eLife

Latest preprint reviews

1. CD56 ^dim CD16 ^dim NK cells are the dominant effector cells against HIV-infected primary T-cells

   This article has 6 authors:

   1. William Howell
   2. Courtney Branch
   3. Jeffrey Ward
   4. Zachary Davis
   5. Emma Geatches
   6. Edward Barker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study compares the anti-HIV activity of human natural killer cell subsets and identifies CD56^dim^CD16^dim^ cells as a potentially key effector population against HIV-infected autologous T cells. The evidence supporting the central conclusions seems incomplete because the interpretation may be substantially confounded by activation-induced CD16 downregulation, making it difficult to distinguish intrinsic functional differences from phenotypic changes that occur during target-cell engagement. Additional experiments using purified NK-cell subsets and appropriate controls would substantially strengthen the evidence supporting the major conclusions.

   Reviewed by eLife

2. Reprogrammed peptidoglycan elongation reveals plasticity in bacterial growth modes

   This article has 3 authors:

   1. Carolina Basurto De Santiago
   2. Isabella S. Lin
   3. Beiyan Nan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper demonstrates that relocating the MreB-Rod complex to the poles of E. coli can reprogram cell-wall synthesis, causing cells to elongate through peptidoglycan incorporation at the poles rather than along the cell length. This is a valuable finding for understanding how bacterial growth can be spatially reprogrammed and provides insight into how distinct modes of bacterial growth might arise. However, the evidence is currently incomplete, particularly regarding the nature of the polar structures, their relationship to cell shape and growth, and the requirement for a pre-existing pole.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.64898/2026.05.07.723469

4. We couldn't get details of this article at this time:
   10.64898/2026.06.01.729353

5. WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate

   This article has 7 authors:

   1. Volodymyr I. Dzhala
   2. Fu Hung Shiu
   3. Negah Rahmati
   4. Aloe Carroll
   5. Reagan Bae
   6. Kristopher T. Kahle
   7. Kevin J Staley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable investigation of how inhibition of the WNK-SPAK/OSR1 pathway influences neuronal chloride homeostasis and seizure-like activity in organotypic hippocampal slice cultures. The evidence supporting the principal mechanistic conclusions is incomplete because several proposed mechanisms are inferred from changes in chloride dynamics rather than directly demonstrated. The work will be of interest to researchers studying chloride homeostasis, inhibitory neurotransmission, and epilepsy.

   Reviewed by eLife

6. Persistent Microglial HIV Infection Drives Neuroinflammation Despite Viral Suppression: Insights from Rapid Postmortem Brain Biopsies

   This article has 19 authors:

   1. M. Nühn Marieke
   2. Nadia Sabet
   3. Nanouk Zuidmeer
   4. C.J. van Abeelen Kirsten
   5. E. Hermans Lucas
   6. J. Schipper Pauline
   7. Raphael Kübler
   8. E. Basson Adriaan
   9. Tanvier Omar
   10. Ebrahim Variava
   11. A. Martinson Neil
   12. Stefanie Giacopazzi
   13. D. F. Venter Willem
   14. J. Muraro Mauro
   15. M. J. Wensing Annemarie
   16. D. de Witte Lot
   17. A. Papathanasopoulos Maria
   18. Monique Nijhuis
   19. Jori Symons

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study that contributes to our understanding of transcriptomic responses in microglia to HIV infection in the human brain. The evidence provided remains incomplete, and further analyses are required (i.e., a bigger sample size) to eliminate confounding factors so that the study can unequivocally ascertain the persistent inflammatory state of microglia in HIV-suppressed brains.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.05.11.723797

8. We couldn't get details of this article at this time:
   10.1101/2025.09.29.679272

9. We couldn't get details of this article at this time:
   10.1101/2025.07.18.665565

10. We couldn't get details of this article at this time:
    10.64898/2026.03.25.714244