eLife

Latest preprint reviews

1. UBR-1 deficiency leads to ivermectin resistance in Caenorhabditis elegans

   This article has 6 authors:

   1. Yi Li
   2. Long Gong
   3. Jing Wu
   4. Wesley Hung
   5. Mei Zhen
   6. Shangbang Gao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study allows for a better understanding of anthelmintic drug resistance in nematodes. The authors provide a detailed analysis of the role of UBR-1 and its underlying mechanism in ivermectin resistance using convincing behavioural and genetic experiments with C. elegans. Although the authors have addressed the concerns of the reviewers, it would be prudent for the authors to disclose the Dyf phenotype in ubr-1 mutants. The authors should at the very least report the Dyf phenotype and the experiment on which they base the argument that the Dyf phenotype does not affect their conclusions.

   Reviewed by eLife

2. Progressive neural engagement within the IFG-pMTG circuit as gesture and speech entropy and MI advances

   This article has 4 authors:

   1. Wanying Zhao
   2. Zhouyi Li
   3. Xiang Li
   4. Yi Du

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study uses brain stimulation and electroencephalography to study speech-gesture integration. It investigates the role of frontotemporal regions in integrating linguistic and extra-linguistic information during communication, focusing on the inferior frontal gyrus and posterior middle temporal gyrus. Reliance on activation patterns of tightly-coupled brain regions over short timescales leads to incomplete support for the study's conclusions due to conceptual and methodological limitations.

   Reviewed by eLife

3. Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical trial

   This article has 13 authors:

   1. Shiyu Zhang
   2. Min Zhou
   3. Chi Shao
   4. Yu Zhao
   5. Mingzhe Liu
   6. Lei Ni
   7. Zhiyao Bao
   8. Qiurui Zhang
   9. Ting Zhang
   10. Qun Luo
   11. Jieming Qu
   12. Zuojun Xu
   13. Wei Zuo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes a first-in-human trial of autologous p63+ stem cells in patients with idiopathic pulmonary fibrosis, a lethal condition for which effective treatments are lacking. The authors provide convincing evidence that P63+ progenitor cell therapy can be safely delivered in patients with ILD, warranting movement to a Phase 2. However, given that this is a Phase 1 study with a small sample size, conclusions regarding efficacy should not yet be made.

   Reviewed by eLife

4. DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

   This article has 18 authors:

   1. Hilda Tateossian
   2. Amy Southern
   3. Pratik Vikhe
   4. Eva Lana-Elola
   5. Sheona Watson-Scales
   6. Dorota Gibbins
   7. Debbie Williams
   8. Thomas Purnell
   9. Philomena Mburu
   10. Andrew Parker
   11. Dominic P Norris
   12. Regie Lyn P Santos-Cortez
   13. Brian W Herrmann
   14. Sara Wells
   15. Heena V Lad
   16. Elizabeth MC Fisher
   17. Victor LJ Tybulewicz
   18. Steve DM Brown

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study addresses fundamental questions surrounding otitis media effusion in Down syndrome, identifying DYRK1A as a key gene involved in the condition. The findings are compelling, highlighting DYRK1A as a promising therapeutic target for addressing hearing loss in patients with Down syndrome.

   Reviewed by eLife

5. Control of pili synthesis and putrescine homeostasis in Escherichia coli

   This article has 7 authors:

   1. Iti Mehta
   2. Jacob B Hogins
   3. Sydney R Hall
   4. Gabrielle Vragel
   5. Sankalya Ambagaspitiye
   6. Philippe E Zimmern
   7. Larry Reitzer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents an interesting analysis of the role of the polyamine precursor putrescine in the pili-dependent surface motility of a laboratory strain of Escherichia coli. The overall data convincingly demonstrate a role in this case. This study presents interesting findings for those studying uropathogenic bacteria, and those studying bacterial polyamine function.

   Reviewed by eLife

6. Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

   This article has 6 authors:

   1. Ana Cristina Chang-Gonzalez
   2. Aoi Akitsu
   3. Robert J Mallis
   4. Matthew J Lang
   5. Ellis L Reinherz
   6. Wonmuk Hwang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study reports detailed molecular dynamics (MD) simulations of T-cell receptors (TCRs) in complex with a peptide/MHC complex, for a better understanding of the mechanism of T-cell activation. The MD simulations provide solid evidence supporting that different TCRs can respond mechanically in different ways upon binding to the same pMHC complex. The analyses are systematic and provide testable predictions that can be evaluated by future mutagenesis and force microscopy studies.

   Reviewed by eLife

7. The Role of ATP Synthase Subunit e (ATP5I) in Mediating the Metabolic and Antiproliferative Effects of Metformin

   This article has 12 authors:

   1. Guillaume Lefrançois
   2. Emilie Lavallée
   3. Marie-Camille Rowell
   4. Véronique Bourdeau
   5. Farzaneh Mohebali
   6. Thierry Bertomeu
   7. Ana Maria Duman
   8. Maya Nikolova
   9. Mike Tyers
   10. Simon-Pierre Gravel
   11. Andréea R Schmitzer
   12. Gerardo Ferbeyre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript describes ATP5I, a subunit of F1Fo-ATP synthase, as a key target of medicinal biguanides. The knockout of ATP5I in pancreatic cancer cells mimics biguanide treatment, inducing a metabolic switch from OXPHOS to glycolysis due to a compromised expression of the Complex I protein NDUFB8. This results in a markedly decreased NAD/NADH ratio and decreased cell proliferation. These solid findings point out ATP5I as a promising mitochondrial target for cancer therapies and contribute to our understanding of metformin's mechanism of action since many of its molecular mechanisms remain poorly understood.

   Reviewed by eLife

8. Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland

   This article has 10 authors:

   1. Gabriel Magno de Freitas Almeida
   2. Iker Arriaga
   3. Bruna Luiza de Azevedo
   4. Miika Leppänen
   5. Jonatas S Abrahão
   6. Julien Andreani
   7. Davide Zabeo
   8. Janne J Ravantti
   9. Nicola GA Abrescia
   10. Lotta-Riina Sundberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes an important study of the giant virus Jyvaskylavirus. The characterisation presented is compelling. The work will be of interest to virologists working on giant viruses as well as those working with other members of the PRD1/Adenoviridae lineage.

   Reviewed by eLife

9. Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice

   This article has 8 authors:

   1. Shuo He
   2. Lei Huang
   3. Zhuozheng Chen
   4. Ze Yuan
   5. Yue Zhao
   6. Lingfang Zeng
   7. Yi Zhu
   8. Jinlong He

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents valuable findings on the role of Aff3ir, a gene implicated in flow-induced atherosclerosis and regulating the inflammation-associated transcription factor, IRF5. The in vivo data are solid in providing evidence on the role of Aff3ir in shear stress and formation of atheromatous plaques. The work will be of interest to clinical researchers and biologists focusing on inflammation and atherosclerosis in cardiovascular disease with a broad eLife readership.

   Reviewed by eLife

10. Structure of the human CTF18−RFC clamp loader bound to PCNA

    This article has 10 authors:

    1. Giuseppina R Briola
    2. Mohammad Tehseen
    3. Amani Al-Amodi
    4. Grace Young
    5. Ammar U Danazumi
    6. Phong Quoc Nguyen
    7. Christos G Savva
    8. Mark Hedglin
    9. Samir M Hamdan
    10. Alfredo De Biasio

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This paper reports new data on the structure of the human CTF18-RFC clamp loader complex bound to the PCNA clamp. The new and convincing data complement previous reports of CTF-RFC-PCNA structures and as such, represents an important contribution.

    Reviewed by eLife