eLife

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1. We couldn't get details of this article at this time:
   10.64898/2026.03.25.714244

2. We couldn't get details of this article at this time:
   10.1101/2025.07.02.662782

3. We couldn't get details of this article at this time:
   10.1101/2025.02.13.638167

4. We couldn't get details of this article at this time:
   10.64898/2025.12.03.692065

5. We couldn't get details of this article at this time:
   10.64898/2026.05.28.728389

6. Dual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae

   This article has 5 authors:

   1. Ying Du
   2. Aiyang Lin
   3. Joshua A.R. Brown
   4. LeAnn J. Howe
   5. Wei Xiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies an upstream repressive region in the Saccharomyces cerevisiae DDI2/3 promoter and shows that chemical stress induced by cyanamide or MMS is accompanied by reduced histone abundance and decreased nucleosome occupancy across the DDI2/3 locus. Genetic histone depletion is sufficient to enhance DDI2/3 expression, while MNase-seq and genetic analyses support a model in which the transcription factor Fzf1 both activates transcription through its established promoter-binding function and promotes chromatin changes that relieve nucleosome-mediated repression, helping to explain the unusually strong induction of DDI2/3 relative to other Fzf1 targets. The study is significant, as it provides a conceptually interesting extension of Fzf1-mediated stress regulation. The strength of the evidence is solid, although additional controls and a more cautious treatment of whether Fzf1 directly drives nucleosome eviction versus acting indirectly through transcriptional recruitment or chromatin-remodeling factors would further strengthen the mechanistic conclusions.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.06.05.730320

8. We couldn't get details of this article at this time:
   10.1101/2025.07.10.664092

9. Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for LMNA -related Cardiomyopathy

   This article has 14 authors:

   1. Hananeh Fonoudi
   2. Ali Negahi Shirazi
   3. Hui-Hsuan Kuo
   4. Carlos G. Vanoye
   5. Xiaozhi Gao
   6. Susan Doody
   7. Mariam Jouni
   8. Brian Lenny
   9. Achal Neupane
   10. Janavi Kotamarthi
   11. Yadav Sapkota
   12. Jane E. Wilcox
   13. Alfred L. George
   14. Paul W. Burridge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable patient-derived human cell platform for investigating LMNA-associated cardiomyopathy and identifies cyproheptadine as a compound that improves abnormal calcium handling across multiple LMNA variants in vitro. The experimental approaches are generally rigorous and establish reproducible disease-associated cellular phenotypes; however, the evidence remains incomplete because the mechanistic basis of the observed rescue is not established, and the translational conclusions substantially exceed the presented data.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.64898/2026.06.11.731622