eLife

Latest preprint reviews

1. Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

   This article has 8 authors:

   1. Christopher D Adam
   2. Ehsan Mirzakhalili
   3. Kimberly G Gagnon
   4. Carlo Cottone
   5. John D Arena
   6. Alexandra V Ulyanova
   7. Victoria E Johnson
   8. John A Wolf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important paper that reports in vivo physiological abnormalities in the hippocampus of a rat model of traumatic brain injury (TBI). In this study, authors focused on changes in theta-gamma phase coupling and action potential entrainment to theta, phenomena hypothesized to be critical for cognition. The authors provide convincing evidence of deficits in both features post-TBI and contributes new understanding to how disruptions in oscillatory coordination and spike timing may relate to cognitive impairment.

   Reviewed by eLife

2. Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

   This article has 5 authors:

   1. Besma Brahmia
   2. Yahaira Naaldijk
   3. Pallabi Sarkar
   4. Loukia Parisiadou
   5. Sabine Hilfiker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable contribution follows past descriptions of ciliation defects, potentially linked to cholinergic neuronal dysfunction, associated with mutated G2019S Lrrk2 expression. The strength of evidence is considered solid and broadly supportive of the claims concerning well-characterized cilia changes in cholinergic neurons over time in the model; however, additional work may be required to define the specificity of the pRab12 antibody in the IHC technique, dependence on LRRK2, and clarification of the cilia phenotype in sporadic PD brains that exists (for the moment) only in a non-peer-reviewed pre-print, despite the prominence of these (preliminary) results highlighted in the abstract and text of the current manuscript. It is hoped that the authors will begin to address the feedback provided by the expert reviewers to help provide a more mechanistic basis for the audience interested in cholinergic defects associated with Parkinson's disease.

   Reviewed by eLife

3. Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress

   This article has 11 authors:

   1. Alina Malita
   2. Anne H Skakkebaek
   3. Olga Kubrak
   4. Xiaokang Chen
   5. Takashi Koyama
   6. Elizabeth C Connolly
   7. Nadja Ahrentloev
   8. Ditte S Andersen
   9. Michael J Texada
   10. Kenneth Halberg
   11. Kim Rewitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work by Malita et al. describes a mechanism by which an intestinal infection causes an increase in daytime sleep through signaling from the gut to the blood-brain barrier. Their findings suggest that cytokines upd3 and upd2 produced by the intestine following infection act on glia of the blood brain barrier to regulate sleep by modulating Allatostatin A signaling. The evidence is compelling and elegantly performed using the ample Drosophila genetic toolbox, making this work appealing for a broad group of neuroscience researchers interested in sleep and gut-brain interactions.

   Reviewed by eLife

4. Integration of sensory and fear memories in the rat medial temporal lobe

   This article has 6 authors:

   1. Francesca S Wong
   2. Alina B Thomas
   3. Simon Killcross
   4. Vincent Laurent
   5. R Fred Westbrook
   6. Nathan M Holmes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study by Wong et al. addresses a longstanding question in the field of associative learning regarding how a motivationally relevant event can be inferred from prior learning based on neutral stimulus-stimulus associations. The research provides convincing behavioral and neurophysiological evidence to address this question. The manuscript will be interesting for researchers in behavioral and cognitive neuroscience.

   Reviewed by eLife

5. Normative evidence weighing and accumulation in correlated environments

   This article has 3 authors:

   1. Nathan Tardiff
   2. Jiwon Kang
   3. Joshua I Gold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work combines theory and experiment to demonstrate convincingly how humans make decisions about sequences of pairs of correlated observations. The proposed model for evidence integration in correlated environments will be of use for the study of decision-making.

   Reviewed by eLife

6. Supralinear dendritic integration in murine dendrite-targeting interneurons

   This article has 3 authors:

   1. Simonas Griesius
   2. Amy Richardson
   3. Dimitri Michael Kullmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this manuscript, Griesius et al analyze the dendritic integration properties of NDNF and OLM interneurons, and suggest that the supralinear NMDA receptor-dependent synaptic integration may be associated with dendritic calcium transients only in NDNF interneurons. These findings are important because they suggest there might be functional heterogeneities in the mechanisms underlying synaptic integration in different classes of interneurons of the mouse neocortex and hippocampus. The revised work remains incomplete due to remaining concerns about experimental methodology, cell health, and lack of dendritic Na-spikes which have been recorded in previous works.

   Reviewed by eLife

7. Serotonin modulates infraslow oscillation in the dentate gyrus during non-REM sleep

   This article has 9 authors:

   1. Gergely F Turi
   2. Sasa Teng
   3. Xinyue Chen
   4. Emily CY Lim
   5. Carla Dias
   6. Ruining Hu
   7. Ruizhi Wang
   8. Fenghua Zhen
   9. Yueqing Peng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that a very slow (infraslow) oscillation occurs in voltage recordings from the dentate gyrus of the adult mouse. The authors suggest that it is related to sleep stage and serotonin acting at one type of serotonin receptor in the dentate gyrus. The results are significant because they suggest new insight into how a slow oscillation affects memory through serotonin receptors in the dentate gyrus. Convincing data are provided to support the claims.

   Reviewed by eLife

8. Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

   This article has 8 authors:

   1. Iuliia Ferling
   2. Steffen Pfalzgraf
   3. Lea Moutounet
   4. Lanhui Qiu
   5. Yumeng Li
   6. Yuhuan Zhou
   7. Sergio Grinstein
   8. Spencer A Freeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, Ferling and colleagues provide convincing evidence demonstrating that myeloid cells exert distinct, cargo-dependent responses during and after phagocytosis. These important findings establish previously unrecognized insights into the function(s) of myeloid cells in immunosurveillance and are thus likely to be broadly impactful across the spectrum of biomedical disciplines including immunology and cell biology. Notwithstanding these clear strengths of the article, some minor issues were noted pertinent to the relative opaqueness of the mechanisms underpinning context-specific RhoA activation.

   Reviewed by eLife

9. Inclusive, exclusive and hierarchical atlas of NFATc1+/PDGFR-α+ cells in dental and periodontal mesenchyme

   This article has 7 authors:

   1. Xue Yang
   2. Chuyi Han
   3. Changhao Yu
   4. Bin Zhou
   5. Ling Ye
   6. Feifei Li
   7. Fanyuan Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Utilizing transgenic lineage tracing techniques and tissue clearing-based advanced imaging and three-dimensional slices reconstruction, the authors comprehensively mapped the distribution atlas of NFATc1+ and PDGFR-α+ cells in dental and periodontal mesenchyme and tracked their in vivo fate trajectories. This important work extends our understanding of NFATc1+ and PDGFR-α+ cells in dental and periodontal mesenchyme homeostasis, and should provide impact on clinical application and investigation. The strength of this work is compelling in employing CRISPR/Cas9-mediated gene editing to generate two dual recombination systems, and mapped gNFATc1+ and PDGFR-α+cells residing in dental and periodontal mesenchyme, their capacity for progeny cell generation, and their inclusive, exclusive and hierarchical relations in homeostasis, generating a spatiotemporal atlas of these skeletal stem cell population.

   Reviewed by eLife

10. Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

    This article has 7 authors:

    1. Tomohiro Umeda
    2. Ayumi Sakai
    3. Rumi Uekado
    4. Keiko Shigemori
    5. Ryota Nakajima
    6. Kei Yamana
    7. Takami Tomiyama

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The authors made a useful finding that Zizyphi spinosi semen, a traditional Chinese medicine, has demonstrated excellent biological activity and potential therapeutic effects against Alzheimer's disease (AD). The researchers presented the effects, but the research evidence for the mechanism was incomplete. The main claims were only partially supported.

    Reviewed by eLife