eLife

Latest preprint reviews

1. Ancestral secretory programs underlie the evolution of morphological innovations across Spiralia

   This article has 7 authors:

   1. Yitian Bai
   2. Kunyin Jiang
   3. Hong Yu
   4. Lingfeng Kong
   5. Shaojun Du
   6. Shikai Liu
   7. Qi Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript examines the evolution of molluscan shells using single-cell analyses of the adult mantle of Crassostrea gigas and compares these data with previous datasets from embryonic and larval stages of this species and other spiralians. The authors provide important support for a scenario in which secretory cells are broadly conserved across spiralians, and the incorporation of lineage-restricted genes contributes to the evolution of molluscan shells. While some of the conclusions of the authors are convincing, many aspects of the manuscript remain incomplete and could be improved, especially aspects of cell-type classification and validation.

   Reviewed by eLife

2. Winding-Up of Fibrin Fibers as a Novel Mechanism of Platelet-Mediated Fiber Compaction

   This article has 9 authors:

   1. Alexei Grichine
   2. Tatiana Kovalenko
   3. Florence Appaix
   4. Anne-Sophie Ribba
   5. Anita Eckly
   6. Jean-Yves Rinckel
   7. Mikhail Panteleev
   8. Laurence Lafanechère
   9. Karin Sadoul

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable perspective on platelet-mediated fibrin compaction, proposing that fibrin fibers undergo "winding" or coiling, an intriguing framework with potential implications for thrombosis and clot mechanics. However, the evidence supporting an active platelet-driven winding mechanism remains incomplete, relying largely on correlative observations without direct or quantitative validation of the proposed dynamics. Overall, the work is thought-provoking and of clear interest to the field, but stronger mechanistic evidence will be required to substantiate the central claims.

   Reviewed by eLife

3. The Training Village: an open platform for continuous testing of rodents in cognitive tasks

   This article has 10 authors:

   1. Balma Serrano-Porcar
   2. Rafael Marin-Campos
   3. Javier Rodríguez
   4. Caterina Barezzi
   5. Harshkumar Vasoya
   6. Donna Kean
   7. Duncan Pottinger
   8. Alex Taylor
   9. Hernando Martínez Vergara
   10. Jaime de la Rocha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study introduces the "Training Village," a valuable system for which solid evidence shows that it enables group-housed rodents to autonomously learn complex tasks while preserving natural social interactions. The platform is flexible, allowing animals to learn multiple tasks sequentially and supporting applications in continual learning. This approach is likely to be of broad interest to behavioral researchers using rodent models in systems and cognitive neuroscience.

   Reviewed by eLife

4. A functional influence based circuit motif that constrains the set of plausible algorithms of cortical function

   This article has 2 authors:

   1. Anna Vasilevskaya
   2. Georg B. Keller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work significantly advances our understanding of the circuit-level implementation of predictive processing by elucidating the functional influence between putative prediction error neurons in layer 2/3 and putative internal representation neurons in layer 5. The evidence demonstrating that neither the hierarchical nor the non-hierarchical variant of predictive processing fully accounts for the presented data is convincing. Moving forward, this line of work would benefit from explicitly comparing different theories, thereby clearly articulating the points raised in this paper.

   Reviewed by eLife

5. Probing the role of sequential sampling and integration in decisions about protracted, noiseless stimuli

   This article has 4 authors:

   1. Hadiseh Hajimohammadi
   2. Kieran S Mohr
   3. Redmond G O’Connell
   4. Simon P Kelly

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable contribution to our understanding of the neural basis of perceptual decision-making by jointly modeling behavioral outcomes and EEG signals in a contrast comparison task. The methods and analyses are solid, systematically comparing standard models assuming continuous evidence accumulation with models that track evidence without temporal integration (extrema detection). The authors show that behavior and neural signals are equally consistent with both alternatives, highlighting limitations in current modeling approaches and questioning the generality of evidence accumulation mechanisms.

   Reviewed by eLife

6. Environmental temperature is a strong driver of subspecies competition in the Drosophila microbiome

   This article has 5 authors:

   1. Bosco Gracia-Alvira
   2. Stefanie Migotti
   3. Xiaomeng Tian
   4. Viola Nolte
   5. Christian Schlötterer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study explores changes in the Drosophila microbiome in response to environmental temperature over more than ten years. The evidence showing that temperature leads to diversification of bacterial clades is solid, but additional information would help clarify how subspecies competition impacts microbiome composition and the host. The work will interest researchers working with microbiomes, microbial ecology, and evolutionary biology.

   Reviewed by eLife

7. Theta-Beta Ratio in Attention Deficit Hyperactivity Disorder: A Multiverse Analysis

   This article has 3 authors:

   1. Dawid Strzelczyk
   2. Andrea Vetsch
   3. Nicolas Langer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript addresses an important question in clinical neuroscience: the use of the theta/beta ratio as a biomarker of attention deficit hyperactivity disorder (ADHD). The study takes an exceptional "multiverse" analysis approach to show that aperiodic activity differences between healthy controls and people with ADHD are driving the apparent theta/beta ratio differences. From a neuroscientific perspective, this is a critical finding because it has a major impact on guiding research on the diagnosis and treatment of ADHD.

   Reviewed by eLife

8. Do monkeys see the way we do? Qualitative similarities and differences between monkey and human perception

   This article has 3 authors:

   1. Thomas Cherian
   2. Georgin Jacob
   3. SP Arun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a comprehensive comparison of human and macaque monkey behavior across a range of visual perceptual phenomena. The use of a unified oddball visual search paradigm enables direct cross-species comparison while minimizing task-related confounds. It provides solid evidence that visual perception is largely similar between these two species, with some interesting exceptions. These insights into qualitative and quantitative differences between species are relevant for evaluating macaques as a model organism for understanding human vision.

   Reviewed by eLife

9. Object manifold geometry across the mouse cortical visual hierarchy

   This article has 11 authors:

   1. Emmanouil Froudarakis
   2. Uri Cohen
   3. Maria Diamantaki
   4. Saumil Patel
   5. Zheng Tan
   6. Taliah Muhammad
   7. Edgar Y Walker
   8. Jacob Reimer
   9. Philipp Berens
   10. Haim Sompolinsky
   11. Andreas S Tolias

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study examined the geometry of visual object representations across hierarchically organized stages of the mouse visual cortex. The use of large-scale training and recording techniques provides solid evidence for changes along the hierarchy that may contribute to invariant object recognition. These findings, particularly if they could be supported by further analyses and clarifications to rule out alternative explanations, including influences of low-level features on behavior and neural activity, help establish the potential usefulness of the mouse to understand the neural basis of object recognition.

   Reviewed by eLife

10. Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons

    This article has 2 authors:

    1. Sophie R Liebergall
    2. Ethan M Goldberg

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study shows that action potentials undergo frequency-dependent failure along the axons of fast-spiking interneurons during sustained high-frequency firing, offering a mechanistic explanation for why inhibition may fail to restrain seizures. The evidence is solid, though additional analyses could further strengthen the mechanistic interpretation. The work will be of broad interest to neuroscientists studying axonal physiology, cortical inhibition, and epilepsy.

    Reviewed by eLife