eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2025.03.31.646362

2. We couldn't get details of this article at this time:
   10.1101/2025.02.10.637530

3. We couldn't get details of this article at this time:
   10.1101/2024.08.14.608002

4. We couldn't get details of this article at this time:
   10.1101/2022.03.03.482809

5. We couldn't get details of this article at this time:
   10.1101/2025.03.04.640448

6. Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis

   This article has 6 authors:

   1. Weilun Guo
   2. Shruti S Apte
   3. Mary S Dickinson
   4. So Young Kim
   5. Miriam Kutsch
   6. Jörn Coers

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a fundamental discovery revealing two independent IFNγ-induced pathways that restrict bacterial motility: one GBP1-dependent and the other GVIN1-dependent. The findings are supported by compelling evidence. While the paper is already very strong, there are a few points that could be addressed editorially or through the addition of a few key experiments.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2024.12.12.628175

8. Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

   This article has 3 authors:

   1. Mei Ling Leong
   2. Christiane Ruedl
   3. Klaus Karjalainen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further mechanistic analyses. These data will be interesting to cancer biologists, especially those trying to understand late-stage complications such as cachexia and wasting, a major cause of cancer morbidity and mortality.

   Reviewed by eLife

9. Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healing

   This article has 6 authors:

   1. Yunpei Zhang
   2. Pingting Wang
   3. Lingling Neng
   4. Kushal Sharma
   5. Allan Kachelmeier
   6. Xiaorui Shi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study exploring the role of TRPV1 signaling in recruiting macrophages and promoting angiogenesis during tympanic membrane wound healing presents useful findings. However, the strength of evidence supporting the central claims is incomplete, as the mechanistic links between TRPV1 activation and immune cell recruitment remain largely correlative and rely heavily on previously published datasets without sufficient functional validation. The work will be of interest to researchers studying wound healing and sensory-immune interactions, though substantial revisions are needed to support its broader significance.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2024.12.17.628892