eLife

Latest preprint reviews

1. Congenital aphantasia reveals frontotemporal and cingulate structural alterations underlying conscious access to imagery

   This article has 5 authors:

   1. Yusaku Takamura
   2. Romain Delsanti
   3. Laurent Cohen
   4. Paolo Bartolomeo
   5. Jianghao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides novel evidence that congenital aphantasia is associated with structural differences in frontotemporal and cingulate systems, with relative sparing of early visual regions and major visual pathways. The multimodal structural imaging approach is carefully implemented and will be of interest to researchers studying mental imagery and aphantasia. However, the strength of evidence is incomplete because the data cannot adjudicate between alternative cognitive interpretations, and the multiple discovery streams make the findings better viewed as key exploratory evidence, rather than as establishing a definitive structural phenotype of aphantasia.

   Reviewed by eLife

2. Cooperative antibiotic response in coupled biofilm and planktonic E. faecalis communities

   This article has 6 authors:

   1. Gabriela Fernandes Martins
   2. Keanu Alexander Guardiola-Flores
   3. Luis Zaman
   4. Jordan M. Horowitz
   5. Kelsey M. Hallinen
   6. Kevin Wood

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study combines experiments and mathematical modeling to show that antibiotic protection provided by resistant cells can extend across both surface-associated and freely growing bacterial populations. Notably, they show that treatment efficacy depends on population composition and density. The evidence supporting the main conclusions is incomplete, primarily because the biofilm context is not adequately characterized and demonstrated, raising the concern that it might represent only an aggregate of cells on the surface (rather than a biofilm) under the studied experimental conditions.

   Reviewed by eLife

3. Astrocytic Nonsense-mediated mRNA decay regulates calcium signaling to support synapse function and restrain anxiety

   This article has 7 authors:

   1. Pablo J. Lituma
   2. Aykut Deveci
   3. Estibaliz Barrio-Alonso
   4. Kun Tan
   5. Miles F. Wilkinson
   6. Pablo E. Castillo
   7. Dilek Colak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides the first in vivo evidence that nonsense-mediated mRNA decay (NMD) in mature astrocytes regulates astrocyte function, synaptic plasticity, and anxiety-related behavior. Using a broad range of approaches, the authors show that conditional deletion of Upf2 alters astrocyte morphology and calcium signaling while impairing synaptic transmission and plasticity, providing solid support for the central conclusion that astrocytic NMD influences neural circuit function. Some key mechanistic claims remain incompletely supported, including whether phenotypes reflect astrocyte remodeling versus loss, the interpretation of synaptic engulfment data, the link between NMD targets and calcium signaling, and the extent to which calcium dysregulation explains the observed synaptic and behavioral effects.

   Reviewed by eLife

4. CHOP promotes the transition to chronic integrated stress response signaling with suppression of hepatocyte identity

   This article has 7 authors:

   1. Theo F. Velarde
   2. Kaihua Liu
   3. Zewei Zhang
   4. Reed C. Adajar
   5. Chaoxian Zhao
   6. Huojun Cao
   7. D. Thomas Rutkowski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental manuscript describes a key role for the integrated stress response-regulated transcription factor CHOP in regulating liver biology in response to endoplasmic reticulum stress through both the downregulation of transcription factors involved in regulating hepatic identity and altering the capacity for integrated stress response and unfolded protein response signaling to induce protective signaling. The data supporting this model is convincing, but including some additional discussion on the mechanism and importance of the work in the context of the published literature would be helpful to better define the complex importance of CHOP signaling. This work will be of interest to a wide range of biologists interested in liver biology, stress-responsive signaling, and ER stress.

   Reviewed by eLife

5. Nanoscale organization of betaII-spectrin within segments of the membrane-associated periodic skeleton in mouse sciatic nerve axons

   This article has 9 authors:

   1. Nahir Guadalupe Gazal
   2. Gonzalo Escalante
   3. Lucía F. Lopez
   4. Laurence Goutebroze
   5. Mariano Bisbal
   6. E. Axel Gorostiza
   7. Alan M. Szalai
   8. Fernando D. Stefani
   9. Nicolás Unsain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable paper looking at nanoscale organization of the membrane associated periodic cytoskeleton in mouse sciatic nerve axons. Despite previous studies, the precise organisation of the structure remains unclear, especially in vivo, and this manuscript significantly adds to this knowledge with solid data. An unexpected observation is the presence of discrete nanoscale clusters, regularly distributed around sections of axons. However, the paper misses a description of these clusters along the longitudinal axis of the axons.

   Reviewed by eLife

6. Fourfold lifespan extension in C. elegans daf-2 mutant males

   This article has 5 authors:

   1. Mike Russell
   2. Michelle Lin
   3. Alexander Tate Lasher
   4. Steven N Austad
   5. Liou Y Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study reports on lifespan extension in C. elegans males that carry a mutation in a gene for an insulin receptor; while the observations are striking, the strength of evidence is currently incomplete. The central claim of male-specificity is undermined by the absence of direct hermaphrodite healthspan comparisons, and the reliance on a single mutant allele leaves open the possibility that background mutations, rather than daf-2 loss-of-function, drive the phenotype. Methodological details critical for reproducibility are also lacking, particularly regarding male housing density, censoring of plate-leaving animals, and the adequacy of replication for the key epistasis experiment. The work could be substantially strengthened by a targeted set of additional experiments and fuller engagement with the existing literature on sex-specific aging in C. elegans.

   Reviewed by eLife

7. PCNA-Polκ-Polδ/USP18 axes stabilize replication fork and restart to reduce cisplatin cytotoxicity

   This article has 5 authors:

   1. Ipsita Subhadarsini
   2. Jugal Kishor Sahu
   3. Shweta Thakur
   4. Rupesh Dash
   5. Narottam Acharya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Building on earlier studies, this manuscript reports a role for pol kappa in cisplatin resistance in the very specific scenarios of head and neck squamous cell carcinoma, providing evidence that the PIP box of Pol kappa is critical for cisplatin resistance in these cells. The findings are of a highly focused relevance and will be useful in the field, but the conclusions are limited to very specific cancer cells. Conclusions cannot be generalized to all cisplatin resistance mechanisms and cell types and are based on incomplete evidence that presents uncertainties and discrepancies that need to be resolved.

   Reviewed by eLife

8. Primate Hippocampus Reveals Distinct Rules for Associative Synaptic Plasticity

   This article has 9 authors:

   1. Anoop Manakkadan
   2. Krishna Kumar
   3. Yee Song Chong
   4. Wong Lik-Wei
   5. Sheeja Navakkode
   6. Yuk Peng Wong
   7. Soong Tuck Wah
   8. Camilo Libedinsky
   9. Sreedharan Sajikumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a potentially important study comparing LTP mechanisms between primates and rodents. The experimental methods have some possible confounds, and the power (replicates) and design of the statistical methods could be strengthened, hence the support for the central claims of species differences is currently incomplete.

   Reviewed by eLife

9. Estimating the replicability of Brazilian biomedical science

   This article has 214 authors:

   1. The Brazilian Reproducibility Initiative
   2. Olavo Bohrer Amaral
   3. Clarissa França Dias Carneiro
   4. Kleber Neves
   5. Ana Paula Wasilewska Sampaio
   6. Bruna Valério Gomes
   7. Mariana Boechat de Abreu
   8. Pedro Batista Tan
   9. Gabriel Paz Souza Mota
   10. Ricardo Netto Goulart
   11. Nathalia Raquel de Souza Fernandes
   12. Jimmy Hayden Linhares
   13. Adriana Mércia Guaratini Ibelli
   14. Adriano Defini Andricopulo
   15. Adriano Sebollela
   16. Adryano Augustto Valladão de Carvalho
   17. Airton Pereira e Silva
   18. Alana Silva Oliveira Souza
   19. Alessandra Catarina Chagas de Lima
   20. Alessandra Mara de Sousa
   21. Alexander Birbrair
   22. Alexandre Urban Borbely
   23. Aline Maria Machado
   24. Alinne do Carmo Costa
   25. Aliny Pereira de Vasconcelos
   26. Alvaro Henrique Bernardo de Lima Silva
   27. Amanda de Souza
   28. Ana Beatriz Rezende Paula
   29. Ana Carolina Caetano Nunes
   30. Ana Maria de Lauro Castrucci
   31. Ana Paula Almeida Bastos
   32. Ana Paula Farias Waltrick
   33. Ana Paula Herrmann
   34. Andre Gustavo Ferreira de Macedo
   35. Andrelson Wellington Rinaldi
   36. André Souza Mecawi
   37. Andrés Delgado Canedo
   38. Anna Paula Marçal
   39. Anna Paula Perin Vidigal
   40. Antonio Martins Monteiro
   41. Beatriz Gonçalves Silva Rocha
   42. Bianca Cruz Pachane
   43. Brenda da Silva Andrade
   44. Bruna Carla Casali
   45. Bruno Popik
   46. Camila Pasquini de Souza
   47. Camila da Silva Dos Santos
   48. Camilla Mendes Gonçalves
   49. Camilla Ribeiro Barroso do Nascimento
   50. Carla Pires Veríssimo
   51. Carlos Eduardo Neves Girardi
   52. Carmen Penido
   53. Carolina Batista
   54. Carolina Panis
   55. Carolina Saibro-Girardi
   56. Carolina da Silva Gouveia Pedrosa
   57. Caroline de Carvalho Picoli
   58. Cristiane Regina Guerino Furini
   59. Daniel Pens Gelain
   60. Daniel Sturza Lucas Caetano
   61. Daniela Costa Silva
   62. Daniele Cristina de Aguiar
   63. Demetrius Antonio Machado De Araújo
   64. Deoclécio Alves Chianca Júnior
   65. Dilza Balteiro Pereira de Campos
   66. Débora Aguirre Gonçalves
   67. Débora Santos da Silva
   68. Eduarda Godfried Nachtigall
   69. Eloiza Lopes Lira Tanabe
   70. Erika Seki Kioshima
   71. Fabio Rodrigues Ferreira Seiva
   72. Fabrício de Araujo Moreira
   73. Felipe Saceanu Leser
   74. Felipe Vanz
   75. Fernanda Cacilda dos Santos Silva
   76. Fernanda Magalhães Ferrão
   77. Fernanda Nogueira Lotz
   78. Flavia Fonseca Bloise
   79. Flavia Regina Souza Lima
   80. Flávio Alves Lara
   81. Franciana Aparecida Volpato
   82. Francieli Moro Stefanello
   83. Francisca Nathalia de Luna Vitorino
   84. Francisco Noé Fonseca
   85. Fábio Jorge Moreira da Silva
   86. Fábio de Almeida Mendes
   87. Gabriel Vasata Furtado
   88. Gilda Angela Neves
   89. Giovanna Zanetti
   90. Giulia Scarcella Cancelliero
   91. Graziele Fernanda Deriggi Pisani
   92. Guilherme Curi Aiub Casagrande
   93. Gustavo Roberto Villas-Boas
   94. Heitor Roque Oliveira Alvez da Cruz
   95. Helena Lobo Borges
   96. Heloisa Sobreiro Selistre De Araujo
   97. Helvécio Cardoso Corrêa Póvoa
   98. Hilana dos Santos Sena Brunel
   99. Hugo Bayer
   100. Igor Luchini Baptista
   101. Isabel Werle
   102. Isabela Alcântara Barretto Araújo Jardim
   103. Isabela Aparecida Divino
   104. Janaina Menezes Zanoveli
   105. Jane de Oliveira Peixoto
   106. Jaqueline de Carvalho Rinaldi
   107. Jeane Bachi Ferreira
   108. Jeferson Luis Franco
   109. Jeronimo Marteleto Nunes Rugani
   110. Jociane de Carvalho Myskiw
   111. Jorge Alberto Quillfeldt
   112. José Marcos Janeiro Pereira da Costa
   113. João Victor Roza Cruz
   114. Julia Helena Oliveira de Barros
   115. Julia Mello Barros
   116. Julia Pinheiro Chagas da Cunha
   117. Juliana Nunes Roson
   118. Júlia Dummer Rodrigues de Freitas
   119. Júlia Grigorini Mori Ayub
   120. Karen Steponavicius Cruz Borbely
   121. Karina Barbosa de Queiroz
   122. Karina Dutra Asensi
   123. Karoline dos Santos Rodrigues
   124. Kellyne de Castro Vieira
   125. Keyla Silva Nobre Pires
   126. Kétlyn Talise Knak Guerra
   127. Lays Adrianne Mendonça Trajano-Silva
   128. Leandro Jose Bertoglio
   129. Leonardo Vinicius Monteiro de Assis
   130. Leticia Menezes Vasconcelos
   131. Leticia Miranda Santos Lery
   132. Letícia de Oliveira Marinho da Silva
   133. Lorena de O Fernandes-Siqueira
   134. Lucas De Oliveira Alvares
   135. Lucas Gabriel Vieira
   136. Lucas Henrique de Melo Falcione
   137. Lucas Dos Santos da Silva
   138. Lucianne Fragel Madeira
   139. Luis Eduardo Duarte Nunes
   140. Luiz Gustavo de Almeida Chuffa
   141. Luiza Marques Prates Behrens
   142. Marcos Vinicius Esteca
   143. Maria Luiza Saraiva-Pereira
   144. Maria Nathália Moraes
   145. Maria Sueli Soares Felipe
   146. Mariana Saldanha Viegas Duarte
   147. Mariana Souza da Silveira
   148. Marimelia A Porcionatto
   149. Marisa Salvi
   150. Maryana Albino Clavero
   151. Mateus Lobato Ferreira
   152. Matheus Alves de Moura
   153. Matheus Gallas-Lopes
   154. Mauro César Isoldi
   155. Mayara Terra Villela Vieira Mundim
   156. Michael Andrades
   157. Micheline Freire Donato
   158. Milena Piaia Barboza
   159. Miliane Martins de Andrade Fagundes
   160. Miriane Avelino Silva
   161. Morgana Duarte da Silva
   162. Munira Muhammad Abdel Baqui
   163. Mychelle Pacheco de Souza
   164. Mônica Corrêa Ledur
   165. Nathalia Stark Pedra
   166. Natália Iorio Lopes Pontes Póvoa
   167. Natália Karla Bellini
   168. Nauana Somensi
   169. Nicolly Maria Payva Nunes
   170. Nícia Pedreira Soares
   171. Nívea Ferreira Silva
   172. Pablinny Moreira Galdino de Carvalho
   173. Paola Alejandra Cappelletti
   174. Patricia Pestana Garcez
   175. Patrícia Kellen Martins Oliveira Brito
   176. Patrícia Rocha Martins
   177. Paulo Roberto Moreira Lauar
   178. Priscila Nicolicht-Amorim
   179. Rafael Chitolina
   180. Raiana Andrade Quintanilha Barbosa
   181. Raul Alexander Gonzales Cordova
   182. Regina Coeli Dos Santos Goldenberg
   183. Rejane Giacomelli Tavares
   184. Renata Krogh
   185. Renata de Freitas Saito
   186. Roberto Andreatini
   187. Roberto Farina Almeida
   188. Rodrigo Cunha Alvim de Menezes
   189. Rodrigo Rorato
   190. Roger Chammas
   191. Rosangela Vieira de Andrade
   192. Roselia Maria Spanevello
   193. Rosiane Andrade Costa
   194. Rubens Lima do Monte-Neto
   195. Sabrina Alves dos Reis
   196. Scheila Iria Kraus
   197. Silvana Chedraoui Silva
   198. Simone Michelan-Duarte
   199. Stevens Kastrup Rehen
   200. Sylvana Izaura Salyba Rendeiro de Noronha
   201. Tania Maria Ortiga-Carvalho
   202. Tanira da Silveira Prieto
   203. Tatiane Renata Fagundes
   204. Thabatta Karollynne Estevam Nakamura
   205. Thadeu Estevam Moreira Maramaldo Costa
   206. Tharcísio Citrângulo Tortelli Junior
   207. Thays Barboza da Luz
   208. Thiago Aparecido da Silva
   209. Tiago Goss Dos Santos
   210. Vanessa Beijamini
   211. Victória Regina de Siqueira Monteiro
   212. Vinícius Alexandre Wippel
   213. Viviane Medeiros Oliveira Valença
   214. Wanessa Fernanda Altei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study assessed the replicability of a selection of lab-based biomedical experiments in papers published by authors based in Brazil. The study adds a unique perspective to the literature on replication, and provides rich data on the approach taken, the outcomes, and the challenges involved in conducting large-scale crowd-sourced research. The evidence supporting the claims is convincing, but there is scope for clarifying the presentation of the results and extending the discussion section.

   Reviewed by eLife

10. Yoda molecules agonize PIEZO2

    This article has 5 authors:

    1. Tharaka D Wijerathne
    2. Aneesh Chandrasekharan
    3. Aashish Bhatt
    4. Yun L Luo
    5. Jérôme J Lacroix

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents an important finding regarding the effect of Yoda molecules on PIEZO2 function, challenging the assumption that they selectively activate PIEZO1. The evidence supporting this claim is solid, but several methodological and conceptual issues need to be addressed. Overall, this work will be of broad interest to researchers working with PIEZO channels across various biological scales.

    Reviewed by eLife