eLife

Latest preprint reviews

1. Context makes the difference: Temporally Resolved Dopaminergic Teaching Signals Shape Associative Memory in Drosophila Larvae

   This article has 5 authors:

   1. Denise Weber
   2. Anna-Maria Jürgensen
   3. Juliane Kinnigkeit
   4. Martin P. Nawrot
   5. Andreas S. Thum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into how the timing of dopamine signals can influence associative learning and memory in fruit fly larvae at the single-cell level. Combining optogenetic manipulation of individual dopaminergic neurons and computational modeling of circuit computations provides some convincing evidence for the underlying circuit-level mechanisms. However, there are also aspects of incomplete evidence that require key control and validation experiments. The work will be of interest to researchers studying the neural mechanisms of learning and memory.'

   Reviewed by eLife

2. The psychedelic DOI decreases the modularity of the cortical network by increasing cortico-cortical and thalamo-cortical functional influence

   This article has 3 authors:

   1. Roman Doronin
   2. Eduard Stroukov
   3. Georg B. Keller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study combines cortex-wide activity imaging and optogenetics to characterize large-scale changes in functional connectivity following administration of the psychedelic DOI, as well as the circuit mechanisms underlying them. It provides solid evidence that DOI reduces the modularity of cortical networks and has concurrent effects on both cortico-cortical and cortico-thalamic functional connectivity. The study will be of broad interest to basic scientists working on the circuit mechanisms of psychedelics, as well as to researchers studying humans who may wish to reverse-translate their findings into mice.

   Reviewed by eLife

3. Correlative light–electron microscopy reveals fundamentally different axonal architectures for fast and modulatory transmission

   This article has 10 authors:

   1. KS Lee
   2. DA Sahlender
   3. JR Blanc
   4. A Jorstad
   5. C Gasselin
   6. S Clerc-Rosset
   7. F Markopoulos
   8. CCH Petersen
   9. A Holtmaat
   10. GW Knott

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper provides fundamental data on the ultrastructural signatures of neuromodulatory axons in mouse cortex obtained from exceptionally high-quality correlated light- and volume electron microscopy. They report unique vesicle and synapse configurations of cholinergic and serotonergic axons, providing compelling structural support for volume transmission.

   Reviewed by eLife

4. Extinction risk in terrestrial vertebrates is associated with niche limits that reflect climatic vulnerability

   This article has 2 authors:

   1. Matthew Nagy-Watson
   2. Jeremy T. Kerr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the relationship between climatic niche limits and extinction risk across more than 23,000 terrestrial vertebrate species. The large comparative dataset and phylogenetic analyses indicate solid evidence that species with lower upper thermal niche limits are more likely to be classified as threatened, whereas associations with aridity limits are less consistent. However, the treatment of data-deficient species and unclear definitions of niche metrics warrant further scrutiny, and the analyses do not establish that climate or land-use change drives the observed patterns. The findings will interest researchers in macroecology, global change biology, and conservation.

   Reviewed by eLife

5. Number, order and time influence how the brain integrates distinct experiences

   This article has 5 authors:

   1. Alina B. Thomas
   2. Francesca S. Wong
   3. A. Simon Killcross
   4. Fred Westbrook
   5. Nathan M. Holmes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides an important set of findings using sensory preconditioning procedures that advance our understanding of the circumstances that influence the integration of discrete learning experiences. The evidence supporting the conclusions is solid, as the study used multiple different conditions to differentiate between different theories of memory integration. Moreover, the findings should be of broader interest to the learning and memory field for considering the role of the medial temporal lobe in how separate experiences are integrated.

   Reviewed by eLife

6. High-dimensional Characterization of Genome–Environment Fitness Landscapes in Klebsiella pneumoniae

   This article has 15 authors:

   1. Ge Zhou
   2. Georgia Williams
   3. Mathew T. Millner
   4. Raneem AlHirayban
   5. Wejdan Alosaimi
   6. Omniya Fallatah
   7. Adam J Hart
   8. Mohammed Malaikah
   9. Sara Iftikhar
   10. Huda Ahmad
   11. Mohammad Roghanian
   12. Ville Mustonen
   13. Rfeef AlYami
   14. Manuel Banzhaf
   15. Danesh Moradigaravand

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable mapping of how genomic variation from a large collection of Klebsiella pneumoniae clinical isolates shapes bacterial fitness across 214 conditions. Solid data describe that fitness is strongly condition-dependent and that features can be advantageous under selection. Though the predictive, plasmid causality and GWAS association findings would be further strengthened by additional analyses ruling out population-structure confounding, these findings are of value for our understanding of the power of genotype to predict phenotype for this important human pathogen.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.07.16.733837

8. Thermotaxis behavior of Drosophila melanogaster : A quantitative analysis of sensory-motor integration and heat avoidance

   This article has 5 authors:

   1. Zeinab Moradi
   2. Sara Jahedazad
   3. Ehsan Hosseinian
   4. Tayebeh Minaei
   5. Ali Sadighi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study utilizes a two-choice assay to examine how groups of Drosophila melanogaster respond to temperature changes. The findings are useful, offering focused importance for the collective decision-making community. However, the strength of the evidence is incomplete, as the current data only partially support the primary claims and the work lacks the necessary integration into the existing literature to contextualize the findings.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.64898/2026.08.17.745251

10. Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

    This article has 9 authors:

    1. Corey E. Hayford
    2. Blake Baleami
    3. Philip E. Stauffer
    4. B. Bishal Paudel
    5. Aziz Al’Khafaji
    6. Amy Brock
    7. Vito Quaranta
    8. Darren R. Tyson
    9. Leonard A. Harris

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study uses single-cell profiling, lineage barcoding, and functional assays to examine drug-tolerant persisters in a BRAF-inhibited melanoma cell line. The data provide solid evidence that persisters arise from many lineages and have altered calcium handling and increased sensitivity to ferroptosis, although the lineage result is difficult to interpret without knowing how many cells survived treatment. The broader claim that these cells represent substates within a single persister state is less well supported, as it rests largely on transcriptomic projections, lacks time-resolved data, and has been examined in only one cell line.

    Reviewed by eLife