Latest preprint reviews

  1. Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies

    This article has 7 authors:
    1. Runa I. Løberg
    2. Helena A. Abdi-Dezfuli
    3. Liv Kleppa
    4. Alisa E. Dewan
    5. Maureen T. Meling
    6. Ludvig M. Sollid
    7. M. Fleur du Pré
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study shows that induced expression of transglutaminase 2 (TG2) fused to an antigenic peptide in mouse intestinal epithelial cells can trigger an anti-TG2 autoantibody response similar to that seen in celiac disease. The conclusions are supported by convincing evidence from a well-designed mouse model, although some additional experiments would strengthen the study. The work will be of interest to researchers studying celiac disease, other autoimmune conditions, and mucosal immunologists.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Synaptic Organization of Surface AMPARs Changes by Brain Region and Tauopathy

    This article has 13 authors:
    1. Rohit M. Vaidya
    2. Jiahao Zhang
    3. Duncan Nall
    4. Rujuta Pendharkar
    5. Yongjae Lee
    6. Eung Chang Kim
    7. Donghan Ma
    8. Fang Huang
    9. Hiroshi Nonaka
    10. Shigeki Kiyonaka
    11. Itaru Hamachi
    12. Hee Jung Chung
    13. Paul R. Selvin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study that establishes a novel and enabling 3D super-resolution imaging approach for visualizing the nanoscale organization of AMPA receptors in thick mouse brain tissue. The biological findings are of importance and interest to the neuroscience field, with potential implications for neurodegenerative disease research. Some of the biological conclusions would benefit from strengthened quantitative analysis and revisions to the manuscript to ensure that the interpretations are appropriately aligned with what is supported by the analysis.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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