eLife

Latest preprint reviews

1. The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

   This article has 11 authors:

   1. Wenqin Fang
   2. Xiaoyu Zai
   3. Jia Chen
   4. Yakubu Saddeeq Abubakar
   5. Qiuqiu Wu
   6. Zhenyu Fang
   7. Xiuwei Huang
   8. Xiang Gan
   9. Daniel J Ebbole
   10. Zonghua Wang
   11. Wenhui Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides strong evidence for the development of a penetration ring during Magnaporthe oryzae infection and, supported by knockout and expression studies, shows that Ppe1 is involved in the virulence of the fungus. Although the authors demonstrated the close association of Ppe1 with the host plasma membrane, the work fell short in providing direct evidence for its role at the host-pathogen interface and the precise molecular function of the penetration ring. Therefore, the study presented strong structural and phenotypic characterization but remains incomplete regarding mechanistic insights of Ppe1.

   Reviewed by eLife

2. Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking

   This article has 6 authors:

   1. Claire Cooper
   2. Daniel Parthier
   3. Jeremie Sibille
   4. John J Tukker
   5. Nicolas Tritsch
   6. Dietmar Schmitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that slow fluctuations in serotonin release during wakefulness and non-REM sleep correspond to periods of heightened arousal or enhanced offline information processing. The evidence supporting this claim is convincing, and the methodology is robust and broadly applicable, likely to benefit many researchers in the field. This work will be of significant interest to neuroscientists studying sleep, memory, and neuromodulation.

   Reviewed by eLife

3. Prosapip1 (encoded by the Lzts3 gene) in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

   This article has 10 authors:

   1. Zachary W Hoisington
   2. Himanshu Gangal
   3. Khanhky Phamluong
   4. Chhavi Shukla
   5. Jeffrey J Moffat
   6. Alexandra Salvi
   7. Gregg Homanics
   8. Jun Wang
   9. Yann Ehinger
   10. Dorit Ron

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study aims to understand the function of ProSAP-interacting protein 1 (Prosapip1) in the brain. Using a conditional Prosapip1 KO mouse (floxed prosapip1 crossed with Syn1-Cre line), the authors performed analysis including protein biochemistry, synaptic physiology, and behavioral learning. Convincing evidence from this study supports a role of Prosapip 1 in synaptic protein composition, synaptic NMDA responses, LTP, and spatial memory.

   Reviewed by eLife

4. Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory

   This article has 5 authors:

   1. Daniel Reznik
   2. Piotr Majka
   3. Marcello GP Rosa
   4. Menno P Witter
   5. Christian F Doeller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work discusses the phylogenetic conservation of the hippocampal region and primary sensory cortical regions in mammalian species. The authors propose that species-specific differences in behavior and mnemonic functions may be due to differences in cortico-hippocampal connectivity patterns. However, the manuscript, in its present form, is speculative, and the strength of evidence for this proposition is incomplete.

   Reviewed by eLife

5. Endogenous precision of the number sense

   This article has 2 authors:

   1. Arthur Prat-Carrabin
   2. Michael Woodford

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important research investigates the precision of numerosity perception in two types of tasks and concludes that human performance aligns with an efficient coding model optimized for current environmental statistics and task goals. The proposed model receives compelling evidence from two numerosity perception experiments and a reanalysis of an existing dataset of risky decision-making. These findings have theoretical implications for our understanding of numerosity perception and decision-making as well as the ongoing debate on different efficient coding models.

   Reviewed by eLife

6. Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

   This article has 25 authors:

   1. Kevin C Lister
   2. Calvin Wong
   3. Sonali Uttam
   4. Marc Parisien
   5. Patricia Stecum
   6. Nicole Brown
   7. Weihua Cai
   8. David Ho-Tieng
   9. Mehdi Hooshmandi
   10. Ning Gu
   11. Mehdi Amiri
   12. Francis Beaudry
   13. Seyed Mehdi Jafarnejad
   14. Diana Tavares-Ferreira
   15. Nikhil Nageshwar Inturi
   16. Khadijah Mazhar
   17. Hien T Zhao
   18. Bethany Fitzsimmons
   19. Christos G Gkogkas
   20. Nahum Sonenberg
   21. Theodore J Price
   22. Luda Diatchenko
   23. Yaser Atlasi
   24. Jeffrey S Mogil
   25. Arkady Khoutorsky

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using a combination of innovative and robust techniques, this study outlines cell-type-specific translational landscape changes that occur in the spinal cord neurons in the early and late phases of nerve injury. The authors provided compelling evidence suggesting an essential role of protein synthesis regulation in the chronic phase of neuropathic pain. Although additional mechanisms contributing to late-phase neuropathic pain beyond altered PV+ neuron excitability remain to be elucidated, this is a fundamental and significant study toward a comprehensive understanding of the molecular pathways involved in neuropathic pain.

   Reviewed by eLife

7. A causal role of the NMDA receptor in recurrent processing during perceptual integration

   This article has 5 authors:

   1. Samuel Noorman
   2. Timo Stein
   3. Jasper Zantvoord
   4. Johannes Fahrenfort
   5. Simon van Gaal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a new, fundamental finding to the field interested in recurrent processing and its neuromodulatory underpinnings, finding unexpectedly that memantine (blocking NMDA-receptors) enhances the decoding of features thought to rely on NMDA-receptors. This interesting, compelling result identifies new directions for researchers studying consciousness, sensory processing, attention, and neurotransmitters.

   Reviewed by eLife

8. A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

   This article has 3 authors:

   1. Sean A Ridout
   2. Priyathama Vellanki
   3. Ilya Nemenman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This theoretical study makes a useful contribution to our understanding of a subtype of type 2 diabetes - ketosis-prone diabetes mellitus (KPD) - with a potential impact on our broader understanding of diabetes and glucose regulation. The article presents an ordinary differential equation-based model for KPD that incorporates a number of distinct timescales - fast, slow, as well as intermediate, incorporating a key hypothesis of reversible beta cell deactivation. The presented evidence is solid and shows that observed clinical disease trajectories may be explained by a simple mathematical model in a particular parameter regime.

   Reviewed by eLife

9. The extra-islet pancreas supports autoimmunity in human type 1 diabetes

   This article has 15 authors:

   1. Graham L Barlow
   2. Christian M Schürch
   3. Salil S Bhate
   4. Darci J Phillips
   5. Arabella Young
   6. Shen Dong
   7. Hunter A Martinez
   8. Gernot Kaber
   9. Nadine Nagy
   10. Sasvath Ramachandran
   11. Janet Meng
   12. Eva Korpos
   13. Jeffrey A Bluestone
   14. Garry P Nolan
   15. Paul L Bollyky

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study leverages innovative high-dimensional imaging strategies to interrogate pancreatic immune cell profiles and distributions throughout stages of type 1 diabetes (T1D). Despite a notable limitation in the number of donor samples analyzed, the authors identify a series of intriguing "immune signatures" and histopathological features that collectively constitute a solid foundation for future investigations into immunological processes underpinning the pathogenesis of T1D. Accordingly, the work will be of considerable interest to the community of T1D researchers and clinicians.

   Reviewed by eLife

10. Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

    This article has 11 authors:

    1. Affiong Ika Oqua
    2. Kin Chao
    3. Liliane El Eid
    4. Lisa Casteller
    5. Billy P Baxter
    6. Alba Miguéns-Gómez
    7. Sebastian Barg
    8. Ben Jones
    9. Jorge Bernardino de la Serna
    10. Sarah L Rouse
    11. Alejandra Tomas

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The study presents a valuable finding on the role of cholesterol-binding sites on GLP-1 receptors although the clinical ramifications are unclear and not eminent at this point. Based on the detailed and persuasive responses provided by authors to the concerns raised by reviewers, the revised manuscript is improved substantially and is convincing enough in its scientific merit. The study is a good addition to the scientific community working on receptor biology and drug development for GLP-1 R.

    Reviewed by eLife