eLife reviews preprints in the life sciences and medicine.

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  1. A Sequential Assembly Mechanism for Stable Cdc13 Dimerization on Telomeric DNA

    1. Po-Wei Chiu
    2. Yu-Ting Lin
    3. Pei-Ru Lai
    4. Tzu-Yu Lee
    5. Yu-Chen Cheng
    6. Yan-Zhu Hsieh
    7. Hung-Wen Li
    8. Jing-Jer Lin

    • Curated by eLife

      eLife Assessment

      This important study uses biochemical and single-molecule approaches to characterize how yeast Cdc13 assembles on single-stranded telomeric DNA and contributes to telomere protection. The evidence supporting the proposed model for Cdc13 assembly and its role at telomeres is solid. The findings provide insight into how Cdc13 contributes to the maintenance and protection of chromosome ends. This work will be of interest to researchers in telomere biology, DNA replication, biochemistry, and single-molecule biophysics.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Non-invasive measurement of neurotransmitter-specific glucose metabolism in the human brain using proton-observed proton-edited 13 C-MRS (POPE 13 C-MRS)

    1. Antoine Cherix
    2. Oliver Haermson
    3. Mohamed Tachrount
    4. Jon Campbell
    5. William T Clarke
    6. Jason P Lerch
    7. Charlotte Stagg

    • Curated by eLife

      eLife Assessment

      This valuable proof-of-concept study tests and validates a novel magnetic resonance-based method - proton-observed proton-edited MRS - for tracking glucose metabolism in the brain beyond simple substrate uptake, without the need for specialist hardware typically restricted to research settings. The approach offers a promising way to assess excitation/inhibition balance by detecting labelled glucose metabolites. The pre-clinical data in mouse models provide convincing support for the authors' hypothesis. The evidence in the human brain is incomplete: the results would require further optimisation of the experimental set-up and validation in a larger group of volunteers. This work will be of broad interest to researchers studying psychiatric, neurodevelopmental, and related brain disorders.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Dissociation between impaired explicit spatial remapping and preserved implicit neural dynamics in Alzheimer’s disease

    1. Xueling Wang
    2. Yimeng Wang
    3. Keliang Pang
    4. Chenguang Zheng

    • Curated by eLife

      eLife Assessment

      There is a significant need for improved understanding of the neural circuit mechanisms for learning and memory dysfunction in Alzheimers disease. In this valuable study, Zheng and colleagues compare neural coding between wild-type and App knock-in rats experiencing different contexts. Solid evidence of a difference emerges when "spatial" and "temporal" neural coding dynamics are considered separately. However, the lack of a link between neural coding and behaviorally measured learning, and minor issues with the analyses, are limiting factors of the evidence and the significance of the work.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Primary cilia in the growing limb are preferentially orientated, uncoupled from centriolar position

    1. T Johnson
    2. S Midha
    3. AM Julé
    4. G Randall
    5. K Apolinova
    6. J Miotla-Zarebska
    7. SN Sansom
    8. TL Vincent
    9. AKT Wann

    • Curated by eLife

      eLife Assessment

      This valuable study provides a detailed three-dimensional characterization of primary cilia organization in the postnatal mouse growth plate, revealing reproducible spatial patterns in ciliation, ciliary length, and orientation. The evidence supporting these descriptive findings is solid, based on high-quality quantitative imaging and complementary genetic, mechanical, and transcriptomic approaches. However, evidence for the broader mechanistic conclusions is incomplete, particularly regarding whether ciliary orientation is uncoupled from basal-body and cell orientation and whether its stability under altered mechanical loading reflects a cell-intrinsic program. The study provides a helpful foundation for understanding primary cilia organization and mechanobiology in the growing skeleton, while the mechanisms underlying these observations remain to be established.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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