eLife reviews preprints in the life sciences and medicine.

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  1. Reassessing Choice Probability: What 59 Macaque Studies Tell Us About Decision-Related Activity in Visual Cortex

    1. Anton Pletenev
    2. Richard T. Born
    3. Gregory C. DeAngelis
    4. Raymond Doudlah
    5. Ichiro Fujita
    6. Joshua I. Gold
    7. Robbe L. T. Goris
    8. Alexander C. Huk
    9. Kristine Krug
    10. Pooya Laamerad
    11. Richard D. Lange
    12. Aaron J. Levi
    13. Hendrikje Nienborg
    14. Christopher C. Pack
    15. Andrew J. Parker
    16. Ari Rosenberg
    17. Mehdi Sanayei
    18. Takanori Uka
    19. Xuefei Yu
    20. Adam Zaidel
    21. Corey M. Ziemba
    22. Ralf M. Haefner

    • Curated by eLife

      eLife Assessment

      This meta-analysis provides a valuable contribution by integrating findings from dozens of macaque electrophysiology studies to reconcile discrepancies in choice probability and identify factors that robustly influence choice signals in the visual cortex. Such systematic synthesis across studies is rare in this field, and the analysis provides solid evidence for several important conclusions, including the cross-study consistency of the relationship between choice probability and sensitivity and the distinctiveness of V1.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. A Sequential Assembly Mechanism for Stable Cdc13 Dimerization on Telomeric DNA

    1. Po-Wei Chiu
    2. Yu-Ting Lin
    3. Pei-Ru Lai
    4. Tzu-Yu Lee
    5. Yu-Chen Cheng
    6. Yan-Zhu Hsieh
    7. Hung-Wen Li
    8. Jing-Jer Lin

    • Curated by eLife

      eLife Assessment

      This important study uses biochemical and single-molecule approaches to characterize how yeast Cdc13 assembles on single-stranded telomeric DNA and contributes to telomere protection. The evidence supporting the proposed model for Cdc13 assembly and its role at telomeres is solid. The findings provide insight into how Cdc13 contributes to the maintenance and protection of chromosome ends. This work will be of interest to researchers in telomere biology, DNA replication, biochemistry, and single-molecule biophysics.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  8. Primary cilia in the growing limb are preferentially orientated, uncoupled from centriolar position

    1. T Johnson
    2. S Midha
    3. AM Julé
    4. G Randall
    5. K Apolinova
    6. J Miotla-Zarebska
    7. SN Sansom
    8. TL Vincent
    9. AKT Wann

    • Curated by eLife

      eLife Assessment

      This valuable study provides a detailed three-dimensional characterization of primary cilia organization in the postnatal mouse growth plate, revealing reproducible spatial patterns in ciliation, ciliary length, and orientation. The evidence supporting these descriptive findings is solid, based on high-quality quantitative imaging and complementary genetic, mechanical, and transcriptomic approaches. However, evidence for the broader mechanistic conclusions is incomplete, particularly regarding whether ciliary orientation is uncoupled from basal-body and cell orientation and whether its stability under altered mechanical loading reflects a cell-intrinsic program. The study provides a helpful foundation for understanding primary cilia organization and mechanobiology in the growing skeleton, while the mechanisms underlying these observations remain to be established.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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