Latest preprint reviews

  1. Probing the force-from-lipid mechanism with synthetic polymers

    This article has 9 authors:
    1. Miranda L Jacobs
    2. Jan Steinkühler
    3. Audra Lemley
    4. Megan J Larmore
    5. Taylor F Gunnels
    6. Leo CT Ng
    7. Stephanie M Cologna
    8. Paul G DeCaen
    9. Neha P Kamat
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Gating of mechanosensitive channels has been explained by the force-from-lipids model in which mechanical coupling of the channel protein to the plasma membrane transfers force from membrane tension to open the channel. In this important manuscript, the authors provide evidence for this mechanism in two different mechanically gated channels. The experiments were carried out in the same membranes, but the evidence is incomplete without a clear explanation of the relationship between measured mechanical parameters and membrane interfacial tension.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Mitochondrial metabolism in Drosophila macrophage-like cells regulates body growth via modulation of cytokine and insulin signaling

    This article has 5 authors:
    1. Shrivani Sriskanthadevan-Pirahas
    2. Abdul Qadeer Tinwala
    3. Michael J Turingan
    4. Shahoon Khan
    5. Savraj S Grewal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental work demonstrates that compartmentalized cellular metabolism is a dominant input into cell size control in a variety of mammalian cell types and in Drosophila. The authors show that increased pyruvate import into the mitochondria in liver-like cells and in primary hepatocytes drives gluconeogenesis but reduces cellular amino acid production, suppressing protein synthesis. The evidence supporting the conclusions is compelling, with a variety of genetic and pharmacologic assays rigorously testing each step of the proposed mechanism. This work will be of interest to cell biologists, physiologists, and researchers interested in cell metabolism, and is significant because stem cells and many cancers exhibit metabolic rewiring of pyruvate metabolism.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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