eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2023.05.09.539921

2. Diverse Genotype-by-Weather Interactions in Switchgrass

   This article has 13 authors:

   1. Alice H MacQueen
   2. Li Zhang
   3. Samuel Pattillo Smith
   4. Jason E Bonnette
   5. Arvid R Boe
   6. Philip A Fay
   7. Felix B Fritschi
   8. David B Lowry
   9. Robert B Mitchell
   10. Francis M Rouquette
   11. Yanqi Wu
   12. Arbel Harpak
   13. Thomas E Juenger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study reports valuable findings on the nature of genotype-by-climate interaction, parameterised in a framework that allows integrating genetics and ecophysiological variation in switchgrass. The evidence provided is solid overall but the analysis could be improved to better support some of the claims.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2024.12.17.629055

4. We couldn't get details of this article at this time:
   10.1101/2025.01.03.631168

5. We couldn't get details of this article at this time:
   10.1101/2025.02.04.636335

6. We couldn't get details of this article at this time:
   10.1101/2025.01.20.633986

7. The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity

   This article has 5 authors:

   1. Andrew C Fleming
   2. Nalini R Rao
   3. Matthew Wright
   4. Jeffrey N Savas
   5. Evangelos Kiskinis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Fleming et al sought to better understand DNAJC7's function in motor neurons as mutations in this gene have been associated with amyotrophic lateral sclerosis (ALS). Using iPSC-derived motor neurons, interactome, and transcriptomic data, they provide solid evidence that loss-of-function mutations in DNAJC7 disrupt RNA binding proteins and resistance to proteasomal stress. These important findings advance our understanding of DNAJC7 in motor neurons while providing clues to how its loss may be causal for ALS; nonetheless, the experiments were performed with a single iPSC line, while at least 3 are deemed to be required to validate the results. Furthermore, the mechanistic evidence is still incomplete with respect to how DNAJC7 mutations lead to HSF1 impaired activity, and whether it is direct or not.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2023.12.14.570333

9. We couldn't get details of this article at this time:
   10.1101/2024.03.14.584957

10. We couldn't get details of this article at this time:
    10.1101/2024.12.12.628179