eLife

Latest preprint reviews

1. MicroRNA spatial profiling for assessing drug efficacy in BRCA1 -related triple-negative breast tumors

   This article has 8 authors:

   1. Omar N. Mohd
   2. Lin Wang
   3. Brian R. Sardella
   4. David Jou
   5. Gerburg M. Wulf
   6. Frank J. Slack
   7. Yujing J. Heng
   8. Patrick S. Doyle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The work provides a valuable analytical and technical framework for relating spatial microRNA patterns to therapeutic response and features of the tumor immune environment in a BRCA1-associated model of triple-negative breast cancer. The evidence supporting the main conclusions is solid, although additional validation and statistical analyses would strengthen claims regarding biomarker performance and the specific contribution of spatial measurements.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2024.10.25.620167

3. Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

   This article has 14 authors:

   1. Yichen Zhu
   2. Xinyuan Shen
   3. Yuning Chen
   4. Nathan Ma
   5. Catherine Zhang
   6. Annabel S. Zhao
   7. Yanxin Tian
   8. Shreya Gumate
   9. Jie Huang
   10. Siyu Lin
   11. Aijun Wang
   12. Vatche G. Agopian
   13. Yan-Ruide Li
   14. Lili Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript presents a primary important finding, namely that microbial riboflavin-derived MR1 ligands are pharmacological activators of human MAIT cells and that MR1 ligand stimulation enhances MAIT-mediated tumor killing across multiple tumor models. While the evidence presented is generally solid, there are some limitations of the in vitro and in vivo models used, as well as some overstatements about the broader applicability of the research, which should be revised.

   Reviewed by eLife

4. Partial input loss differentially modifies neural pathways

   This article has 8 authors:

   1. Joo Yeun Lee
   2. Jeffrey Yang
   3. Scott C. Harris
   4. Jeremiah V. John
   5. Natalia S. Stone
   6. Luca Della Santina
   7. David B. Kastner
   8. Felice A. Dunn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study shows that partial cone photoreceptor loss induces pathway-specific circuit remodeling in the mouse retina, with alpha OFF-sustained and OFF-transient retinal ganglion cells adapting differently through changes in their pre- and postsynaptic circuits. The results are valuable because they provide a key understanding of the diversity of circuit remodeling in retinal degeneration. The data are convincing, although clearer reporting of the numbers of independent animals and retinas, a more rigorous distinction between compensation and circuit change, and discussion of the functional consequences would strengthen the mechanistic insights.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.64898/2026.05.27.728267

6. We couldn't get details of this article at this time:
   10.64898/2026.04.09.717548

7. We couldn't get details of this article at this time:
   10.64898/2026.05.18.725950

8. We couldn't get details of this article at this time:
   10.64898/2026.06.11.731529

9. We couldn't get details of this article at this time:
   10.64898/2026.04.28.721293

10. We couldn't get details of this article at this time:
    10.1101/2025.03.18.643888