eLife

Latest preprint reviews

1. Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

   This article has 12 authors:

   1. Ana Catarina Costa
   2. Blanca R Murillo
   3. Rita Bessa
   4. Ricardo Ribeiro
   5. Tiago Ferreira da Silva
   6. Patrícia Porfírio-Rodrigues
   7. Gabriel G Martins
   8. Pedro Brites
   9. Matthias Kneussel
   10. Thomas Misgeld
   11. Monika S Brill
   12. Monica M Sousa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In their important manuscript, Costa et al. establish an in vitro model for dorsal root ganglion (DRG) axonal asymmetry, revealing that central and peripheral axon branches have distinct patterns of microtubule populations that are linked to their differential regenerative capacities. The authors employ creative tissue culture methods to demonstrate how these branches develop uniquely in vitro, offering a potential explanation for long-observed regeneration disparities. The convincing evidence provides a contribution to our understanding of the neuronal cytoskeleton and axonal regeneration.

   Reviewed by eLife

2. A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus

   This article has 15 authors:

   1. Marcel Rühling
   2. Fabio Schmelz
   3. Kim Ulbrich
   4. Fabian Schumacher
   5. Julia Wolf
   6. Maximilian Pfefferle
   7. Magdalena Priester
   8. Adriana Moldovan
   9. Nadine Knoch
   10. Andreas Iwanowitsch
   11. Christian Kappe
   12. Kerstin Paprotka
   13. Burkhard Kleuser
   14. Christoph Arenz
   15. Martin J Fraunholz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study proposes a novel rapid-entry mechanism for Staphylococcus aureus, involving the rapid release of calcium from lysosomes. The paper's strength lies in its very interesting hypothesis. The methods used are solid and adequately support the conclusions.

   Reviewed by eLife

3. Still waters run deep in large-scale genome rearrangements of morphologically conservative Polyplacophora

   This article has 5 authors:

   1. Julia D Sigwart
   2. Yunlong Li
   3. Zeyuan Chen
   4. Katarzyna Vončina
   5. Jin Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of genome annotations for chiton genomes. It provides a solid estimation of syntentic relationships for the chromosomes of the four new genomes plus an analysis linking these to other available chiton genomes, and an update for how these relate to molluscan genomes.

   Reviewed by eLife

4. The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

   This article has 9 authors:

   1. Haibin Liu
   2. Lulu Yu
   3. Vladimir Majerciak
   4. Thomas J Meyer
   5. Ming Yi
   6. Peter F Johnson
   7. Maggie Cam
   8. Douglas R Lowy
   9. Zhi-Ming Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports important new insights into the roles of a long noncoding RNA, lnc-FANCI-2, in the progression of cervical cancer induced by a type of human papillomavirus. Through a blend of cell biological, biochemical, and genetic analyses of RNA and protein expression, protein-protein interaction, cell signaling, and cell morphology, the authors provide convincing evidence that lnc-FANCI-2 affects cervical cancer outcome by regulating the RAS signaling pathway. These findings will be of interest to scientists in the fields of cervical cancer, long noncoding RNA, and cell signaling.

   Reviewed by eLife

5. Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

   This article has 12 authors:

   1. Yanbin Wang
   2. Yuqi Wu
   3. Hong Zhang
   4. Xinyue Liu
   5. Jing Ling
   6. Xiao Zhou
   7. Anping Song
   8. Li Sun
   9. Hong Qiu
   10. Xianglin Yuan
   11. Hua Xiong
   12. Yanmei Zou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important revised manuscript presents compelling findings by delineating two molecularly distinct liver cancer subtypes through comprehensive multi-omics integration and constructing a rigorously validated prognostic model. The authors have strengthened the analytical framework and validation across multiple datasets, including single-cell RNA sequencing. The evidence remains robust, with enhanced methodological clarity and expanded validation in both internal and independent cohorts. The revisions have improved the study's rigor and translational relevance.

   Reviewed by eLife

6. Atomic-Level Free Energy Landscape Reveals Cooperative Symport Mechanism of Melibiose Transporter

   This article has 2 authors:

   1. Ruibin Liang
   2. Lan Guan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this potentially important study, the authors employed advanced computational techniques to explore a detailed atomistic description of the mechanism and energetics of substrate translocation in the MelB transporter. The overall approach is solid and reveals the coupling between sodium binding and melibiose transport through a series of conformational transitions, and the results for a mutant are also in qualitative agreement with the experiment, providing further support to the computational analyses. Nevertheless, the level of evidence is considered incomplete since there are concerns regarding the convergence and initial guess of the string calculations, leaving doubts that the computed pathway does not reflect the most energetically favorable mechanism.

   Reviewed by eLife

7. Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia

   This article has 8 authors:

   1. Marc-Antoine Guery
   2. Sukai Ceesay
   3. Sainabou Drammeh
   4. Fatou K Jaiteh
   5. Umberto D'Alessandro
   6. Teun Bousema
   7. David J Conway
   8. Antoine Claessens

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This article presents a valuable genetic spatio-temporal analysis of malaria-infected individuals from four villages in a highly seasonal transmission setting in The Gambia, covering the period between December 2014 and May 2017. Evidence generated by the study's laboratory and data processing approaches is solid and helps to advance the understanding of malaria in The Gambia, particularly due to its longitudinal design and the inclusion of asymptomatic cases.

   Reviewed by eLife

8. Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

   This article has 13 authors:

   1. M Reza Bahranifard
   2. Jessica Chan
   3. A Thomas Read
   4. Guorong Li
   5. Lin Cheng
   6. Babak N Safa
   7. Seyed Mohammad Siadat
   8. Anamik Jhunjhunwala
   9. Hans E Grossniklaus
   10. Stanislav Y Emelianov
   11. W Daniel Stamer
   12. Markus H Kuehn
   13. C Ross Ethier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study has fundamental findings that support the potential application of exogenous stem cell therapy as a viable therapeutic option for the management of intraocular pressure (IOP) and to increase outflow facility. The evidence supporting the clinical application of stem cells is compelling, using a combination of established in vivo and ex vivo experimental techniques. The work will be of interest to both basic stem cell biologists and clinical glaucoma specialists.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/kt7dm

10. Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening

    This article has 7 authors:

    1. Deb Sankar Banerjee
    2. Tafadzwa Chigumira
    3. Rachel M Lackner
    4. Josiah C Kratz
    5. David M Chenoweth
    6. Shiladitya Banerjee
    7. Huaiying Zhang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this potentially valuable study, the authors employed in vivo experiments and theoretical modeling to study the growth dynamics of nuclear condensates. They observed that condensates can exhibit distinct growth modes, as dictated by the competition between condensate surface tension and local elasticity of chromatin. While the theoretical model appears to capture the experimental observations, the level of evidence supporting the proposed growth mechanism is incomplete due to, among other limitations, the multiple fitting parameters and poorly justified Neo-Hookean elasticity.

    Reviewed by eLife