Latest preprint reviews

  1. Estimation of Rotavirus Vaccine Effectiveness Based on Whole Genome Sequences

    This article has 15 authors:
    1. Jiye Kwon
    2. Jose Jaimes
    3. Mary E Wikswo
    4. Eileen J Klein
    5. Mary Allen Staat
    6. James D Chappell
    7. Geoffrey A Weinberg
    8. Christopher J Harrison
    9. Rangaraj Selvarangan
    10. Coreen Johnson
    11. Daniel M Weinberger
    12. Joshua L Warren
    13. Mathew D Esona
    14. Michael D Bowen
    15. Virginia E Pitzer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Kwon et al. present an important paper using a novel approach to estimating rotavirus vaccine efficacy using data from a passive surveillance network in the US. They provide convincing evidence to support their conclusion that using the whole genome, rather than previous use of two surface proteins, enhances our understanding of strain-specific vaccine efficacy. These findings have implications for this vaccine specifically as well as type-specific vaccine evaluation more generally.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

    This article has 11 authors:
    1. Tim Ott
    2. Amelie Brugger
    3. Emmanuelle Szenker-Ravi
    4. Yvonne Kurrle
    5. Olivia Aberle
    6. Matthias Tisler
    7. Martin Blum
    8. Sandra Whalen
    9. Patrice Bouvagnet
    10. Bruno Reversade
    11. Axel Schweickert
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This report explores the role of matrix metalloprotease MMP21 in left-right patterning in Xenopus. Based on a series of compelling experiments, the authors demonstrate that MMP21 can be secreted and acts upstream of dand5 without affecting cilia flow. The experiments are interesting and valuable; however, the claims by the authors lack consideration of other models that could also explain their findings.

    Reviewed by eLife

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
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