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  2. Primary cilia in the growing limb are preferentially orientated, uncoupled from centriolar position

    1. T Johnson
    2. S Midha
    3. AM Julé
    4. G Randall
    5. K Apolinova
    6. J Miotla-Zarebska
    7. SN Sansom
    8. TL Vincent
    9. AKT Wann

    • Curated by eLife

      eLife Assessment

      This valuable study provides a detailed three-dimensional characterization of primary cilia organization in the postnatal mouse growth plate, revealing reproducible spatial patterns in ciliation, ciliary length, and orientation. The evidence supporting these descriptive findings is solid, based on high-quality quantitative imaging and complementary genetic, mechanical, and transcriptomic approaches. However, evidence for the broader mechanistic conclusions is incomplete, particularly regarding whether ciliary orientation is uncoupled from basal-body and cell orientation and whether its stability under altered mechanical loading reflects a cell-intrinsic program. The study provides a helpful foundation for understanding primary cilia organization and mechanobiology in the growing skeleton, while the mechanisms underlying these observations remain to be established.

    Reviewed by eLife

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