eLife

Latest preprint reviews

1. Kinesin-2 autoinhibition requires elbow phosphorylation

   This article has 6 authors:

   1. Guanghan Chen
   2. Zhengyang Guo
   3. Zhiwen Zhu
   4. Shanshan Xie
   5. Tianhua Zhou
   6. Guangshuo Ou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In their important manuscript, Chen et al. investigate the phospho-regulation of the C. elegans kinesin-2 motor protein OSM-3, revealing that the kinase, NEKL-3, phosphorylates a serine/threonine patch at the hinge region of the motor to mediate autoinhibition until it reaches the ciliary middle segment. The findings are supported by robust genetic data, in vivo imaging, and motility assays with wild-type and mutant motors. Overall, the study provides a compelling contribution to understanding the regulation of OSM-3 kinesin activity both on the molecular and cellular levels.

   Reviewed by eLife

2. AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

   This article has 8 authors:

   1. Assmaa Elsheikh
   2. Camden M Driggers
   3. Ha H Truong
   4. Zhongying Yang
   5. John Allen
   6. Niel M Henriksen
   7. Katarzyna Walczewska-Szewc
   8. Show-Ling Shyng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that screening by artificial intelligence can identify relevant novel compounds for interacting with KATP channels. The experimental work is compelling. The broader significance of this work relates to the possibility that KATP channel mutations linked to congenital hyperinsulinism may be effectively rescued to the cell surface with a drug, which could normalize insulin secretion or enhance the effectiveness of existing KATP channel activators such as diazoxide.

   Reviewed by eLife

3. Elucidating the selection mechanisms in context-dependent computation through low-rank neural network modeling

   This article has 3 authors:

   1. Yiteng Zhang
   2. Jianfeng Feng
   3. Bin Min

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important set of analyses and theoretical derivations to understand the mechanisms used by recurrent neural networks (RNNs) to perform context-dependent accumulation of evidence. The results regarding the dimensionality and neural dynamical signatures of RNNs are convincing and provide new avenues to study the mechanisms underlying context-dependent computations. This manuscript will be of interest to a broad audience in systems and computational neuroscience.

   Reviewed by eLife

4. Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

   This article has 7 authors:

   1. Zhiwei Huang
   2. Songhao Luo
   3. Zihao Wang
   4. Zhenquan Zhang
   5. Benyuan Jiang
   6. Qing Nie
   7. Jiajun Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents DeepTX, a valuable methodological tool that integrates mechanistic stochastic models with single-cell RNA sequencing data to infer transcriptional burst kinetics at genome scale. The approach is broadly applicable and of interest to subfields such as systems biology, bioinformatics, and gene regulation. The evidence supporting the findings is solid, with appropriate validation on synthetic data and thoughtful discussion of limitations related to identifiability and model assumptions.

   Reviewed by eLife

5. Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

   This article has 4 authors:

   1. Luke J Dillard
   2. Gina Calabrese
   3. Larry Mesner
   4. Charles Farber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that provides compelling data from a diverse set of approaches from single cell transcriptome data and network analysis from genetically diverse mouse cells to identify novel driver genes underlying human GWAS associations. The authors present evidence that network analysis of scRNA-seq data from genetically diverse mouse bone-marrow derived stromal cells can be informative for identifying human BMD GWAS driver genes. Their approach should be broadly used and applicable to other GWAS studies.

   Reviewed by eLife

6. Correlated spontaneous activity sets up multi-sensory integration in the developing higher-order cortex

   This article has 10 authors:

   1. JaeAnn M Dwulet
   2. Nawal Zabouri
   3. Jan H Kirchner
   4. Marina E Wosniack
   5. Alessandra Raspanti
   6. Deyue Kong
   7. Gerrit J Houwen
   8. Paloma P Maldonado
   9. Christian Lohmann
   10. Julijana Gjorgjieva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study combines experiments and theory to investigate the putative role of spontaneous correlated activity in establishing aligned topographic maps of neural activity in higher-order sensory areas, and will be of interest to researchers studying multisensory integration and brain development. However, the evidence presented is incomplete, as there are notable disconnects between the experimental data and the modeling setup, and there are methodological details that are either unclear or missing, limiting the strength of the claims.

   Reviewed by eLife

7. Enhanced neural speech tracking through noise indicates stochastic resonance in humans

   This article has 1 author:

   1. Björn Herrmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important contribution to the understanding of neural speech tracking, demonstrating how minimal background noise can enhance the neural tracking of the amplitude-onset envelope. The evidence, through a well-designed series of EEG experiments, is convincing. This work will be of interest to auditory scientists, particularly those investigating biological markers of speech processing.

   Reviewed by eLife

8. Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling

   This article has 9 authors:

   1. Benjamin Le Gac
   2. Marine Tournissac
   3. Esther Belzic
   4. Sandrine Picaud
   5. Isabelle Dusart
   6. Hédi Soula
   7. Dongdong Li
   8. Serge Charpak
   9. Bruno Cauli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important findings on the role of pyramidal cells driving vasoconstriction in brain arteries through a COX-2/PGE2 pathway, with additional contributions from NPY (interneurons) and 20-HETE (astrocytes). Optogenetic stimulation of cortical pyramidal neurons induces vasoconstriction, potentially leading to oxygen and nutrient undersupply in regions with sustained activation - a mechanism potentially relevant under pathological conditions. The authors provide convincing evidence from brain slice experiments and some in vivo data from anesthetized animals, carefully discussing the strengths and limitations of both approaches.

   Reviewed by eLife

9. GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

   This article has 7 authors:

   1. Dhanesh Sivadasan Bindu
   2. Justin T Savage
   3. Nicholas Brose
   4. Luke Bradley
   5. Kylie Dimond
   6. Christabel Xin Tan
   7. Cagla Eroglu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The present study described GEARBOCS, an adeno-associated virus tool for in vivo gene editing in astrocytes, which is both timely and of importance for glial biologists, who often are troubled by efficient gene targeting in astrocytes. Overall, the finding is valuable, and the strength of the evidence is solid. Presumably, there will be great potential associated with GEARBOCS applications in the future.

   Reviewed by eLife

10. Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation

    This article has 11 authors:

    1. Jie Wang
    2. Jun Nishiyama
    3. Paula Parra-Bueno
    4. Elwy Okaz
    5. Goksu Oz
    6. Xiaodan Liu
    7. Tetsuya Watabe
    8. Irena Suponitsky-Kroyter
    9. Timothy E McGraw
    10. Erzsebet M Szatmari
    11. Ryohei Yasuda

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is an important study that describes the development of optical biosensors for various Rab GTPases and explores the contributions of Rab10 and Rab4 to structural and functional plasticity at hippocampal synapses during glutamate uncaging. The evidence supporting the conclusions of the paper is solid, and several improvements were noted by the reviewers upon revision, although some persisting inconsistencies would benefit from further clarification.

    Reviewed by eLife