eLife reviews preprints in the life sciences and medicine.

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  1. On the Polymorph-Selection Determinants of α- Synuclein Amyloid Fibrils Studied at Atomic Resolution

    1. Lukas Frey
    2. David Rhyner
    3. Witek Kwiatkowski
    4. Dhiman Ghosh
    5. Kristina Biedermann
    6. Roland Riek
    7. Jason Greenwald

    • Curated by eLife

      eLife Assessment

      This important study identifies underappreciated experimental factors that influence α-synuclein amyloid polymorphism, with practical implications for the reproducibility of in vitro fibril preparations. Extensive cryo-EM analyses provide convincing evidence that protein purity, monomer preparation, and agitation conditions influence polymorph selection, including substantial effects from small amounts of an N-terminally truncated variant. The study provides a substantial resource for researchers studying amyloid assembly and synucleinopathies, although the proposed nucleation mechanisms need stronger kinetic support and reliable protocols for producing specific polymorphs require further development.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Golgi CATCHR complexes function as organizing hubs for vesicle tethering and fusion

    1. Walter S. Aragon-Ramirez
    2. Amrita Khakurel
    3. Irina Pokrovskaya
    4. Farhana Taher Sumya
    5. Vladimir V. Lupashin

    • Curated by eLife

      eLife Assessment

      This study provides a valuable and comprehensive in vivo map of proteins in proximity to three vesicle-tethering complexes. The evidence supporting the overall proximity mapping is convincing. However, some aspects of the functional characterization of selected candidates remain incomplete.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. A pleiotropic EPAS1 enhancer mediating Tibetan adaptation to hypoxia is active in adipocytes

    1. Alexis G. Thornburg
    2. Soo-Young Park
    3. Li Zhang
    4. Ivy Aneas
    5. Débora R. Sobreira
    6. Isabella M. Salamone
    7. Noboru J. Sakabe
    8. Kathryn M. Farris
    9. Zachary T. Weber
    10. Olivia A. Gray
    11. Jennifer Yoo
    12. Hae Kyung Im
    13. Anna Di Rienzo
    14. Marcelo A. Nóbrega

    • Curated by eLife

      eLife Assessment

      The observations in this study related to a pleiotropic EPAS1 enhancer that mediates adaptation to hypoxia in adipocytes of Tibetans are a valuable contribution. The data are solid, but additional experiments would strengthen the claims.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Large scale loss-of-function mutations during chicken evolution and domestication

    1. Siwen Wu
    2. Kun Wang
    3. Xuehai Ge
    4. Tengfei Dou
    5. Sisi Yuan
    6. Shixiong Yan
    7. Zhiqiang Xu
    8. Yong Liu
    9. Zonghui Jian
    10. Jingying Zhao
    11. Rouhan Zhao
    12. Xiannian Zi
    13. Dahai Gu
    14. Lixian Liu
    15. Qihua Li
    16. Dong-Dong Wu
    17. Junjing Jia
    18. Changrong Ge
    19. Zhengchang Su

    • Curated by eLife

      eLife Assessment

      This useful study reports potential loss-of-function variants, pseudogenes and gene presence-absence variation across multiple chicken genomes, with potential implications for understanding genome evolution and domestication. The evidence for the central claims is unfortunately incomplete, as the inferences of gene loss are not sufficiently robust to account for assembly and annotation artifacts, and, in addition, the analyses can not distinguish between positive selection and relaxed constraint. The overall claim of large-scale gene loss being adaptive and thus being a major driver of chicken evolution and domestication is therefore not sufficiently supported. The area of the study is of interest to colleagues in evolutionary and comparative genomics as well as animal domestication.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. GDNF regenerates the missing enteric nervous system of Hirschsprung mice via non-canonical signaling in diverse subtypes of tissue-resident progenitors

    1. Alassane Gary
    2. Rodolphe Soret
    3. Marie A. Lefevre
    4. Nejia Lassoued
    5. Ann Aspirot
    6. Christophe Faure
    7. Nicolas Pilon

    • Curated by eLife

      eLife Assessment

      This important study investigates how GDNF treatment restores nerve cells in the bowel of a mouse model of Hirschsprung disease, and proposes that this regeneration occurs through diverse resident precursor cells and a non-canonical signaling pathway. The evidence is solid for the ability of the treatment to induce new bowel nerve cells and for a contribution from multiple precursor populations, supported by extensive cell tracing and imaging experiments. This work will be of interest to researchers in developmental biology and peripheral neurobiology.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  8. Reinforcement learning for closed-loop optimisation of spatiotemporal stimulation in patterned neuronal networks

    1. Benedikt Maurer
    2. Vaiva Vasiliauskaitė
    3. Julian Hengsteler
    4. Gino Cathomen
    5. Tobias Ruff
    6. Cedric Schmid
    7. János Vörös
    8. Stephan J. Ihle

    • Curated by eLife

      eLife Assessment

      This study presents an open-source reinforcement learning framework for the real-time, closed-loop optimization of spatiotemporal electrical stimulation in engineered neuronal networks. Using single-spike-resolution activity as continuous feedback, the authors provide solid evidence that their platform can identify stimulation patterns that drive specific activity motifs within a structurally constrained four-node circuit. While this reproducible system offers a valuable and accessible tool for interacting with biological neural networks in an adaptive manner, further validation is needed to determine how well these stimulation strategies generalize to larger, unstructured, or more conventional network architectures.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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