eLife

Latest preprint reviews

1. The Generalized Haldane (GH) model tracking population size changes and resolving paradoxes of genetic drift

   This article has 11 authors:

   1. Yongsen Ruan
   2. Xiaopei Wang
   3. Mei Hou
   4. Liying Huang
   5. Wenjie Diao
   6. Miles Tracy
   7. Shuhua Xu
   8. Weiwei Zhai
   9. Zhongqi Liufu
   10. Haijun Wen
   11. Chung-I Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a useful model of genetic drift by incorporating variance in reproductive success, aiming to address several apparent paradoxes in molecular evolution. However, some of the apparent paradoxes only arise in the most basic version of standard models and have been reconciled in more advanced models. Nonetheless, this paper offers intuitive explanations for these apparent paradoxes, by adopting a new perspective and solid modeling and analysis. More broadly, the proposed model provides an alternative framework to address puzzling observations in molecular evolution, which will be of interest to evolutionary and population geneticists.

   Reviewed by eLife

2. Loss of dihydroceramide desaturase drives neurodegeneration by disrupting endoplasmic reticulum and lipid droplet homeostasis in glial cells

   This article has 8 authors:

   1. Yuqing Zhu
   2. Kevin Cho
   3. Haluk Lacin
   4. Yi Zhu
   5. Jose T DiPaola
   6. Beth A Wilson
   7. Gary Patti
   8. James B Skeath

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study on the loss of DEGS1 in the developing larval brain convincingly shows the accumulation of dihydroceramide in the CNS which induces severe alterations in the morphology of glial subtypes as well as a reduction in glial number. The localization of DEGS1/ifc primarily to the ER is also compelling and interesting, and the loss of DEGS1/ifc clearly drives ER expansion and reduces the levels of TGs. This is an important contribution to the role of lipid metabolism in neural development and disease.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2112.05098v5

4. A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

   This article has 3 authors:

   1. Hyo Jun Kwon
   2. Devi Santhosh
   3. Zhen Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study describes a link between beta-amyloid monomers, regulation of microglial activity and assembly of neocortex during development. It brings valuable findings that have theoretical and practical implications in the field of neuronal migration, neuronal ectopia and type II lissencephaly. Unfortunately, the evidence is incomplete and the manuscript would benefit from additional experiments to clarify the relationship between Ric8a and APP and bolster the findings.

   Reviewed by eLife

5. A temporally restricted function of the dopamine receptor Dop1R2 during memory formation

   This article has 6 authors:

   1. Jenifer C Kaldun
   2. Emanuele Calia
   3. Ganesh Chinmai Bangalore Mukunda
   4. Cornelia Fritsch
   5. Nikita Komarov
   6. Simon G Sprecher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors design and implement an elegant strategy to delete genomic sequences encoding the dopamine receptor dop1R2 from specific subsets of mushroom body neurons (ab, a'b' and gamma) and show that while none of these manipulations affect short term appetitive or aversive memory, loss of dop1R2 from ab or a'b' block the ability of flies to display measurable forms of longer forms of memory. These findings are important in confirming and extending prior observations, and well supported by convincing evidence that build on precise techniques for genetic perturbation.

   Reviewed by eLife

6. A toolbox for genetic targeting of the claustrum

   This article has 10 authors:

   1. Joël Tuberosa
   2. Madlaina Boillat
   3. Julien Dal Col
   4. Leonardo Marconi
   5. Julien Codourey
   6. Loris Mannino
   7. Elena Georgiou
   8. Marc Menoud
   9. Alan Carleton
   10. Ivan Rodriguez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable research identifies Smim32 as a new genetic marker for the claustrum and generates transgenic mouse lines aimed at enhancing specificity when studying this brain region. However, the evidence supporting the increased specificity of this marker and its associated transgenic lines is inadequate, as Smim32's specificity to the claustrum is limited. Nevertheless, this work will be of interest to researchers studying the molecular organization of the claustrum.

   Reviewed by eLife

7. A split-GAL4 driver line resource for Drosophila neuron types

   This article has 84 authors:

   1. Geoffrey W Meissner
   2. Allison Vannan
   3. Jennifer Jeter
   4. Kari Close
   5. Gina M DePasquale
   6. Zachary Dorman
   7. Kaitlyn Forster
   8. Jaye Anne Beringer
   9. Theresa Gibney
   10. Joanna H Hausenfluck
   11. Yisheng He
   12. Kristin Henderson
   13. Lauren Johnson
   14. Rebecca M Johnston
   15. Gudrun Ihrke
   16. Nirmala A Iyer
   17. Rachel Lazarus
   18. Kelley Lee
   19. Hsing-Hsi Li
   20. Hua-Peng Liaw
   21. Brian Melton
   22. Scott Miller
   23. Reeham Motaher
   24. Alexandra Novak
   25. Omotara Ogundeyi
   26. Alyson Petruncio
   27. Jacquelyn Price
   28. Sophia Protopapas
   29. Susana Tae
   30. Jennifer Taylor
   31. Rebecca Vorimo
   32. Brianna Yarbrough
   33. Kevin Xiankun Zeng
   34. Christopher T Zugates
   35. Heather Dionne
   36. Claire Angstadt
   37. Kelly Ashley
   38. Amanda Cavallaro
   39. Tam Dang
   40. Guillermo A Gonzalez
   41. Karen L Hibbard
   42. Cuizhen Huang
   43. Jui-Chun Kao
   44. Todd Laverty
   45. Monti Mercer
   46. Brenda Perez
   47. Scarlett Rose Pitts
   48. Danielle Ruiz
   49. Viruthika Vallanadu
   50. Grace Zhiyu Zheng
   51. Cristian Goina
   52. Hideo Otsuna
   53. Konrad Rokicki
   54. Robert R Svirskas
   55. Han SJ Cheong
   56. Michael-John Dolan
   57. Erica Ehrhardt
   58. Kai Feng
   59. Basel EI Galfi
   60. Jens Goldammer
   61. Stephen J Huston
   62. Nan Hu
   63. Masayoshi Ito
   64. Claire McKellar
   65. Ryo Minegishi
   66. Shigehiro Namiki
   67. Aljoscha Nern
   68. Catherine E Schretter
   69. Gabriella R Sterne
   70. Lalanti Venkatasubramanian
   71. Kaiyu Wang
   72. Tanya Wolff
   73. Ming Wu
   74. Reed George
   75. Oz Malkesman
   76. Yoshinori Aso
   77. Gwyneth M Card
   78. Barry J Dickson
   79. Wyatt Korff
   80. Kei Ito
   81. James W Truman
   82. Marta Zlatic
   83. Gerald M Rubin
   84. FlyLight Project Team

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a resource for researchers using Drosophila to study neural circuits, in the form of a collection of split-Gal4 lines with an online search engine, which will facilitate the mapping of neuronal circuits. The evidence is convincing to demonstrate the utility of these new tools, and of the search engine, for understanding expression patterns in adults and larvae, and differences between the sexes. These resources will be of broad interest to Drosophila researchers in the field of neurobiology.

   Reviewed by eLife

8. Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

   This article has 7 authors:

   1. Suguru Takagi
   2. Shiina Takano
   3. Tomohiro Kubo
   4. Yusaku Hashimoto
   5. Shu Morise
   6. Xiangsunze Zeng
   7. Akinao Nose

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Takagi and colleagues is an important contribution to the question of how homologous neuronal circuits might be wired differently to elicit specific behaviours. The authors combine genetic, neuroanatomical, and behavioral data to provide convincing evidence that Dfz2/DWnt4 signaling controls the innervation pattern of wave command neurons in the fly larva, and thereby behavioral locomotion program selection.

   Reviewed by eLife

9. Untangling stability and gain modulation in cortical circuits with multiple interneuron classes

   This article has 4 authors:

   1. Hannah Bos
   2. Christoph Miehl
   3. Anne-Marie Michelle Oswald
   4. Brent Doiron

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper explores how diverse forms of inhibition impact firing rates in models for cortical circuits. In particular, the paper studies how the network operating point affects the balance of direct inhibition from SOM inhibitory neurons to pyramidal cells, and disinhibition from SOM inhibitory input to PV inhibitory neurons. This is an important issue as these two inhibitory pathways have largely been studied in isolation. A combination of analytical calculations and direct numerical simulations provides convincing evidence that the interplay of these inhibitory circuits can separately control network gain and stability.

   Reviewed by eLife

10. T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells

    This article has 8 authors:

    1. Josep Garnica
    2. Patricia Sole
    3. Jun Yamanouchi
    4. Joel Moro
    5. Debajyoti Mondal
    6. Cesar Fandos
    7. Pau Serra
    8. Pere Santamaria

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides important information on pre-existing epigenetic modification in T cell plasticity. The evidence supporting the conclusions is compelling, supported by comprehensive transcriptional and epigenetic analyses. The work will be of interest to immunologists and colleagues studying transcriptional regulation.

    Reviewed by eLife