eLife

Latest preprint reviews

1. Allocentric and egocentric cues constitute an internal reference frame for real-world visual search

   This article has 2 authors:

   1. Yan Chen
   2. Zhe-Xin Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that visual search for upright and rotated objects is affected by rotating participants in a VR and gravitational reference frame. However, the evidence supporting this conclusion is incomplete, given the authors' use of normalized response time and the assumption that object recognition across rotations requires mental rotation.

   Reviewed by eLife

2. Frequency and Laminar Profile of Feature Specific Visual Activity Revealed by Interleaved EEG-fMRI

   This article has 4 authors:

   1. Tommy Clausner
   2. José P Marques
   3. René Scheeringa
   4. Mathilde Bonnefond

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses simultaneous EEG and fMRI recordings to shed light on the relationship between alpha and gamma oscillations and specific cortical layers. The sophisticated methodology provides solid evidence for correlations between oscillatory power and the strength and contents of fMRI signals in different cortical layers, though some caveats remain. This paper will be of interest to neuroscientists studying the role and mechanisms of alpha and gamma oscillations.

   Reviewed by eLife

3. Adult-neurogenesis allows for representational stability and flexibility in early olfactory system

   This article has 2 authors:

   1. Zhen Chen
   2. Krishnan Padmanabhan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents a valuable theory and analysis of the role of neurogenesis and inhibitory plasticity in the drift of neural representations in the olfactory system. For one of the findings, regarding the impact of neurogenesis on the drift, the evidence remains incomplete. The reason lies in the differences in variability/drift of the mitral/tufted cell responses observed in the model compared to experimental observations, where these responses remain stable over extended time scales.

   Reviewed by eLife

4. Absence of Systematic Effects of Internalizing Psychopathology on Learning Under Uncertainty

   This article has 7 authors:

   1. Muhammad H Satti
   2. Katharina Wille
   3. Matthew R Nassar
   4. Radoslaw M Cichy
   5. Nicolas W Schuck
   6. Peter Dayan
   7. Rasmus Bruckner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important results with regard to the ongoing debate of the relationship between internalizing psychopathology and learning under uncertainty. The methods and analyses are solid, and the results are backed by a large sample size, yet the study could still benefit from a more detailed discussion about the difference in experimental design and analysis compared to previous studies. If these concerns are addressed, this study would be of interest to researchers in clinical and computational psychiatry for the behavioral markers of psychopathological symptoms.

   Reviewed by eLife

5. Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

   This article has 3 authors:

   1. J Ignacio Gutierrez
   2. Claudia Edgar
   3. Jessica K Tyler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses innovative microfluidics-based single-cell imaging to monitor replicative lifespan, protein localization, and intracellular iron levels in aging yeast cells. The evidence for the proposed role of Ssd1 and reduced nutrients for lifespan through limiting iron uptake is convincing, even though some mechanistic details remain unclear. This work will be of interest to cell biologists working on aging and iron metabolism.

   Reviewed by eLife

6. Active regulation of the epidermal growth factor receptor by the membrane bilayer

   This article has 6 authors:

   1. Shwetha Srinivasan
   2. Xingcheng Lin
   3. Xuyan Chen
   4. Raju Regmi
   5. Bin Zhang
   6. Gabriela S Schlau-Cohen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors describe an interesting approach to studying the dynamics and function of membrane proteins in different lipid environments. The important findings have theoretical and practical implications beyond the study of EGFR to all membrane signalling proteins. The evidence supporting the conclusions is convincing, based on the use of a nanodisk system to study membrane proteins in vitro, combined with state-of-the-art single-molecule FRET. The work will be of broad interest to cell biologists and biochemists.

   Reviewed by eLife

7. Explainable machine learning-assisted exploration of chromatin dynamics reveals chromosome-specific response to serum starvation

   This article has 6 authors:

   1. Taras Redchuk
   2. Antti Pennanen
   3. Harri Jäälinoja
   4. Olli Natri
   5. Lassi Paavolainen
   6. Maria K Vartiainen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This interesting study adapts machine learning tools to analyze movements of a chromatin locus in living cells in response to serum starvation. The machine learning approach developed is useful, the experiments are well controlled, and the data are solid. The study would be greatly strengthened by testing key predictions made using perturbation experiments. This work will be of interest to those studying chromosome biology and gene expression patterns.

   Reviewed by eLife

8. Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

   This article has 5 authors:

   1. Philip MM Ruppert
   2. Aylin S Güller
   3. Marcus Rosendal
   4. Natasa Stanic
   5. Jan-Wilhelm Kornfeld

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The present study employed transcriptomics to investigate the impact of methionine restriction (MR) and cold exposure (CE) on liver and adipose tissues in mice. The authors demonstrate that responses to MR and CE are tissue-specific, while both MR and CE have a similar effect on beige adipose tissue. While these findings are somewhat descriptive, this work is considered important, as it provides a comprehensive resource for enhancing our understanding of these lifestyle interventions. The study is of high scientific quality, and the analyses are convincing.

   Reviewed by eLife

9. Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

   This article has 4 authors:

   1. Chengrui Shi
   2. Chaofei Su
   3. Kaixiang Zhang
   4. Hang Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study investigates how intrinsically disordered domains can interact to dictate the sub-cellular localization of a major innate immune sensor termed cGAS. The data from various cellular and biochemical assays are mostly solid, but the main conclusions from these experiments need to be validated further. This paper is relevant to immunologists, especially those interested in cytosolic DNA-sensing pathways.

   Reviewed by eLife

10. Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration

    This article has 3 authors:

    1. Bogdan Beirowski
    2. Haoran Huang
    3. Elisabetta Babetto

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this valuable study, through carefully executed and rigorously controlled experiments, the authors challenged a previously reported role of the Death Receptor 6 (DR6/Tnfrsf21) in Wallerian degeneration (WD). Using two DR6 knockout mouse lines and multiple WD assays, both in vitro and in vivo, the authors provided convincing evidence that loss of DR6 in mice does not protect peripheral axons from WD after injury. Questions remain about whether this conclusion is generalizable to CNS axonal degeneration in disease models such as ALS, AD, and prion diseases. In addition, the authors need to provide information about the sex, age, and genetic background of their animal studies to allow readers to better assess the basis for inconsistencies from previous reports on the protective effects of DR6.

    Reviewed by eLife