eLife

Latest preprint reviews

1. TET2-mediated epigenetic modification promotes stress senescence of pancreatic β cells in type 2 diabetes mellitus

   This article has 6 authors:

   1. Weijuan Cai
   2. Qingqing Song
   3. Xiaoqing Mo
   4. Huaqian Li
   5. Yuling Song
   6. Liang Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts are novel and of interest, the study presents incomplete evidence to fully support its main conclusions.

   Reviewed by eLife

2. Auditory perception and neural representation of temporal features are altered by age but not by cochlear synaptopathy

   This article has 5 authors:

   1. Friederike Steenken
   2. Rainer Beutelmann
   3. Henning Oetjen
   4. Christine Köppl
   5. Georg M Klump

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study tested the specific hypothesis that age-related changes to hearing involve a partial loss of synapse connections between sensory cells in the ear and the nerve fibers that carry information about sounds to the brain, and that this interferes with the ability to discriminate rapid temporal fluctuations in sounds. Physiological, behavioral, and histological analyses provide a powerful combination to test this hypothesis in gerbils. Contrary to previous suggestions, it was found that chemically-induced isolated synaptopathy (at similar levels as observed in aged gerbils) did not result in worse performance on a behavioral task measuring sensitivity to temporal fine-structure, nor did it produce degradations in auditory-nerve fiber encoding of fine structure. Aged gerbils showed degraded behavior and stronger than normal envelope responses, but temporal fine-structure coding was not affected; interpreted by the authors as suggesting central processing contributions to aging effects on discrimination. These findings are important for advancing our knowledge of the mechanistic bases for age-related changes to hearing, and the evidence provided is solid with the results largely supporting the claims made and minor limitations related to possible confounds discussed in reasonable depth.

   Reviewed by eLife

3. TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

   This article has 10 authors:

   1. Christopher Nass Rudzitis
   2. Monika Lakk
   3. Ayushi Singh
   4. Sarah N Redmon
   5. Denisa Kirdajová
   6. Yun-Ting Tseng
   7. Michael L De Ieso
   8. W Daniel Stamer
   9. Samuel Herberg
   10. David Krizaj

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work extends our understanding of the role of TGFβ2 as a modulator of mechanosensing in the eye and identifies the TRPV4 ion channel as a common regulator of Trabecular Meshwork (TM) contractility and pathological OHT and the data and evidence provided are convincing. This work will clearly be of interest to researchers investigating the role of mechanosensors in the TM and may underpin future research into treatments that aim to lower intra ocular pressure. This work will additionally be of interest to the growing field of researchers investigating the regulation of force sensing via ion channels and their roles in health and disease, in particular the ion channel TRPV4.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/kcwm8

5. Machine learning of honey bee olfactory behavior identifies repellent odorants in free flying bees in the field

   This article has 7 authors:

   1. Joel Kowalewski
   2. Barbara Baer-Imhoof
   3. Tom Guda
   4. Matthew Luy
   5. Payton DePalma
   6. Boris Baer
   7. Anandasankar Ray

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important manuscript reports a very interesting view of how pesticides can be toxic to beneficial insects like the honeybee. The study uses machine learning for the discovery of new honeybee-repellent odorants. The solid evidence predicts compounds that were validated in the lab and in the field. This work will be of great interest to researchers in ecology, pest control and sensory biology.

   Reviewed by eLife

6. Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

   This article has 9 authors:

   1. Hyun Beom Song
   2. Laura Campello
   3. Anupam Mondal
   4. Holly Y Chen
   5. Milton A English
   6. Michael Glen
   7. Phillip Vanlandingham
   8. Rafal Farjo
   9. Anand Swaroop

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important Research Advance presents compelling evidence on the neuroprotective effects of reserpine in a well-established model of retinitis pigmentosa (P23H-1). This study builds on previous work establishing reserpine as a neuroprotectant in models of Leber congenital amaurosis. Here authors show reserpine's disease gene-independent influence on photoreceptor survival and emphasizes the importance of considering biological sex in understanding inherited retinal degeneration and the impact of drug treatments on mutant retinas. The work will be of interest to vision researchers as well as a broad audience in translational research.

   Reviewed by eLife

7. Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

   This article has 7 authors:

   1. Tanya Wolff
   2. Mark Eddison
   3. Nan Chen
   4. Aljoscha Nern
   5. Preeti Sundaramurthi
   6. Divya Sitaraman
   7. Gerald M Rubin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a fundamental body of work reporting anatomical, molecular, and functional mapping of the central complex in Drosophila. There were a few concerns of a minor nature, and all were addressed by the authors. The tools generated and the findings, which include characterization of neuromodulators used by different cells, will undoubtedly serve as a foundation for future studies of this brain region. The data are compelling and likely to have a major impact.

   Reviewed by eLife

8. Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

   This article has 16 authors:

   1. Yiran Zhang
   2. Hanyang Guan
   3. Shijin Liu
   4. Haoquan Li
   5. Zili Bian
   6. Jiashuai He
   7. Zhan Zhao
   8. Shenghui Qiu
   9. Tianmu Mo
   10. Xiangwei Zhang
   11. Zuyang Chen
   12. Hui Ding
   13. Xiaoxu Zhao
   14. Liang Wang
   15. Yunlong Pan
   16. Jinghua Pan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study found Gamma Knife SBRT combined with tislelizumab offers a safe and powerful later-line option for pMMR/MSS/MSI-L metastatic CRC patients who were unresponsive to the first and second-line chemotherapy. The authors implemented a well-structured experimental protocol and provide convincing evidence to substantiate the conclusions. This work would be of broad interest to oncologists working on colorectal cancer.

   Reviewed by eLife

9. Integration of parallel pathways for flight control in a hawkmoth reflects prevalence and relevance of natural visual cues

   This article has 3 authors:

   1. Ronja Bigge
   2. Rebecca Grittner
   3. Anna Lisa Stöckl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how hummingbird hawkmoths integrate stimuli from across their visual field to guide flight behavior. Cue conflict experiments provide solid evidence for an integration hierarchy within the visual field: hawkmoths prioritize the avoidance of dorsal visual stimuli, potentially to avoid crashing into foliage, while they use ventrolateral optic flow to guide flight control. These findings will be of broad interest to enthusiasts of visual neuroscience and flight behavior.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.48550/arxiv.2407.21115v1