eLife

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1. The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

   This article has 12 authors:

   1. Artem N Bonchuk
   2. Konstantin I Balagurov
   3. Rozbeh Baradaran
   4. Konstantin M Boyko
   5. Nikolai N Sluchanko
   6. Anastasia M Khrustaleva
   7. Anna D Burtseva
   8. Olga V Arkova
   9. Karina K Khalisova
   10. Vladimir O Popov
   11. Andreas Naschberger
   12. Pavel G Georgiev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work offers an experimental structural characterization of the Tramtrack-like BTB/POZ domains in insects, revealing that these domains form stable hexameric assemblies. The structural evidence is convincing, and validated by fold prediction and evolutionary pathway analyses. This paper would be of interest to structural and evolutionary biologists.

   Reviewed by eLife

2. CCL28 modulates neutrophil responses during infection with mucosal pathogens

   This article has 21 authors:

   1. Gregory T Walker
   2. Araceli Perez-Lopez
   3. Steven Silva
   4. Michael H Lee
   5. Elisabet Bjånes
   6. Nicholas Dillon
   7. Stephanie L Brandt
   8. Romana R Gerner
   9. Karine Melchior
   10. Grant J Norton
   11. Felix A Argueta
   12. Frenchesca Dela Pena
   13. Lauren Park
   14. Victor A Sosa-Hernandez
   15. Rodrigo Cervantes-Diaz
   16. Sandra Romero-Ramirez
   17. Monica Cartelle Gestal
   18. Jose L Maravillas-Montero
   19. Sean-Paul Nuccio
   20. Victor Nizet
   21. Manuela Raffatellu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, Perez-Lopez and colleagues examine an important function of the chemokine CCL28 in mucosal host defenses against the gut bacterial pathogen Salmonella Typhimurium and lung pathogen Acinetobacter baumanii. They find that CCL28-CCR3 axis regulates neutrophil recruitment and function, and promotes bacterial clearance in one infectious context but exacerbates disease against the other pathogen. Therefore, CCL28 plays a critical role in mucosal immunity and neutrophil biology that differentially affects host defenses against pathogens.

   Reviewed by eLife

3. Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics

   This article has 6 authors:

   1. Hui Li
   2. Jun Yang
   3. Su-fang Kuang
   4. Huan-zhe Fu
   5. Hui-yin Lin
   6. Bo Peng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study explored the influence of magnesium on phenotypic antibiotic resistance in two strains of Vibrios: V. alginolyticus ATCC33787 and V. parahaemolyticus VP01. This research is fundamental for revealing the phenotypic antibiotic resistance mechanism utilized by the specified model bacteria in elevated levels of magnesium. The study produced convincing evidence indicating that in high concentrations of magnesium, the efficacy of selected antibiotics was diminished due to decreased biosynthesis of unsaturated fatty acids and PE, along with an increase in the biosynthesis of PG.

   Reviewed by eLife

4. Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

   This article has 13 authors:

   1. Zewei Zhao
   2. Longyun Hu
   3. Bigui Song
   4. Tao Jiang
   5. Qian Wu
   6. Jiejing Lin
   7. Xiaoxiao Li
   8. Yi Cai
   9. Jin Li
   10. Bingxiu Qian
   11. Siqi Liu
   12. Jilu Lang
   13. Zhonghan Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study highlights adhesion G-protein-coupled receptor A3 (ADGRA3) as a potential target for activating adaptive thermogenesis in both white and brown adipose tissue. This finding offers valuable insights for researchers in the field of adipose tissue biology and metabolism. The authors have presented additional evidence to address the reviewers' comments, including experiments conducted on primary stromal vascular fractions from adipose tissues. However, the revised manuscript fails to address several reviewer concerns, such as the measurement of whole-body energy expenditure through indirect calorimetry and the assessment of food intake. Furthermore, the nanoparticle-mediated knockdown of Adgra3 did not adequately address the tissue selectivity of ADGRA in mice. As a result, the primary claims of the study are only partially supported by the available data, leading to the conclusion that the research is deemed incomplete.

   Reviewed by eLife

5. Direct and indirect salt effects on homotypic phase separation

   This article has 3 authors:

   1. Matt MacAinsh
   2. Souvik Dey
   3. Huan-Xiang Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this potentially important study, the authors conducted atomistic simulations to probe the salt-dependent phase separation of the low-complexity domain of hnRN-PA1 (A1-LCD). The authors have identified both direct and indirect mechanisms of salt modulation, provided explanations for four distinct classes of salt dependence, and proposed a model for predicting protein properties from amino acid composition. There is a range of opinions regarding the strength of evidence, with some considering the evidence as incomplete due to the limitations in the length and statistical errors of the computationally intense atomistic MD simulations.

   Reviewed by eLife

6. Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex

   This article has 24 authors:

   1. Jittoku Ihara
   2. Yibin Huang
   3. Yoichi Takami
   4. Yoichi Nozato
   5. Toshimasa Takahashi
   6. Akemi Kakino
   7. Cheng Wang
   8. Ziwei Wang
   9. Yu Guo
   10. Weidong Liu
   11. Nanxiang Yin
   12. Ryoichi Ohara
   13. Taku Fujimoto
   14. Shino Yoshida
   15. Kazuhiro Hongyo
   16. Hiroshi Koriyama
   17. Hiroshi Akasaka
   18. Hikari Takeshita
   19. Shinsuke Sakai
   20. Kazunori Inoue
   21. Yoshitaka Isaka
   22. Hiromi Rakugi
   23. Tatsuya Sawamura
   24. Koichi Yamamoto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides useful in vitro evidence to support a mechanism whereby dyslipidemia could accelerate renal functional decline through the activation of the AT1R/LOX1 complex by oxLDL and AngII. As such, it improves the knowledge regarding the complex interplay between dyslipidemia and renal disease and provides a solid basis for the discovery of novel therapeutic strategies for patients with lipid disorders. The methods, data, and analyses partly support the presented findings, although the observed variability and need for further in vivo validation require additional research in this key area.

   Reviewed by eLife

7. Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

   This article has 13 authors:

   1. Xiexiang Shao
   2. Xingzuan Lin
   3. Hao Zhou
   4. Minghui Wang
   5. Lili Han
   6. Xin Fu
   7. Sheng Li
   8. Siyuan Zhu
   9. Shenao Zhou
   10. Wenjun Yang
   11. Jianhua Wang
   12. Zhanghua Li
   13. Ping Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors demonstrate the valuable discovery that human CD29+/CD56+ myogenic progenitors can differentiate into tendon through the TGFβ pathway, addressing mouse and human interspecies differences in regard to the potential of muscle stem cells. The in vivo transplantation experiments provide convincing evidence for the conclusion, as human CD29+/CD56+ myogenic progenitors contribute to tendon regeneration, resulting in functional recovery in mouse model. The authors' approach can be used for the development of cell therapy for tendon-injured patients.

   Reviewed by eLife

8. Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs

   This article has 15 authors:

   1. Shuo Chao
   2. Jun Lu
   3. Li-Jun Li
   4. Hong-Yan Guo
   5. Kuipeng Xu
   6. Ning Wang
   7. Shu-Xian Zhao
   8. Xiao-Wen Jin
   9. Shao-Ge Wang
   10. Shen Yin
   11. Wei Shen
   12. Ming-Hui Zhao
   13. Gui-An Huang
   14. Qing-Yuan Sun
   15. Zhao-Jia Ge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports important findings on the impact of maternal obesity on offspring metabolism. It presents solid evidence that maternal obesity induces genomic methylation alterations in oocytes, which can be partly transmitted to F2 in females, and that melatonin is involved in regulating the hyper-methylation of high fat diet oocytes by increasing the expression of DNMTs via the cAMP/PKA/CREB pathway. This study would be of interest to biologists in the fields of epigenetics and metabolism.

   Reviewed by eLife

9. Decoding the physics of observed actions in the human brain

   This article has 2 authors:

   1. Moritz F Wurm
   2. Doruk Yiğit Erigüç

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In an important fMRI study with an elegant experimental design and rigorous cross-decoding analyses, this work shows a convincing dissociation between two parietal regions in visually processing actions. Specifically, aIPL is found to be sensitive to the causal effects of observed actions, while SPL is sensitive to the patterns of body motion involved in those actions. The work will be of broad interest to cognitive neuroscientists, particularly vision and action researchers.

   Reviewed by eLife

10. Muscarinic receptors mediate motivation via preparatory neural activity in humans

    This article has 6 authors:

    1. John P Grogan
    2. Matthias Raemaekers
    3. Maaike MH van Swieten
    4. Alexander L Green
    5. Martin J Gillies
    6. Sanjay G Manohar

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The authors have reported an important study in which they use a double-blind design to explore pharmacological manipulations in the context of a behavioral task. While the sample size is small, the use of varied methodology, including electrophysiology, behavior, and pharmacology, makes this manuscript particularly notable. Overall, the findings are solid and motivate future explanations into the relationships between acetylcholine and motivation.

    Reviewed by eLife