eLife

Latest preprint reviews

1. ARID5B mutations cause a neurodevelopmental syndrome with neuroinflammation episodes

   This article has 62 authors:

   1. Hendrikus J. van Heesbeen
   2. Nazim Rabouhi
   3. Aurélie Gouronc
   4. Angéline Preto
   5. Justine Rousseau
   6. Jade Charbonneau
   7. Antonio Vitobello
   8. Ange-Line Bruel
   9. Anne-Sophie Denommé-Pichon
   10. Estelle Colin
   11. Bertrand Isidor
   12. Sophie Nambot
   13. Desiree DeMille
   14. Pinar Bayrak-Toydemir
   15. Nicola Longo
   16. Boris Keren
   17. Alexandra Afenjar
   18. Jolien S. Klein Wassink-Ruiter
   19. Ingrid P.C. Krapels
   20. Hannah Titheradge
   21. Gavin Ryan
   22. Matias Wagner
   23. Jill A. Rosenfeld
   24. David R. Witt
   25. Anirudh Saronwala
   26. Yaping Yang
   27. Annick Rein-Rothschild
   28. Ortal Barel
   29. Reena Jethva
   30. Saskia B. Wortmann
   31. Katharina Diepold
   32. Kevin Rostasy
   33. Lola K. Clarkson
   34. Kathryn T. Drazba
   35. Raymond J. Louie
   36. Himanshu Goel
   37. Outi Kuismin
   38. Pekka Nokelainen
   39. Jianling Ji
   40. Ashley Mills
   41. Matthew A. Deardorff
   42. María Palomares-Bralo
   43. María-Ángeles Gómez-Cano
   44. Alberto Fernández-Jaén
   45. Peter J. Hulick
   46. Maureen Jacob
   47. Benjamin Cogne
   48. Kandamurugu Manickam
   49. Xueqi Wang
   50. Gail Graham
   51. Bert Callewaert
   52. Mercedes Zoeteman
   53. Michael L. Raff
   54. Marion Aubert Mucca
   55. Médéric Jeanne
   56. Grace Raines
   57. Amy Crunk
   58. Sureni V Mullegama
   59. Taila Hartley
   60. Kristin Kernohan
   61. Kym Boycott
   62. Philippe M. Campeau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies a novel neurodevelopmental syndrome caused by variants in ARID5B, supported by solid human genetic evidence from a well-characterized cohort. While the clinical data establish a clear genotype-phenotype correlation, the functional evidence regarding the proposed molecular mechanisms remains incomplete. Addressing the gaps in the functional characterization and refining the clinical assertions would significantly strengthen the conclusions.

   Reviewed by eLife

2. Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans

   This article has 9 authors:

   1. Zhimin Xu
   2. Xiaoting Feng
   3. Haochen Lyu
   4. Yong-Hong Yan
   5. Yongqi Zhou
   6. Zhizhi Wang
   7. Fang Bai
   8. Meng-Qiu Dong
   9. Yingchuan B. Qi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of developmental timing mechanisms by studying the cleavage, nuclear translocation, and oscillation of the transcription factor MYRF-1 (vertebrate MYRF) during C. elegans larval development. The evidence supporting the conclusions is solid, with elegant genome engineering experiments and state-of-the-art microscopy. The work will be of broad interest to cell and developmental biologists.

   Reviewed by eLife

3. Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules

   This article has 1 author:

   1. John Karanicolas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important findings by identifying small molecules that can stabilize and refold missense-mutated VHL tumor suppressor protein, offering a potential therapeutic approach for clear cell renal cell carcinoma. The computational design approach is well-executed, but the evidence is incomplete due to insufficient demonstration that HIF2 downregulation occurs through on-target VHL rescue rather than off-target effects. Additional experiments with appropriate controls are needed to establish the specificity of the mechanism.

   Reviewed by eLife

4. Amino acid homorepeats act as buffers to maintain proteostasis and constrain the compatible sequence space of proteomes

   This article has 7 authors:

   1. Yukihiro Murase
   2. Naoki Kitamura
   3. Shotaro Namba
   4. Ayano Satoh
   5. Takashi Makino
   6. Ayako Moriya
   7. Hisao Moriya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study analyzed the impact of amino acid homorepeats on protein expression and solubility in yeast and E. coli. The authors provided convincing evidence that hydrophobic and positively charged amino acids are toxic and that counterselection during evolution reduced the occurrence of such proteotoxic protein sequences. This study will be of interest to cell biologists and biochemists, particularly those working on proteostasis.

   Reviewed by eLife

5. Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

   This article has 11 authors:

   1. Jing-Xin Feng
   2. Mei-Ting Yang
   3. Lili Li
   4. Caiyi C Li
   5. Ferenc Livák
   6. Jack Chen
   7. Yongmei Zhao
   8. Dunrui Wang
   9. Avinash Bhandoola
   10. Naomi Taylor
   11. Giovanna Tosato

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript by Feng et al. provides valuable evidence regarding the hematopoietic differentiation of bone marrow endothelial cells in the adult mouse. Overall, the authors have addressed our main concerns. Solid data now more strongly support long-term multi-lineage reconstitution of the adult hemogenic endothelial cells. However, critical data, especially regarding the endothelial cells' hematopoietic identity and functional capacity, remain insufficient, which limits the strength of the hemogenic claim, especially the assertion that these adult hemogenic ECs generate bona fide HSCs. Additional experiments would be necessary to fully rule out alternative explanations.

   Reviewed by eLife

6. Miniscope Processing Suite (MPS): An Intuitive, No-Code, Scalable Pipeline for Long-Duration Calcium Imaging

   This article has 4 authors:

   1. Ari Peden-Asarch
   2. Meredith Weinstock
   3. Kevin R Coffey
   4. John F Neumaier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study introduces MPS, an open-source pipeline that addresses a significant technical bottleneck by making miniscope data analysis more accessible. Characterized by speed and a low barrier to entry, the software's performance is supported by solid evidence. This work will be of interest to miniscope users seeking a streamlined, memory-efficient, end-to-end analysis solution.

   Reviewed by eLife

7. A Coma Pattern-Based Autofocusing Method Resolves Bacterial Cold Shock Response at Single-Cell Level

   This article has 8 authors:

   1. Sihong Li
   2. Zhixin Ma
   3. Yue Yu
   4. Jinjuan Wang
   5. Yaxin Shen
   6. Xiaodong Cui
   7. Xiongfei Fu
   8. Shuqiang Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study introduces LUNA, a new autofocusing method that achieves nanoscale precision and robustly corrects focus drift during time-lapse microscopy, improving imaging under temperature shifts. The authors exploit this technical advance to investigate the bacterial cold shock response, providing solid evidence that individual cells continue to grow and divide in a highly coordinated process that cannot be observed in population-level measurements. This work offers a technical and conceptual framework for reconciling discrepancies between bulk and single-cell growth measurements, with broad relevance for cell biology and microbiology.

   Reviewed by eLife

8. Boosting Hyperalignment Performance with Age-specific Templates

   This article has 4 authors:

   1. Yuqi Zhang
   2. Maria Ida Gobbini
   3. James V Haxby
   4. Ma Feilong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study advances our understanding of best practices for analyzing population-level data using advanced functional alignment methods. It provides convincing evidence that demographic-specific functional templates improve functional neuroimaging studies that use hyperalignment. This study will be of interest to cognitive neuroscientists, neuroimaging methodologists, and computational researchers with an interest in the human brain.

   Reviewed by eLife

9. A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory

   This article has 13 authors:

   1. Tingliang Jian
   2. Wenjun Jin
   3. Mengru Liang
   4. Xiang Liao
   5. Kuan Zhang
   6. Shanshan Liang
   7. Chunqing Zhang
   8. Chao He
   9. Hongbo Jia
   10. Yanjiang Wang
   11. Jian Han
   12. Xiaowei Chen
   13. Han Qin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study systematically characterizes the activity patterns of a lateral supramammillary nucleus (SuM)-medial septum (MS)-hippocampus circuit across sleep-wake cycles and its role in memory consolidation. This work is fundamental because it identifies a previously unrecognized brain hub that helps coordinate how different types of memory are supported during a specific sleep state, advancing our understanding of how sleep contributes to memory organization. The work is well-designed, and the data are solid, supporting clear and significant conclusions; however, some mechanistic details and causal relationships would benefit from further clarification or additional experiments. The paper provides new insights into how distinct memory modalities could be processed by parallel, sleep-active subcortical-hippocampal circuits, which would be of general interest to a broad neuroscience audience.

   Reviewed by eLife

10. Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

    This article has 14 authors:

    1. Leonardo Diaz
    2. Ally Xinyi Kong
    3. Ping Zhang
    4. Jinhua Chi
    5. Khoa Pham
    6. Maja Johnson
    7. Aiden Eno
    8. Isabelle Douglas
    9. Yuxuan Mao
    10. James W MacDonald
    11. Julia Yue Cui
    12. Theo Bammler
    13. Haiwei Gu
    14. Yijie Geng

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable manuscript demonstrates that embryonic exposure to the pesticide chlorpyrifos (CPF) impairs juvenile zebrafish social behavior and sets out to define the underlying mechanism. The authors provide solid evidence that butyrate and class I histone deacetylases are involved, as their modulation rescues the phenotype. However, claims that CPF acts through the microbiome and nitric oxide signaling remain correlative and incomplete. Additional validation would strengthen the intriguing hypotheses raised by this work.

    Reviewed by eLife