eLife

Latest preprint reviews

1. Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory

   This article has 10 authors:

   1. Ilaria Borghi
   2. Lucia Mencarelli
   3. Michele Maiella
   4. Elias Paolo Casula
   5. Matteo Ferraresi
   6. Francesca Candeo
   7. Elena Savastano
   8. Martina Assogna
   9. Sonia Bonnì
   10. Giacomo Koch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents important findings suggesting that a combination of transcranial stimulation approaches applied for a short period could improve memory performance. Solid methods and evidence, in line with current standards for non-invasive stimulation and recording, are included to broadly support the main findings. The results potentially have implications for non-invasive enhancement of cognitive functions.

   Reviewed by eLife

2. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2309.15174v2

3. The Drosophila EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch

   This article has 5 authors:

   1. Marie Baldenius
   2. Steffen Kautzmann
   3. Rita Kottmeier
   4. Jaqueline Zipfel
   5. Christian Klämbt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies a new key factor in orchestrating the process of glial wrapping of axons in Drosophila wandering larvae. The evidence supporting the claims of the authors is convincing and the EM studies are of outstanding quality. After the revision, the authors have addressed most of the concerns and the manuscript has been significantly improved. Both reviewers have agreed on the significance of the work. The work will be of interest to neuroscientists working on glial cell biology.

   Reviewed by eLife

4. Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

   This article has 11 authors:

   1. Wencong Lyu
   2. Haochen Wang
   3. Zhehao Du
   4. Ran Wei
   5. Jianuo He
   6. Fanju Meng
   7. Jinlong Bi
   8. Lijun Zhang
   9. Chao Zhang
   10. Yiting Guan
   11. Wei Tao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the anti-senescence effects of enalapril, identifying pSmad1/5/9 signaling and associated antioxidant pathways as key mediators of its physiological benefits in aged mice. The authors present solid experimental evidence across both in vitro and in vivo systems, demonstrating improved organ function and reduced senescence markers following treatment. Overall, the work supports the repurposing potential of enalapril in aging research and expands understanding of its molecular targets.

   Reviewed by eLife

5. The title and authors for this article are not available from our external data provider yet:
   10.1101/2024.05.23.595569

6. Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

   This article has 9 authors:

   1. Laura Sophie Kremer
   2. Guanbin Gao
   3. Giovanni Rigoni
   4. Roberta Filograna
   5. Mara Mennuni
   6. Rolf Wibom
   7. Ákos Végvári
   8. Camilla Koolmeister
   9. Nils-Göran Larsson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. With convincing evidence, the authors have demonstrated that TFAM's counteractive role in mtDNA mutator mice is tissue-specific. The study does a thorough job of assessing the impact of modulating TFAM levels in a polg mutator mouse model of aging. The authors have thoroughly addressed all the points raised during the first round of review.

   Reviewed by eLife

7. Synthetic gene circuits that selectively target RAS-driven cancers

   This article has 3 authors:

   1. Gabriel Valentin Senn
   2. Leon Nissen
   3. Yaakov Benenson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the claims is convincing. As a proof-of-concept, this will be of broad interest to researchers in synthetic biology and therapeutics development, while future work will be required to help translate this technology toward clinical applications in cancer therapeutics and address potential limitations of the strategy.

   Reviewed by eLife

8. Interpreting prediction intervals and distributions for decoding biological generality in meta-analyses

   This article has 5 authors:

   1. Yefeng Yang
   2. Daniel WA Noble
   3. Alistair M Senior
   4. Malgorzata Lagisz
   5. Shinichi Nakagawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study provides a novel perspective on assessing the generalizability of meta-analytic findings by introducing prediction intervals (and distributions) as tools to evaluate whether future studies will likely yield non-zero effects. The methodology is generally solid, with a thorough exploration of a large set of published meta-analyses that broadens our understanding of between-study heterogeneity. However, some critical details are incomplete, requiring refinement to ensure statistical rigor.

   Reviewed by eLife

9. Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

   This article has 7 authors:

   1. Adam Kim
   2. Megan R McMullen
   3. Annette Bellar
   4. David Streem
   5. Jaividhya Dasarathy
   6. Nicole Welch
   7. Srinivasan Dasarathy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This potentially useful manuscript addresses the 3D chromatin architecture in monocytes from a few patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the concept and methodological approach are interesting in principle, the evidence is incomplete as a result of insufficient sample sizes as well as other substantive analytical concerns.

   Reviewed by eLife

10. Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model

    This article has 6 authors:

    1. Mohammad E Torki
    2. Fan Liu
    3. Rongguang Xu
    4. Yunfeng Chen
    5. Jeffery Fredberg
    6. Zi Chen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents a valuable nonlinear mathematical model that addresses how cell shape transitions in response to ECM stiffness. The evidence supporting the claims of the authors is solid, although additional work is required to improve the manuscript. For instance, the authors should improve the overall readability of the text and amend the experimental validation section. The work will be of interest to scientists working on a spectrum of fields including cell mechanics, cell behaviors, and cancer research.

    Reviewed by eLife