Latest preprint reviews

  1. Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

    This article has 14 authors:
    1. Yichen Zhu
    2. Xinyuan Shen
    3. Yuning Chen
    4. Nathan Ma
    5. Catherine Zhang
    6. Annabel S. Zhao
    7. Yanxin Tian
    8. Shreya Gumate
    9. Jie Huang
    10. Siyu Lin
    11. Aijun Wang
    12. Vatche G. Agopian
    13. Yan-Ruide Li
    14. Lili Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript presents a primary important finding, namely that microbial riboflavin-derived MR1 ligands are pharmacological activators of human MAIT cells and that MR1 ligand stimulation enhances MAIT-mediated tumor killing across multiple tumor models. While the evidence presented is generally solid, there are some limitations of the in vitro and in vivo models used, as well as some overstatements about the broader applicability of the research, which should be revised.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Partial input loss differentially modifies neural pathways

    This article has 8 authors:
    1. Joo Yeun Lee
    2. Jeffrey Yang
    3. Scott C. Harris
    4. Jeremiah V. John
    5. Natalia S. Stone
    6. Luca Della Santina
    7. David B. Kastner
    8. Felice A. Dunn
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study shows that partial cone photoreceptor loss induces pathway-specific circuit remodeling in the mouse retina, with alpha OFF-sustained and OFF-transient retinal ganglion cells adapting differently through changes in their pre- and postsynaptic circuits. The results are valuable because they provide a key understanding of the diversity of circuit remodeling in retinal degeneration. The data are convincing, although clearer reporting of the numbers of independent animals and retinas, a more rigorous distinction between compensation and circuit change, and discussion of the functional consequences would strengthen the mechanistic insights.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
Page 1 of 865 Older