eLife

Latest preprint reviews

1. B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size

   This article has 9 authors:

   1. Sung Hoon Cho
   2. Marissa A Jones
   3. Kaylor Meyer
   4. David M Anderson
   5. Sergiy Chetyrkin
   6. M Wade Calcutt
   7. Richard M Caprioli
   8. Clay F Semenkovich
   9. Mark R Boothby

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides useful insights into the ways in which germinal center B cell metabolism, particularly lipid metabolism, affects cellular responses. The authors use sophisticated mouse models to convincingly demonstrate that ether lipids are relevant for B cell homeostasis and efficient humoral responses. The authors then conducted in vivo as well as in vitro experiments, thereby strengthening their conclusions.

   Reviewed by eLife

2. Humans adapt rationally to approximate estimates of uncertainty

   This article has 2 authors:

   1. Erdem Pulcu
   2. Michael Browning

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study makes an important contribution by showing that humans adapt learning rates rationally to environmental volatility yet systematically misattribute noise as volatility, demonstrating approximate rationality with simplified internal models. The evidence is compelling, encompassing a cleverly designed volatility-versus-noise paradigm, innovative lesion-based comparisons between reinforcement-learning and degraded Bayesian Observer Models, and convergent behavioural and pupillometric data. Expanding formal model comparisons (e.g., BIC/AIC) and directly contrasting RL and Bayesian fits to physiological markers would further enhance the work, but these are minor limitations that do not detract from the core findings.

   Reviewed by eLife

3. Canonical neurodevelopmental trajectories of structural and functional manifolds

   This article has 6 authors:

   1. Alicja Monaghan
   2. Richard AI Bethlehem
   3. Danyal Akarca
   4. Daniel S Margulies
   5. the CALM Team
   6. Duncan E Astle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides insights into the neurodevelopmental trajectories of structural and functional connectivity gradients in the human brain and their potential associations with behaviour and psychopathology. The evidence supporting the findings is solid. This study will be of interest to neuroscientists interested in understanding functional connectivity across development.

   Reviewed by eLife

4. Sex-specific behavioral and thalamo-accumbal circuit adaptations after oxycodone abstinence

   This article has 10 authors:

   1. Yanaira Alonso-Caraballo
   2. Yan Li
   3. Nicholas J Constantino
   4. Megan A Neal
   5. Gillian S Driscoll
   6. Yunona Manasian
   7. Grace K Cai
   8. Maria Mavrikaki
   9. Vadim Y Bolshakov
   10. Elena H Chartoff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable evidence of sex differences in oxycodone relapse-related behavior alongside novel characterization of synaptic adaptations in the paraventricular thalamus - nucleus accumbens shell circuit. The authors show that females exhibit heightened cue-induced seeking after 14 days, but not 1 day, of abstinence, while both sexes display similar time-dependent strengthening of paraventricular thalamus - nucleus accumbens shell glutamatergic transmission. The revised manuscript strengthens the work through improved statistical analyses, clearer interpretation, and expanded integration with prior literature. The strength of evidence is solid. However, association among experiments is incomplete, as the sex-specific behavioral effect is not reflected in circuit-level plasticity, and no causal manipulations test pathway involvement in relapse. Future work could link these circuit adaptations to sex-specific relapse vulnerability.

   Reviewed by eLife

5. Emergence of Dip2-mediated specific DAG-based PKC signalling axis in eukaryotes

   This article has 10 authors:

   1. Sakshi Shambhavi
   2. Sudipta Mondal
   3. Arnab Chakraborty
   4. Nikita Shukla
   5. Bapin Kumar Panda
   6. Santhosh Kumar
   7. Priyadarshan Kinatukara
   8. Biswajit Pal
   9. Siddhesh S Kamat
   10. Rajan Sankaranarayanan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an interesting study that adds useful new data addressing how different DAG pools influence cellular signaling. The study dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from the lipid metabolism DAG pool utilized in membrane production. Overall the analysis is solid and broadly supports the claims.

   Reviewed by eLife

6. Dilated cardiomyopathy-associated RNA-binding motif protein 20 regulates long pre-mRNAs in neurons

   This article has 6 authors:

   1. Giulia Di Bartolomei
   2. Raúl Ortiz
   3. Dietmar Schreiner
   4. Susanne Falkner
   5. Esther EJM Creemers
   6. Peter Scheiffele

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports that the RNA binding and cardiomyopathy-associated protein RBM20 is expressed in specific populations of neurons in the CNS, where it binds to and regulates the expression of synapse-related RNAs. This is an important finding because it reveals a new mechanism for gene regulation in neurons by an RNA binding protein previously studied in the heart; the authors also provide data to suggest that the mechanism by which RBM20 acts in neurons may be distinct from the splicing regulation studied in cardiac tissue. The data in support of the binding and regulation of RNAs by RBM20 is compelling, using leading edge sequencing methods to determine RNA binding profiles, and cell type specific genetics for evaluation of function.

   Reviewed by eLife

7. The geometry and dimensionality of brain-wide activity

   This article has 10 authors:

   1. Zezhen Wang
   2. Weihao Mai
   3. Yuming Chai
   4. Kexin Qi
   5. Hongtai Ren
   6. Chen Shen
   7. Shiwu Zhang
   8. Guodong Tan
   9. Yu Hu
   10. Quan Wen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows a surprising scale-invariance of the covariance spectrum of large-scale recordings in the zebrafish brain in vivo. A convincing analysis demonstrates that a Euclidean random matrix model of the covariance matrix recapitulates these properties. The results provide several new and insightful approaches for probing large-scale neural recordings.

   Reviewed by eLife

8. Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

   This article has 16 authors:

   1. Mengyun Li
   2. Huan Jin
   3. Yongxiang Liu
   4. Zining Wang
   5. Lin Li
   6. Tiantian Wang
   7. Xiaojuan Wang
   8. Hongxia Zhang
   9. Bitao Huo
   10. Tiantian Yu
   11. Shoujie Wang
   12. Wei Zhao
   13. Jinyun Liu
   14. Peng Huang
   15. Jun Cui
   16. Xiaojun Xia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors use a range of techniques to examine the role of Aurora Kinase A (AurA) in trained immunity. The study is hypothesis driven, it uses solid experimental approaches, and the data are presented in a logical manner. The findings are valuable to the trained immunity field because they provide an in-depth look at a common inducer of trained immunity, beta-glucan.

   Reviewed by eLife

9. Dissociation of the nuclear basket triggers chromosome loss in aging yeast

   This article has 7 authors:

   1. Mihailo Mirkovic
   2. Jordan McCarthy
   3. Anne Cornelis Meinema
   4. Julie Parenteau
   5. Sung Sik Lee
   6. Sherif Abou Elela
   7. Yves Barral

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study reveals that aging in yeast leads to chromosome mis-segregation due to asymmetric partitioning of chromosomes, driven by disruption of the nuclear pore complex and pre-mRNA leakage. The findings are convincingly supported by carefully-designed experimental data with a combination of genetic, molecular biology and cell biology approaches.

   Reviewed by eLife

10. Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration

    This article has 11 authors:

    1. Cong Chen
    2. Tong-Yao Gao
    3. Hua-Wei Yi
    4. Yi Zhang
    5. Tong Wang
    6. Zhi-Ling Lou
    7. Tao-Feng Wei
    8. Yun-Bi Lu
    9. Tingting Li
    10. Chun Tang
    11. Wei-Ping Zhang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides important insights into the role of polyUbiquitination in neurodegenerative diseases, elucidating how pUb promotes neurodegeneration by affecting proteasomal function. The findings not only offer a new perspective on the pathophysiology of neurodegenerative diseases but also provide potential targets for developing new therapeutic strategies. The results provide solid evidence to support the conclusions.

    Reviewed by eLife