eLife reviews preprints in the life sciences and medicine.

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  1. Theta phase and theta-gamma coupling organise the spoken language network

    1. Haya Akkad
    2. Daniel Bush
    3. Robert Seymour
    4. Tae Twomey
    5. Susanne Pelke
    6. Sasha Ondobaka
    7. Sven Bestmann
    8. Jenny Crinion

    • Curated by eLife

      eLife Assessment

      This study provides useful data on oscillatory coupling during speech planning, particularly suggesting that theta-band phase coupling may differentiate networks involved in object recognition and semantic-lexical retrieval. However, the strength of the evidence is incomplete because the absence of a linguistic manipulation and key confounds between the naming and control conditions limit the ability to attribute the reported effects specifically to word production, leaving the main mechanistic conclusions only partially supported.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Synaptic Organization of Surface AMPARs Changes by Brain Region and Tauopathy

    1. Rohit M. Vaidya
    2. Jiahao Zhang
    3. Duncan Nall
    4. Rujuta Pendharkar
    5. Yongjae Lee
    6. Eung Chang Kim
    7. Donghan Ma
    8. Fang Huang
    9. Hiroshi Nonaka
    10. Shigeki Kiyonaka
    11. Itaru Hamachi
    12. Hee Jung Chung
    13. Paul R. Selvin

    • Curated by eLife

      eLife Assessment

      This is an important study that establishes a novel and enabling 3D super-resolution imaging approach for visualizing the nanoscale organization of AMPA receptors in thick mouse brain tissue. The biological findings are of importance and interest to the neuroscience field, with potential implications for neurodegenerative disease research. Some of the biological conclusions would benefit from strengthened quantitative analysis and revisions to the manuscript to ensure that the interpretations are appropriately aligned with what is supported by the analysis.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. The microtubule-associated proteins CKAP2 and its paralog CKAP2- Like control ciliogenesis in human cells

    1. Luiz E. da Silva
    2. Gabriel Campolina-Silva
    3. Jenine Afani
    4. Clémence Belleannée
    5. Susanne Bechstedt

    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors build on previous work demonstrating that the microtubule-associated protein CKAP2 functions at the mitotic spindle to regulate microtubule dynamics for proper chromosome segregation. Here, the authors show that CKAP2 and its paralog CKAP2L also function at the cilium to regulate cilium formation and Hedgehog signaling. The writing is clear, the experiments and data are generally convincing, and the proper data analysis is carried out; however, the evidence supporting the proposal that CKAP2 and CKAP2L compensate for each other is incomplete. Overall, the findings advance the field in our knowledge of microtubule-associated proteins with roles in both the mitotic spindle and the cilium.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity
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