Latest preprint reviews

1. Rediscovering the Rete Ovarii : a secreting auxiliary structure to the ovary

   This article has 5 authors:

   1. Dilara N. Anbarci
   2. Jennifer McKey
   3. Daniel S. Levic
   4. Michel Bagnat
   5. Blanche Capel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports the developmental dynamics and molecular markers of the rete ovarii during ovarian development. However, the data supporting the main conclusions remain incomplete. This study will be of interest to developmental and reproductive biologists.

   Reviewed by eLife

2. The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

   This article has 22 authors:

   1. Rion Brattig Correia
   2. Joana M. Almeida
   3. Margot J. Wyrwoll
   4. Irene Julca
   5. Daniel Sobral
   6. Chandra Shekhar Misra
   7. Sara Di Persio
   8. Leonardo G. Guilgur
   9. Hans-Christian Schuppe
   10. Neide Silva
   11. Pedro Prudêncio
   12. Ana Nóvoa
   13. Ana S. Leocádio
   14. Joana Bom
   15. Sandra Laurentino
   16. Moisés Mallo
   17. Sabine Kliesch
   18. Marek Mutwil
   19. Luis M. Rocha
   20. Frank Tüttelmann
   21. Jörg D. Becker
   22. Paulo Navarro-Costa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports the deep evolutionary conservation of a core genetic program regulating spermatogenesis in flies, mice, and humans. The data presented are supportive of the main conclusion and generally convincing. This work will be of interest to evolutionary and reproductive biologists.

   Reviewed by eLife

3. Benchmarking reveals superiority of deep learning variant callers on bacterial nanopore sequence data

   This article has 10 authors:

   1. Michael B. Hall
   2. Ryan R. Wick
   3. Louise M. Judd
   4. An N. T. Nguyen
   5. Eike J. Steinig
   6. Ouli Xie
   7. Mark R. Davies
   8. Torsten Seemann
   9. Timothy P. Stinear
   10. Lachlan J. M. Coin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides evidence for a combination of the latest generation of Oxford Nanopore Technology long reads with state-of-the art variant callers enabling bacterial variant discovery at accuracy that matches or exceeds the current "gold standard" with short reads. The evidence supporting the claims of the authors is convincing, although the inclusion of a larger number of reference genomes would further strengthen the study. The work will be of interest to anyone performing sequencing for outbreak investigations, bacterial epidemiology, or similar studies.

   Reviewed by eLife

4. Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis

   This article has 38 authors:

   1. Lianlei Wang
   2. Sen Zhao
   3. Xinyu Yang
   4. Pengfei Zheng
   5. Wen Wen
   6. Kexin Xu
   7. Xi Cheng
   8. Qing Li
   9. Anas M. Khanshour
   10. Yoshinao Koike
   11. Junjun Liu
   12. Xin Fan
   13. Nao Otomo
   14. Zefu Chen
   15. Yaqi Li
   16. Lulu Li
   17. Haibo Xie
   18. Panpan Zhu
   19. Xiaoxin Li
   20. Yuchen Niu
   21. Shengru Wang
   22. Sen Liu
   23. Suomao Yuan
   24. Chikashi Terao
   25. Ziquan Li
   26. Shaoke Chen
   27. Xiuli Zhao
   28. Pengfei Liu
   29. Jennifer E Posey
   30. Zhihong Wu
   31. Guixing Qiu
   32. Shiro Ikegawa
   33. James Lupski
   34. Jonathan J Rios
   35. Carol A Wise
   36. Jianguo Zhang
   37. Chengtian Zhao
   38. Nan Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors combined human genetic analysis with zebrafish experiments to produce evidence that alleles that impair the function of EPHA4 cause idiopathic scoliosis (IS), a common spinal deformity. The significance of the findings is important because the cellular and molecular mechanisms that contribute to IS remain poorly understood. The human genetic data are quite convincing whereas the zebrafish data, although supportive, are incomplete.

   Reviewed by eLife

5. Mapping Spatial Patterns to Energetic Benefits in Groups of Flow-coupled Swimmers

   This article has 3 authors:

   1. Sina Heydari
   2. Haotian Hang
   3. Eva Kanso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides a modeling regime that provides new insight into the energy-preservation parameters among schooling fish. The strength of the evidence supporting observations such as distilled dynamics between leading and lagging schooling fish which are derived from emergent properties is convincing. Overall, the study provides exciting insights into energetic coupling with respect to group swimming dynamics. Some potential improvements to strengthen the study include clarification regarding degrees of freedom and parameter ranges in the model.

   Reviewed by eLife

6. Alasemenia , the earliest ovule with three wings and without cupule

   This article has 7 authors:

   1. Deming Wang
   2. Jiangnan Yang
   3. Le Liu
   4. Yi Zhou
   5. Peng Xu
   6. Min Qin
   7. Pu Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful manuscript describes the second earliest known winged ovule without a capule in the Famennian of Late Devonian. Using solid mathematical analysis, the authors demonstrate that three-winged seeds are more adapted to wind dispersal than one-, two- and four-winged seeds. The manuscript will help the scientific community to understand the origin and early evolutionary history of wind dispersal strategy of early land plants.

   Reviewed by eLife

7. ^UFM Track: Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

   This article has 9 authors:

   1. Mykhailo Vladymyrov
   2. Luca Marchetti
   3. Sidar Aydin
   4. Sasha Soldati
   5. Adrien Mossu
   6. Arindam Pal
   7. Laurent Gueissaz
   8. Akitaka Ariga
   9. Britta Engelhardt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work is important because it attempts to elucidate how immune cells migrate across the blood brain barrier. The authors developed a convincing framework to visualize, recognize and track the movement of different immune cells across primary human and mouse brain microvascular endothelial cells without the need for fluorescence-based imaging using microfluidic devices. The data gathered are solid, and this work will be of interest to the cancer biology, immunology and medical therapeutics fields.

   Reviewed by eLife

8. Coupling of saccade plans to endogenous attention during urgent choices

   This article has 3 authors:

   1. Allison T Goldstein
   2. Terrence R Stanford
   3. Emilio Salinas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides insights into the interplay of endogenous orienting and the planning of goal-directed gaze shifts (saccades). Using an elegant experimental protocol and detailed analyses of the time course of saccadic choices, the authors provide compelling evidence for independent mechanisms that guide early, reflexive eye movements and later, voluntary gaze shifts. This work will be of interest to neuroscientists and psychologists working on vision and motor control and to those researching decision-making across disciplines.

   Reviewed by eLife

9. Visual to default network pathways: A double dissociation between semantic and spatial cognition

   This article has 12 authors:

   1. Tirso RJ Gonzalez Alam
   2. Katya Krieger-Redwood
   3. Dominika Varga
   4. Zhiyao Gao
   5. Aidan Horner
   6. Tom Hartley
   7. Michel Thiebaut de Schotten
   8. Magdalena W Sliwinska
   9. David Pitcher
   10. Daniel S. Margulies
   11. Jonathan Smallwood
   12. Elizabeth Jefferies

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful experiment seeks to better understand how memory interacts with incoming visual information to effectively guide human behavior. Using several methods, the authors report two distinct pathways relating visual processing to the default mode network: one that emphasizes "semantic" cognition, and the other, spatial cognition. Despite the impressive array of methods employed, the evidence supporting a clear distinction is currently incomplete.

   Reviewed by eLife

10. GABA-ergic inhibition in human MT predicts visuo-spatial intelligence mediated by reverberation with frontal cortex

    This article has 12 authors:

    1. Yuan Gao
    2. Yong-Chun Cai
    3. Dong-Yu Liu
    4. Juan Yu
    5. Jue Wang
    6. Ming Li
    7. Bin Xu
    8. Teng-Fei Wang
    9. Gang Chen
    10. Georg Northoff
    11. Ruiliang Bai
    12. Xue Mei Song

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study employed a comprehensive approach to examining how the MT+ region integrates into a complex cognition system in mediating human visuo-spatial intelligence. While the findings are useful, the experimental evidence is incomplete and the study design, hypothesis, analyses, writing, and presentation need to be improved. The work will be of interest to researchers in psychology, cognitive science, and neuroscience.

    Reviewed by eLife