eLife

Latest preprint reviews

1. CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

   This article has 3 authors:

   1. Jessie Kulsuptrakul
   2. Michael Emerman
   3. Patrick S Mitchell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this study, the authors investigated whether HIV-1 cell-to-cell transmission activates the CARD8 inflammasome in macrophages. The data convincingly support the idea that CARD8 is activated by the viral protease, promoting inflammation. The study's significance is further enhanced by including time-course analyses in primary T cells and macrophages and provides valuable insights into the role of CARD8 in HIV-induced inflammation.

   Reviewed by eLife

2. Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice

   This article has 8 authors:

   1. Andrés Pablo Varani
   2. Caroline Mailhes-Hamon
   3. Romain W Sala
   4. Marie Sarraudy
   5. Sarah Fouda
   6. Jimena L Frontera
   7. Clément Léna
   8. Daniela Popa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Varani et al present important findings regarding the role of distinct cerebellothalamic connections in motor learning and performance. The evidence supporting the main claims is convincing, with multiple replications, validation of their techniques, and appropriate controls. The work will be of broad interest to neuroscientists interested in central mechanisms of motor learning and control, as well as thalamic physiology.

   Reviewed by eLife

3. Learning and cognition in highspeed decision making

   This article has 3 authors:

   1. Martin Krause
   2. Wolfram Schulze
   3. Stefan Schuster

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study investigates the adaptability of prey capture by archerfish, which hunt insects by spitting at them and then rapidly turning to reach their landing point on the water surface. The results of elaborate behavioral experiments and measurements show that, even though the visuomotor behavior unfolds very rapidly (in less than 100 ms), it is not hardwired and can adapt to different simulated physics and different prey shapes. The data are convincing and should be of relevance to those interested in rapid decision making in general, beyond the archerfish model.

   Reviewed by eLife

4. Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex

   This article has 6 authors:

   1. Sara Jamali
   2. Sophie Bagur
   3. Enora Bremont
   4. Timo Van Kerkoerle
   5. Stanislas Dehaene
   6. Brice Bathellier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of the way neurons in the auditory cortex of mice respond to unpredictable sounds. Through the use of state-of-the-art recording methods, compelling evidence is provided that responses to local and global violations in sound sequences are prediction errors and not simply the consequence of stimulus-specific adaptation. Although the cell-type-specific results are intriguing, further work is needed to establish their reliability.

   Reviewed by eLife

5. Olfactory cortical outputs recruit and shape distinct brain-wide spatiotemporal networks

   This article has 9 authors:

   1. Teng Ma
   2. Xunda Wang
   3. Xuehong Lin
   4. Junjian Wen
   5. Linshan Xie
   6. Pek-Lan Khong
   7. Peng Cao
   8. Ed X Wu
   9. Alex TL Leong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study partially fills the gap in the knowledge of olfaction at the level of the Anterior Olfactory Nucleus (AON) and Piriform Cortex with functional magnetic resonance imaging, electrophysiology, and modeling. The methods used are convincing. Some of the findings confirm ongoing hypotheses, such as the behavioral importance of AON for odor source discrimination. Other results shed light on the dynamics of the connection between the olfactory system and the rest of the brain.

   Reviewed by eLife

6. A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis

   This article has 8 authors:

   1. Michelle Jin
   2. Simon O Ogundare
   3. Marcos Lanio
   4. Sophia Sorid
   5. Alicia Ruth Whye
   6. Sofia Leal Santos
   7. Alessandra Franceschini
   8. Christine Ann Denny

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes methods and software, called SMARTR, to map neuronal networks using markers of neuronal activity. They illustrate their approach using tissue from mice that have undergone behavioral tasks. The reviewers considered the study important to the field and compelling in that the methods and analyses were an advance over current tools.

   Reviewed by eLife

7. Selective attention and sensitivity to auditory disturbances in a virtually real classroom

   This article has 7 authors:

   1. Orel Levy
   2. Shirley Libman Hackmon
   3. Yair Zvilichovsky
   4. Adi Korisky
   5. Aurelie Bidet-Caulet
   6. Julie B Schweitzer
   7. Elana Zion Golumbic

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how AD(H)D affects attention using neural and physiological measures in a Virtual Reality (VR) environment. Solid evidence is provided that individuals diagnosed with AD(H)D differ from control participants in both the encoding of the target sound and the encoding of acoustic interference. The VR paradigm here can potentially bridge lab experiments and real-life experiments. The study is of potential interests to researchers who are interested in auditory cognition, education, and ADHD.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2406.03212v1

9. Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

   This article has 6 authors:

   1. Yiting Deng
   2. Yuanhang He
   3. Juan Xu
   4. Haoting He
   5. Manling Zhang
   6. Guang Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a comprehensive analysis of gene expression and bioinformatics data, offering important insights into the roles of fibroblasts in cardiac development. The large and well-analyzed single-cell RNA sequencing (scRNA-seq) dataset is compelling and a significant contribution to the field, and will be of broad interest to the scientific community.

   Reviewed by eLife

10. Repeated activation of preoptic area recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states

    This article has 3 authors:

    1. Zhiping Cao
    2. Wing-Ho Yung
    3. Ya Ke

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study identifies one way in which episodic heat exposure can result in negative changes in motivated and affective behaviors. This work positively expands the field of thermoregulation. The data were collected using a myriad of next-generation approaches, including extensive behavior testing, thermal monitoring, electrophysiology, circuit mapping, and manipulations. There is convincing evidence that neurons of the paraventricular thalamus change plastically over three weeks of episodic heat stimulation this affects behavioral outputs such as social interactions and anxiety-related behavior. Conclusions regarding the specificity of the POA-pPVT pathway compared to other inputs to the PVT in the control of observed effects would benefit from further validation. The study will be of interest to behavioral neuroscientists, climate/environmental biologists, and pre-clinical neuropsychiatrists.

    Reviewed by eLife