eLife

Latest preprint reviews

1. Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

   This article has 9 authors:

   1. Yanping Li
   2. Xiaoxin Xie
   3. Daqi Deng
   4. Zhiyuan Sun
   5. Zhaoan Huang
   6. Yisen Tang
   7. Liang Fang
   8. Wei Chen
   9. Qionghua Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the mutational order for common alterations in colorectal cancer. The evidence of in vitro growth assays comparing mutations is solid, although inclusion of biological replicates for the transcriptional assessments and in vivo experiments would have strengthened the study. The work will be of interest to scientists working in the field of colon cancer.

   Reviewed by eLife

2. Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation

   This article has 11 authors:

   1. Collin Laaker
   2. Martin Hsu
   3. Andy Madrid
   4. Jenna Port
   5. Sophia M Vrba
   6. Melinda Herbath
   7. Cameron Baenen
   8. Mohan Kumar
   9. Thanthrige Thiunuwan Priyathilaka
   10. Matyas Sandor
   11. Zsuzsanna Fabry

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Laaker et al. make an important finding that the cribriform plate acts as a unique neuroimmune interface that shapes local myeloid cell states during EAE-induced neuroinflammation. Using immuohistochemistry, flow cytometry, and single-cell RNAseq of doublets to interrogate cell-cell interactions, the authors provide solid evidence that macrophages, migratory dendritic cells (DCs), and fibroblasts interact at the site of CSF outflow, with DCs showing characteristics of immune tolerance. While the functional consequences of these cell states remain to be established, the work shows that the cribiform plate can play a key role in influencing immune cell composition and interactions with stromal cells.

   Reviewed by eLife

3. Arousal modulates functional connectivity through structured and hemispherically asymmetric community architecture during wakefulness

   This article has 3 authors:

   1. Xiangyu Kong
   2. Siyu Li
   3. Gaolang Gong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers a valuable analysis of how moment-to-moment fluctuations in arousal are associated with structured, non-uniform patterns of brain-wide functional connectivity during wakefulness. Using data-driven analyses of resting-state and naturalistic fMRI with eye tracking, the authors present convincing evidence that arousal is a dynamic, continuous process that shapes brain activity in a structured way beyond a simple global effect. However, the strength of the conclusions is limited by a reliance on specific analytical choices and the need for additional controls and robustness analyses. This paper sheds light on the link between brain activity and ongoing fluctuations in arousal and will be of interest to researchers studying large-scale brain functional organization and links between the brain and body.

   Reviewed by eLife

4. TAD boundary architecture and gene activity are uncoupled

   This article has 7 authors:

   1. Faisal Almansour
   2. Nadezda A Fursova
   3. Adib Keikhosravi
   4. Kathleen S Metz Reed
   5. Daniel R Larson
   6. Gianluca Pegoraro
   7. Tom Misteli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, DNA and RNA are co-imaged in single cells to show that the proximity of topologically associated domain (TAD) boundaries is uncoupled from the transcriptional activity of nearby genes. The evidence supporting these conclusions is convincing for the regions examined, with high-throughput imaging providing robust statistics. This work will be of interest to researchers studying genome architecture and its relationship to gene regulation.

   Reviewed by eLife

5. Exercise Engages Coordinated Neuron–Glia Signaling to Shape Spinal Cord Plasticity

   This article has 6 authors:

   1. Shivani Mansingh
   2. Sedat Dilbaz
   3. Danilo Ritz
   4. Gesa Santos
   5. Stefan A Steurer
   6. Christoph Handschin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable data regarding gene expression and molecular changes that occur in the mouse spinal cord from exercise and motor activity. Overall, the findings and methods are solid, although additional independent validation experiments would improve the rigor of the study. The work provides resources for neuroscientists who investigate communication between neurons and non-neurons and both basic and translational scientists with interests in how physical activity impacts the nervous system function, with potential therapeutic outcomes.

   Reviewed by eLife

6. Boosting the signal: Expectation-driven gain modulation of preparatory spatial attention

   This article has 2 authors:

   1. Dirk van Moorselaar
   2. Stefan Van der Stigchel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable evidence regarding our expectations about task difficulty and how this might influence proactive attention. The findings suggest that anticipated demands enhance the strength of attentional selection at cued locations. The evidence is solid but not definitive, as the conclusions rely on the absence of changes in spatial breadth and would benefit from clearer statistical justification and a more cautious interpretation of alternative mechanisms.

   Reviewed by eLife

7. Environmental dynamics shape human learning: change points versus random walks

   This article has 3 authors:

   1. Cedric Foucault
   2. Lilian A Weber
   3. Laurence Hunt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Foucault and colleagues examine how human adaptive learning depends on the structure of the learning task. The authors provide useful findings clarifying the differences in how people learn in environments that are continuously versus discontinuously changing. While they provide solid evidence for most conclusions, support for some of the claims is incomplete in the current form.

   Reviewed by eLife

8. Fine-tuning of outer membrane–peptidoglycan tethering by the redox-active lipoprotein LppB from Salmonella enterica

   This article has 4 authors:

   1. Elisa S. Pierre Despas
   2. Seung-Hyun Cho
   3. Bogdan I. Iorga
   4. Jean-François Collet

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study convincingly demonstrates how bacterial cells can modulate outer membrane-peptidoglycan tethering by expressing two different Lpp homologs with distinct cross-linking efficiencies, revealing that Salmonella typhimurium LppB forms disulfide-based homodimers (or heterotrimers with Lpp when present) and is covalently attached to peptidoglycan primarily via the L,D-transpeptidase LdtB at residue K58. The evidence supporting the authors' claims is solid, including the regulatory role of LppB dimerization for its abundance in E. coli and its ability to inhibit Lpp/A crosslinking to peptidoglycan, although additional analysis and quantification of muropeptides in wild-type E. coli overexpressing LppB would further strengthen the findings. Overall, the work will be of great interest to microbiologists studying cell envelope biogenesis.

   Reviewed by eLife

9. Serial Dependence Predicts Generalization in Perceptual Learning

   This article has 3 authors:

   1. Noga Pinchuk-Yacobi
   2. Dov Sagi
   3. Yoram S Bonneh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes long-range serial dependence of performance on a visual texture discrimination training task that manipulated conditions to induce differing degrees of location transfer of learning. The authors re-analyzed a previously-published behavioral data set, generating compelling evidence from converging approaches that serial dependence effects can persist across multiple days post-training, and are impacted by whether training promotes more or less location transfer. Although underlying mechanisms for these processes remain unclear, these results will interest neuroscientists in general by informing our understanding of the importance of temporal integration to long-term perceptual learning and its propensity towards specificity or generalizability.

   Reviewed by eLife

10. Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals

    This article has 5 authors:

    1. Mary L Phillips
    2. Nicolai T Urban
    3. Taddeo Salemi
    4. Zhe Dong
    5. Ryohei Yasuda

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The new development of Neuroplex, a pipeline that links projection-defined neuronal identity to in vivo calcium activity within the same animal, is a valuable contribution to the field of neuroscience and beyond. The strength of evidence is judged to be solid, as the methods, data, and analyses broadly support the stated claims.

    Reviewed by eLife