eLife

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1. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2401.04873v3

2. Mitochondrial metabolism in Drosophila macrophage-like cells regulates body growth via modulation of cytokine and insulin signaling

   This article has 5 authors:

   1. Shrivani Sriskanthadevan-Pirahas
   2. Abdul Qadeer Tinwala
   3. Michael J Turingan
   4. Shahoon Khan
   5. Savraj S Grewal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work demonstrates that compartmentalized cellular metabolism is a dominant input into cell size control in a variety of mammalian cell types and in Drosophila. The authors show that increased pyruvate import into the mitochondria in liver-like cells and in primary hepatocytes drives gluconeogenesis but reduces cellular amino acid production, suppressing protein synthesis. The evidence supporting the conclusions is compelling, with a variety of genetic and pharmacologic assays rigorously testing each step of the proposed mechanism. This work will be of interest to cell biologists, physiologists, and researchers interested in cell metabolism, and is significant because stem cells and many cancers exhibit metabolic rewiring of pyruvate metabolism.

   Reviewed by eLife

3. The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

   This article has 15 authors:

   1. Jie Fang
   2. Shivendra Singh
   3. Brennan Wells
   4. Qiong Wu
   5. Hongjian Jin
   6. Laura J Janke
   7. Shibiao Wan
   8. Jacob A Steele
   9. Jon P Connelly
   10. Andrew J Murphy
   11. Ruoning Wang
   12. Andrew Davidoff
   13. Margaret Ashcroft
   14. Shondra M Pruett-Miller
   15. Jun Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides potentially important findings examining in 2D and 3D models in MYC liver cancer cells changes in DNA repair genes and programs in response to hypoxia. The authors use convincing methodology in most cases, but there is some concern that the analysis is incomplete.

   Reviewed by eLife

4. NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

   This article has 20 authors:

   1. Shengsheng Zhao
   2. Ji Lin
   3. Bingzi Zhu
   4. Yin Jin
   5. Qiantong Dong
   6. Xiaojiao Ruan
   7. Dan Jin
   8. Yongdong Yi
   9. Binglong Bai
   10. Hongzheng Li
   11. Danna Liang
   12. Jianhua Lu
   13. Letian Meng
   14. Xiang Wang
   15. Yuekai Cui
   16. Yuyang Gu
   17. Xian Shen
   18. Xufeng Lu
   19. Shangrui Rao
   20. Weijian Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. After major revisions, the evidence supporting the conclusions is solid. However, some new experiments are needed to draw more robust conclusions regarding the ferroptosis-associated studies.

   Reviewed by eLife

5. Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C

   This article has 14 authors:

   1. Sara Jaber
   2. Eliana Eldawra
   3. Jeanne Rakotopare
   4. Iva Simeonova
   5. Vincent Lejour
   6. Marc Gabriel
   7. Tatiana Cañeque
   8. Vitalina Volochtchouk
   9. Monika Licaj
   10. Anne Fajac
   11. Raphaël Rodriguez
   12. Antonin Morillon
   13. Boris Bardot
   14. Franck Toledo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work is of fundamental significance and has an exceptional level of evidence for the role of a mutant p53 in regulation of tumorigenesis using an in vivo mouse model. The study is well-conducted and will be of interest to a broad audience including those interested in p53, transcription factors and cancer biology.

   Reviewed by eLife

6. Monitoring circulating cell-free HPV DNA in metastatic or recurrent cervical cancer: clinical significance and treatment implications

   This article has 7 authors:

   1. Zhuomin Yin
   2. Tao Feng
   3. Qing Xu
   4. Wumin Dai
   5. Maowei Ni
   6. Juan Ni
   7. Hanmei Lou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents useful findings on the application of HPV cfDNA as a marker for monitoring treatment response and prognosis in patients with recurrent or metastatic cervical cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples would have strengthened the study. The work will be of interest to medics and biologists working on cervical cancer.

   Reviewed by eLife

7. SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

   This article has 7 authors:

   1. Li Tian
   2. Zongzheng Zhao
   3. Wenying Gao
   4. Zirui Liu
   5. Xiao Li
   6. Wenyan Zhang
   7. Zhaolong Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of how the SARS-CoV-2 Nsp16 protein is regulated by host E3 ligases to promote viral mRNA capping. Support for the overall claims in the revised manuscript is convincing . This work will be of interest to those working in host-viral interactions and the role of the ubiquitin-proteasome system in viral replication.

   Reviewed by eLife

8. Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

   This article has 14 authors:

   1. Laura Lopez-Blanch
   2. Cristina Rodríguez-Marin
   3. Federica Mantica
   4. Luis P Iñiguez
   5. Jon Permanyer
   6. Elizabeth M Kita
   7. Tahnee Mackensen
   8. Mireia Codina-Tobias
   9. Francisco Romero-Ferrero
   10. Jordi Fernandez-Albert
   11. Myriam Cuadrado
   12. Xosé R Bustelo
   13. Gonzalo de Polavieja
   14. Manuel Irimia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work examines how microexons contribute to brain activity, structure, and behavior. The authors find that loss of microexon sequences generally has subtle impacts on these metrics in larval zebrafish, with few exceptions. The evidence is convincing, using modern high-throughput phenotyping methodology in zebrafish. Overall, this work will be of interest to neuroscientists and generate further studies of interest to the field.

   Reviewed by eLife

9. Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity

   This article has 8 authors:

   1. Anjali Bisht
   2. Srikanth Pippadpally
   3. Snehasis Majumder
   4. Athulya T Gopi
   5. Abhijit Das
   6. Chandan Sahi
   7. Mani Ramaswami
   8. Vimlesh Kumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work details the finding that in at least one of the subunits of the heterohexameric chaperone complex Pfdn5 has additional functions beyond its contribution to cytoskeletal protein folding in Drosophila. The authors provide convincing evidence that it is a hitherto unknown microtubule associated protein in addition to regulating microtubule organization and levels of tubulin monomers. The important findings show that Pfdn5 loss exaggerates pathological manifestations of mutant human Tau bearing FTDP-17 linked mutations in Drosophila, while its overexpression suppresses them, suggesting that the latter may constitute a future therapeutic approach.

   Reviewed by eLife

10. Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function

    This article has 10 authors:

    1. Caleb CS Calhoun
    2. Mary ES Capps
    3. Kristie Muya
    4. William C Gannaway
    5. Verdion Martina
    6. Claire L Conklin
    7. Morgan C Klein
    8. Jhodi M Webster
    9. Emma G Torija-Olson
    10. Summer B Thyme

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important work examines how microexons contribute to brain activity, structure, and behavior. The authors find that loss of microexon sequences generally has subtle impacts on these metrics in larval zebrafish, with few exceptions. The evidence is solid, using modern high-throughput phenotyping methodology in zebrafish. Overall, this work will be of interest to neuroscientists and generate further studies of interest to the field.

    Reviewed by eLife