eLife

Latest preprint reviews

1. The Drosophila IR20a Integrates L-arginine and Salt Signals via Distinct Subunit Assemblies

   This article has 5 authors:

   1. Bo Wang
   2. Guangnan Qu
   3. Xutong Wang
   4. Hubert Amrein
   5. Yan Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study uses genetic, behavioural, neuronal activity and cell-based assays to show that the Drosophila ionotropic receptor IR20a contributes to the detection of arginine and low-sodium salt, and suggests that peripheral receptor combinations may help integrate these nutrient cues. The evidence for a role for IR20a and associated co-receptors in these responses is solid, but the evidence that distinct receptor assemblies mediate receptor-level multimodal integration is incomplete, as this central model is inferred from functional data and leaves some discrepancies between behaviour, physiology and prior work unresolved. The study will be of interest to sensory neuroscientists and chemosensory biologists.

   Reviewed by eLife

2. Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors

   This article has 6 authors:

   1. L. Kaplan
   2. A.L. Green
   3. J. Pang
   4. M. Pavlou
   5. J. Wohlschlegel
   6. T.A Reh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important contribution to retinal regeneration research by using overexpression of pro-neural factors to reprogram fetal human RPE cells into retinal neurons. The authors provide solid evidence of fetal RPE reprogramming into neural and photoreceptor-like states using scRNA-seq and imaging validation; however, there are concerns regarding comparisons between the effectiveness of different combinatorial transcription factor codes.

   Reviewed by eLife

3. A nanoscale atlas of extracellular vesicles and particles in Drosophila olfactory sensilla

   This article has 7 authors:

   1. Pawel Vijayakumar
   2. Kalyani Cauwenberghs
   3. Muskaan Garg
   4. Jonathan Choy
   5. Shadi Charara
   6. Quintyn McKaughan
   7. Chih-Ying Su

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study presents an ultrastructural atlas of extracellular vesicles and non-vesicular particles in Drosophila olfactory sensilla, using cryofixation-based serial block-face electron microscopy to catalogue roughly 7,800 particles across four antennal regions. The evidence is compelling: the cryofixation minimizes fixation artifacts, and the rigorous, well-validated methodology and morphometric analyses provide strong support for the structural classifications and spatial distributions, though some conclusions require moderation or additional evidence. The work provides a potentially foundational resource for researchers studying extracellular-particle signaling in sensory organs.

   Reviewed by eLife

4. Prophase Chromosomes Relocalization to Nuclear Periphery in NPP-3/NUP205 Depletion Protects Genome Stability

   This article has 3 authors:

   1. Ling Jiang
   2. Yu Chung Tse
   3. Karen Wing Yee Yuen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the functional consequences of nuclear envelope rupture caused by the depletion of nuclear pore complex subunits on the behaviour and organisation of chromosomes during mitosis in C. elegans embryos. The experiments are generally well-designed and executed; however, the evidence for some of the main conclusions is incomplete. This work is of potential interest to cell biologists working on cell division.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.64898/2026.06.15.732353

6. Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets

   This article has 3 authors:

   1. Peter Chovanec
   2. Shiyang He
   3. Yi Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using sci-L3-Strand-seq, this study shows genome-wide, single-cell evidence that DSBs triggered by CRISPR/Cas9 are frequently resolved through sister chromatid exchange (SCE), which is undetectable with conventional whole-genome sequencing approaches. This important work provides helpful metrics quantifying the occurrence of SCE events at targeted and repetitive genomic loci that are of particular interest to those working in gene editing, DNA repair, genome instability, or repetitive genomic loci. However, the evidence supporting the proposed involvement of under-replicated region/replication-termination-zone resolution and TRAIP/URR-like pathways is currently incomplete and could be strengthened with an increased number of reciprocal daughter-cell pairs and by genetic or molecular perturbation, or alternatively, this can be addressed by changing the discussion.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.10.01.679817

8. We couldn't get details of this article at this time:
   10.64898/2026.05.31.729150

9. We couldn't get details of this article at this time:
   10.64898/2026.05.27.728092

10. We couldn't get details of this article at this time:
    10.64898/2026.05.13.724957