eLife reviews preprints in the life sciences and medicine.

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  1. Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

    1. Magdalena A. Czubala
    2. Patricia Rodrigues
    3. Natacha Ipseiz
    4. Marcela Rosas
    5. Sandra Dimonte
    6. Iestyn Pope
    7. Christine Hinz
    8. Dina Fathalla
    9. Jorge Alvarez-Jarreta
    10. Victoria J. Tyrrell
    11. Wolfgang Langbein
    12. Paola Borri
    13. Robert Andrews
    14. Valerie B. O’Donnell
    15. Philip R. Taylor

    • Curated by eLife

      eLife Assessment

      This is an important study that provides evidence that GATA6-dependent programming of peritoneal macrophages helps to regulate lipid metabolism and influences eosinophil survival. The evidence linking GATA6 deficiency to altered lipid profiles and eosinophil accumulation is solid, although the proposed mechanistic pathway connecting sphingolipid remodelling, LTE4 production and eosinophil survival currently remains incomplete. Strengthening these links and/or appropriately calming the conclusions would help to increase the impact of the study.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Emergent particle collection by cyanobacteria through gliding motility and filament buckling

    1. Rebecca N. Poon
    2. Kelsey Cremin
    3. Alberto Scarampi
    4. Mary Coates
    5. Albane Théry
    6. Orkun S. Soyer

    • Curated by eLife

      eLife Assessment

      This manuscript presents important work on macrostructure formation in a freshwater filamentous cyanobacterium, focusing on its ability to aggregate and buckle. The authors employ a wide range of experiments and approaches, including time-lapse imaging and 3D theoretical modelling, to establish the physical dynamics of filaments, such as gliding motility and buckling. They demonstrate that, in addition to gliding motility, filament length and flexibility are essential for the ability of cyanobacteria to capture particles and form aggregates. Overall, the study provides convincing evidence and advances our understanding of the role of microbial motility in the environment. It will be of broad interest to biophysicists and environmental microbiologists.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  3. Loss of canonical sex steroid signaling correlates with prostate cancer progression and induces tumor escape in Drosophila

    1. M. Vialat
    2. E. Baabdaty
    3. C. Vachias
    4. F. Degoul
    5. A. Trousson
    6. P. Pouchin
    7. JMA. Lobaccaro
    8. S. Baron
    9. L. Morel
    10. C. de Joussineau

    • Curated by eLife

      eLife Assessment

      This valuable study provides insights into the role of steroid signaling during tumorigenesis in the adult male drosophila accessory gland (functional equivalent of the prostate gland in mammals), hinting at a possible counterintuitive anti-tumoral role of sex hormones during prostate cancer in certain patients. While the Drosophila model provides an elegant way to study the hypothesis derived from the Cancer Atlas analysis, the analyses of public prostate cancer expression data are incomplete and critical knowledge on patients' treatment modalities and normalization across different datasets is missing. This work would be of interest to prostate cancer researchers as it suggests that the absence of androgen receptor signaling in humans could constitute a mechanism promoting tumor escape.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

    1. Varun Ravishankar
    2. Laidy M. Alvero-González
    3. Agathe Hubert
    4. Zaiwei Zhang
    5. Chloé Markarian
    6. Valérie Prima
    7. Sirine Chergui
    8. Roberto Melero
    9. Florian Stengel
    10. Stéphen Manon
    11. Jean-Pierre Duneau
    12. Maria Queralt-Martin
    13. Lucie Bergdoll

    • Curated by eLife

      eLife Assessment

      This work provides important findings that reveal a mechanistic model of how VDAC2 influences BAX activation in mitochondria during BAX-mediated apoptosis. The experimentally supported model is convincing, with several experiments strengthening its validity. Major strengths include the complementary biochemical, biophysical, structural, and computational approaches, as well as the study's broad relevance.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity

    1. Shaoyu Tu
    2. Yue Du
    3. Wei Liang
    4. Xiaoyi Xu
    5. Jiahui Zou
    6. Yuchao Yang
    7. Chuhan Xiong
    8. Yanglin Li
    9. Meijun Jiang
    10. Aotian Ouyang
    11. Tong Chen
    12. Meilin Jin
    13. Huanchun Chen
    14. Hongbo Zhou

    • Curated by eLife

      eLife Assessment

      This valuable study reveals a role for lactylation in influenza polymerase function and virus replication. The evidence supporting the claims is solid, although the direct involvement of ATAT1 and SIRT1 in this modification and the functional relevance of the identified sites can be further substantiated. These findings will appeal broadly to influenza virologists studying polymerase regulation, as well as researchers investigating the functional roles of lactylation.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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