eLife

Latest preprint reviews

1. Glucocorticoids desensitize hypothalamic CRH neurons to norepinephrine and somatic stress activation via rapid nitrosylation-dependent regulation of α1 adrenoreceptor trafficking

   This article has 8 authors:

   1. Grant L Weiss
   2. Laura M Harrison
   3. Zhiying Jiang
   4. Alyssa M Nielsen
   5. Maximillian S Feygin
   6. Sandy Nguyen
   7. Parker S Tirrell
   8. Jeffrey Tasker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes work that is fundamental to our understanding of the mechanism of how stress regulates the noradrenergic system and the CRH system. Using a combination of ex vivo physiology and in vitro methods, the study provides compelling evidence as to the signaling mechanisms of how glucocorticoids impact adrenergic GPCRs in CRH cells via receptor trafficking. While the ex vivo work is specific to the hypothalamus, the mechanisms here could be extrapolated and investigated in other brain regions that may have similar signaling regulation.

   Reviewed by eLife

2. Opposing roles for Bmp signalling during the development of electrosensory lateral line organs

   This article has 8 authors:

   1. Alexander S Campbell
   2. Martin Minařík
   3. Roman Franěk
   4. Michaela Vazačová
   5. Miloš Havelka
   6. David Gela
   7. Martin Pšenička
   8. Clare VH Baker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports analysis of the formation of electrosensory ampullary organs in non-model organisms, the sterlet sturgeon. By using a combination of targeted gene knock-out and inhibition, the study provides overall convincing evidence for differential roles of BMP signaling in lateral-line development, with few aspects that could be improved. The study is particularly valuable for understanding the development of a still-mysterious sensory system, and for its evolutionary implications.

   Reviewed by eLife

3. Social experience shapes fighting strategies in Drosophila

   This article has 6 authors:

   1. Can Gao
   2. Mingze Ma
   3. Jie Chen
   4. Xiaoxiao Ji
   5. Qionglin Peng
   6. Yufeng Pan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The important paper presents a new behavioral assay for Drosophila aggression and demonstrates that social experience influences fighting strategies, with group-housed males favoring high-intensity but low-frequency tussling over aggressive lunging observed in isolated males. The experiments are solid and the conclusions are of interest to researchers studying the impact of social isolation on aggression.

   Reviewed by eLife

4. Imaging of brain electric field networks with spatially resolved EEG

   This article has 6 authors:

   1. Lawrence R Frank
   2. Vitaly L Galinsky
   3. Olave Krigolson
   4. Susan Tapert
   5. Stephan Bickel
   6. Antigona Martinez

   Reviewed by eLife

5. Prefrontal working memory signal controls phase-coded information within extrastriate cortex

   This article has 6 authors:

   1. Mohsen Parto-Dezfouli
   2. Isabel Vanegas
   3. Mohammad Zarei
   4. William H Nesse
   5. Kelsey L Clark
   6. Behrad Noudoost

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigates how the maintenance of a spatial location in working memory affects the representation of visual information in area V4 of monkeys. As such, it is important not only for understanding vision but also for determining how working memory impacts perceptual signals and their underlying circuits. The data provide convincing evidence of a direct communication between prefrontal circuits that store spatial information and V4, which, under the current experimental conditions, manifests mainly as changes in temporal activity patterns (oscillations).

   Reviewed by eLife

6. Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

   This article has 5 authors:

   1. Eleonore Schiltz
   2. Martijn Broux
   3. Cagatay Aydin
   4. Pedro Goncalves
   5. Sebastian Haesler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes the progressive transformation of olfactory information across five different brain regions in the olfactory pathway, including a comparison of responses to familiar and unfamiliar odors. This dataset is of broad interest for olfactory researchers and provides a solid analysis of a graded change in representations of odor identity and experience in different locations in the pathway.

   Reviewed by eLife

7. An evolutionarily conserved Hox-Gbx segmentation code in the rice coral Montipora capitata

   This article has 9 authors:

   1. Shuonan He
   2. Emma Rangel-Huerta
   3. Eric Hill
   4. Lacey Ellington
   5. Shiyuan (Cynthia) Chen
   6. Sofia Robb
   7. Eva Majerová
   8. Crawford Drury
   9. Matthew C Gibson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors studied the development of mesentery borders in the rice coral Montipora, a new experimental system, to complement existing data from the sea anemone Nematostella. They make a solid case that in Montipora, there is a sequence of Hox-Gbx genes whose staggered expression in the unsegmented larva is suggestive of their role in subdividing the gastric cavity into repeated units bordered by mesenteries, as in the sea anemone Nematostella. Pharmacological experiments also point to the involvement of the BMP pathway in this process, but additional experiments validating this are necessary. This is a valuable contribution to the field of cnidarian evolution, suggesting that BMP- and "Hox-Gbx code"-dependent patterning of the directive axis was ancestral for Anthozoa.

   Reviewed by eLife

8. Physical constraints and biological regulations underlie universal osmoresponses

   This article has 3 authors:

   1. Yiyang Ye
   2. Qirun Wang
   3. Jie Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript develops a theoretical model of osmotic pressure adaptation in microbes by osmolyte production and wall synthesis. The prediction of a rapid increase in growth rate on osmotic shock is experimentally validated using fission yeast. By using phenomenological rules rather than detailed molecular mechanisms, the model can potentially apply to a wide range of microbes, providing important insights that would be of interest to the wider community studying the regulation of cell size and mechanics. The level of coarse-graining and the assumptions and limitations of the model have been well described, providing a convincing foundation for making predictions. However, further experimental work on the validity of the core assumptions across a range of microbial organisms is needed to assess the universality of the model.

   Reviewed by eLife

9. Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

   This article has 4 authors:

   1. Nelson V Simwela
   2. Eleni Jaecklein
   3. Christopher M Sassetti
   4. David G Russell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reveals that disrupting fatty acid metabolism in macrophages significantly restricts the growth of Mycobacterium tuberculosis, showing that impaired lipid processing triggers various antimicrobial responses. Overall, the approach is robust, utilizing CRISPR-Cas9 knockout of multiple genes involved in lipid metabolism which yielded convincing data. This work highlights how host lipid metabolism affects the ability of tubercle bacilli to thrive intracellularly, pointing to potential new therapeutic targets.

   Reviewed by eLife

10. Drosophila hamlet mediates epithelial tissue assembly of the reproductive system

    This article has 5 authors:

    1. Huazhen Wang
    2. Ludivine Bertonnier-Brouty
    3. Isabella Artner
    4. Jiayu Wen
    5. Qi Dai

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study addresses an essential morphogenetic process-epithelial fusion-by identifying the transcription factor Hamlet as a potential master regulator. Using a combination of genetic, cell biological, and omics approaches, including a comprehensive RNAi screen and high-quality imaging, the authors provide compelling evidence for Hamlet's role in coordinating cell fate and differentiation. The findings are robust and of broad interest to developmental biologists and geneticists.

    Reviewed by eLife