuki Hama
   5. Ruli Zhang
   6. Jeffrey Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work describes an inference technique for extracting information about relative contributions of excitatory and inhibitory synaptic drive onto single neurons in neural networks. The electrophysiological techniques and results are of high quality, and the analytical work is novel and potentially powerful, yet with several untested assumptions underlying the approach. This is nevertheless solid work that will be valuable to neuroscience labs interested in exploring alternative approaches to studies of integrated synaptic connectivity.

   Reviewed by eLife

3. Characterizing the Spatial Distribution of Dendritic RNA at Single Molecule Resolution

   This article has 5 authors:

   1. Jihoon Kim
   2. Jean G Rosario
   3. Eric Mendoza
   4. Da Kuang
   5. Junhyong Kim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study combines multiplexed RNA-FISH with downstream analyses and modelling to describe novel dendritic mRNA distribution and behavioural features. Although the downstream analysis pipeline is novel, the results from this study are as of yet incomplete. Further inclusion of key missing controls, further work to better assess the physiological relevance, or additional modelling to expand their conclusions would make this work of greater interest to RNA biologists.

   Reviewed by eLife

4. Engineering Microglial Cells to Promote Spinal Cord Injury Recovery

   This article has 6 authors:

   1. Qingsheng Zhou
   2. Jianchao Liu
   3. Qiongxuan Fang
   4. Chunming Zhang
   5. Wei Liu
   6. Yifeng Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study is useful for advancing understanding of spinal cord injuries, but it presents inadequate evidence due to the use of multiple datasets. Data were collected from different models of spinal cord injury, various regions of the spinal cord, and an iPSC model, with the differences between these models making it difficult to draw reliable conclusions.

   Reviewed by eLife

5. Electrophysiology and morphology of human cortical supragranular pyramidal cells in a wide age range

   This article has 6 authors:

   1. Pál Barzó
   2. Ildikó Szöts
   3. Martin Tóth
   4. Éva Adrienn Csajbók
   5. Gábor Molnár
   6. Gábor Tamás

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this revised work, Barzó et al. assessed the electrophysiological and anatomical properties of a large number of layer 2/3 pyramidal neurons in brain slices of human neocortex across a wide range of ages, from infancy to elderly individuals, using whole-cell patch clamp recordings and anatomical reconstructions. This large data set represents an important contribution to our understanding of how these properties change across the human lifespan, supported by convincing data and analyses. The authors have addressed the concerns raised in previous reviews. Overall, this study strengthens our understanding of how the neural properties of human cortical neurons change with age and will contribute to building more realistic models of human cortical function.

   Reviewed by eLife

6. Photoreceptor loss does not recruit neutrophils despite strong microglial activation

   This article has 3 authors:

   1. Derek Power
   2. Justin Elstrott
   3. Jesse Schallek

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Power and colleagues is important, as elucidating the dynamic immune responses to photoreceptor damage in vivo potentiates future work in the field to better understand the disease process. The evidence supporting the authors' claims is compelling.

   Reviewed by eLife

7. An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

   This article has 6 authors:

   1. Mofida Abdelmageed
   2. Premkumar Palanisamy
   3. Victoria Vernail
   4. Yuval Silberman
   5. Shilpi Paul
   6. Anirban Paul

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript details important findings that DNA polymerase kappa shows age-related changes in subcellular localization within different cell types in the brains of mice, from the nucleus in young cells to the cytoplasm in old cells. The authors' findings suggest that age-related alterations in POLK localization could drive mechanistic and functional changes in the aging brain. The authors provide solid evidence for their study, with data broadly supporting their claims with minor weaknesses.

   Reviewed by eLife

8. Reproducibility of in vivo electrophysiological measurements in mice

   This article has 46 authors:

   1. International Brain Laboratory
   2. Kush Banga
   3. Julius Benson
   4. Jai Bhagat
   5. Dan Biderman
   6. Daniel Birman
   7. Niccolò Bonacchi
   8. Sebastian A Bruijns
   9. Kelly Buchanan
   10. Robert AA Campbell
   11. Matteo Carandini
   12. Gaelle A Chapuis
   13. Anne K Churchland
   14. M Felicia Davatolhagh
   15. Hyun Dong Lee
   16. Mayo Faulkner
   17. Berk Gerçek
   18. Fei Hu
   19. Julia Huntenburg
   20. Cole Lincoln Hurwitz
   21. Anup Khanal
   22. Christopher Krasniak
   23. Petrina Lau
   24. Christopher Langfield
   25. Nancy Mackenzie
   26. Guido T Meijer
   27. Nathaniel J Miska
   28. Zeinab Mohammadi
   29. Jean-Paul Noel
   30. Liam Paninski
   31. Alejandro Pan-Vazquez
   32. Cyrille Rossant
   33. Noam Roth
   34. Michael Schartner
   35. Karolina Z Socha
   36. Nicholas A Steinmetz
   37. Karel Svoboda
   38. Marsa Taheri
   39. Anne E Urai
   40. Shuqi Wang
   41. Miles Wells
   42. Steven J West
   43. Matthew R Whiteway
   44. Olivier Winter
   45. Ilana B Witten
   46. Yizi Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper represents an important contribution to the field. Summarizing results from neural recording experiments in mice across ten labs, the work provides compelling evidence that basic electrophysiology features, single-neuron functional properties, and population-level decoding are fairly reproducible across labs with proper preprocessing. The results and suggestions regarding preprocessing and quality metrics may be of significant interest to investigators carrying out such experiments in their own labs.

   Reviewed by eLife

9. Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus

   This article has 6 authors:

   1. My Tran
   2. Angel J Hernandez Viera
   3. Patricia Q Tran
   4. Erick D Nilsen
   5. Lily Tran
   6. Charlie Y Mo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript explores how bacterial evolution in the presence of lytic phages modulates b-lactams resistance and virulence properties in methicillin-resistant Staphylococcus aureus (MRSA). This important work improves our knowledge of how mutation in genes required for phage infection confers sensitivity to b-lactams and alter virulence properties. Altogether, the findings are convincing.

   Reviewed by eLife

10. Location- and feature-based selection histories make independent, qualitatively distinct contributions to urgent visuomotor performance

    This article has 3 authors:

    1. Emily E Oor
    2. Emilio Salinas
    3. Terrence R Stanford

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Oor and colleagues report the potentially independent effects of the spatial and feature-based selection history on visuomotor choices. They outline compelling evidence, tracking the dynamic history effects based on their extremely clever experimental design (urgent version of the search task). Their finding is of fundamental significance, broadening the framework to identify variables contributing to choice behavior and their neural correlates in future studies.

    Reviewed by eLife