eLife reviews preprints in the life sciences and medicine.

About Followers

Latest preprint reviews

  1. Dawn of segmented bilaterians unveiled by soft-bodied fossils in microbial pseudomorphs from the Basal Cambrian

    1. Xiaoguang Yang
    2. Deng Wang
    3. Farid Saleh
    4. Zhiliang Zhang
    5. Jie Sun
    6. Wenjing Hao
    7. Kentaro Uesugi
    8. Tsuyoshi Komiya
    9. Xing Wang
    10. Jian Han

    • Curated by eLife

      eLife Assessment

      This important manuscript reports exceptionally preserved, millimeter-scale segmented bilaterian microfossils from the early Cambrian Fortunian Kuanchuanpu Formation in South China. The authors propose that these non-biomineralized animals were preserved through microbial pseudomorphs rather than direct phosphatization, filling a critical taphonomic and evolutionary gap in early animal evolution. The physical preservation and high-resolution imaging of the fossils are convincing, but the theoretical grounds for establishing "true segmentation" versus superficial annulation/homonomy remain underdeveloped and need revision and further context. The new fossils and their taphonomy will be of broad interest to the paleontology community and those interested in early animal evolution.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. The cell cycle regulates cell-penetrating peptide cytosolic uptake via differential expression of KCNH1 potassium channel

    1. Francisco Tomás Ribeiro
    2. Ali Hallaj
    3. Roger Mora
    4. Anita Lüthi
    5. Evgeniya Trofimenko
    6. Christian Widmann

    • Curated by eLife

      eLife Assessment

      This study reveals valuable links between cell-penetrating peptide uptake and the cell cycle, membrane voltage and an endogenous potassium channel. The evidence is solid, and further experiments would strengthen the proposed mechanism and the degree of the mechanism's generalization. The findings will interest researchers working on delivery of therapeutic molecules into cells.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex

    1. Irina Bregy
    2. Robin Benjamin Eberle
    3. Julika Radecke
    4. Amin Khosrozadeh
    5. Jaime Llodrá
    6. Akira Noga
    7. Hugo van den Hoek
    8. Mara Kern
    9. Beat Haenni
    10. Benjamin D. Engel
    11. Philip Stettler
    12. André Schneider
    13. C. Alistair Siebert
    14. Takashi Ishikawa
    15. Benoît Zuber
    16. Torsten Ochsenreiter

    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into the architecture of the tripartite attachment complex in Trypanosoma brucei and how it may preserve mitochondrial genome anchoring during basal body movement. Cryo-electron tomography and structural modelling provide solid support for the observed variability in filament length and basal body positioning, although the proposed mechanism involving p197 repeat orientation awaits direct molecular validation. These findings will interest researchers studying mitochondrial DNA inheritance, organelle organization, and the cell biology of kinetoplastid parasites.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a g BRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

    1. Ezra Y. Rosen
    2. Marie-Claude Mathieu
    3. Gino B. Ferraro
    4. Philippe Mochirian
    5. Claude Godbout
    6. Hugo Poirier
    7. Sara Fournier
    8. Danielle Henry
    9. Hyeyeon Kim
    10. Robert Papp
    11. Shou Yun Yin
    12. Marie-Eve Leclaire
    13. Robert Houle
    14. Parham Nejad
    15. Joseph D. Schonhoft
    16. Karl E. Zahn
    17. W. Cameron Black
    18. Michel Gallant
    19. Insil Kim
    20. Danielle Ulanet
    21. Paul Basciano
    22. Artur Veloso
    23. Victoria Rimkunas
    24. Timothy A. Yap
    25. Robin Guo
    26. Nicholas Mai
    27. Maria Koehler
    28. Michael Zinda
    29. Anne Roulston
    30. Michal Zimmermann
    31. Stephen J. Morris
    32. Agnel Sfeir

    • Curated by eLife

      eLife Assessment

      Loss of POLQ function is synthetically lethal with BRCA1 or BRCA2 deficiency, as is pharmacological inhibition of its motor (ATPase) or polymerase activity. This important manuscript validates an inhibitor of the DNA polymerase theta (POLθ) motor domain in biochemical and cell-based assays and provides evidence of its efficacy against homologous recombination-deficient tumors in preclinical and clinical settings, particularly in combination with PARP inhibitors. The experiments are rigorous, the evidence is convincing, and the results are appropriately interpreted. This work will be of considerable interest to the ovarian cancer research community.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Lipid-Driven Biophysical Selection of β-Furanoside-5'-Phosphate as the Sole Scaffold of Extant RNA

    1. Ze-Run Zhao
    2. Qian-Qian Chen
    3. Hao-Xing Xu
    4. Bing-Yue Zhao
    5. Cheng-Cheng Gu
    6. Xiao Wang

    • Curated by eLife

      eLife Assessment

      The study reports on the relative lipid permeabilities of different ribonucleotide isomers. The findings are valuable for prebiotic chemistry and protocell research because they offer an additional possible explanation for how the canonical ribonucleotide isomers were selected. The strength of the evidence is solid, being supported by experimental and computational approaches, although the step from differential permeability to selection is less firmly supported.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  6. Connectomic Analysis of Mitochondria in the Central Brain of Drosophila

    1. Kit D. Longden
    2. Patricia K. Rivlin
    3. Michał Januszewski
    4. Erika Neace
    5. Louis K. Scheffer
    6. Christopher Ordish
    7. Jody Clements
    8. Elliott Phillips
    9. Natalie Smith
    10. Satoko Takemura
    11. Lowell Umayam
    12. Claire Walsh
    13. Emily A. Yakal
    14. Timothy F. Musial
    15. Michael J. Devine
    16. Michael B. Reiser
    17. Stephen M. Plaza
    18. Stuart Berg

    • Curated by eLife

      eLife Assessment

      This study provides a valuable resource describing the size, density, and synaptic proximity of mitochondria across thousands of neurons in the Drosophila brain, drawn from a well-annotated electron microscopy dataset. The evidence supporting the main descriptive findings is mostly solid, though some measured parameters contain internal inconsistencies and the proposed links between mitochondrial properties and neural activity or energy use remain speculative. The work will interest neuroscientists studying mitochondrial biology, energetics, and connectomics, and lays a foundation for future studies connecting mitochondrial organization to neural circuit function.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity
Page 1 of 873 Older