eLife

Latest preprint reviews

1. Population-level temporal decoding and dynamical structure in frontostriatal circuits during decision making

   This article has 7 authors:

   1. Adam B. Goldring
   2. Anandita De
   3. Tanner Stevenson
   4. Kendall Stewart
   5. Aya Akhmetzhanova
   6. Rishidev Chaudhuri
   7. Timothy D. Hanks

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides new insight into how frontostriatal circuits encode elapsed time and exhibit decision-related dynamics during an auditory change-detection task. Analyses of simultaneously recorded neurons from the frontal orienting field (FOF) and anterior dorsal striatum (ADS) provide solid evidence that FOF and ADS show similar dynamics during evidence accumulation, but that FOF shows stronger movement-aligned reorganization near the time of the decision report. However, the mechanistic interpretation would be strengthened by clearer links between the population-level analyses, single-neuron activity, and relevant circuit anatomy. The work will be of broad interest to systems neuroscientists studying timing, decision-making, and frontostriatal dynamics.

   Reviewed by eLife

2. A transient hypothalamic CRH signal coordinates social investigation in mice

   This article has 5 authors:

   1. Ibukun Akinrinade
   2. Meenakshi Pardasani
   3. Toni-Lee Sterley
   4. Tamás Füzesi
   5. Jaideep S. Bains

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study combines behavioral testing, fiber photometry recordings, and optogenetic manipulations to understand the role of CRH+ neurons in the PVN of the hypothalamus in social and non-social settings, while varying the degree of familiarity. The approaches used and the finding that these neurons respond to various social (and non-social) stimuli are strong; however, the conclusion that the activity of these neurons is driven solely by unfamiliar situations and the lack of dynamic analysis of fiber photometry data leaves the manuscript incomplete. This elegant study will likely be of interest to the field of social neuroscience and, if outstanding issues are addressed, would expand our understanding of the role of the PVN in behavior.

   Reviewed by eLife

3. Alzheimer disease—The proposed role of tanycytes in the formation of tau tangles and amyloid beta plaques in human brain

   This article has 3 authors:

   1. Ruth Fabian-Fine
   2. Abigail G. Roman
   3. Adam L. Weaver

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors propose the existence of an AQP4-positive tanycyte-associated canal system in the hippocampus based on histological, ultrastructural, immunohistochemical, and RNA-based approaches. There are serious concerns regarding the evidence, and the identification of the tanycyte-related structures can be questioned. At this stage, the evidence for the central claims of the manuscript has to be regarded as inadequate.

   Reviewed by eLife

4. An innovative tool for non-invasive contact-free pathogen monitoring in animal saliva

   This article has 13 authors:

   1. Maristela Martins de Camargo
   2. Aspen Caim Fernandes Gonçalves
   3. Diana Netto Hernandez Blazquez
   4. Maggie E. Weber
   5. Washington Agostinho
   6. Zubin Kremer Guha
   7. Melissa Sá Fernandes
   8. Mariana Furtado
   9. Aaron Dollar
   10. Paulo Brandão
   11. Serap Aksoy
   12. Vanessa O. Ezenwa
   13. Dawn Zimmerman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work describes a valuable method for monitoring pathogens using an innovative, field-deployable device that attracts animals and collects saliva on filter paper in a non-invasive manner. While the strategy is effective at collecting samples and ensuring their preservation, support for some claims remains incomplete. This study will interest scientists in various fields, ranging from biodiversity, ecology, and conservation to infectious diseases and public health.

   Reviewed by eLife

5. Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics

   This article has 18 authors:

   1. Jian Qiu
   2. Martha A. Bosch
   3. Mya Wolfe
   4. Ksenija Korac
   5. Stefano Rizzo
   6. Todd L. Stincic
   7. Scotland E. Farley
   8. Wendy Fitzgerald
   9. Megha Rajendran
   10. Aurélien Laguerre
   11. Frank Stein
   12. Philip F. Copenhaver
   13. Oline K. Rønnekleiv
   14. Sean M. Rønnekleiv-Kelly
   15. Tatiana K. Rostovtseva
   16. Sergey M. Bezrukov
   17. Carsten Schultz
   18. Martin J. Kelly

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study employs an innovative chemoproteomic and multi-modal experimental approach to support VDAC2 as a key functional mediator of STX effects on mitochondrial bioenergetics. However, concerns remain regarding the physiological and disease relevance, including the reliance on cell lines, lack of loss-of-function validation, unresolved binding specificity, and limited justification for focusing on POMC neurons in the context of Alzheimer's disease. As a result, the evidence is incomplete for a link between VDAC2 and Alzheimer's pathogenesis, and aspects of the binding data raise alternative interpretations, including a potential role for other VDAC isoforms.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.64898/2026.06.02.729491

7. We couldn't get details of this article at this time:
   10.64898/2026.05.04.722201

8. We couldn't get details of this article at this time:
   10.64898/2026.04.30.721916

9. We couldn't get details of this article at this time:
   10.1101/2025.07.15.664935

10. We couldn't get details of this article at this time:
    10.64898/2026.05.22.727292