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  1. The tuxedo sea urchin Mespilia globulus : A fast-developing and tractable model for genomic and developmental biology

    1. Omar Matar
    2. Marie Emilie Maeland
    3. Lucas King
    4. Elise Parey
    5. Grace Birkett
    6. Clara Santangelo
    7. Laura Piovani
    8. Jamie Craggs
    9. Jeffrey R. Thompson
    10. Nathalie Oulhen
    11. Gary Wessel
    12. Ferdinand Marlétaz

    • Curated by eLife

      eLife Assessment

      This study establishes the fast-developing tuxedo sea urchin, Mespilia globulus, as a genome-enabled experimental model. With the tools and methods described here, the authors provide a valuable platform with particular potential for developmental biology and physiology as well as comparative studies. The evidence supporting the principal claims of experimental tractability and quality of genomic resources is solid, although fuller documentation, e.g., of husbandry, aquarium-stock provenance and genetic diversity as well as gene-editing efficiency and imaging set up, would strengthen the work. This work will be of particular interest to developmental and evolutionary biologists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Parallel connectivity and genomic divergence but heterogeneous demographic history in sympatric Mediterranean clingfishes

    1. Maximilian Wagner
    2. Stephan Koblmüller
    3. Ariane Droin
    4. Nadine Klar
    5. Sandra Bračun
    6. Stamatis Zogaris
    7. Kristina M. Sefc
    8. Hannes Svardal

    • Curated by eLife

      eLife Assessment

      The study presents a valuable dataset and analysis on two sympatric Mediterranean clingfishes which will be of interest to the fields of evolutionary genomics, population genetics and comparative phylogeography, and especially to marine biologists working on population connectivity. The comparative design provides solid evidence that contemporary connectivity is more predictable across species than deeper phylogeographic and demographic history. The analysis of the genomic data, which is still incomplete, would benefit from further work and clarification, particularly regarding the evidence for parallel genomic divergence.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2

    1. John P. Miller
    2. Kyu Kwang Kim
    3. Cameron WA Snyder
    4. Negar Khazan
    5. Niloy A. Singh
    6. Megan E. Boyer
    7. Elizabeth Lamere
    8. Myla Strawderman
    9. Sonali Sharma
    10. Ronald Lakony
    11. Michelle Whittum
    12. Mark Anderson
    13. Rick Keenan
    14. Elizabeth Pritchett
    15. Cameron Baker
    16. John Ashton
    17. Manoj K. Khera
    18. Michael R. Elliott
    19. Christina M. Annunziata
    20. Jeevisha Bajaj
    21. Laura M. Calvi
    22. Michael W. Becker
    23. Rachael Rowswell-Turner
    24. Richard G. Moore
    25. Rakesh K. Singh

    • Curated by eLife

      eLife Assessment

      This valuable study identifies the IL1R1-IRAK4 axis as a mediator of inflammation-associated ovarian cancer implantation. The evidence is convincing, supported by complementary genetic and pharmacological approaches across multiple in vivo models. These findings advance our understanding of how inflammatory signaling shapes metastatic niche formation and highlight IRAK4 as a potential therapeutic target.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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