eLife

Latest preprint reviews

1. Neural responses during natural vision are action-timed rather than locked to the onset of stable foveal input

   This article has 6 authors:

   1. Carmen Amme
   2. Philip Sulewski
   3. Eelke Spaak
   4. Martin N. Hebart
   5. Peter König
   6. Tim C. Kietzmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that neural responses to visual input during active vision are more closely aligned with self-generated eye movements than with fixation onset. The evidence for neural responses being more aligned to saccade-related events than fixation-related events is convincing, but the evidence for the more novel finding that neural responses are most closely aligned to peak saccade curvature is currently incomplete. This work will be of interest to visual perception and sensory processing researchers.

   Reviewed by eLife

2. Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

   This article has 14 authors:

   1. Yichen Zhu
   2. Xinyuan Shen
   3. Yuning Chen
   4. Nathan Ma
   5. Catherine Zhang
   6. Annabel S. Zhao
   7. Yanxin Tian
   8. Shreya Gumate
   9. Jie Huang
   10. Siyu Lin
   11. Aijun Wang
   12. Vatche G. Agopian
   13. Yan-Ruide Li
   14. Lili Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript presents a primary important finding, namely that microbial riboflavin-derived MR1 ligands are pharmacological activators of human MAIT cells and that MR1 ligand stimulation enhances MAIT-mediated tumor killing across multiple solid-tumor models. While the evidence presented is generally solid, there are some limitations of the in vitro and in vivo models used, as well as some overstatements about the broader applicability of the research, which should be revised.

   Reviewed by eLife

3. Partial input loss differentially modifies neural pathways

   This article has 8 authors:

   1. Joo Yeun Lee
   2. Jeffrey Yang
   3. Scott C. Harris
   4. Jeremiah V. John
   5. Natalia S. Stone
   6. Luca Della Santina
   7. David B. Kastner
   8. Felice A. Dunn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study shows that partial cone photoreceptor loss induces pathway-specific circuit remodeling in the mouse retina, with alpha OFF-sustained and OFF-transient retinal ganglion cells adapting differently through changes in their pre- and postsynaptic circuits. The results are valuable because they provide a key understanding of the diversity of circuit remodeling in retinal degeneration. The data are convincing, although clearer reporting of the numbers of independent animals and retinas, a more rigorous distinction between compensation and circuit change, and discussion of the functional consequences would strengthen the mechanistic insights.

   Reviewed by eLife

4. The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa

   This article has 5 authors:

   1. Michael Telias
   2. Leonor Afrima
   3. Jared Endres
   4. Bristol Denlinger
   5. Richard H. Kramer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings regarding the role of the P2X7 receptor in retinoic acid signaling-mediated retinal remodeling following photoreceptor degeneration. However, the evidence supporting the main conclusions is currently incomplete, as key comparisons are confounded by differences in genetic background, and the cellular source of receptor expression is not sufficiently resolved. While the work offers mechanistic insights of interest to researchers studying retinal degeneration, additional experimental controls are needed to fully support the authors' claims.

   Reviewed by eLife

5. The stability of thought: using experience sampling and brain imaging to determine the contextually bound nature of human cognition

   This article has 16 authors:

   1. Louis Chitiz
   2. Samyogita Hardikar
   3. Ian Goodall-Halliwell
   4. Raven Wallace
   5. Bridget Mullholland
   6. Samuel Ketcheson
   7. Bronte McKeown
   8. Michael Milham
   9. Ting Xu
   10. Daniel Margulies
   11. Nerissa Ho
   12. Theo Karapanagiotidis
   13. Giulia Poerio
   14. Robert Leech
   15. Elizabeth Jefferies
   16. Jonathan Smallwood

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work considerably advances our understanding of the nature of ongoing thought across individuals and across task contexts. Using a combination of fMRI brain data and experience sampling, they find that activation of the MDN leads to greater stability of deliberate task-focused thoughts during task performance. The evidence supporting the claims is convincing and both analytically strong and creative, offering a novel approach to capture thought stability and its relationship to independent brain maps. The findings will be of broad interest to cognitive scientists and neuroimagers.

   Reviewed by eLife

6. Error-driven representation learning in the mesolimbic system

   This article has 4 authors:

   1. George Cai
   2. Max F. Scheller
   3. Wolfgang Kelsch
   4. Samuel J. Gershman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study presents compelling evidence for dopamine-based representation learning in the mouse olfactory tubercle. While this work suggests that gradient descent in deep networks serves as a helpful framework for understanding neural representations, the empirical evidence provided remains incomplete. Nonetheless, this work will be of significant interest to systems and computational neuroscientists, cognitive scientists, and machine learning theorists.

   Reviewed by eLife

7. Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

   This article has 15 authors:

   1. Magdalena A. Czubala
   2. Patricia Rodrigues
   3. Natacha Ipseiz
   4. Marcela Rosas
   5. Sandra Dimonte
   6. Iestyn Pope
   7. Christine Hinz
   8. Dina Fathalla
   9. Jorge Alvarez-Jarreta
   10. Victoria J. Tyrrell
   11. Wolfgang Langbein
   12. Paola Borri
   13. Robert Andrews
   14. Valerie B. O’Donnell
   15. Philip R. Taylor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that provides evidence that GATA6-dependent programming of peritoneal macrophages helps to regulate lipid metabolism and influences eosinophil survival. The evidence linking GATA6 deficiency to altered lipid profiles and eosinophil accumulation is solid, although the proposed mechanistic pathway connecting sphingolipid remodelling, LTE4 production and eosinophil survival currently remains incomplete. Strengthening these links and/or appropriately calming the conclusions would help to increase the impact of the study.

   Reviewed by eLife

8. Emergent particle collection by cyanobacteria through gliding motility and filament buckling

   This article has 6 authors:

   1. Rebecca N. Poon
   2. Kelsey Cremin
   3. Alberto Scarampi
   4. Mary Coates
   5. Albane Théry
   6. Orkun S. Soyer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents important work on macrostructure formation in a freshwater filamentous cyanobacterium, focusing on its ability to aggregate and buckle. The authors employ a wide range of experiments and approaches, including time-lapse imaging and 3D theoretical modelling, to establish the physical dynamics of filaments, such as gliding motility and buckling. They demonstrate that, in addition to gliding motility, filament length and flexibility are essential for the ability of cyanobacteria to capture particles and form aggregates. Overall, the study provides convincing evidence and advances our understanding of the role of microbial motility in the environment. It will be of broad interest to biophysicists and environmental microbiologists.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2025.03.18.643888

10. We couldn't get details of this article at this time:
    10.64898/2026.07.13.738215