eLife

Latest preprint reviews

1. Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

   This article has 12 authors:

   1. Malika Hale
   2. Kennidy K Takehara
   3. Christopher D Thouvenel
   4. Dina A Moustafa
   5. Andrea Repele
   6. Mary F Fontana
   7. Jason Netland
   8. Sharon McNamara
   9. Ronald L Gibson
   10. Joanna B Goldberg
   11. David J Rawlings
   12. Marion Pepper

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Treatment of Pseudomonas aeruginosa (PA) infections is challenging because of intrinsic and acquired antibiotic resistance to most antibiotic drug classes. Therefore, by using donor B cells in subjects with cystic fibrosis who undergo intermittent or chronic airway PA infections, the authors aimed to isolate B-cell receptors against PA virulence factors and examined their biological activities. The data are solid and the protective antibodies identified in this study could be useful for protection against PA.

   Reviewed by eLife

2. Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

   This article has 12 authors:

   1. Alannah Lejeune
   2. Chunyi Zhou
   3. Defne Ercelen
   4. Gregory Putzel
   5. Xiaomin Yao
   6. Alyson R Guy
   7. Miranda Pawline
   8. Magdalena Podkowik
   9. Alejandro Pironti
   10. Victor J Torres
   11. Bo Shopsin
   12. Ken Cadwell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study highlights potential mechanisms underlying the sex-dependent bias in susceptibility to gut colonization by Methicillin-resistant Staphylococcus aureus (MRSA). The evidence supporting the conclusion is compelling. The work will interest biologists who study intestinal infection and immunity.

   Reviewed by eLife

3. Cortico-striatal action control inherent of opponent cognitive-motivational styles

   This article has 2 authors:

   1. Cassandra Avila
   2. Martin Sarter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript investigated the role of glutamate signaling in the dorsomedial striatum of rats in a treadmill-based task and reported that it differs in goal-trackers compared to sign-trackers in a way that corresponds to differences in behaviour. The evidence supporting these claims is solid but could be further strengthened by adding more analyses and more detailed descriptions of current analyses. These findings will primarily be of interest to behavioural neuroscientists.

   Reviewed by eLife

4. Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

   This article has 8 authors:

   1. Siying Zeng
   2. Yuqi Wang
   3. Minfeng Ying
   4. Chengmeng Jin
   5. Chang Ying
   6. Di Wang
   7. Hao Wu
   8. Xun Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an assessment of the effect of lactate dehydrogenase (LDH) inhibition on the activity of glycolysis and tricarboxylic acid cycle. The data were collected and analyzed using solid and validated methodology. This paper makes a useful contribution to the field as it considers a control analysis of LDH flux. The findings differ from other published findings likely due to the time course of the incubations used to assess metabolism. While such comparative studies were not presented in the manuscript, the manuscript should be interpreted in light of this critical distinction.

   Reviewed by eLife

5. ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

   This article has 6 authors:

   1. Tejan Lodhiya
   2. Aseem Palande
   3. Anjali Veeram
   4. Gerald J Larrouy-Maumus
   5. Dany JV Beste
   6. Raju Mukherjee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important work, Lodhiya et al. provide evidence that excessive ATP underlies the killing of the model organism Mycobacterium smegmatis by two mechanistically-distinct antibiotics. The data are generally solid as the authors deploy multiple, orthogonal readouts and methods for manipulating reactive oxygen species and ATP. The work will be of interest to those studying antibiotic mechanisms of action.

   Reviewed by eLife

6. A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model

   This article has 17 authors:

   1. Mitsuru Sugimoto
   2. Tadayuki Takagi
   3. Tomohiro Suzuki
   4. Hiroshi Shimizu
   5. Goro Shibukawa
   6. Yuki Nakajima
   7. Yutaro Takeda
   8. Yuki Noguchi
   9. Reiko Kobayashi
   10. Hidemichi Imamura
   11. Hiroyuki Asama
   12. Naoki Konno
   13. Yuichi Waragai
   14. Hidenobu Akatsuka
   15. Rei Suzuki
   16. Takuto Hikichi
   17. Hiromasa Ohira

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study discusses a hot topic in post-endoscopic retrograde cholangiopancreatography pancreatitis. The new score for predicting post-ERCP pancreatitis offers an idea about the risk of pancreatitis before the procedure. Although most scores depend on intraprocedural manoeuvres, such as the number of attempts to cannulate the papilla, this is a solid retrospective single-center study in one country. To be validated in the future, this score will need to be done in many countries and on large numbers of patients.

   Reviewed by eLife

7. History-dependent spiking facilitates efficient encoding of polarization angles in neurons of the central complex

   This article has 3 authors:

   1. Lisa Rother
   2. Anna Stöckl
   3. Keram Pfeiffer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines electrophysiology experiments and modeling to investigate the encoding of dynamic patterns of polarized light by identified neurons of the bumblebee central complex. The scientific question and methodology are compelling. However, the evidence supporting the authors' conclusions is incomplete without more comprehensive statistical analyses.

   Reviewed by eLife

8. Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

   This article has 6 authors:

   1. Masaya Muramoto
   2. Nozomi Hanawa
   3. Misako Okumura
   4. Takahiro Chihara
   5. Masayuki Miura
   6. Natsuki Shinoda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies a mechanism by which caspases are activated in a non-lethal context to induce functional modulation in Drosophila olfactory receptor neurons. To deliver, the authors generated a new reporter of caspases, used TurboID to identify proteins proximal of the Drosophila executioner caspases Drice, and then focused on Fasciclin 3 as a mediator. The experimental results and the main conclusions are convincing. This substantial body of work will be of interest to researchers across fields, from neuroscience of olfaction to development and cell biology.

   Reviewed by eLife

9. Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

   This article has 7 authors:

   1. Sihui Cai
   2. Jie Zhou
   3. Xiaotong Luo
   4. Chenqiu Zhang
   5. Shouheng Jin
   6. Jian Ren
   7. Jun Cui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that interferon beta stimulation induces WTAP transition from aggregates to liquid droplets, coordinating m6A modification of a subset of mRNAs that encode interferon-stimulated genes and restricting their expression. The evidence presented is solid, supported by microscopy, immunoprecipitations, m6A sequencing, and ChIP, to show that WTAP phosphorylation controls phase transition and its interaction with STAT1 and the methyltransferase complex.

   Reviewed by eLife

10. Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease

    This article has 9 authors:

    1. Edwin A Homan
    2. Ankit Gilani
    3. Alfonso Rubio-Navarro
    4. Maya A Johnson
    5. Odin M Schaepkens
    6. Eric Cortada
    7. Renan Pereira de Lima
    8. Lisa Stoll
    9. James C Lo

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study investigates the role of Complement 3a Receptor 1 (C3aR) in the pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) using mouse models with specific target deletions in various cell types. While the general relevance of C3aR in inflammatory contexts has been established before, the authors provide solid evidence here that C3aR does not contribute significantly to MASLD pathogenesis in their models. The work will be of interest to colleagues studying diseases of the liver and the intersection with inflammation.

    Reviewed by eLife