Latest preprint reviews

  1. Glucocorticoids desensitize hypothalamic CRH neurons to norepinephrine and somatic stress activation via rapid nitrosylation-dependent regulation of α1 adrenoreceptor trafficking

    This article has 8 authors:
    1. Grant L Weiss
    2. Laura M Harrison
    3. Zhiying Jiang
    4. Alyssa M Nielsen
    5. Maximillian S Feygin
    6. Sandy Nguyen
    7. Parker S Tirrell
    8. Jeffrey Tasker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript describes work that is fundamental to our understanding of the mechanism of how stress regulates the noradrenergic system and the CRH system. Using a combination of ex vivo physiology and in vitro methods, the study provides compelling evidence as to the signaling mechanisms of how glucocorticoids impact adrenergic GPCRs in CRH cells via receptor trafficking. While the ex vivo work is specific to the hypothalamus, the mechanisms here could be extrapolated and investigated in other brain regions that may have similar signaling regulation.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Prefrontal working memory signal controls phase-coded information within extrastriate cortex

    This article has 6 authors:
    1. Mohsen Parto-Dezfouli
    2. Isabel Vanegas
    3. Mohammad Zarei
    4. William H Nesse
    5. Kelsey L Clark
    6. Behrad Noudoost
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study investigates how the maintenance of a spatial location in working memory affects the representation of visual information in area V4 of monkeys. As such, it is important not only for understanding vision but also for determining how working memory impacts perceptual signals and their underlying circuits. The data provide convincing evidence of a direct communication between prefrontal circuits that store spatial information and V4, which, under the current experimental conditions, manifests mainly as changes in temporal activity patterns (oscillations).

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  3. An evolutionarily conserved Hox-Gbx segmentation code in the rice coral Montipora capitata

    This article has 9 authors:
    1. Shuonan He
    2. Emma Rangel-Huerta
    3. Eric Hill
    4. Lacey Ellington
    5. Shiyuan (Cynthia) Chen
    6. Sofia Robb
    7. Eva Majerová
    8. Crawford Drury
    9. Matthew C Gibson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors studied the development of mesentery borders in the rice coral Montipora, a new experimental system, to complement existing data from the sea anemone Nematostella. They make a solid case that in Montipora, there is a sequence of Hox-Gbx genes whose staggered expression in the unsegmented larva is suggestive of their role in subdividing the gastric cavity into repeated units bordered by mesenteries, as in the sea anemone Nematostella. Pharmacological experiments also point to the involvement of the BMP pathway in this process, but additional experiments validating this are necessary. This is a valuable contribution to the field of cnidarian evolution, suggesting that BMP- and "Hox-Gbx code"-dependent patterning of the directive axis was ancestral for Anthozoa.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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