eLife

Latest preprint reviews

1. Krüppel Regulates Cell Cycle Exit and Limits Adult Neurogenesis of Mushroom Body Neural Progenitors in Drosophila

   This article has 7 authors:

   1. Dongni Shao Chen
   2. Jin Man
   3. Xian Shu
   4. Haoer Shi
   5. Xue Xia
   6. Yusanjiang Abula
   7. Yuu Kimata

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important insights into the regulation of neuroblast lifespan and proliferation in the Drosophila mushroom body, identifying Krüppel (Kr) as a key transcription factor promoting timely termination of these neuroblasts by repressing Imp expression, and proposes an antagonistic role of Krüppel homolog 1 (Kr-h1), whose overexpression leads to prolonged mushroom body neuroblast proliferation and tumor-like expansion. The findings are impactful for researchers interested in temporal patterning and neural development, and the methods and data analysis are solid, however, the precise regulatory interactions between Kr and Kr-h1 and their modes of action remain incompletely tested. Further experiments would be required to fully elucidate the mechanistic interplay between the factors involved.

   Reviewed by eLife

2. The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster

   This article has 8 authors:

   1. Geovana S Garcia
   2. Murilo F Othonicar
   3. Antonio Thiago P Campos
   4. Eric A Kilbourn
   5. Kênia C Bícego
   6. Johannes Lerchner
   7. Jason M Tennessen
   8. Marcos T Oliveira

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The findings in this manuscript are important because they demonstrate the key role of metabolism in insect development. The data were collected and analyzed using solid and validated methodologies, but the evidence is incomplete, as the extent of the involvement of AOX activity in vivo and in physiological conditions is not addressed. This manuscript will be of interest for the fields of mitochondrial bioenergetics, metabolism and development.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2025.02.03.636262

4. We couldn't get details of this article at this time:
   10.1101/2025.03.31.646306

5. We couldn't get details of this article at this time:
   10.1101/2025.03.26.645624

6. We couldn't get details of this article at this time:
   10.1101/2025.02.26.640323

7. We couldn't get details of this article at this time:
   10.1101/2025.01.22.634222

8. We couldn't get details of this article at this time:
   10.1101/2025.03.04.641450

9. We couldn't get details of this article at this time:
   10.1101/2025.02.27.640565

10. We couldn't get details of this article at this time:
    10.1101/2025.02.24.639930