eLife reviews preprints in the life sciences and medicine.

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  1. Pharmacogenetic manipulation of Locus coeruleus activity in monkeys demonstrates its role in cognitive effort

    1. Pauline Perez
    2. Sebastien Bouret

    • Curated by eLife

      eLife Assessment

      This valuable study uses chemogenetic inactivation techniques in behaving macaque monkeys to ask whether the locus coeruleus (LC), an area that is involved in the control of arousal, is also involved in regulating access to mental resources for a task that requires working memory. The data show that moderate locus coeruleus inhibition impairs foraging efficiency without affecting response times, total rewards accrued, or overall motivation. However, the evidence supporting the more specific claim that the locus coeruleus regulates cognitive and/or working memory function is currently incomplete, as the experimental design is confounded by elapsed time, lacks formal statistical interaction tests, and relies on behavioral measures that cannot cleanly separate effort allocation from working memory capacity or strategy shifts. These limitations may be ameliorated with further analyses.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Inhibitory Control, Shifting, and Working Memory Updating Domains form Cognitive Phenotypes in Non-human Primates

    1. Xuan Wen
    2. Leo Malchin
    3. Adam Neumann
    4. Thilo Womelsdorf

    • Curated by eLife

      eLife Assessment

      The primary aim of this study is to measure the different dimensions of executive function in non-human primates and the classification of animals into distinct cognitive phenotypes. To achieve this, it uses a multi-task touchscreen battery for six rhesus macaques with repeated measurements to examine how performance across inhibitory control, shifting/learning, working memory, and updating covaries within and across individuals. Overall, this is an important finding with relevance for anyone interested in behavioural assessment of cognitive functions in non-human primates or dimensionality of executive functions. The strength of evidence is overall convincing, with some minor methodological weaknesses that should be addressable in future versions.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. A Sterol-Binding Cavity Underlies Sterol Recognition and Differential Activation of the ABCG5/G8

    1. Fatemeh Rezaei
    2. Isra F. Omar
    3. Danny Farhat
    4. Zi-Wen Weng
    5. Kadambari Vijay Sai
    6. Qing-Fang Xiao
    7. Yuan-Chih Chang
    8. Shang-Te Danny Hsu
    9. Jyh-Yeuan Lee

    • Curated by eLife

      eLife Assessment

      This work presents valuable findings that identify ergosterol binding by the human ABC transporter ABCG5/G8 and show that ergosterol stimulates its ATPase activity more strongly than cholesterol, advancing understanding of sterol recognition and transport. The evidence from single-particle cryo-EM, molecular dynamics simulations, and biochemical assays is convincing and solid, although additional structures and mutational studies would strengthen the proposed mechanism. These results provide key insight into the molecular basis of sterol recognition and regulation of ABCG5/G8 and will be of interest to researchers studying sterol transport and ABC transporter function.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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