Latest preprint reviews

  1. Alzheimer disease—The proposed role of tanycytes in the formation of tau tangles and amyloid beta plaques in human brain

    This article has 3 authors:
    1. Ruth Fabian-Fine
    2. Abigail G. Roman
    3. Adam L. Weaver
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors propose the existence of an AQP4-positive tanycyte-associated canal system in the hippocampus based on histological, ultrastructural, immunohistochemical, and RNA-based approaches. There are serious concerns regarding the evidence, and the identification of the tanycyte-related structures can be questioned. At this stage, the evidence for the central claims of the manuscript has to be regarded as inadequate.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. An innovative tool for non-invasive contact-free pathogen monitoring in animal saliva

    This article has 13 authors:
    1. Maristela Martins de Camargo
    2. Aspen Caim Fernandes Gonçalves
    3. Diana Netto Hernandez Blazquez
    4. Maggie E. Weber
    5. Washington Agostinho
    6. Zubin Kremer Guha
    7. Melissa Sá Fernandes
    8. Mariana Furtado
    9. Aaron Dollar
    10. Paulo Brandão
    11. Serap Aksoy
    12. Vanessa O. Ezenwa
    13. Dawn Zimmerman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work describes a valuable method for monitoring pathogens using an innovative, field-deployable device that attracts animals and collects saliva on filter paper in a non-invasive manner. While the strategy is effective at collecting samples and ensuring their preservation, support for some claims remains incomplete. This study will interest scientists in various fields, ranging from biodiversity, ecology, and conservation to infectious diseases and public health.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics

    This article has 18 authors:
    1. Jian Qiu
    2. Martha A. Bosch
    3. Mya Wolfe
    4. Ksenija Korac
    5. Stefano Rizzo
    6. Todd L. Stincic
    7. Scotland E. Farley
    8. Wendy Fitzgerald
    9. Megha Rajendran
    10. Aurélien Laguerre
    11. Frank Stein
    12. Philip F. Copenhaver
    13. Oline K. Rønnekleiv
    14. Sean M. Rønnekleiv-Kelly
    15. Tatiana K. Rostovtseva
    16. Sergey M. Bezrukov
    17. Carsten Schultz
    18. Martin J. Kelly
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study employs an innovative chemoproteomic and multi-modal experimental approach to support VDAC2 as a key functional mediator of STX effects on mitochondrial bioenergetics. However, concerns remain regarding the physiological and disease relevance, including the reliance on cell lines, lack of loss-of-function validation, unresolved binding specificity, and limited justification for focusing on POMC neurons in the context of Alzheimer's disease. As a result, the evidence is incomplete for a link between VDAC2 and Alzheimer's pathogenesis, and aspects of the binding data raise alternative interpretations, including a potential role for other VDAC isoforms.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Closed-loop neurofeedback reshapes preparatory brain states to bias subsequent pain processing

    This article has 8 authors:
    1. Yinhua Zhang
    2. Shuang Qiu
    3. Qianqian Zheng
    4. Shihao Chen
    5. Jia Li
    6. Xiaoyun Li
    7. Richu Jin
    8. Weiwei Peng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, Zhang et al. investigated EEG neurofeedback as a method to modulate brain activity prior to painful stimulation and examined its effect on pain perception in a well-powered, double-blind study. Results showed that real, but not sham, feedback enabled learning-dependent enhancement of pre-stimulus α oscillations. However, the evidence for a neurofeedback-specific reduction in pain remains incomplete, as the current paradigm cannot distinguish between genuine neurofeedback effects and placebo effects. Nonetheless, this work is likely to be of interest to researchers in the fields of neurofeedback and pain.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. A shared neural code for gender across faces, bodies, and objects in the human brain

    This article has 7 authors:
    1. Wenjie Liu
    2. Xiqian Lu
    3. Yuhui Cheng
    4. Ruidi Wang
    5. Xinquan Lu
    6. Xiangyong Yuan
    7. Yi Jiang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates whether perceived gender is represented in the brain in a category-invariant manner across faces, bodies, and objects, identifying the right middle temporal gyrus (rMTG) as a potential locus. The evidence is incomplete due to major conceptual concerns, weak statistical methods, and unaddressed low-level confounds like stimulus size and motion. This work will be of interest to psychology and social neuroscience researchers in face and person perception literature, provided the authors temper their claims regarding abstract representation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Reproductive experience promotes permanent body growth independently of growth hormone

    This article has 13 authors:
    1. Gabriel O. de Souza
    2. Willian O. dos Santos
    3. Frederick Wasinski
    4. Ligia M. M. de Sousa
    5. Andressa G. Amaral
    6. Daniela O. Gusmao
    7. Edward O. List
    8. John J. Kopchick
    9. Gimena Fernandez
    10. Mario Perelló
    11. Carla R. P. Oliveira
    12. Manuel H. Aguiar-Oliveira
    13. Jose Donato
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study reports a novel phenomenon of maternal growth during pregnancy that is independent of growth hormone (GH), adding a new dimension to maternal biology of reproduction. The evidence is convincing and supported by state-of-the-art methodologies conducted in mice and persuasive observations in humans with hereditary isolated GH deficiency. Revised discussion should focus on possible mechanisms, including the role of IGF2, and on directions for future research.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Hierarchical Neural Circuit Theory of Normalization and Inter-areal Communication

    This article has 4 authors:
    1. Asit Pal
    2. Shivang Rawat
    3. David J. Heeger
    4. Stefano Martiniani
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study extends a model of cortical normalization (ORGaNICs) to interacting cortical areas and shows that communication through coherence and communication subspaces can arise from a single set of dynamics. The evidence is solid, showing analytically that contrast-dependent gamma dynamics and a low-dimensional inter-areal communication subspace arise from one parameter set, though the comparisons to data remain qualitative and the analytics rest on a linearization that is not checked against numerical simulation. The work will interest neuroscientists and theorists concerned with inter-areal communication, cortical oscillations, and divisive normalization.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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