eLife

Latest preprint reviews

1. VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

   This article has 13 authors:

   1. Varun Ravishankar
   2. Laidy M. Alvero-González
   3. Agathe Hubert
   4. Zaiwei Zhang
   5. Chloé Markarian
   6. Valérie Prima
   7. Sirine Chergui
   8. Roberto Melero
   9. Florian Stengel
   10. Stéphen Manon
   11. Jean-Pierre Duneau
   12. Maria Queralt-Martin
   13. Lucie Bergdoll

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides important findings that reveal a mechanistic model of how VDAC2 influences BAX activation in mitochondria during BAX-mediated apoptosis. The experimentally supported model is convincing, with several experiments strengthening its validity. Major strengths include the complementary biochemical, biophysical, structural, and computational approaches, as well as the study's broad relevance.

   Reviewed by eLife

2. E-Selectin Orchestrates IL-1β–Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy

   This article has 23 authors:

   1. Hana Starobova
   2. Ammar Alshammari
   3. Nikhil Nageshwar Inturi
   4. Nicolette Tay
   5. Svetlana Shatunova
   6. Ali Lam
   7. Quan Nguyen
   8. Marisol Mancilla Moreno
   9. Diana Tavares Ferreira
   10. Federico Iseppon
   11. Virginia Rodriguez-Menendez
   12. Cristina Meregalli
   13. Brittany Hill
   14. Larissa Labzin
   15. Simranpreet Kaur
   16. Darren L. Brown
   17. Guido Cavaletti
   18. Theodore Price
   19. Avril Robertson
   20. Allison Pettit
   21. Jennifer L. Stow
   22. Ingrid G Winkler
   23. Irina Vetter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper provides a useful assessment of the role of macrophages in the development of functional paw withdrawal, which is a feature in the mouse model of vincristine-induced peripheral neuropathy (VIND). The authors suggest a role for E-selectin as a critical molecule promoting VIPN, acting via immune cell recruitment and inflammasome-mediated signalling; however, their data on NLRP3 inflammasome activation in vivo remains somewhat incomplete. This study will be of interest for immunologists.

   Reviewed by eLife

3. TRPML1 positions lysosomes and regulates actin-membrane linkers in astrocyte processes

   This article has 8 authors:

   1. Maeve L. Spivey
   2. Madison L. Fuller
   3. Serena J. Chen
   4. David K. Sidibe
   5. Yingqi Wang
   6. Janardhan Bhattarai
   7. Minghong Ma
   8. Sandra Maday

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the dynamics of late endosomes and lysosomes (LEL) in cultured astrocytes, leading to a model of how synaptic activity might regulate astrocytic specializations surrounding synapses via the lysosomal calcium channel TRPML1, LEL motility, and proteins involved in regulating actin-membrane association. The experimental work is convincing, including appropriate controls and combining different tools (multiple markers, pharmacology, genetic knock-downs) to test each conclusion, although issues with the specificity of some of the drugs or confounding factors arising from genetic knock-downs limit the strength of some conclusions. Dysfunction in glia-neuron crosstalk as well as lysosomal dysfunction are increasingly recognized as highly relevant for neurodegenerative disease development, so this manuscript will be of interest to the wider neuroscience community, as well as scientists interested in the cell biology of astrocytes and lysosomes.

   Reviewed by eLife

4. Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity

   This article has 14 authors:

   1. Shaoyu Tu
   2. Yue Du
   3. Wei Liang
   4. Xiaoyi Xu
   5. Jiahui Zou
   6. Yuchao Yang
   7. Chuhan Xiong
   8. Yanglin Li
   9. Meijun Jiang
   10. Aotian Ouyang
   11. Tong Chen
   12. Meilin Jin
   13. Huanchun Chen
   14. Hongbo Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reveals a role for lactylation in influenza polymerase function and virus replication. The evidence supporting the claims is solid, although the direct involvement of ATAT1 and SIRT1 in this modification and the functional relevance of the identified sites can be further substantiated. These findings will appeal broadly to influenza virologists studying polymerase regulation, as well as researchers investigating the functional roles of lactylation.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.64898/2026.07.01.735787

6. We couldn't get details of this article at this time:
   10.64898/2026.06.01.729383

7. We couldn't get details of this article at this time:
   10.1101/2025.09.19.677475

8. We couldn't get details of this article at this time:
   10.64898/2026.03.29.715140

9. We couldn't get details of this article at this time:
   10.64898/2026.07.01.735930

10. Break-induced replication drives large-scale genomic amplifications in cancer cells

    This article has 4 authors:

    1. Mouadh Benamar
    2. Rebeka Eki
    3. Kang-Ping Du
    4. Tarek Abbas

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents important findings that genome-wide DNA double-strand breaks trigger large-scale genomic amplification (DIGA), which does not require origin re-licensing, but is dependent on some proteins that are involved in break-induced replication (BIR). While the findings and model are compelling, the evidence supporting the claims is largely incomplete, as it depends primarily on a single assay to examine amplification. This work will be of interest to scientists in the DNA repair, replication, and cell cycle fields, as well as cancer biologists.

    Reviewed by eLife