eLife

Latest preprint reviews

1. LiFE, a multimodal circadian intervention, improves sleep, glycemic control, and recognition memory

   This article has 13 authors:

   1. Yu Shi
   2. Stephen D. Rozen
   3. Jordan T. Swint
   4. Williams A. McRoberts
   5. Sophia N. McCurry
   6. Ricardo Salinas
   7. Elizabeth G. Moffett
   8. Clara M. Pollock
   9. Lila R. Goldstein
   10. Soraya S. Katzev
   11. Matthew E. Carter
   12. George S. Bloom
   13. Ali D. Güler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important findings regarding the efficacy of a chronotherapeutic protocol (termed LiFE), combining timed light, food, and exercise exposure in improving several physiological and health metrics in a rodent model. The evidence advanced in wild-type mice is solid but inconclusive and underpowered when applied to two transgenic mouse models of Alzheimer's Disease. Additionally, the potential of such protocols in clinical human studies is an open question. Overall, the study suggests that LiFE intervention may have positive effects on metabolic and brain health.

   Reviewed by eLife

2. Meaning-based guidance of attention in rhesus monkeys during naturalistic scene viewing

   This article has 7 authors:

   1. Orhan Soyuhos
   2. Taylor R. Hayes
   3. Wenqing Hu
   4. Taylor P. Hamel
   5. Brinda Sevak
   6. John M. Henderson
   7. Xiaomo Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study shows that macaque monkeys preferentially fixate regions in natural scenes that are classified as "meaningful" by a computational model - an earlier model that was developed to identify locations that are semantically informative to humans - suggesting that overt attention to structured visual content is shared across primates. However, support is incomplete for the stronger claim that macaques are guided by semantic meaning, which is confounded by lower-level visual features that co-vary with it and by methodological limitations that complicate interpretation. If the semantic interpretation were more reliably established, the significance of the findings would increase, as they would connect the human cognitive process of scene understanding to neural circuit mechanisms accessible in non-human primates.

   Reviewed by eLife

3. Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation

   This article has 7 authors:

   1. Alejandro G. Rey Hipolito
   2. Michael P. Dew
   3. Jason S. Gill
   4. Janelle E. Allen
   5. Karissa A. Chesky
   6. Mariam Hull
   7. Roy V. Sillitoe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies inhibitory cerebellar nuclei neurons as drivers of dystonic crisis and shows that their modulation can both induce and alleviate severe motor symptoms, proposing a cerebello-thalamic circuit mechanism with clear therapeutic relevance. The evidence is convincing, supported by rigorous bidirectional optogenetic manipulations, iCNN-to-CL thalamic monosynaptic tracing, and deep brain stimulation experiments, although the specificity of the genetic strategy remains to be fully resolved. The study will be of broad interest to neuroscientists and clinicians working on movement disorders and circuit-based therapies.

   Reviewed by eLife

4. Tonic feedback motor commands predict visuomotor learning

   This article has 3 authors:

   1. Yuto Makino
   2. Toshiki Kobayashi
   3. Daichi Nozaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study rigorously examines how motor learning is influenced by the feedback response to a previous movement error. Using a series of well-conducted experiments, the authors provide solid evidence that the learning response following a cursor jump does not depend on the timing of the perturbation and is influenced by the tonic component of the feedback responses. Further work is needed to determine whether this generalizes to other perturbation paradigms and to more fully understand the relationship between learning and the tonic and phasic components of the feedback response.

   Reviewed by eLife

5. A surviving beta cell subpopulation enriched in patients with T1D

   This article has 3 authors:

   1. Maxwell Spurrell
   2. John S. Tsang
   3. Kevan C Herold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study leverages publicly available datasets to confirm, validate and extend the knowledge of the transcriptional profile of beta cells that resist destruction in Type 1 diabetes. The significance of the findings is considered valuable as they could be used for engineering stem cell-derived islets and for identifying therapeutic targets to preserve beta cell survival. The strength of the evidence is solid, in that the findings are supported by a sophisticated bioinformatic analysis pipeline and are largely consistent with and extend the existing literature.

   Reviewed by eLife

6. Feedback control of recurrent circuits imposes dynamical constraints on learning

   This article has 3 authors:

   1. Harsha Gurnani
   2. Weixuan Liu
   3. Bingni W Brunton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses a feedback-driven recurrent neural network framework to explore the dynamics underlying learning of BCI decoder perturbations. With convincing evidence, the authors demonstrate that behavioral learning trajectories that match those of primates learning within-manifold and outside-manifold perturbations are likely tied to the dynamical controllability of the network and input-driven learning. This work is likely to motivate a new generation of BCI and learning experiments combining large-scale neural recordings with latent dynamical systems analyses.

   Reviewed by eLife

7. RNF25 is activated as a response to amino acid starvation-induced ribosome collisions in competition with GCN2

   This article has 3 authors:

   1. Ivan Kisly
   2. Ivo Zemp
   3. Ulrike Kutay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides conditionally useful evidence that amino acid starvation and other stresses induce RNF25-dependent ubiquitination of RPS27A/eS31, extending this pathway beyond A-site-trapping conditions and implicating GCN1. However, incomplete and largely indirect evidence was provided to support key mechanistic claims-notably competition between RNF25 and GCN2 for GCN1 and a role in resolving ribosome collisions. Additional direct and orthogonal evidence is required to substantiate these conclusions.

   Reviewed by eLife

8. Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer

   This article has 6 authors:

   1. Ningjun Duan
   2. Yijia Hua
   3. Zhengxing Zhou
   4. Nan Jin
   5. Wei Li
   6. Yongmei Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding that coordinated changes in epigenetic modifications and three-dimensional chromatin architecture may drive primary trastuzumab resistance in HER2+ breast cancer. Moreover, this manuscript identifies SGK1 as a potential therapeutic target. The evidence supporting the claims of the authors is solid, although the inclusion of a more direct validation of the key findings using tumor samples from patients with clinical trastuzumab resistance would have strengthened the study. The work will be of interest to scientists or clinicians working in the field of BCs.

   Reviewed by eLife

9. Opposing BOLD signals and oxygen metabolism largely arise from statistical uncertainty in metabolic estimates

   This article has 3 authors:

   1. Ole Goltermann
   2. Alexander Huth
   3. Christian Büchel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides a timely and important statistical re-evaluation of a paper by Epp et al., on the discordance of BOLD and CMRO2 measures. The authors present a convincing case based on rigorous re-analysis of the data that these previous results arise predominantly from uncertainty in measurement, rather than physiological features. These findings have implications that are of importance to all studies of brain function using BOLD FMRI.

   Reviewed by eLife

10. How local antibiotic use, carriage duration, resistance costs and international travel shape resistance frequency in E. coli in France

    This article has 10 authors:

    1. Olivier Cotto
    2. André Birgy
    3. Mélanie Magnan
    4. Stéphane Béchet
    5. Stéphane Bonacorsi
    6. Robert Cohen
    7. Corinne Levy
    8. Forough L Nowrouzian
    9. Olivier Tenaillon
    10. François Blanquart

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable paper uses a mathematical model applied to a dataset of E coli / ESBL carriage and transmission to infer drivers of drug resistance in France. The strength of support for the study findings is incomplete. While the research question is of importance, and the mathematical model has structural and methodological integrity, numerous issues are noted: insufficient description of the data, lack of included equations and code, definitions of antibiotic use that are not complete, low sensitivity of assays for carriage, technical issues with statistical prior selection and parameter identification, and application of non-regional ECDC surveillance data to France.

    Reviewed by eLife