eLife reviews preprints in the life sciences and medicine.

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  1. Reinforcement learning for closed-loop optimisation of spatiotemporal stimulation in patterned neuronal networks

    1. Benedikt Maurer
    2. Vaiva Vasiliauskaitė
    3. Julian Hengsteler
    4. Gino Cathomen
    5. Tobias Ruff
    6. Cedric Schmid
    7. János Vörös
    8. Stephan J. Ihle

    • Curated by eLife

      eLife Assessment

      This study presents an open-source reinforcement learning framework for the real-time, closed-loop optimization of spatiotemporal electrical stimulation in engineered neuronal networks. Using single-spike-resolution activity as continuous feedback, the authors provide solid evidence that their platform can identify stimulation patterns that drive specific activity motifs within a structurally constrained four-node circuit. While this reproducible system offers a valuable and accessible tool for interacting with biological neural networks in an adaptive manner, further validation is needed to determine how well these stimulation strategies generalize to larger, unstructured, or more conventional network architectures.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Limitations of pupil diameter as a proxy for modes of locus coeruleus activity

    1. Lowell W. Thompson
    2. Joshua I. Gold

    • Curated by eLife

      eLife Assessment

      This valuable study examines the relationship between simultaneous LC single-unit recordings and pupillometry, both within and across baseline and evoked epochs, finding that cross-epoch relationships are unreliable. The evidence is solid and suggests that care should be taken when interpreting pupil responses as reflecting LC activity. This manuscript will be interesting to basic and clinical researchers working in cognitive and decision neuroscience as well as computational psychiatry.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. Neurofeedback enhances a neural signature of selective attention to speech in cocktail-party settings

    1. Ram K. Pari
    2. Marina Inyutina
    3. Hoang Lam Thanh Hoang
    4. Camille Dedies
    5. Manuela Jaeger
    6. Stefanie Enriquez-Geppert
    7. Mathieu Marx
    8. Stefan Debener
    9. Christoph S. Herrmann
    10. Benedikt Zoefel

    • Curated by eLife

      eLife Assessment

      This study addresses a key question concerning whether neurofeedback can enhance the neural representation of a selected speaker during competing continuous speech and whether such enhancement translates into behavioral benefits. The solid findings provide important insights into the online modulation of auditory attention and the extent to which selective listening can be voluntarily controlled. Although the observed effects were relatively small and did not consistently persist beyond the feedback period, the study advances understanding in an under-explored area and provides a helpful foundation for future research on sustained learning and behavioral transfer.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Top-down processing alone activates the early somatosensory nuclei

    1. Paige Howell
    2. Lynn Farner
    3. Finn Rabe
    4. Tim Emmenegger
    5. Maryam Seif
    6. Patrick Freund
    7. Nicole Wenderoth
    8. Sanne Kikkert

    • Curated by eLife

      eLife Assessment

      This important study provides convincing evidence that somatosensory relay nuclei remain engaged during attempted hand movements following chronic cervical spinal cord injury, including in individuals with severe motor impairment. The combination of functional and quantitative MRI with physiological controls supports the main findings and may have implications that are of importance in understanding sensorimotor processing after spinal cord injury. However, the interpretation of this activity as specifically reflecting top-down, and particularly corticocuneate, signaling may be overstated. The origin and anatomical route of the observed activity appears to remain less firmly established.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Reassessing Choice Probability: What 59 Macaque Studies Tell Us About Decision-Related Activity in Visual Cortex

    1. Anton Pletenev
    2. Richard T. Born
    3. Gregory C. DeAngelis
    4. Raymond Doudlah
    5. Ichiro Fujita
    6. Joshua I. Gold
    7. Robbe L. T. Goris
    8. Alexander C. Huk
    9. Kristine Krug
    10. Pooya Laamerad
    11. Richard D. Lange
    12. Aaron J. Levi
    13. Hendrikje Nienborg
    14. Christopher C. Pack
    15. Andrew J. Parker
    16. Ari Rosenberg
    17. Mehdi Sanayei
    18. Takanori Uka
    19. Xuefei Yu
    20. Adam Zaidel
    21. Corey M. Ziemba
    22. Ralf M. Haefner

    • Curated by eLife

      eLife Assessment

      This meta-analysis provides a valuable contribution by integrating findings from dozens of macaque electrophysiology studies to reconcile discrepancies in choice probability and identify factors that robustly influence choice signals in the visual cortex. Such systematic synthesis across studies is rare in this field, and the analysis provides solid evidence for several important conclusions, including the cross-study consistency of the relationship between choice probability and sensitivity and the distinctiveness of V1.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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