eLife

Latest preprint reviews

1. Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism

   This article has 4 authors:

   1. Priyojit Das
   2. Rebeca San Martin
   3. Tian Hong
   4. Rachel Patton McCord

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study explores the role of spatial genome organization in oncogenic transformation, addressing an ambitious and significant topic. The authors have assembled comprehensive datasets from various subtypes of localized and lung-metastatic breast cancer cells, as well as from healthy and cancerous lung cells. They identified switching patterns in the 3D genome organization of lung-metastatic breast cancer cells, revealing a reconfiguration of genome architecture that resembles that of lung cells. This provides solid evidence with significant biomedical implications for epigenetic regulation in both normal physiology and disease.

   Reviewed by eLife

2. Differential destinations, dynamics, and functions of high- and low-order features in the feedback signal during object processing

   This article has 3 authors:

   1. Wenhao Hou
   2. Sheng He
   3. Jiedong Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports important findings about the nature of feedback to primary visual cortex (V1) during object recognition. The state-of-the-art functional MRI evidence for the main claims is solid, and the combination of high-resolution fMRI with MEG yields significant insight into neural mechanisms. The findings presented here are relevant to a number of scientific fields such as object recognition, categorisation and predictive coding.

   Reviewed by eLife

3. Different serotonergic neurons regulate appetite for sucrose and hunger for proteins

   This article has 4 authors:

   1. Katharina Dorn
   2. Magdalena Gompert
   3. Jianzheng He
   4. Henrike Scholz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents the state-dependent role of serotonin for the protein and sugar intake of Drosophila by expressing a dominant-negative serotonin transporter in subsets of serotoninergic neurons. This paper is valuable for neuroscientists working on neuromodulation and the effects of internal states such as hunger, however the characterization of behavioral and neuroanatomical data is incomplete.

   Reviewed by eLife

4. Unique longitudinal contributions of sulcal interruptions to reading acquisition in children

   This article has 4 authors:

   1. Florence Bouhali
   2. Jessica Dubois
   3. Fumiko Hoeft
   4. Kevin S Weiner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study relating brain anatomy to reading ability in children studied longitudinally finds that a difference in sulcal anatomy is more predictive of reading ability than cognitive measures. The evidence that this anatomical difference is predictive and confers some benefit in the connectivity between brain areas is based on careful analyses and is solid. The findings would be of interest to researchers studying brain and cognitive development.

   Reviewed by eLife

5. SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

   This article has 5 authors:

   1. Pavla Nedbalová
   2. Nikola Kaislerova
   3. Lenka Chodakova
   4. Martin Moos
   5. Tomáš Doležal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper provides a valuable contribution to our understanding of how adenosine acts as a signal of nutrient insufficiency and extends this idea to suggest that adenosine is released by metabolically active cells in proportion to the activity of methylation events. Convincing data supports this idea. The authors use metabolic tracing approaches to identify the biochemical pathways that contribute to the regulation of adenosine levels and the S-adenosylmethionine cycle in Drosophila larval hemocytes in response to wasp egg infection.

   Reviewed by eLife

6. Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

   This article has 7 authors:

   1. Delaney Kaper
   2. Uroš Radović
   3. Per-Olof Bergh
   4. August Qvist
   5. Marcus Henricsson
   6. Jan Borén
   7. Marc Pilon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study investigates the role of polyunsaturated fatty acids (PUFAs) in physiology and membrane biology, using a unique model to perform a thorough genetic screen that demonstrates that PUFA synthesis defects cannot be compensated for by mutations in other pathways. These findings are supported by compelling evidence from a high quality genetic screen, functional validation of their hits, and lipid analyses. This study will appeal to researchers in membrane biology, lipid metabolism, and C. elegans genetics.

   Reviewed by eLife

7. Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

   This article has 12 authors:

   1. Yevheniia Ishchenko
   2. Amanda T Jeng
   3. Shufang Feng
   4. Timothy Nottoli
   5. Cindy Manriquez-Rodriguez
   6. Khanh K Nguyen
   7. Melissa G Carrizales
   8. Matthew J Vitarelli
   9. Ellen E Corcoran
   10. Charles A Greer
   11. Samuel A Myers
   12. Anthony J Koleske

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study explores how heterozygosity for specific neurodevelopmental disorder-associated TRIO variants affects brain function in mice. The authors conducted thorough analyses on mouse lines harboring TRIO-variants associated with autism spectrum disorder, schizophrenia, and bipolar disorder, and the results provide compelling evidence demonstrating unique alterations of each variant in synaptic functions and behavior. These findings highlight a fundamental aspect of TRIO variants contributing to brain functions and neuropsychiatric disorders.

   Reviewed by eLife

8. Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes

   This article has 9 authors:

   1. Dylan A Valencia
   2. Angela N Koeberlein
   3. Haruko Nakano
   4. Akos Rudas
   5. Aanand A Patel
   6. Airi Harui
   7. Cassandra Spencer
   8. Atsushi Nakano
   9. Margot E Quinlan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Valencia et al. combine elegant in vitro biochemical experiments with functional assays in cardiomyocytes to determine which properties of the FHOD3 formin are essential for sarcomere assembly. Using separation-of-function mutants, they show that FHOD3's elongation activity, rather than its nucleation, capping, or bundling activities, is key to its sarcomeric function. This is an important finding and the data presented in the manuscript are convincing; however, the presence of FHOD3 at filament barbed ends in the TIRF elongation assays should probably be verified directly in a future study.

   Reviewed by eLife

9. Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells

   This article has 10 authors:

   1. Soumita Banerjee
   2. Soniya Sanjay Shende
   3. Laxmi Kata
   4. Relestina Simon Lopes
   5. Swathika Praveen
   6. Ruchi Joshi
   7. Naveen Kumar Khare
   8. Gorantla V Raghuram
   9. Snehal Shabrish
   10. Indraneel Mittra

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors examine the effect of cell-free chromatin particles (cfChPs) derived from human serum or from dying human cells on mouse cells in culture and propose that these cfChPs can serve as vehicles for cell-to-cell active transfer of foreign genetic elements. The work presented in this paper is intriguing and potentially important, but it is incomplete. At this stage, the claim that horizontal gene transfer can occur via cfChPs is not well supported because it is only based on evidence from one type of methodological approach (immunofluorescence and fluorescent in situ hybridization (FISH)) and is not validated by whole genome sequencing.

   Reviewed by eLife

10. SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

    This article has 2 authors:

    1. Ashwin Govindan
    2. Nicholas K Conrad

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides fundamental insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the functional role of the splicing regulator SFSWAP. The evidence supporting the claims of the authors is convincing; the authors performed an elegant state-of-the-art CRISPR knockout strategy and sophisticated bioinformatic analysis to identify SFSWAP as a negative regulator of alternative splicing. The work will be of interest to researchers in the fields of splicing and glycobiology.

    Reviewed by eLife