eLife

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   10.1101/2025.10.09.681498

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   10.64898/2026.02.19.706918

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   10.64898/2026.04.21.719818

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   10.64898/2026.06.16.732532

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   10.64898/2026.06.09.731211

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   10.64898/2026.06.14.732185

9. Super compensatory substitutions restore protein function and flatten fitness landscapes

   This article has 5 authors:

   1. Wenhong Jiang
   2. Hengchuang Yin
   3. Saad S. Khan
   4. Yiparemu Abuduhaibaier
   5. Lucas B. Carey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies and characterizes a set of amino acid states that can rescue protein function in the presence of substantially deleterious mutations. Some of these super-compensatory substitutions also confer substantial mutational robustness, with broader implications for understanding epistasis, protein evolution, and protein engineering. The evidence is convincing, supported by a creative reanalysis of a large deep-mutational-scanning dataset, statistically rigorous treatment of anticipated error rates, experimental validation, and analyses of additional proteins, although clearer presentation and deeper investigation of the evolutionary implications and structural mechanisms would further strengthen the study.

   Reviewed by eLife

10. High basal autophagic activity in the brain revealed by systemic quantitative analysis using GFP-LC3-RFP mice

    This article has 7 authors:

    1. Yuki Kanda
    2. Tomoya Eguchi
    3. Hideaki Morishita
    4. Yutaro Hama
    5. Manabu Abe
    6. Kenji Sakimura
    7. Noboru Mizushima

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The ability to measure autophagic flux in vivo in response to physiological stresses remains a challenge for investigators in the field; the novel mouse model present in this work is significant and should prove valuable to investigators in addressing shortcomings of existing models. In addition, the development of the microplate reader approach to permit semi-high-throughput analysis of samples is convincing and a significant advance. The application of these approaches to measuring autophagy in multiple tissues is appreciated but raises some questions that need to be answered and highlighted, including what new biological insight has been generated for tissues under study, how overall autophagy versus rates of flux are determined, and how the sex of the animal affects outcomes. The neuronal populations under study should be reassessed.

    Reviewed by eLife