eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2024.12.12.628111

2. We couldn't get details of this article at this time:
   10.1101/2024.11.22.24317764

3. Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation

   This article has 4 authors:

   1. Pei-Tzu Chen
   2. Jia-Yin Yeh
   3. Jui-Hsia Weng
   4. Kuen-Phon Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors employed state-of-the-art biochemistry, cryo-EM, and HDX mass spec approaches to study the formation of the binary Uba7-UBE2L6 and ternary UBA7-UBE2L6-ISG15 complexes. The results established mechanisms by which UBA7 and UBE2L6 form disulfide bonds, disrupting the ISG15 transfer cascade. While the biochemical and structural experiments are largely convincing, the mechanism under in vivo conditions remains unclear, due to the limited use of a single E2 enzyme. The authors need to repeat their experiments with a representative panel of human E2 enzymes.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2024.07.12.603090

5. We couldn't get details of this article at this time:
   10.1101/2024.09.11.612488

6. In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

   This article has 12 authors:

   1. Daniel T Hass
   2. Elizabeth Giering
   3. John YS Han
   4. Celia M Bisbach
   5. Kriti Pandey
   6. Brian M Robbings
   7. Thomas O Mundinger
   8. Nicholas D Nolan
   9. Stephen H Tsang
   10. Neal S Peachey
   11. Nancy J Philp
   12. James B Hurley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This research is valuable as it investigates metabolic shuttling between photoreceptors and retinal pigment epithelium (RPE) using in vivo infusion techniques and mouse models. The authors find that the retina significantly relies on circulating glucose, with photoreceptors being the primary consumers of glucose, which is convincing. However, the study has incomplete evidence to support the claims that photoreceptors can use lactate as a fuel source, that lactate exported from photoreceptors is utilized by the RPE, and that lactate contributes to the TCA cycle in the RPE. These claims need substantial revision to include potential alternative explanations or perform key experiments.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.01.13.632717

8. We couldn't get details of this article at this time:
   10.1101/2024.12.30.630730

9. CILP Inhibits hyaline cartilage fibrosis and chondrocyte ferroptosis via keap1-Nrf2 axis in early osteoarthritis exercise therapy

   This article has 11 authors:

   1. Shuangshuo Jia
   2. Zhehan Hu
   3. Zihan Li
   4. Weiming Zhang
   5. Liang Chen
   6. Changping Niu
   7. Ziqi Zhao
   8. Yuhan Sun
   9. Gang Yao
   10. Yang Wang
   11. Yue Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript by Jia et al. investigates the role of cartilage intermediate layer protein (CILP) and moderate exercise in maintaining hyaline cartilage integrity following anterior cruciate ligament transection (ACLt) in rats. Solid data support the downregulation of CILP in human OA cartilage and its potential role in regulating Keap1/Nrf2 interaction and chondrocyte ferroptosis. However, the data supporting a role for CILP in exercise-mediated inhibition of hyaline cartilage fibrosis in early OA are incomplete.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2024.10.19.619220