eLife

Latest preprint reviews

1. A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis

   This article has 8 authors:

   1. Michelle Jin
   2. Simon O Ogundare
   3. Marcos Lanio
   4. Sophia Sorid
   5. Alicia Ruth Whye
   6. Sofia Leal Santos
   7. Alessandra Franceschini
   8. Christine Ann Denny

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes methods and software, called SMARTR, to map neuronal networks using markers of neuronal activity. They illustrate their approach using tissue from mice that have undergone behavioral tasks. The reviewers considered the study important to the field and compelling in that the methods and analyses were an advance over current tools.

   Reviewed by eLife

2. Selective attention and sensitivity to auditory disturbances in a virtually real classroom

   This article has 7 authors:

   1. Orel Levy
   2. Shirley Libman Hackmon
   3. Yair Zvilichovsky
   4. Adi Korisky
   5. Aurelie Bidet-Caulet
   6. Julie B Schweitzer
   7. Elana Zion Golumbic

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how AD(H)D affects attention using neural and physiological measures in a Virtual Reality (VR) environment. Solid evidence is provided that individuals diagnosed with AD(H)D differ from control participants in both the encoding of the target sound and the encoding of acoustic interference. The VR paradigm here can potentially bridge lab experiments and real-life experiments. The study is of potential interests to researchers who are interested in auditory cognition, education, and ADHD.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2406.03212v1

4. Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

   This article has 6 authors:

   1. Yiting Deng
   2. Yuanhang He
   3. Juan Xu
   4. Haoting He
   5. Manling Zhang
   6. Guang Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a comprehensive analysis of gene expression and bioinformatics data, offering important insights into the roles of fibroblasts in cardiac development. The large and well-analyzed single-cell RNA sequencing (scRNA-seq) dataset is compelling and a significant contribution to the field, and will be of broad interest to the scientific community.

   Reviewed by eLife

5. Repeated activation of preoptic area recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states

   This article has 3 authors:

   1. Zhiping Cao
   2. Wing-Ho Yung
   3. Ya Ke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies one way in which episodic heat exposure can result in negative changes in motivated and affective behaviors. This work positively expands the field of thermoregulation. The data were collected using a myriad of next-generation approaches, including extensive behavior testing, thermal monitoring, electrophysiology, circuit mapping, and manipulations. There is convincing evidence that neurons of the paraventricular thalamus change plastically over three weeks of episodic heat stimulation this affects behavioral outputs such as social interactions and anxiety-related behavior. Conclusions regarding the specificity of the POA-pPVT pathway compared to other inputs to the PVT in the control of observed effects would benefit from further validation. The study will be of interest to behavioral neuroscientists, climate/environmental biologists, and pre-clinical neuropsychiatrists.

   Reviewed by eLife

6. Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)

   This article has 42 authors:

   1. James B Isbister
   2. András Ecker
   3. Christoph Pokorny
   4. Sirio Bolaños-Puchet
   5. Daniela Egas Santander
   6. Alexis Arnaudon
   7. Omar Awile
   8. Barros-Zulaica Natali
   9. Jorge Blanco Alonso
   10. Elvis Boci
   11. Giuseppe Chindemi
   12. Jean-Denis Courcol
   13. Tanguy Damart
   14. Thomas Delemontex
   15. Alexander Dietz
   16. Gianluca Ficarelli
   17. Mike Gevaert
   18. Joni Herttuainen
   19. Genrich Ivaska
   20. Weina Ji
   21. Daniel Keller
   22. James King
   23. Pramod Kumbhar
   24. Samuel Lapere
   25. Polina Litvak
   26. Darshan Mandge
   27. Eilif B Muller
   28. Fernando Pereira
   29. Judit Planas
   30. Rajnish Ranjan
   31. Maria Reva
   32. Armando Romani
   33. Christian Rössert
   34. Felix Schürmann
   35. Vishal Sood
   36. Aleksandra Teska
   37. Anil Tuncel
   38. Werner Van Geit
   39. Matthias Wolf
   40. Henry Markram
   41. Srikanth Ramaswamy
   42. Michael W Reimann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports a model of 8 somatosensory areas of the rat cortex consisting of 4.2 million morphologically and electrically detailed neurons. The authors carry out simulation experiments aimed at understanding how multiscale organization of the cortical network shapes neural activity. While the reviewers found the results to be solid, they note that they could have likely been obtained using a much smaller portion of the model. Nonetheless, the release of the modeling platform represents a significant contribution to the field by providing a valuable resource for the scientific community.

   Reviewed by eLife

7. Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

   This article has 13 authors:

   1. András Ecker
   2. Daniela Egas Santander
   3. Marwan Abdellah
   4. Jorge Blanco Alonso
   5. Sirio Bolaños-Puchet
   6. Giuseppe Chindemi
   7. Dhuruva Priyan Gowri Mariyappan
   8. James B Isbister
   9. James King
   10. Pramod Kumbhar
   11. Ioannis Magkanaris
   12. Eilif B Muller
   13. Michael W Reimann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents a biologically realistic, large-scale cortical model of the rat's non-barrel somatosensory cortex, investigating synaptic plasticity of excitatory connections under varying patterns of external activations and characterizing relations between network architecture and plasticity outcomes. The model offers an impressive level of biological detail, addressing many aspects of the cellular and network anatomy and properties, and investigating their relationships to the biologically plausible plasticity. The numerical simulations appear to be well executed and documented, providing an excellent resource to the community. The evidence supporting the main conclusions is solid with results being more observational in nature, and minor weaknesses relating to the lack of explanatory power of causal relationships and mechanisms.

   Reviewed by eLife

8. Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

   This article has 11 authors:

   1. Tony Marchand
   2. Kemi E Akinnola
   3. Shoichiro Takeishi
   4. Maria Maryanovich
   5. Sandra Pinho
   6. Julien Saint-Vanne
   7. Alexander Birbrair
   8. Thierry Lamy
   9. Karin Tarte
   10. Paul Frenette
   11. Kira Gritsman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents valuable insights into the role of periosteal stem cells in bone marrow regeneration. The evidence is convincing. The data broadly support their claims and in line with state-of-art methodology. Future study on their model will help to strengthen their discovery further.

   Reviewed by eLife

9. Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

   This article has 3 authors:

   1. Benedikt M Mortzfeld
   2. Shakti K Bhattarai
   3. Vanni Bucci

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important advances in the discovery and assessment of microcins that improve our understanding of their prevalence and roles. The bioinformatics analysis, expression, and antimicrobial assays are solid, although the diverging evaluations also indicated the need for additional support regarding the sequence analysis and validation to fully back some of the claims and conclusions. This study will appeal to researchers working on the discovery and analysis of novel peptide natural products.

   Reviewed by eLife

10. Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

    This article has 4 authors:

    1. Chinmaya Jena
    2. Saillesh Chinnaraj
    3. Soham Deolankar
    4. Nishad Matange

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study explores the interplay between gene dosage and gene mutations in the evolution of antibiotic resistance. The authors provide compelling evidence connecting proteostasis with gene duplication during experimental evolution in a model system. This paper is likely to be of interest to researchers studying antibiotic resistance, proteostasis, and bacterial evolution.

    Reviewed by eLife