eLife reviews preprints in the life sciences and medicine.

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  1. IFN γ and IFN γ mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation

    1. Prasanna Babu Araveti
    2. Shivraj M. Yabaji
    3. Muhammad Zainul Arifin
    4. Suruchi Lata
    5. Yuriy O. Alekseyev
    6. Alexander A. Gimelbrant
    7. William R. Bishai
    8. Vadim Zhernovkov
    9. Oleksii S. Rukhlenko
    10. Boris N. Kholodenko
    11. Igor Kramnik

    • Curated by eLife

      eLife Assessment

      Using a range of complementary approaches, this study examines how type I and type II interferon (IFN) programs exert opposing effects on macrophage responses relevant to tuberculosis. The work addresses a key biological question and provides valuable mechanistic insights. However, the data to support several key conclusions is incomplete and requires further strengthening; in particular, the role of ferritin needs to be established more definitively, the TNF stimulation findings should be validated in the context of M. tuberculosis infection, and in vivo evidence is needed to support the proposed therapeutic strategy. Additionally, aspects of iron metabolism, lipid peroxidation, and the translatability of the findings between mouse and human macrophages would benefit from greater clarity and deeper mechanistic investigation.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Break-induced replication drives large-scale genomic amplifications in cancer cells

    1. Mouadh Benamar
    2. Rebeka Eki
    3. Kang-Ping Du
    4. Tarek Abbas

    • Curated by eLife

      eLife Assessment

      This study presents important findings that genome-wide DNA double-strand breaks trigger large-scale genomic amplification (DIGA), which does not require origin re-licensing, but is dependent on some proteins that are involved in break-induced replication (BIR). While the findings and model are compelling, the evidence supporting the claims is largely incomplete, as it depends primarily on a single assay to examine amplification. This work will be of interest to scientists in the DNA repair, replication, and cell cycle fields, as well as cancer biologists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo

    1. Marie Kubota
    2. Julia M. Abitbol
    3. Paul K. Lee
    4. Maggie S. Matern
    5. Sonia Bustos Barocio
    6. Taha A. Jan
    7. Alan G. Cheng
    8. Stefan Heller

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on a potential new regulatory mechanism for cellular proliferation in the mammalian cochlea, taking advantage of the organoid-forming potential of cells from the greater epithelial ridge (GER), or Kolliker's organ, a transient structure in the developing cochlea. The authors highlight three potential regulators - galectin 1, galectin 3, and Myc - providing solid evidence for potential roles in modulating the proliferation of cochlear GER cells using gene expression studies, single-cell profiling, pharmacological inhibition, and genetic overexpression both in vitro and in vivo. However, some of the analyses and interpretations are incomplete, and a better understanding of how the compounds and the gene overexpression studies affect the cells and modulate cell survival/death would aid a fuller interpretation of the data.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. A new diagnostic modality for bovine tuberculosis: accurate and robust classification of infected cattle using transcriptomics and machine learning

    1. John F. O’Grady
    2. Adriana Ivich
    3. Gillian P. McHugo
    4. Adnan Khan
    5. Thomas J. Hall
    6. Sarah L. Faherty O’Donnell
    7. Carolina N. Correia
    8. John A. Browne
    9. Valentina Riggio
    10. James G. D. Prendergast
    11. Emily L. Clark
    12. Hubert Pausch
    13. Kieran G. Meade
    14. Isobel C. Gormley
    15. Eamonn Gormley
    16. Stephen V. Gordon
    17. Casey S. Greene
    18. David E. MacHugh

    • Curated by eLife

      eLife Assessment

      This valuable study provides a proof of concept for the utility of transcriptomic methods to develop novel diagnostic tests for bovine tuberculosis. A comprehensive analysis using a suite of machine learning models provides convincing evidence for the use of mRNA biomarkers to distinguish between infected and disease-free animals. The analysis also provides major insights into both the levels of individual variation in expression between animals as well as systematic changes with respect to the time from infection.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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