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  1. Life-stage-specific specialities in the cell atlases of the Clytia hemisphaerica planula and medusa

    1. Anna Ferraioli
    2. Julia Ramon Mateu
    3. Marc Meynadier
    4. Thomas Lamonerie
    5. Sophie Pagnotta
    6. Sandra Chevalier
    7. Marta Iglesias
    8. Sebastian R Najle
    9. Arnau Sebé-Pedrós
    10. Marie-Jeanne Arguel
    11. Julie Cazareth
    12. Virginie Magnone
    13. Evelyn Houliston
    14. Richard R. Copley

    • Curated by eLife

      eLife Assessment

      This study provides a useful single-cell atlas of the Clytia hemisphaerica planula, complemented by an updated medusa dataset, ultrastructural analyses and in situ validation of expression patterns. The cross-stage comparison and cluster-similarity framework offer a promising basis for investigating cellular diversification across the life cycle. The evidence has the potential to be convincing, but is currently incomplete due to documentation deficits and insufficient cross-referencing with prior work. It should be relatively easy to address these issues, which should make this a valued resource for cnidarian researchers and for colleagues studying cell-type evolution.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Genome-wide architecture of prolonged starvation adaptation in experimentally evolved Drosophila and comparative enrichment in human orthologs

    1. Gaurav Yadav
    2. Prachi Mishra
    3. Ranjan Kumar Sahu
    4. Vijendra Sharma
    5. Pawel Michalak
    6. Dau Dayal Aggarwal

    • Curated by eLife

      eLife Assessment

      This study offers valuable insights into the genetic and evolutionary basis of the starvation response by confirming the hypothesis about the mito-nuclear etiology of this trait. The level of evidence is currently incomplete but could be improved if controls were designed better, particularly by including analysis of variation in the initial, common population prior to all treatments. Overall, this work would be interesting to a broad audience, beyond the Drosophila community, if the analysis of the candidate genes against Human ortholog loci were to be conducted with more careful controls.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Eco-genomic analysis uncovers precision-conservation targets for the western Pacific’s southernmost salmonid

    1. Yi-Chien Lee
    2. Zong-Yu Shen
    3. Wei-Ren Lin
    4. Tzi-Yuan Wang
    5. Mark Liu
    6. Yu-Chen Yeh
    7. Shih-Fan Chan
    8. Mei-Yeh Jade Lu
    9. Hui-Yu Wang
    10. Lin-Yan Liao
    11. Wen-Hsiung Li
    12. Jen-Pan Huang
    13. Isheng Jason Tsai
    14. Sheng-Feng Shen

    • Curated by eLife

      eLife Assessment

      This valuable study combines a chromosome-level genome assembly with population resequencing and demographic modelling to reassess the status of the Formosan landlocked salmon, a critically endangered salmonid at the southern edge of the genus. The assembly and the evidence for extensive lineage-specific chromosomal fusions are genuinely well done, and the discovery of an overlooked, genetically distinct population in Hehuan Creek is sound and of clear management relevance. Evidence for the headline claims is incomplete: species rank is asserted but nowhere argued, and gene flow is excluded using a coalescent model that contains no migration parameter. Support for the population-viability conclusions is also not complete, as the demographic mechanisms invoked in the discussion are not borne out by the supplementary tables.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  5. Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors

    1. L. Kaplan
    2. A.L. Green
    3. J. Pang
    4. M. Pavlou
    5. J. Wohlschlegel
    6. T.A Reh

    • Curated by eLife

      eLife Assessment

      This study provides an important contribution to retinal regeneration research by using overexpression of pro-neural factors to reprogram fetal human RPE cells into retinal neurons. The authors provide solid evidence of fetal RPE reprogramming into neural and photoreceptor-like states using scRNA-seq and imaging validation; however, there are concerns regarding comparisons between the effectiveness of different combinatorial transcription factor codes.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  6. A nanoscale atlas of extracellular vesicles and particles in Drosophila olfactory sensilla

    1. Pawel Vijayakumar
    2. Kalyani Cauwenberghs
    3. Muskaan Garg
    4. Jonathan Choy
    5. Shadi Charara
    6. Quintyn McKaughan
    7. Chih-Ying Su

    • Curated by eLife

      eLife Assessment

      This important study presents an ultrastructural atlas of extracellular vesicles and non-vesicular particles in Drosophila olfactory sensilla, using cryofixation-based serial block-face electron microscopy to catalogue roughly 7,800 particles across four antennal regions. The evidence is compelling: the cryofixation minimizes fixation artifacts, and the rigorous, well-validated methodology and morphometric analyses provide strong support for the structural classifications and spatial distributions, though some conclusions require moderation or additional evidence. The work provides a potentially foundational resource for researchers studying extracellular-particle signaling in sensory organs.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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