Latest preprint reviews

  1. Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis

    This article has 4 authors:
    1. Nicholas A Dillon
    2. Elise A Lamont
    3. Muzafar A Rather
    4. Anthony D Baughn
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reports important advances in understanding how pyrazinamide, a first-line antibiotic for tuberculosis treatment, is effective in vivo. The experimental design and data provide solid evidence that the production of reactive oxygen species by host cells contributes to how pyrazinamide is more potent in the host than in culture conditions; however, additional experiments and controls would strengthen these conclusions. This work is of interest to the antibiotic drug development field.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Clonal analysis of murine HSC self-renewal and differentiation in native hematopoiesis

    This article has 4 authors:
    1. Chenyu You
    2. Zhen Zhang
    3. Li Lin
    4. Jianlong Sun
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      You et al. present an important study that applied a high-resolution transposon-based barcoding system to show the clonal contribution of hematopoietic stem and progenitor cells during aging, after 5-FU treatment, and upon transplantation. The results are convincing and show that there are different categories of multipotent progenitors that are either active or indolent, and that long-term fates are dominated by clones that either favor differentiation or self-renewal. This study will be of broad interest to stem-cell biologists and could reach an even wider audience with a clearer and more concise presentation and discussion of the results.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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