eLife reviews preprints in the life sciences and medicine.

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  1. RelB proximity proteomics and CRISPR screening define chromatin regulators of noncanonical NF-κB control of HIV latency and reactivation

    1. Cameron R. Bussey-Sutton
    2. Carley N. Gray
    3. Benjamin J. Wu
    4. Jackson J. Peterson
    5. Samuel D. Burgos
    6. C. Allie Mills
    7. Laura E. Herring
    8. Edward P. Browne
    9. Anne-Marie W. Turner
    10. David M. Margolis
    11. Michael Emerman
    12. Brian D. Strahl

    • Curated by eLife

      eLife Assessment

      By integrating RelB proximity labeling with targeted CRISPR screening, the authors identify several potential regulators of HIV latency and provide evidence implicating RelB, KAT7, and p300 in AZD5582-mediated HIV reactivation. While the study is important, the current work is incomplete, as it needs to establish physiological relevance. The findings require validation in primary latency models, and the unusually high basal RelB expression in the experimental system raises concerns about whether the observed effects accurately reflect endogenous mechanisms regulating HIV latency.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Evidence for flexible regulation of movement and decision vigor in a reward-oriented task

    1. Adrien Conessa
    2. Arnaud Boutin
    3. Bastien Berret

    • Curated by eLife

      eLife Assessment

      This valuable study introduces an innovative task and framework for examining whether movement vigor and reward-seeking behavior are governed by common or separate processes. The behavioral findings provide solid evidence that these behaviors can be differentially influenced by effort and delay, but support for the proposed model and its mechanistic claims remains incomplete, requiring more rigorous validation and analyses to address potential confounds. The work will be of interest to researchers studying motor control, decision-making, and effort-based behavior.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. Two Interacting Neural Processes Support Speech Planning during Naturalistic Conversation

    1. Hiroyoshi Yamasaki
    2. Philippe Blache
    3. Daniele Schön

    • Curated by eLife

      eLife Assessment

      This useful study shows that neural activity before a conversational response contains information about the duration and timing of the subsequent turn. The evidence that this information originates from speech-production planning is incomplete. Because the analyzed EEG is recorded during processing of the partner's speech, and because that speech causally determines the subsequent response, production planning and comprehension/context are confounded in the current analyses. It would strengthen the production interpretation considerably if the authors could show that the relationship with forthcoming duration survives richer controls for the preceding turn, or ideally after accounting for EEG variance driven by the incoming speech.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Small circuit principles for learning in large worlds

    1. Dhruva V. Raman
    2. Christopher R. Dunne
    3. Katie Davyson
    4. Timothy O’Leary

    • Curated by eLife

      eLife Assessment

      This important study introduces Hetlearn, a novel learning algorithm that demonstrates that an ensemble of simple sub-learners with varying learning rates can effectively manage inference in complex, unstable environments. While the theoretical framework and its proposed application to parallel memory traces in the insect mushroom body are intriguing, the evidence supporting the core claims is currently incomplete. To fully validate the authors' conclusions, further exploration is needed to rigorously define the boundaries of the model's hyperparameter space, along with a deeper justification and clarification of its biological plausibility.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity
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