eLife

Latest preprint reviews

1. Reverse engineering of motor unit discharge in multiple sclerosis reveals heterogeneity of voluntary motor commands

   This article has 8 authors:

   1. Laura M. McPherson
   2. Keith R. Lohse
   3. Skyler M. Simon
   4. Daniel B. Free
   5. James A. Beauchamp
   6. Francesco Negro
   7. Robert T. Naismith
   8. Anne H. Cross

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides a very large data set of motor unit recordings in people with multiple sclerosis and, as such, could impact both foundational and clinical studies of the neuromuscular system. The study reports increased variability in firing rate profiles across participants and suggests that this observation reflects differences in the excitatory, inhibitory, and neuromodulatory drive reaching motor neurons. The descriptive finding is solid, but the link to specific neural mechanisms is incomplete as it depends heavily on assumptions related to its model-based framework.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.64898/2026.07.23.740292

3. We couldn't get details of this article at this time:
   10.64898/2026.06.16.732606

4. IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2

   This article has 25 authors:

   1. John P. Miller
   2. Kyu Kwang Kim
   3. Cameron WA Snyder
   4. Negar Khazan
   5. Niloy A. Singh
   6. Megan E. Boyer
   7. Elizabeth Lamere
   8. Myla Strawderman
   9. Sonali Sharma
   10. Ronald Lakony
   11. Michelle Whittum
   12. Mark Anderson
   13. Rick Keenan
   14. Elizabeth Pritchett
   15. Cameron Baker
   16. John Ashton
   17. Manoj K. Khera
   18. Michael R. Elliott
   19. Christina M. Annunziata
   20. Jeevisha Bajaj
   21. Laura M. Calvi
   22. Michael W. Becker
   23. Rachael Rowswell-Turner
   24. Richard G. Moore
   25. Rakesh K. Singh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies the IL1R1-IRAK4 axis as a mediator of inflammation-associated ovarian cancer implantation. The evidence is convincing, supported by complementary genetic and pharmacological approaches across multiple in vivo models. These findings advance our understanding of how inflammatory signaling shapes metastatic niche formation and highlight IRAK4 as a potential therapeutic target.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.64898/2026.04.26.720929

6. We couldn't get details of this article at this time:
   10.64898/2026.07.10.737753

7. We couldn't get details of this article at this time:
   10.64898/2026.01.12.698824

8. We couldn't get details of this article at this time:
   10.1101/2024.10.25.620167

9. We couldn't get details of this article at this time:
   10.64898/2026.07.24.740456

10. We couldn't get details of this article at this time:
    10.1101/2025.02.14.638366