eLife

Latest preprint reviews

1. Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

   This article has 9 authors:

   1. Javier Ruiz-Navarro
   2. Sara Fernández-Hermira
   3. Irene Sanz-Fernández
   4. Pablo Barbeito
   5. Alfonso Navarro-Zapata
   6. Antonio Pérez-Martínez
   7. Francesc R Garcia-Gonzalo
   8. Víctor Calvo
   9. Manuel Izquierdo Pastor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses the Jurkat T cell model to study the role of Formin-like 1 β phosphorylation at S1086 on actin dynamics and exosome release at the immunological synapse. The evidence supporting these findings is compelling within the framework of the Jurkat model. As the Jurkat model is known to have a bias toward formin-mediated actin filament formation at the expense of Arp2/3-mediated branched F-actin foci observed in primary T cells, it will be beneficial in the future to confirm major findings in primary T cells.

   Reviewed by eLife

2. The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

   This article has 12 authors:

   1. Julia Peukes
   2. Charlie Lovatt
   3. Conny Leistner
   4. Jerome Boulanger
   5. Dustin R Morado
   6. Martin JG Fuller
   7. Wanda Kukulski
   8. Fei Zhu
   9. Noboru H Komiyama
   10. John AG Briggs
   11. Seth GN Grant
   12. René AW Frank

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Peukes et al. report compelling ultrastructures of excitatory synapses in the mouse forebrain that will serve as a reference for future work in the field. Their important findings using correlated fluorescence and cryo-electron tomography challenge the textbook view of synaptic structure that emerged from chemically fixed and metal-stained tissues. Instead of a post-synaptic density, these authors reveal the architecture of the cytoskeletal, neurotransmitter receptor clusters, and organelles in the 'synaptoplasm'.

   Reviewed by eLife

3. Desmodium volatiles in ‘push-pull’ cropping systems and protection against the fall armyworm, Spodoptera frugiperda

   This article has 8 authors:

   1. Daria M Odermatt
   2. Frank Chidawanyika
   3. Daniel M Mutyambai
   4. Bernhard Schmid
   5. Luiz A Domeignoz Horta
   6. Collins O Onjura
   7. Amanuel Tamiru
   8. Meredith C Schuman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Research on push-pull systems has often focused on controlled environments, leaving significant gaps in our understanding of how these systems function under real-world conditions. This important and solid study makes a substantial contribution by investigating the volatile emissions and behavioral effects of Desmodium in natural and semi-field contexts which offer insights of broad interest for sustainable agriculture and pest management. While the authors rightly acknowledge some remaining limitations, the revised manuscript now provides a well-supported and transparent assessment of the ecological role of Desmodium volatiles in push-pull systems.

   Reviewed by eLife

4. Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

   This article has 13 authors:

   1. Nicole Foxworth
   2. Julie Wells
   3. Sara Ocaña-Lopez
   4. Sandrine Muller
   5. Pooja Bhayani
   6. James Denegre
   7. Kristina Palmer
   8. Wendy Memishian
   9. Teresa McGee
   10. Steven A Murray
   11. Patricia K Donahoe
   12. Carol J Bult
   13. Maria Loscertales

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important piece of work that sheds light on our understanding of early lung development. There is solid evidence that there is a key new role for Svep1, which may be acting via FGF9. A more precise understanding of the interactions between Svep1 and FGF9, with a possibility of other ECM factors, would add value.

   Reviewed by eLife

5. Ventral Morphology and Ecological Implications of Cindarella eucalla (Artiopoda, Xandarellida) from Chengjiang Biota, China

   This article has 5 authors:

   1. Maoyin Zhang
   2. Yu Liu
   3. Huijuan Mai
   4. Michel Schmidt
   5. Xianguang Hou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents a very well-illustrated specimens of the artiopodan Cindarella eucalla from the Chengjiang Biota, using computer tomography (CT) scanning to illustrate multiple specimens with preserved appendages, a rarity in artiopodans. The description of these fossils is important for expanding our understanding of this taxon and its relatives. The imaging and morphological description are followed by a discussion of how this morphology relates to other Cambrian arthropods and its potential ecological function. The evidence provided in this section about resulting function and ecology is presently incomplete and the conclusions are put forward too strongly. This assessment could be improved if the work is revised with more careful wording and additional data.

   Reviewed by eLife

6. Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen

   This article has 8 authors:

   1. Aryeh Solomon
   2. Noa Bossel Ben-Moshe
   3. Dotan Hoffman
   4. Sébastien Trzebanski
   5. Dror Yehezkel
   6. Leia Vainman
   7. Mihai G Netea
   8. Roi Avraham

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of the contribution of tissue-resident immune cells to trained immunity phenotypes. The evidence supporting the claims is convincing, with results that will be of interest to immunologists and scientists studying the host-pathogen interface.

   Reviewed by eLife

7. Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

   This article has 10 authors:

   1. Sophie Debaenst
   2. Tamara Jarayseh
   3. Hanna De Saffel
   4. Jan Willem Bek
   5. Matthieu Boone
   6. Ivan Josipovic
   7. Pierre Kibleur
   8. Ronald Y Kwon
   9. Paul J Coucke
   10. Andy Willaert

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The paper presents a streamlined new approach for functional validation of genes known to underlie fragile bone disorders in a relatively high throughput, using CRISPR-mediated knockouts and a number of phenotypic assessments in zebrafish. Convincing data demonstrate the feasibility and validity of this approach, which presents an important tool for rapid functional validation of candidate gene(s) associated with heritable bone diseases identified from genetic studies.

   Reviewed by eLife

8. ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation

   This article has 8 authors:

   1. Qi Zeng
   2. Chen Yao
   3. Shimeng Zhang
   4. Yizhi Mao
   5. Jing Wang
   6. Ziyang Wang
   7. Chunjie Sheng
   8. Shuai Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses. The evidence is convincing, with well-executed mechanistic experiments and in vivo validation in syngeneic tumor models. These findings have significant implications for cancer immunotherapy, highlighting ORMDL3 as a potential therapeutic target.

   Reviewed by eLife

9. A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

   This article has 20 authors:

   1. Yuji Miyatake
   2. Takeshi Kamakura
   3. Tomokatsu Ikawa
   4. Ryo Yanagiya
   5. Ryutaro Kotaki
   6. Kazuaki Kameda
   7. Ryo Koyama Nasu
   8. Kazuki Okuyama
   9. Ken-ichi Hirano
   10. Hiroyuki Hosokawa
   11. Katsuto Hozumi
   12. Masato Ohtsuka
   13. Takahiro Kisikawa
   14. Chikako Shibata
   15. Motoyuki Otsuka
   16. Reo Maruyama
   17. Kiyoshi Ando
   18. Tomohiro Kurosaki
   19. Hiroshi Kawamoto
   20. Ai Kotani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study reports that the exogenous expression of the microRNA miR-195 can partially compensate in early B cell development for the loss of EBF1, one of the key transcription factors in B cells. While this finding will be of interest to those studying lymphocyte development, the evidence, particularly with regard to the molecular mechanisms that underpin the effect of miR-195, is currently incomplete.

   Reviewed by eLife

10. Evolution of novel mimicry polymorphisms through Haldane’s sieve and rare recombination

    This article has 5 authors:

    1. Riddhi Deshmukh
    2. Saurav Baral
    3. Athulya Girish Kizhakke
    4. Muktai Kuwalekar
    5. Krushnamegh Kunte

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study provides new and nuanced insights into the evolution of morphs in a textbook example of Batesian mimicry. The evidence supporting the claims about the origin and dominance relationships among morphs is convincing, but the interpretation of signals needs improvement with complementary analysis and some nuanced interpretation. Pending a revision, this work will be of interest to a broad range of evolutionary biologists.

    Reviewed by eLife