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  1. Loss of canonical sex steroid signaling correlates with prostate cancer progression and induces tumor escape in Drosophila

    1. M. Vialat
    2. E. Baabdaty
    3. C. Vachias
    4. F. Degoul
    5. A. Trousson
    6. P. Pouchin
    7. JMA. Lobaccaro
    8. S. Baron
    9. L. Morel
    10. C. de Joussineau

    • Curated by eLife

      eLife Assessment

      This valuable study provides insights into the role of steroid signaling during tumorigenesis in the adult male drosophila accessory gland (functional equivalent of the prostate gland in mammals), hinting at a possible counterintuitive anti-tumoral role of sex hormones during prostate cancer in certain patients. While the Drosophila model provides an elegant way to study the hypothesis derived from the Cancer Atlas analysis, the analyses of public prostate cancer expression data are incomplete and critical knowledge on patients' treatment modalities and normalization across different datasets is missing. This work would be of interest to prostate cancer researchers as it suggests that the absence of androgen receptor signaling in humans could constitute a mechanism promoting tumor escape.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

    1. Varun Ravishankar
    2. Laidy M. Alvero-González
    3. Agathe Hubert
    4. Zaiwei Zhang
    5. Chloé Markarian
    6. Valérie Prima
    7. Sirine Chergui
    8. Roberto Melero
    9. Florian Stengel
    10. Stéphen Manon
    11. Jean-Pierre Duneau
    12. Maria Queralt-Martin
    13. Lucie Bergdoll

    • Curated by eLife

      eLife Assessment

      This work provides important findings that reveal a mechanistic model of how VDAC2 influences BAX activation in mitochondria during BAX-mediated apoptosis. The experimentally supported model is convincing, with several experiments strengthening its validity. Major strengths include the complementary biochemical, biophysical, structural, and computational approaches, as well as the study's broad relevance.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. E-Selectin Orchestrates IL-1β–Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy

    1. Hana Starobova
    2. Ammar Alshammari
    3. Nikhil Nageshwar Inturi
    4. Nicolette Tay
    5. Svetlana Shatunova
    6. Ali Lam
    7. Quan Nguyen
    8. Marisol Mancilla Moreno
    9. Diana Tavares Ferreira
    10. Federico Iseppon
    11. Virginia Rodriguez-Menendez
    12. Cristina Meregalli
    13. Brittany Hill
    14. Larissa Labzin
    15. Simranpreet Kaur
    16. Darren L. Brown
    17. Guido Cavaletti
    18. Theodore Price
    19. Avril Robertson
    20. Allison Pettit
    21. Jennifer L. Stow
    22. Ingrid G Winkler
    23. Irina Vetter

    • Curated by eLife

      eLife Assessment

      This paper provides a useful assessment of the role of macrophages in the development of functional paw withdrawal, which is a feature in the mouse model of vincristine-induced peripheral neuropathy (VIND). The authors suggest a role for E-selectin as a critical molecule promoting VIPN, acting via immune cell recruitment and inflammasome-mediated signalling; however, their data on NLRP3 inflammasome activation in vivo remains somewhat incomplete. This study will be of interest for immunologists.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  5. Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity

    1. Shaoyu Tu
    2. Yue Du
    3. Wei Liang
    4. Xiaoyi Xu
    5. Jiahui Zou
    6. Yuchao Yang
    7. Chuhan Xiong
    8. Yanglin Li
    9. Meijun Jiang
    10. Aotian Ouyang
    11. Tong Chen
    12. Meilin Jin
    13. Huanchun Chen
    14. Hongbo Zhou

    • Curated by eLife

      eLife Assessment

      This valuable study reveals a role for lactylation in influenza polymerase function and virus replication. The evidence supporting the claims is solid, although the direct involvement of ATAT1 and SIRT1 in this modification and the functional relevance of the identified sites can be further substantiated. These findings will appeal broadly to influenza virologists studying polymerase regulation, as well as researchers investigating the functional roles of lactylation.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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