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  1. Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice

    1. Paola Montenegro
    2. Rachel Kim
    3. Mikayla Zedek
    4. Marianna Chicas
    5. Pamela Yeh
    6. Hermes Yeh

    • Curated by eLife

      eLife Assessment

      This important study shows that prenatal alcohol exposure produces lasting changes in amyloid precursor protein processing, including altered APP C-terminal fragments and Notch intracellular domain levels, that persist into adulthood and track with progressive spatial learning and memory deficits, in both wild-type and 3xTg-AD mice. The convincing study was carefully designed and combined biochemical, histological, and behavioral approaches across multiple ages. The work will interest researchers studying fetal alcohol spectrum disorders, Alzheimer's disease risk, and the developmental origins of neurodegeneration. Nonetheless, reviewers identified opportunities to strengthen the conclusions with additional samples and controls.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Multi-timescale dynamics organize descending pain modulation

    1. Carl Ashworth
    2. Melissa Martenson
    3. Zhigang Shi
    4. Caitlynn C. De Preter
    5. Mary Heinricher
    6. Flavia Mancini

    • Curated by eLife

      eLife Assessment

      An intriguing set of electrophysiological and analytical results suggests that adult rat neurons in the medulla oblongata crucial for mediating descending pain modulation are embedded in a network that generates a specific pattern of oscillatory activity. These valuable findings may broaden our understanding of how descending pain modulation is achieved. The supporting evidence is incomplete, and the authors need to provide several methodological clarifications and additional data interpretations to strengthen the manuscript.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  3. S1PR1 signaling biases neutrophils toward long-lived low-inflammatory functional states

    1. Yueh-Chien Lin
    2. Takahiro Seno
    3. Alan Y. Hsu
    4. Andréane Cartier
    5. Andrew Kuo
    6. Michel V Levesque
    7. Avishek Ghosh
    8. Ingo Fohmann
    9. Victoria A. Blaho
    10. Sylvain Galvani
    11. Reed Crocker
    12. Samuel W Kazer
    13. José Ordovás–Montañés
    14. Hongbo R. Luo
    15. Timothy Hla

    • Curated by eLife

      eLife Assessment

      This manuscript examines how overexpression of sphingosine 1-phosphate receptor 1 in a mouse model affects neutrophil distribution, metabolism and function. Given the significance of S1PR1 in inflammatory mechanisms, this work is valuable for uncovering novel aspects of S1PR1 signaling in neutrophil dynamics and function. The evidence provided is solid as it integrates single-cell transcriptomics, flow cytometry, and multiple in vivo studies. This work also raises key questions about distinct physiological and pathophysiological roles of S1PR1 signaling in neutrophils that could become therapeutic targets.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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