eLife

Latest preprint reviews

1. Spatiotemporal patterns of genetic diversity in the world’s coral reefs

   This article has 2 authors:

   1. Oliver Selmoni
   2. Meredith C. Schuman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study attempts to predict spatial patterns of genetic diversity among coral reef dwellers, estimated with a computationally efficient, standardized k-mer pipeline, from satellite-derived seascape variables. The curated dataset of 18 coral reef taxa across 173 reefs is valuable, but the evidence for the central ecological claims is in its current form incomplete: pairwise genetic distances are modelled as independent observations, the reef-level random effects used as the response in the environmental analysis likely conflate species composition with environmental signal, and , and the coverage is likely too sparse to robustly support conclusions about loss of inter-and intra-specific within-reef diversity over time. The work will be of interest to conservation geneticists, marine biologists, and researchers developing Earth-observation approaches to biodiversity monitoring.

   Reviewed by eLife

2. Tracking West Nile virus dynamics using viral loads from trapped mosquitoes

   This article has 5 authors:

   1. Punya Alahakoon
   2. Ian Marchinton
   3. R Koch
   4. Joseph R. Fauver
   5. James A. Hay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable manuscript that leverages information already being collected in mosquito surveillance, but that is currently discarded, building on ideas developed during the SARS-CoV-2 pandemic. The work is mostly rigorous, involving ample data from real-world surveillance, independent laboratory testing, and simulation modeling to validate the inference method. The evidence is solid for demonstrating feasibility and biological plausibility, although some conclusions would be strengthened by additional sensitivity analyses on key assumptions.

   Reviewed by eLife

3. Planetary-scale heterotrophic microbial community modeling assesses metabolic synergy and viral impacts

   This article has 18 authors:

   1. A. Régimbeau
   2. F. Tian
   3. G. Smith
   4. V J. Riddell
   5. C M. Andreani-Gerard
   6. P. Bordron
   7. M. Budinich
   8. C. Howard-Varona
   9. A. Larhlimi
   10. E. Ser-Giacomi
   11. C. Trottier
   12. L. Guidi
   13. S.J. Hallam
   14. D. Iudicone
   15. E. Karsenti
   16. A. Maass
   17. M.B. Sullivan
   18. D. Eveillard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable analysis of the TARA oceans dataset, advancing genome- and ecosystem-scale metabolic modeling. The authors present convincing evidence for the factors that shape microbial ecology at the molecular scale. The work will be of broad interest to oceanographers and scientists in other areas where metabolic interactions in diverse communities are of importance.

   Reviewed by eLife

4. Microscopic PhotoSelection (MiPS) of single cells in mother machine microfluidic devices

   This article has 7 authors:

   1. Jessica James
   2. Idris Kempf
   3. Kirill Sechkar
   4. Jingyu Wang
   5. Gabriel Abrahams
   6. Sebastian Towers
   7. Harrison Steel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript presents a compelling application of the microfluidic mother machine as a "selection" machine. While individual elements of the work have existed for many years across various research communities, the simplicity and elegance of this particular application should make it readily implementable and therefore a useful contribution. The proposed plans for revision are sound, particularly in light of the senior author's stated logistical constraints.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

5. We couldn't get details of this article at this time:
   10.64898/2026.05.28.728389

6. Dual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae

   This article has 5 authors:

   1. Ying Du
   2. Aiyang Lin
   3. Joshua A.R. Brown
   4. LeAnn J. Howe
   5. Wei Xiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies an upstream repressive region in the Saccharomyces cerevisiae DDI2/3 promoter and shows that chemical stress induced by cyanamide or MMS is accompanied by reduced histone abundance and decreased nucleosome occupancy across the DDI2/3 locus. Genetic histone depletion is sufficient to enhance DDI2/3 expression, while MNase-seq and genetic analyses support a model in which the transcription factor Fzf1 both activates transcription through its established promoter-binding function and promotes chromatin changes that relieve nucleosome-mediated repression, helping to explain the unusually strong induction of DDI2/3 relative to other Fzf1 targets. The study is significant, as it provides a conceptually interesting extension of Fzf1-mediated stress regulation. The strength of the evidence is solid, although additional controls and a more cautious treatment of whether Fzf1 directly drives nucleosome eviction versus acting indirectly through transcriptional recruitment or chromatin-remodeling factors would further strengthen the mechanistic conclusions.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.06.05.730320

8. We couldn't get details of this article at this time:
   10.1101/2025.07.10.664092

9. Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for LMNA -related Cardiomyopathy

   This article has 14 authors:

   1. Hananeh Fonoudi
   2. Ali Negahi Shirazi
   3. Hui-Hsuan Kuo
   4. Carlos G. Vanoye
   5. Xiaozhi Gao
   6. Susan Doody
   7. Mariam Jouni
   8. Brian Lenny
   9. Achal Neupane
   10. Janavi Kotamarthi
   11. Yadav Sapkota
   12. Jane E. Wilcox
   13. Alfred L. George
   14. Paul W. Burridge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable patient-derived human cell platform for investigating LMNA-associated cardiomyopathy and identifies cyproheptadine as a compound that improves abnormal calcium handling across multiple LMNA variants in vitro. The experimental approaches are generally rigorous and establish reproducible disease-associated cellular phenotypes; however, the evidence remains incomplete because the mechanistic basis of the observed rescue is not established, and the translational conclusions substantially exceed the presented data.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.64898/2026.06.11.731622