eLife

Latest preprint reviews

1. Cellular and circuit features distinguish mouse dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation

   This article has 5 authors:

   1. Laura Dovek
   2. Mahboubeh Ahmadi
   3. Krista Marrero
   4. Edward Zagha
   5. Vijayalakshmi Santhakumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study describes distinctive characteristics of dentate gyrus granule cells and semilunar cells that are recruited during contextual memory processing. The study provides solid evidence to suggest mechanisms that may be involved in the recruitment of neurons into memory engrams in the dentate gyrus.

   Reviewed by eLife

2. DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

   This article has 17 authors:

   1. Yuzhen Liu
   2. Christopher D McGann
   3. Conor P Herlihy
   4. Mary Krebs
   5. Thomas A Perkins
   6. Rose Fields
   7. Conor K Camplisson
   8. David Z Nwizugbo
   9. Qiaoyi Lin
   10. Nicolas J Longhi
   11. Chris Hsu
   12. Shayan C Avanessian
   13. Ashley F Tsue
   14. Evan E Kania
   15. David M Shechner
   16. Brian J Beliveau
   17. Devin K Schweppe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important new method for probing the DNA and proteins associated with targeted chromatin domains in cells. The authors present solid evidence that the method can map DNA-DNA interactions for individual loci and can detect proteins enriched near repetitive DNA loci or targeted gene clusters. The methodological details of this study will be of particular interest and utility to chromatin biologists.

   Reviewed by eLife

3. Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

   This article has 11 authors:

   1. Yingjie Sun
   2. Changheng Li
   3. Xiaofei Deng
   4. Wenjie Li
   5. Xiaoyi Deng
   6. Weiqi Ge
   7. Miaoyuan Shi
   8. Ying Guo
   9. Yanxun V Yu
   10. Hai-bing Zhou
   11. Youngnam N Jin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents important findings that reveal SEPHS2 and VPS37C as new potential drug targets for dasatinib and hydroxychloroquine respectively in addition to confirming known targets of these drugs. The evidence provided is compelling as observed in the methods, data and analyses. This article will be of great interest to chemical biologists, biochemists, and scientists in drug discovery and diagnostics.

   Reviewed by eLife

4. Tracheal terminal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

   This article has 6 authors:

   1. Judith Bossen
   2. Larissa Fritz
   3. Reshmi Raveendran
   4. Leizhi Shi
   5. Jingjing He
   6. Thomas Roeder

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable report describing tracheal terminal cells (TTCs) in Drosophila as an immune privileged organ. The authors demonstrated that TTCs lack expression of the membrane-associated peptidoglycan recognition receptor PGRP-LC, which protects these cells from immune pathway activation and JNK-mediated cell death to maintain TTC homeostasis. While the genetic experiments using RNAi and overexpression are convincing and solid, the broader biological significance of this phenomenon requires further investigation. This work will be of interest to researchers in innate immunity across various model systems.

   Reviewed by eLife

5. Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development

   This article has 10 authors:

   1. Sharvani Mahadevaraju
   2. Soumitra Pal
   3. Pradeep Bhaskar
   4. Brennan D McDonald
   5. Leif Benner
   6. Luca Denti
   7. Davide Cozzi
   8. Paola Bonizzoni
   9. Teresa M Przytycka
   10. Brian Oliver

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers a valuable genomic dataset, analyses, and functional studies on gonadal sex determination and development. The work addresses long-standing questions regarding the role of the Drosophila sex determination hierarchy, sex chromosomes, and the interaction between the sex determination hierarchy and sex chromosome composition in gonad development. Although this convincing work has been conducted rigorously, the authors missed some key opportunities in their analysis.

   Reviewed by eLife

6. CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration

   This article has 10 authors:

   1. Zhiyuan Wu
   2. Lindi Liu
   3. Chenchen He
   4. Lin Xiao
   5. Duo Yun
   6. Junliang Chen
   7. Zhihao Liu
   8. Wenjun Li
   9. Qingjie Lv
   10. Xiaodong Tan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to investigate the role of an immune marker, CD131, in UC pathogenesis. The study, as presented, is incomplete, as experimental details are lacking, the statistical analyses are deficient, and there is not yet direct evidence for a CD131-mediated mechanism of gut inflammation.

   Reviewed by eLife

7. Image Correlation Spectroscopy is a Robust Tool to Quantify Cellular DNA Damage Response

   This article has 4 authors:

   1. Angelica A Gopal
   2. Bianca Fernandez
   3. Paul W Wiseman
   4. J Matthew Dubach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable paper shows image correlation spectroscopy (ICS) as a new tool to analyze the clustering of proteins involved in DNA damage response (DDR). The convincing evidence presented demonstrates that ICS is more sensitive than traditional foci counting. This new method provides an alternative tool to quantify immunostained foci for researchers in the fields of DDR and cell biology.

   Reviewed by eLife

8. Social and environmental predictors of gut microbiome age in wild baboons

   This article has 10 authors:

   1. Mauna R Dasari
   2. Kimberly E Roche
   3. David Jansen
   4. Jordan Anderson
   5. Susan C Alberts
   6. Jenny Tung
   7. Jack A Gilbert
   8. Ran Blekhman
   9. Sayan Mukherjee
   10. Elizabeth A Archie

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study leverages an impressive and comprehensive longitudinal 16S rRNA gut microbiome dataset from baboons to provide important insight regarding the use of a microbiome-based clock to predict biological age. The evidence for age-associated microbiome features and environmental and social variables that impact microbiome aging is convincing. This study of microbiomes as markers of host age will fuel inquiries and studies and interest a broad range of researchers, especially those interested in alternatives to measuring biological aging.

   Reviewed by eLife

9. Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

   This article has 12 authors:

   1. Gabriella O Estevam
   2. Edmond Linossi
   3. Jingyou Rao
   4. Christian B Macdonald
   5. Ashraya Ravikumar
   6. Karson M Chrispens
   7. John A Capra
   8. Willow Coyote-Maestas
   9. Harold Pimentel
   10. Eric A Collisson
   11. Natalia Jura
   12. James S Fraser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides an important overview of potential resistance mutations within MET Receptor Tyrosine Kinase. The evidence supporting the findings is convincing - it should be pointed out that the approach is comparatively new for the application of protein kinases and the results are therefore of potentially great value. The results will be of value for clinicians facing drug resistance mutations, computational biologists who are training models of drug resistance mechanisms and biologists with an interest in cell signaling.

   Reviewed by eLife

10. Between-species variation in neocortical sulcal anatomy of the carnivoran brain

    This article has 19 authors:

    1. Magdalena Boch
    2. Katrin Karadachka
    3. Kep-Kee Loh
    4. R Austin Benn
    5. Lea Roumazeilles
    6. Mads F Bertelsen
    7. Paul R Manger
    8. Ethan Wriggelsworth
    9. Simon Spiro
    10. Muhammad A Spocter
    11. Philippa J Johnson
    12. Kamilla Avelino-de-Souza
    13. Nina Patzke
    14. Claus Lamm
    15. Karla L Miller
    16. Jérôme Sallet
    17. Alexandre A Khrapitchev
    18. Benjamin C Tendler
    19. Rogier B Mars

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study presents the first detailed and comprehensive description of brain sulcus anatomy of a range of carnivoran species based on a robust manual labeling model allowing species comparisons. The database and method for reconstructing cortical surfaces are compelling, and the evidence supporting the conclusions is solid. Despite the additional specimen, the evaluation of intra-species variations remains limited, but an insight into the inter-individual variability is now available for certain species. Exploring the associations between sulcal length and behavioral characteristics further suggests the potential of sulci as a proxy of functional organization. Setting an instructive foundation for comparative anatomy, this study will be of interest to neuroscientists and neuroimaging researchers interested in that field, as well as in brain morphology and sulcal patterns, their phylogeny and ontogeny in relation to functional development and behaviour.

    Reviewed by eLife