eLife

Latest preprint reviews

1. BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

   This article has 13 authors:

   1. Emilio Rios-Jimenez
   2. Anoek Zomer
   3. Raphael Collot
   4. Mario Barrera Román
   5. Sandra F Archidona
   6. Hendrikus Ariese
   7. Ravian van Ineveld
   8. Michiel Kleinnijenhuis
   9. Nils Bessler
   10. Hannah Johnson
   11. Caleb A Dawson
   12. Anne Rios
   13. Maria Alieva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful tool for code-less analysis of patterns in cell migratory behaviours in vivo using intravital microscopy data and allows correlation with spatial features of the tumour microenvironment. There is a clear need for these tools to make quantitative analysis, comparison and interpretation of complex cell tracking data more accessible and solid evidence is provided of its applicability to tracks generated by both proprietary and open tracking software.

   Reviewed by eLife

2. N6-methyladenosine in DNA promotes genome stability

   This article has 16 authors:

   1. Brooke A Conti
   2. Leo Novikov
   3. Deyan Tong
   4. Qing Xiang
   5. Savon Vigil
   6. Thomas J McLellan
   7. Chuong Nguyen
   8. Nancy De La Cruz
   9. Reshma T Veettil
   10. Prashant Pradhan
   11. Parag Sahasrabudhe
   12. Jason D Arroyo
   13. Lei Shang
   14. Benjamin R Sabari
   15. David J Shields
   16. Mariano Oppikofer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports important findings that the methyltransferase METTL3 is involved in the repair of abasic sites and uracil in DNA, mediating resistance to floxuridine-driven cytotoxicity. The presented evidence is conclusive for the involvement of m6A in DNA involving single cell imaging and mass spectrometry data. The authors present convincing evidence that the m6A signal does not result from bacterial contamination or RNA.

   Reviewed by eLife

3. Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

   This article has 6 authors:

   1. Mehmet Mahsum Kaplan
   2. Erika Hudacova
   3. Miroslav Matejcek
   4. Haneen Tuaima
   5. Jan Křivánek
   6. Ondrej Machon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insight into the role of Meis2 in whisker hair follicle formation and confirms prior work that nerves are dispensable for this process. The solid imaging techniques support the authors' conclusions, however the data provides limited evidence to support the mechanism of Meis2 in whisker formation.

   Reviewed by eLife

4. Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

   This article has 9 authors:

   1. Cheryll M Sia
   2. Rebecca L Ambrose
   3. Mary Valcanis
   4. Patiyan Andersson
   5. Susan A Ballard
   6. Benjamin P Howden
   7. Deborah A Williamson
   8. Jaclyn S Pearson
   9. Danielle J Ingle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides the most comprehensive analysis of Salmonella Dublin to date, uncovering distinct genotypic adaptations, antimicrobial resistance patterns, and virulence strategies that influence epidemiological success. The revised manuscript is very valuable, rigorous and compelling.

   Reviewed by eLife

5. Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

   This article has 10 authors:

   1. Marketa Jirouskova
   2. Karel Harant
   3. Pavel Cejnar
   4. Srikant Ojha
   5. Katerina Korelova
   6. Lenka Sarnova
   7. Eva Sticova
   8. Christoph H Mayr
   9. Herbert B Schiller
   10. Martin Gregor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study suggests that the composition of the extracellular matrix in a mouse model of liver fibrosis changes depending on the cause of liver fibrosis. The data could be used as a foundation for future antifibrotic therapies. The strength of evidence is convincing with respect to the use of animal models and proteomic analysis. The study provides a helpful inventory of proteins up or down-regulated.

   Reviewed by eLife

6. CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

   This article has 3 authors:

   1. Jessie Kulsuptrakul
   2. Michael Emerman
   3. Patrick S Mitchell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this study, the authors investigated whether HIV-1 cell-to-cell transmission activates the CARD8 inflammasome in macrophages. The data convincingly support the idea that CARD8 is activated by the viral protease, promoting inflammation. The study's significance is further enhanced by including time-course analyses in primary T cells and macrophages and provides valuable insights into the role of CARD8 in HIV-induced inflammation.

   Reviewed by eLife

7. Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice

   This article has 8 authors:

   1. Andrés Pablo Varani
   2. Caroline Mailhes-Hamon
   3. Romain W Sala
   4. Marie Sarraudy
   5. Sarah Fouda
   6. Jimena L Frontera
   7. Clément Léna
   8. Daniela Popa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Varani et al present important findings regarding the role of distinct cerebellothalamic connections in motor learning and performance. The evidence supporting the main claims is convincing, with multiple replications, validation of their techniques, and appropriate controls. The work will be of broad interest to neuroscientists interested in central mechanisms of motor learning and control, as well as thalamic physiology.

   Reviewed by eLife

8. Learning and cognition in highspeed decision making

   This article has 3 authors:

   1. Martin Krause
   2. Wolfram Schulze
   3. Stefan Schuster

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study investigates the adaptability of prey capture by archerfish, which hunt insects by spitting at them and then rapidly turning to reach their landing point on the water surface. The results of elaborate behavioral experiments and measurements show that, even though the visuomotor behavior unfolds very rapidly (in less than 100 ms), it is not hardwired and can adapt to different simulated physics and different prey shapes. The data are convincing and should be of relevance to those interested in rapid decision making in general, beyond the archerfish model.

   Reviewed by eLife

9. Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex

   This article has 6 authors:

   1. Sara Jamali
   2. Sophie Bagur
   3. Enora Bremont
   4. Timo Van Kerkoerle
   5. Stanislas Dehaene
   6. Brice Bathellier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of the way neurons in the auditory cortex of mice respond to unpredictable sounds. Through the use of state-of-the-art recording methods, compelling evidence is provided that responses to local and global violations in sound sequences are prediction errors and not simply the consequence of stimulus-specific adaptation. Although the cell-type-specific results are intriguing, further work is needed to establish their reliability.

   Reviewed by eLife

10. Olfactory cortical outputs recruit and shape distinct brain-wide spatiotemporal networks

    This article has 9 authors:

    1. Teng Ma
    2. Xunda Wang
    3. Xuehong Lin
    4. Junjian Wen
    5. Linshan Xie
    6. Pek-Lan Khong
    7. Peng Cao
    8. Ed X Wu
    9. Alex TL Leong

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study partially fills the gap in the knowledge of olfaction at the level of the Anterior Olfactory Nucleus (AON) and Piriform Cortex with functional magnetic resonance imaging, electrophysiology, and modeling. The methods used are convincing. Some of the findings confirm ongoing hypotheses, such as the behavioral importance of AON for odor source discrimination. Other results shed light on the dynamics of the connection between the olfactory system and the rest of the brain.

    Reviewed by eLife