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  1. The microtubule-associated proteins CKAP2 and its paralog CKAP2- Like control ciliogenesis in human cells

    This article has 5 authors:
    1. Luiz E. da Silva
    2. Gabriel Campolina-Silva
    3. Jenine Afani
    4. Clémence Belleannée
    5. Susanne Bechstedt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors build on previous work demonstrating that the microtubule-associated protein CKAP2 functions at the mitotic spindle to regulate microtubule dynamics for proper chromosome segregation. Here, the authors show that CKAP2 and its paralog CKAP2L also function at the cilium to regulate cilium formation and Hedgehog signaling. The writing is clear, the experiments and data are generally convincing, and the proper data analysis is carried out; however, the evidence supporting the proposal that CKAP2 and CKAP2L compensate for each other is incomplete. Overall, the findings advance the field in our knowledge of microtubule-associated proteins with roles in both the mitotic spindle and the cilium.

    Reviewed by eLife

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