eLife

Latest preprint reviews

1. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2405.06500v2

2. Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells

   This article has 6 authors:

   1. Mate Sumegi
   2. Gaspar Olah
   3. Istvan Paul Lukacs
   4. Martin Blazsek
   5. Judit K Makara
   6. Zoltan Nusser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study provides new insights into the plasticity mechanisms underlying the formation of spatial maps in the hippocampus. Supported by a large and comprehensive dataset, the evidence is convincing. This study will be of interest to neuroscientists focusing on spatial navigation, learning, and memory.

   Reviewed by eLife

3. Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

   This article has 22 authors:

   1. Kelsey M Nemec
   2. Genevieve Uy
   3. V Sai Chaluvadi
   4. Freddy S Purnell
   5. Bilal Elfayoumi
   6. Leila Byerly
   7. Micaela L O'Reilly
   8. Carleigh A O'Brien
   9. William H Aisenberg
   10. Sonia I Lombroso
   11. Xinfeng Guo
   12. Niklas Blank
   13. Chet Huan Oon
   14. Fazeela Yaqoob
   15. Brian Temsamrit
   16. Priyanka Rawat
   17. Christoph A Thaiss
   18. Will Bailis
   19. Adam P Williamson
   20. Qingde Wang
   21. Mariko L Bennett
   22. F Chris Bennett

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This revised study describes an important new model for in vivo manipulation of microglia, exploring how mutations in the Adar1 gene within microglia contribute to Aicardi-Goutières Syndome. The methodology is validated with exceptional data, supporting the authors' conclusions. The paper underscores both the advantages and limitations of using transplanted cells as a surrogate for microglia, making it a resource that is of value for biologists studying macrophages and microglia.

   Reviewed by eLife

4. Neural adaptation to the eye’s optics through phase compensation

   This article has 4 authors:

   1. Antoine Barbot
   2. John T Pirog
   3. Cherlyn J Ng
   4. Geunyoung Yoon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper shows convincingly that the human visual system can recalibrate itself to compensate for phase alterations in an image induced by optical blur. This phenomenon is studied using state-of-the-art adaptive optics approaches that allow the manipulation of the eye's optics while making concurrent psychophysical measurements. The findings are broadly important because they highlight a neural mechanism by which flawed information is used to create seemingly accurate perceptions of the visual environment.

   Reviewed by eLife

5. Female moths incorporate plant acoustic emissions into their oviposition decision-making process

   This article has 18 authors:

   1. Rya Seltzer
   2. Guy Zer Eshel
   3. Omer Yinon
   4. Ahmed Afani
   5. Ofri Eitan
   6. Sabina Matveev
   7. Galina Levedev
   8. Michael Davidovitz
   9. Tal Ben Tov
   10. Gayl Sharabi
   11. Yuval Shapira
   12. Neta Shvil
   13. Maya Harari Gibli
   14. Ireen Atallah
   15. Sahar Hadad
   16. Dana Ment
   17. Lilach Hadany
   18. Yossi Yovel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reveals that female moths use ultrasonic sounds emitted by dehydrated plants to guide their oviposition decisions. It highlights sound as an additional sensory modality in host searching, adding an important piece to the puzzle of how insects and plants interact. Through convincing experimental approaches, the authors provide insights that advance our understanding of plant-insect interactions.

   Reviewed by eLife

6. Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes

   This article has 22 authors:

   1. Stephen A Banse
   2. Christine A Sedore
   3. Anna Coleman-Hulbert
   4. Erik Johnson
   5. Brian Onken
   6. David Hall
   7. Erik Segerdell
   8. E Grace Jackson
   9. Yuhua Song
   10. Haley C Osman
   11. Jian Xue
   12. Elena Basttistoni
   13. Suhzen Guo
   14. Anna Foulger
   15. Madhuri Achanta
   16. Mustafa Sheikh
   17. Theresa Fitzgibbon
   18. John H Willis
   19. Gavin C Woodruff
   20. Monica Driscoll
   21. Gordon Lithgow
   22. Patrick C Phillips

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study explores the power of computational methods to predict lifespan-extending small molecules, demonstrating that while these methods significantly increase hit rates, experimental validation remains essential. The study uses all-trans retinoic acid in Caenorhabditis elegans as a model, providing genetic and transcriptomic insights into its longevity effects. The data are compelling in describing a robust, computationally informed screening process for discovering compounds that extend lifespan in this species.

   Reviewed by eLife

7. A sex-specific Mendelian randomization-phenome-wide association study of body mass index

   This article has 4 authors:

   1. Zhu Liduzi Jiesisibieke
   2. Io Ieong Chan
   3. Jack Chun Man Ng
   4. C Mary Schooling

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents valuable findings on Mendelian randomization-phenome-wide association, with BMI associated with health outcomes, and there is a focus on sex differences. The phenotype and genotype data are convincing. The work will be of interest to researchers and clinicians in epidemiology, public health and medicine.

   Reviewed by eLife

8. Probing the force-from-lipid mechanism with synthetic polymers

   This article has 9 authors:

   1. Miranda L Jacobs
   2. Jan Steinkühler
   3. Audra Lemley
   4. Megan J Larmore
   5. Taylor F Gunnels
   6. Leo CT Ng
   7. Stephanie M Cologna
   8. Paul G DeCaen
   9. Neha P Kamat

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Gating of mechanosensitive channels has been explained by the force-from-lipids model in which mechanical coupling of the channel protein to the plasma membrane transfers force from membrane tension to open the channel. In this important manuscript, the authors provide evidence for this mechanism in two different mechanically gated channels. The experiments were carried out in the same membranes, but the evidence is incomplete without a clear explanation of the relationship between measured mechanical parameters and membrane interfacial tension.

   Reviewed by eLife

9. Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles

   This article has 14 authors:

   1. Chiara Tomasini
   2. Celine Cuche
   3. Selen Ay
   4. Maxence Collard
   5. Bin Cui
   6. Mohammad Rashid
   7. Shaoni Bhattacharjee
   8. Bruno Tello-Rubio
   9. Julian Buchrieser
   10. Charlotte Luchsinger
   11. Cinzia Bertelli
   12. Vladimir Uversky
   13. Felipe Diaz-Griffero
   14. Francesca Di Nunzio

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study that presents convincing evidence on the genesis of the CPSF6 condensates that form upon HIV-1 infection and the specific molecular determinants involved in their formation, as well as their interactions with SRRM. The study could be strengthened by assessing the relevance of their findings to infection, and in particular, with reverse transcription and gene expression

   Reviewed by eLife

10. DNA replication in primary hepatocytes without the six-subunit ORC

    This article has 12 authors:

    1. Róża K Przanowska
    2. Yuechuan Chen
    3. Takayuki-Okano Uchida
    4. Etsuko Shibata
    5. Xiaoxiao Hao
    6. Isaac Segura Rueda
    7. Kate Jensen
    8. Piotr Przanowski
    9. Anthony Trimboli
    10. Yoshiyuki Shibata
    11. Gustavo Leone
    12. Anindya Dutta

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data using various methods to genetically remove one or two ORC subunits from specific tissues and still observe replication. The replication appears to be primarily endoreduplication, indicating that ORC-independent replication may promote genome reduplication without mitosis. The mechanism behind this ORC-independent replication remains to be elucidated. The study and mutants described herein lay the groundwork for future research to explore how cells compensate for the absence of ORC and to develop functional approaches to investigate this process. The reviewers suggested the observations could be supported by additional experiments. This work will be of interest to those studying genome duplication and replication.

    Reviewed by eLife, Review Commons