eLife

Latest preprint reviews

1. Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum

   This article has 9 authors:

   1. Qian Xiu
   2. Xiaoru Yin
   3. Yuanyuan Chen
   4. Ziyang Zhang
   5. Yushuai Mao
   6. Tianshi Wang
   7. Jie Zhang
   8. Mingguo Zhou
   9. Yabing Duan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, the authors show the physiological response and molecular pathway mediating the effect of quinofumelin, a developed fungicide with an unknown mechanism. The authors present convincing data suggesting the involvement of the uridine/uracil biosynthesis pathway, by combining in vivo microbiology characterization as well as in vitro biochemical binding results.

   Reviewed by eLife

2. Layilin regulates Treg motility and suppressive capacity in skin

   This article has 18 authors:

   1. Victoire Gouirand
   2. Sean Clancy
   3. Courtney Macon
   4. Jose Valle
   5. Mariela Pauli
   6. Hong-An Truong
   7. Jarish Cohen
   8. Maxime Kinet
   9. Margaret M Lowe
   10. Samuel J Lord
   11. Kristen Skruber
   12. Hobart Harris
   13. Esther Kim
   14. Isaac Neuhaus
   15. Karin Reif
   16. Ali A Zarrin
   17. R Dyche Mullins
   18. Michael D Rosenblum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports valuable findings on the role of Layilin in the motility and suppressive capacity of clonal expanded regulatory T cells (Tregs) in the skin. Although the strength of the study is utilizing conditional knock-out mice and human skin samples, the analysis of the molecular mechanism by which Layilin affects Treg function is incomplete. The study will be of interest to medical scientists working on skin immunology.

   Reviewed by eLife, Arcadia Science

3. CILP from Cartilage Intermediate Zone Inhibits Hyaline Cartilage Fibrosis and Chondrocyte Ferroptosis via Keap1-Nrf2 Axis in Early Osteoarthritis Exercise Therapy

   This article has 11 authors:

   1. Shuangshuo Jia
   2. Zhehan Hu
   3. Zihan Li
   4. Weiming Zhang
   5. Liang Chen
   6. Changping Niu
   7. Ziqi Zhao
   8. Yuhan Sun
   9. Gang Yao
   10. Yang Wang
   11. Yue Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript by Jia et al. investigates the role of cartilage intermediate layer protein (CILP) and moderate exercise in maintaining hyaline cartilage integrity following anterior cruciate ligament transection (ACLt) in rats. Solid data support the downregulation of CILP in human OA cartilage and its potential role in regulating Keap1/Nrf2 interaction and chondrocyte ferroptosis. However, the data supporting a role for CILP in exercise-mediated inhibition of hyaline cartilage fibrosis in early OA are incomplete.

   Reviewed by eLife

4. Neutralizing human monoclonal antibodies that target the PcrV component of the type III secretion system of Pseudomonas aeruginosa act through distinct mechanisms

   This article has 14 authors:

   1. Jean-Mathieu Desveaux
   2. Eric Faudry
   3. Carlos Contreras-Martel
   4. François Cretin
   5. Leonardo Sebastian Dergan-Dylon
   6. Axelle Amen
   7. Isabelle Bally
   8. Victor Tardivy-Casemajor
   9. Fabien Chenavier
   10. Delphine Fouquenet
   11. Yvan Caspar
   12. Ina Attree
   13. Andrea Dessen
   14. Pascal Poignard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful work identifies new monoclonal antibodies produced by cystic fibrosis patients against Pseudomonas aeruginosa type three secretion system. The evidence supporting authors' claim is solid. Nonetheless, the manuscript may benefit from a more in depth description of what the authors learned from their structure-based analyses of antibodies targeting PcrV.

   Reviewed by eLife

5. Cross-modal interaction of human alpha activity does not reflect inhibition of early sensory processing in a frequency-tagging study using EEG and MEG

   This article has 8 authors:

   1. Marion Brickwedde
   2. Rupali Limachya
   3. Roksana Markiewicz
   4. Emma Sutton
   5. Christopher Postzich
   6. Kimron Shapiro
   7. Ole Jensen
   8. Ali Mazaheri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript provides solid evidence regarding the role of alpha oscillations in sensory gain control. The authors use an attention-cuing task in an initial EEG study followed by a separate MEG replication study to demonstrate that whilst (occipital) alpha oscillations are increased when anticipating an auditory target, so is visual responsiveness as assessed with frequency tagging. The findings offer a re-interpretation of the inhibitory role of the alpha rhythm, supporting that alpha oscillations contribute to interareal communication.

   Reviewed by eLife

6. Integration of head and body orientations in the macaque superior temporal sulcus is stronger for upright bodies

   This article has 2 authors:

   1. Yordanka Zafirova
   2. Rufin Vogels

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the neuronal mechanisms underlying visual perception of integrated face and body cues. The innovative paradigm, which employs monkey avatars in combination with electrophysiological recordings from fMRI-defined brain areas, provides compelling evidence on face and body integration. These results should be of wide interest to system and cognitive neuroscientists, psychologists, and behavioural biologists working on visual and social cognition.

   Reviewed by eLife

7. Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

   This article has 3 authors:

   1. Guangzhao Cheng
   2. Aki Vehtari
   3. Lu Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents SegPore, a valuable new method for processing direct RNA nanopore sequencing data, which improves the segmentation of raw signals into individual bases and boosts the accuracy of modified base detection. The evidence presented to benchmark SegPore is solid, and the authors provide a fully documented implementation of the method. SegPore will be of particular interest to researchers studying RNA modifications.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2307.05304v3

9. The role of GABA in semantic memory and its neuroplasticity

   This article has 3 authors:

   1. JeYoung Jung
   2. Steve Williams
   3. Matthew A Lambon Ralph

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Jung et al. present valuable work on the relationship between gamma-aminobutyric acid (GABA) levels within the anterior temporal lobes (ATL) to semantic memory while accounting for inter-individual differences. They provide solid evidence suggesting that inhibitory continuous theta burst transcranial magnetic stimulation (cTBS TMS) increased GABA concentration and decreased the blood-oxygen dependent signal (BOLD) during a semantic task. The results will be of interest to researchers studying the neurobiology of semantic cognition.

   Reviewed by eLife

10. The resource elasticity of control

    This article has 3 authors:

    1. Levi Solomyak
    2. Aviv Emanuel
    3. Eran Eldar

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study makes the valuable claim that people track, specifically, the elasticity of control (that is, the degree to which outcome depends on how many resources - such as money - are invested), and that control elasticity is impaired in certain types of psychopathologies. A novel task is introduced that provides solid evidence that this learning process occurs and that human behavior is sensitive to changes in the elasticity of control. Evidence that elasticity inference is distinct from more general learning mechanisms and is related to psychopathology remains incomplete.

    Reviewed by eLife