eLife

Latest preprint reviews

1. Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

   This article has 22 authors:

   1. Priya Sharma
   2. Raman Deep Sharma
   3. Binayak Sarkar
   4. Varnika Panwar
   5. Mrinmoy Das
   6. Lakshya Veer Singh
   7. Neharika Jain
   8. Shivam Chaturvedi
   9. Lalita Mehra
   10. Aditya Rathee
   11. Shilpa Sharma
   12. Shihui Foo
   13. Andrea Lee
   14. Pavan Kumar N
   15. Prasenjit Das
   16. Vijay Viswanathan
   17. Hardy Kornfeld
   18. Shanshan W Howland
   19. Subash Babu
   20. Vinay Kumar Nandicoori
   21. Amit Singhal
   22. Dhiraj Kumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors provide solid data reporting that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. The specific contribution of neutrophil-derived IL-17 to disease pathogenesis remains to be definitively established through direct demonstration of IL-17 production by neutrophils and targeted depletion studies.

   Reviewed by eLife

2. Cellular coordination underpins rapid reversals in gliding filamentous cyanobacteria and its loss results in plectonemes

   This article has 11 authors:

   1. Jerko Rosko
   2. Rebecca N Poon
   3. Kelsey Cremin
   4. Emanuele Locatelli
   5. Mary Coates
   6. Sarah JN Duxbury
   7. Kieran Randall
   8. Katie Croft
   9. Chantal Valeriani
   10. Marco Polin
   11. Orkun S Soyer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using microscopy experiments and theoretical modelling, the authors present convincing evidence of cellular coordination in the gliding filamentous cyanobacterium Fluctiforma draycotensis. The results are fundamental for the understanding of cyanobacterial motility and the underlying molecular and mechanical pathways of cellular coordination.

   Reviewed by eLife

3. Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

   This article has 9 authors:

   1. Lulu Qin
   2. Chongbin Hu
   3. Qiong Zhao
   4. Yong Wang
   5. Dongdong Fan
   6. Aifu Lin
   7. Lixin Xiang
   8. Ye Chen
   9. Jianzhong Shao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study focuses on the role of a T-cell-specific receptor, ctla-4, in a new zebrafish model of IBD-like phenotype. Although implicated in IBD diseases, the function of ctla-4 has been hard to study in mice as the KO is lethal. Ctla-4 mutant zebrafish exhibited significant intestinal inflammation and dysbiosis, mirroring the pathology of inflammatory bowel disease (IBD) in mammals, providing a new valuable model to the field of IBD research. This is an key study with convincing evidence, comprehensive transcriptomic analysis, histological examinations, and functional assays all supporting the findings.

   Reviewed by eLife

4. Brochosomes as an antireflective camouflage coating for leafhoppers

   This article has 8 authors:

   1. Wei Wu
   2. Qianzhuo Mao
   3. Zhuang-Xin Ye
   4. Zhenfeng Liao
   5. Hong-Wei Shan
   6. Jun-Min Li
   7. Chuan-Xi Zhang
   8. Jian-Ping Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors provide important insights into a system of insect camouflage where a coating of self-made nano-particles (brochosomes) reduces the reflection of UV-light leading to lower predation by spiders. Compelling evidence is provided by micro-UV-Vis spectroscopy, electron microscopy, transcriptome and proteome analysis, histology, in-vivo predation assays and gene knock-downs. The phylogenetic analyses provide evidence that the genes coding for the brochosome proteins are clade-specific and have diversified by gene duplication.

   Reviewed by eLife

5. Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

   This article has 9 authors:

   1. Sytse J Piersma
   2. Shasha Li
   3. Pamela Wong
   4. Michael D Bern
   5. Jennifer Poursine-Laurent
   6. Liping Yang
   7. Diana L Beckman
   8. Bijal A Parikh
   9. Wayne M Yokoyama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study on mouse Ly49 receptors expressed on natural killer (NK) cells shows that Ly49A, in the presence of the corresponding MHC Class I allele, can lead to NK cell licensing, thereby providing valuable insights into the mechanisms of NK cell modulation by Ly49 receptors. The work may have significant implications for studies of human Killer-cell immunoglobulin-like receptors (KIR) expressing and other NK cells. Overall, the study was well-developed with convincing evidence.

   Reviewed by eLife

6. Short heat shock factor A2 regulates heat resistance and growth balance in Arabidopsis

   This article has 7 authors:

   1. Wanxia Chen
   2. Jiaqi Zhao
   3. Zhanxia Tao
   4. Shan Zhang
   5. Xiujuan Bei
   6. Wen Lu
   7. Xiaoting Qi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The paper reports valuable findings about the mechanism of regulation of the heat shock response in plants that acts as a brake to prevent hyperactivation of the stress response, which have theoretical or practical implications for a subfield. The study presented by the authors provides solid methods, data, and analysis that broadly support the claims. This report presents helpful information regarding new spliced HSFs forms in Arabidopsis that highlights key information in the understanding of heat stress and plant growth.

   Reviewed by eLife

7. Confirmation of HLA-II associations with TB susceptibility in admixed African samples

   This article has 6 authors:

   1. Dayna Adrienne Croock
   2. Yolandi Swart
   3. Haiko Schurz
   4. Desiree C Petersen
   5. Marlo Möller
   6. Caitlin Uren

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study confirms the association between the human leukocyte antigen (HLA)-II region and tuberculosis (TB) susceptibility in genetically admixed South African populations, specifically identifying a near-genome-wide significant association in the HLA-DPB1 gene, which originates from KhoeSan ancestry. The evidence supporting the association between the HLA-II region and TB susceptibility is solid, and the work will be of interest to those studying the genetic basis of tuberculosis susceptibility/infection resistance.

   Reviewed by eLife

8. Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

   This article has 22 authors:

   1. Aivaras Vaškevičius
   2. Denis Baronas
   3. Janis Leitans
   4. Agnė Kvietkauskaitė
   5. Audronė Rukšėnaitė
   6. Elena Manakova
   7. Zigmantas Toleikis
   8. Algirdas Kaupinis
   9. Andris Kazaks
   10. Marius Gedgaudas
   11. Aurelija Mickevičiūtė
   12. Vaida Juozapaitienė
   13. Helgi B Schiöth
   14. Kristaps Jaudzems
   15. Mindaugas Valius
   16. Kaspars Tars
   17. Saulius Gražulis
   18. Franz-Josef Meyer-Almes
   19. Jurgita Matulienė
   20. Asta Zubrienė
   21. Virginija Dudutienė
   22. Daumantas Matulis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper reports the synthesis of covalent inhibitors bearing a unique fragment as a protected covalent warhead for irreversible binding to histidine in carbonic anhydrase (CA) enzymes. These findings are important due to the broad utility of the approach for covalent drug discovery applications and could have long-term impacts on related covalent targeting approaches. The data convincingly support the main conclusions of the paper.

   Reviewed by eLife

9. Establishing comprehensive quaternary structural proteomes from genome sequence

   This article has 4 authors:

   1. Edward Alexander Catoiu
   2. Nathan Mih
   3. Maxwell Lu
   4. Bernhard Palsson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important platform for mapping mutation effects onto higher-level protein structural information, addressing a significant gap in current research. While the work is ambitious and incorporates often-overlooked aspects of higher-order structure, the strength of the evidence supporting some results seems incomplete. The quaternary structure modeling appears to underestimate oligomeric proteins compared to previous studies, and the mutation analysis lacks crucial baseline information. Despite these limitations, the method has potential for broader applications and generalization to additional organisms, warranting further development and refinement.

   Reviewed by eLife

10. Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

    This article has 12 authors:

    1. Naidi Sun
    2. Yu-Yo Sun
    3. Rui Cao
    4. Hong-Ru Chen
    5. Yiming Wang
    6. Elizabeth Fugate
    7. Marchelle R Smucker
    8. Yi-Min Kuo
    9. Ellen P Grant
    10. Diana M Lindquist
    11. Chia-Yi Kuan
    12. Song Hu

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is an important study that utilized in vivo optical measurements of the cortical metabolic rate of O2 and blood flow, as well as measurements in isolated mitochondria to assess the uncoupling of the oxidative phosphorylation due to hypoxia-ischemia injury of the neonatal brain, and effects of the hypothermia treatment. The combination of state-of-the-art optical measurements, mitochondrial assays, and the use of various control experiments provides convincing evidence for the derived conclusions. This work will be of interest to those in the mitochrondrial metabolomics, brain injury and hypoxia fields.

    Reviewed by eLife