eLife reviews preprints in the life sciences and medicine.

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  1. Cell junction disruption drives translocation of gasdermin A and gasdermin B from cytoskeleton to plasma membrane during acantholysis

    1. Kidong Kang
    2. Ying Wang
    3. Edward A Miao

    • Curated by eLife

      eLife Assessment

      This valuable study investigates the cleavage-independent functions of Gasdermins in keratinocytes. The data collected using advanced microscopy methods and Western blotting are solid, but the main conclusions from these experiments remain partially supported. This paper is relevant to those studying cell-type specific inflammatory responses and client/cargo specificities of Gasdermins.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

    1. Corey E. Hayford
    2. Blake Baleami
    3. Philip E. Stauffer
    4. B. Bishal Paudel
    5. Aziz Al’Khafaji
    6. Amy Brock
    7. Vito Quaranta
    8. Darren R. Tyson
    9. Leonard A. Harris

    • Curated by eLife

      eLife Assessment

      This valuable study uses single-cell profiling, lineage barcoding, and functional assays to examine drug-tolerant persisters in a BRAF-inhibited melanoma cell line. The data provide solid evidence that persisters arise from many lineages and have altered calcium handling and increased sensitivity to ferroptosis, although the lineage result is difficult to interpret without knowing how many cells survived treatment. The broader claim that these cells represent substates within a single persister state is less well supported, as it rests largely on transcriptomic projections, lacks time-resolved data, and has been examined in only one cell line.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity
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