Latest preprint reviews

  1. Variation of malaria dynamics and its relationship to climate in western Kenya during 2008-2019: a wavelet approach

    This article has 10 authors:
    1. Alexis Martin-Makowka
    2. Bryan O Nyawanda
    3. Anton Beloconi
    4. Godfrey Bigogo
    5. Sammy Khagayi
    6. Stephen Munga
    7. Patrick K Munywoki
    8. Ina Danquah
    9. Jürg Utzinger
    10. Penelope Vounatsou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript presents a useful analysis of the relationship between climate variables and malaria incidence, for local temperature and rainfall and the global climate driver of ENSO from 2008 to 2019 in a lowland region of East Africa, with wavelet analyses and linear regressions after time series decomposition. The paper is convincing albeit not novel in its application of wavelets to the analysis of this type of time series data for a vector-borne infection. It is less persuasive on what is learned about the role of climate variability (non-seasonal climate effects), and it is also unclear how the analysis informs climate change and malaria, and this motivation for the work is not warranted as it pertains to longer time scales than those considered. The work should be better placed in the context of what is known for malaria in East Africa and in different transmission settings.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. A dual ribosomal system in the zebrafish soma and germline

    This article has 8 authors:
    1. Arish N Shah
    2. Friederike Leesch
    3. Laura Lorenzo-Orts
    4. Lorenz Grundmann
    5. Maria Novatchkova
    6. David Haselbach
    7. Eliezer Calo
    8. Andrea Pauli
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Shah and colleagues take advantage of the presence of maternal and somatic ribosomes in zebrafish and confirm their differential expression during development. The authors convincingly show that ribosomes previously found expressed during oogenesis are also expressed in primordial germ cells and that hybrid maternal and somatic ribosomes are formed during development. The question of ribosome heterogeneity, the expression and function of maternal versus somatically provided ribosomes are of broad interest and this fundamental work sets new directions for future functional studies of this interesting phenomenon.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Efficient coding explains neural response homeostasis and stimulus-specific adaptation

    This article has 2 authors:
    1. Edward James Young
    2. Yashar Ahmadian
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work derives a valuable general theory unifying theories of efficient information transmission in the brain with population homeostasis. The general theory provides an explanation for firing rate homeostasis at the level of neural clusters with firing rate heterogeneity within clusters. Applying this theory to the primary visual cortex, the authors present solid evidence that accounts for stimulus-specific and neuron-specific adaptation. Reviewers have provided additional suggestions for improving the readability of the manuscript, as well as discussing previous results on adapting coding as well as those aspects of experimental data that are not fully explained by the present theory.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling

    This article has 2 authors:
    1. Da Guo
    2. Marylka Yoe Uusisaari
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a valuable study, tackling the long-standing issue of the difficulty in imaging the inferior olive and addressing the most relevant questions with a rigorous approach. The technological advance allowed the authors to generate solid experimental evidence with high-quality data. The results are presented clearly and the analyses are rigorous.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain

    This article has 14 authors:
    1. Rubina Dad
    2. Yujuan Wang
    3. Chuyu Fang
    4. Yuncan Chen
    5. Yi Zheng
    6. Yuan Zhang
    7. Xinwen Pan
    8. Xinyue Zhang
    9. Emily Swanekamp
    10. Krish Patel
    11. Matthias TF Wolf
    12. Zhiguang Yuchi
    13. Xueliang Zhu
    14. Hui-Yuan Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors developed a new Agbl5 KO allele, extending the deletion to the N-terminus of CCP5 to explore its function in mouse ependymal cells and trachea. They show that the KO mice exhibit severe hydrocephalus due to mislocated basal bodies and impaired ciliary beating. The findings are valuable with implications in the subfield of cell biology. The evidence is solid in that the methods, data and analyses largely support the claims with only a few remaining weaknesses.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
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