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  1. Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

    This article has 9 authors:
    1. Corey E. Hayford
    2. Blake Baleami
    3. Philip E. Stauffer
    4. B. Bishal Paudel
    5. Aziz Al’Khafaji
    6. Amy Brock
    7. Vito Quaranta
    8. Darren R. Tyson
    9. Leonard A. Harris
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study uses single-cell profiling, lineage barcoding, and functional assays to examine drug-tolerant persisters in a BRAF-inhibited melanoma cell line. The data provide solid evidence that persisters arise from many lineages and have altered calcium handling and increased sensitivity to ferroptosis, although the lineage result is difficult to interpret without knowing how many cells survived treatment. The broader claim that these cells represent substates within a single persister state is less well supported, as it rests largely on transcriptomic projections, lacks time-resolved data, and has been examined in only one cell line.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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