Latest preprint reviews

1. Modulation of aperiodic EEG activity provides sensitive index of cognitive state changes during working memory task

   This article has 5 authors:

   1. Tisa Frelih
   2. Andraž Matkovič
   3. Tjaša Mlinarič
   4. Jurij Bon
   5. Grega Repovš

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work explores the timely idea that aperiodic activity in human electrophysiology recordings shows changes in response to task events, which may be relevant for performance, and that these changes could be misinterpreted as oscillatory changes. While it is a timely and interesting topic in principle, in the present form, the analytic approach is incomplete. Further, the data offer inadequate support for the conclusions related to theta without demonstrations that the task evokes theta power. Impressions were split, but there was consensus that the Discussion should be tempered and that revisions would improve the manuscript.

   Reviewed by eLife

2. Parabrachial CGRP neurons modulates conditioned active defensive behavior under a naturalistic threat

   This article has 5 authors:

   1. Gyeong Hee Pyeon
   2. Hyewon Cho
   3. Byung Min Chung
   4. June-Seek Choi
   5. Yong Sang Jo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of parabrachial CGRP threat function. The evidence supporting CGRP aversive outcome signaling is solid, while the evidence for cue signaling and fear behavior generation is incomplete. The work will be of interest to neuroscientists studying defensive behaviors.

   Reviewed by eLife

3. An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer

   This article has 12 authors:

   1. Chiara Capitani
   2. Jessica Iorio
   3. Elena Lastraioli
   4. Claudia Duranti
   5. Giacomo Bagni
   6. Ginevra Chioccioli Altadonna
   7. Rossella Colasurdo
   8. Giorgia Scarpellino
   9. Scott P. Fraser
   10. Andrea Becchetti
   11. Mustafa B. A. Djamgoz
   12. Annarosa Arcangeli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the identification of a complex consisting of NHE1, hERG1, β1/integrin and NaV1.5 on the membrane of breast cancer cells. The evidence supporting the claims of the authors is somewhat incomplete. The inclusion of clarification of some experimental design and the amendment of cropping Western blot data would have strengthened the study. The work will be of interest to scientists working on breast cancer.

   Reviewed by eLife

4. Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

   This article has 18 authors:

   1. Carla Valenzuela Ripoll
   2. Zhen Guo
   3. Tripti Kumari
   4. Kana N. Miyata
   5. Mualla Ozcan
   6. Ahmed Diab
   7. Amanda Girardi
   8. Li He
   9. Attila Kovacs
   10. Carla Weinheimer
   11. Jess Nigro
   12. Jan Oscarsson
   13. Russell Esterline
   14. Joel Schilling
   15. Mikhail Kosiborod
   16. Christina Christoffersen
   17. Jaehyung Cho
   18. Ali Javaheri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     SGLT2 inhibitors (SGLT2i) have assumed important roles in reducing cardiovascular risk, particularly in those with diabetes. It has become appreciated that its protective effects are likely beyond their ability to lower blood sugar levels. This research presents a novel approach to studying the SGLT2i mechanism of action which is yet to be fully elucidated.

   Reviewed by eLife

5. Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus

   This article has 3 authors:

   1. Mohamed El Amri
   2. Abhay Pandit
   3. Gerhard Schlosser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work addresses the role of Marcks/Markcksl during spinal cord development and regeneration. The study is exceptional in combining molecular approaches to understand the mechanisms of tissue regeneration with behavioural assays, which is not commonly employed in the field. The data presented is convincing and comprehensive, using many complementary methodologies.

   Reviewed by eLife

6. Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

   This article has 14 authors:

   1. Marina Padilha
   2. Victor N. Keller
   3. Paula Normando
   4. Raquel M. Schincaglia
   5. Nathalia C. Freitas-Costa
   6. Samary S. R. Freire
   7. Felipe M. Delpino
   8. Inês R. R. de Castro
   9. Elisa M. A. Lacerda
   10. Dayana R. Farias
   11. Zachary Kroezen
   12. Meera Shanmuganathan
   13. Philip Britz-Mckibbin
   14. Gilberto Kac

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of factors influencing early childhood development. The large sample size and methodology applied make the findings of this study convincing; however, support for some of the claims made by the authors is incomplete. The work will be of interest to researchers in developmental science and early childhood pediatrics.

   Reviewed by eLife

7. Error Prediction Determines the Coordinate System Used for Novel Dynamics Representation

   This article has 2 authors:

   1. Raz Leib
   2. David W. Franklin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable new perspective on how motor learning occurring in one state generalizes to new states (for example, a different limb posture). The proposed model improves upon previous theories in its ability to predict patterns of generalization, but evidence supporting this specific proposed model over possible alternatives is incomplete. The newly proposed theory appears promising but would be more convincing if its conceptual and theoretical basis were clearer and more rigorously derived.

   Reviewed by eLife

8. Balancing safety and efficiency in human decision making

   This article has 4 authors:

   1. Pranav Mahajan
   2. Shuangyi Tong
   3. Sang Wan Lee
   4. Ben Seymour

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work describes results from a set of simulation and empirical studies of a set-up assessing exploratory behavior in a potentially rewarding environment that contains danger. The core idea is that an instrumental agent can be helped to be both effective and safe, thus avoiding excessive danger, during exploratory behavior, if its influence is flexibly gated by an independent Pavlovian fear learning system. The conclusion that safe, but effective exploration can be achieved based on a flexibly weighted combination of a Pavlovian and an instrumental agent is solid.

   Reviewed by eLife

9. Secreted exosomes induce filopodia formation

   This article has 11 authors:

   1. Caitlin McAtee
   2. Mikin Patel
   3. Daisuke Hoshino
   4. Bong Hwan Sung
   5. Ariana von Lersner
   6. Mingjian Shi
   7. Nan Hyung Hong
   8. Anna Young
   9. Evan Krystofiak
   10. Andries Zijlstra
   11. Alissa M Weaver

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors identify a novel relationship between exosome secretion and filopodia formation that has implications for cancer cell metastasis and neuronal synapse formation. Further, they identify the exosomal cargo, THSD7A, as a regulator of this process. The data presented is convincing, and represents an important advancement in our understanding of how these two biological processes are linked and play roles in regulating cell migration and cell-cell communication.

   Reviewed by eLife

10. The flexible stalk domain of sTREM2 modulates its interactions with phospholipids in the brain

    This article has 6 authors:

    1. David Saeb
    2. Emma E Lietzke
    3. Daisy I Fuchs
    4. Emma C Aldrich
    5. Kimberley D Bruce
    6. Kayla G Sprenger

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This useful manuscript addresses some key molecular mechanisms on the neuroprotective roles of soluble TREM2 in neurodegenerative diseases. Thw study will advance our understanding of TREM2 mutations, particularly on the damaging effect of known TREM2 mutations, and also explain why soluble TREM2 can antagonize Aβ aggregation. However, the primary experimental method, MD simulations, suffers from limited sampling, rendering the results incomplete for definite conclusions.

    Reviewed by eLife