eLife

Latest preprint reviews

1. Understanding Pain in Polycystic Ovary Syndrome: Health Risks and Treatment Effectiveness

   This article has 6 authors:

   1. Tess Cherlin
   2. Stephanie Mohammed
   3. Samantha Strydesky
   4. Sasha Ottey
   5. Katherine Sherif
   6. Shefali S Verma

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the high prevalence of pain in women with polycystic ovary syndrome and its association with distinct future health risks across different racial groups. The evidence supporting the conclusions is compelling, utilizing a massive global dataset and rigorous propensity score matching to identify pain as a critical, yet underexplored, clinical marker. The work will be of interest to reproductive endocrinologists, medical biologists, and clinicians involved in the diagnosis and management of polycystic ovary syndrome.

   Reviewed by eLife

2. Transcriptional dynamics uncover the role of BNIP3 in mitophagy during muscle remodeling in Drosophila

   This article has 12 authors:

   1. Hiroki Taoka
   2. Tadayoshi Murakawa
   3. Kohei Kawaguchi
   4. Michiko Koizumi
   5. Tatsuya Kaminishi
   6. Yuriko Sakamaki
   7. Kaori Tanaka
   8. Akihito Harada
   9. Keiichi Inoue
   10. Tomotake Kanki
   11. Yasuyuki Ohkawa
   12. Naonobu Fujita

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the involvement of the BNIP3-ATG18/WIPI axis in mitophagy induction has been reported in mammalian cell culture systems, this study provides the first compelling evidence for this pathway in vivo in animals. The physiological significance of this BNIP3-dependent mitophagy will require further investigation.

   Reviewed by eLife

3. Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

   This article has 7 authors:

   1. Jodie Chandler
   2. M Elise Bullock
   3. Arpit C Swain
   4. Cayman Williams
   5. Christiaan H van Dorp
   6. Benedict Seddon
   7. Andrew J Yates

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper provides a compelling and rigorous quantitative analysis of the turnover and maintenance of CD4+ tissue-resident memory T cell clones, in the skin and the lamina propria. It provides a fundamental advance in our understanding of CD4 T cell regulation. Interestingly, in both tissues, maintenance involves an influx from progenitors on the time scale of months. The evidence that is based on fate mapping and mathematical inference is strong, although open questions on the interpretation of the Ki67-based fate mapping remain.

   Reviewed by eLife

4. Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation

   This article has 13 authors:

   1. Chien-Hsien Lai
   2. Gyeongah Park
   3. Pan Xu
   4. Xiaoqian Sun
   5. Qian Ge
   6. Zhen Jin
   7. Sarah Betts
   8. Xiaojie Liu
   9. Qingsong Liu
   10. Rahul Simha
   11. Chen Zeng
   12. Hui Lu
   13. Jianyang Du

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Du et al. present a valuable study examining neural activation in medial prefrontal cortex (mPFC) subpopulations projecting to the basolateral amygdala (BLA) and nucleus accumbens (NAc) during behavioral tasks assessing anxiety, social preference, and social dominance. The strength of the evidence linking in vivo neural physiology to behavioral outcomes was considered solid. Overall, the reviewers felt that the revised work provides insight into how distinct mPFC→BLA and mPFC→NAc pathways influence anxiety, exploration, and social behaviors.

   Reviewed by eLife

5. Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

   This article has 14 authors:

   1. Lin Yan
   2. Litao Wu
   3. Timothy D Wiggin
   4. Xiaojuan Su
   5. Wei Yan
   6. Hailiang Li
   7. Lei Li
   8. Zhonghua Lu
   9. Yuantao Li
   10. Zhiqiang Meng
   11. Fang Guo
   12. Fan Li
   13. Leslie C Griffith
   14. Chang Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study approaches an important topic providing insight into the neuronal circuitry that interconnects memory consolidation and sleep. The data were collected and analysed using a solid methodology, contributing new findings for neurobiologists working on how memories are stored and the roles of sleep. However, the data is incomplete to support the proposed role of the PAM-DPM circuits as the link between sleep state and long-term memory consolidation.

   Reviewed by eLife

6. Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

   This article has 19 authors:

   1. Antara Sengupta
   2. Soujanya Vinayagamurthy
   3. Dristhi Soni
   4. Rajlekha Deb
   5. Ananda Kishore Mukherjee
   6. Subhajit Dutta
   7. Jushta Jaiswal
   8. Mukta Yadav
   9. Shalu Sharma
   10. Sulochana Bagri
   11. Shuvra Shekhar Roy
   12. Priya Poonia
   13. Ankita Singh
   14. Divya Khanna
   15. Amit Kumar Kumar Bhatt
   16. Akshay Sharma
   17. Suman Saurav
   18. Rajender K Motiani
   19. Shantanu Chowdhury

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors of this important study investigate how telomere length regulates hTERT expression via non-telomeric binding of the telomere-associated protein TRF2. They conclusively show that TRF2 binding to long telomeres results in a reduction in its binding to the hTERT promoter, while short telomeres restore TRF2 binding in the hTERT promoter, recruiting repressor complexes like PRC2, and suppressing hTERT expression. There is convincing support for the claims and the findings should be of broad interest for cell biologists and those working in fields where telomeres alter function, such as cancer and aging.

   Reviewed by eLife

7. Olfactory bulb tracks breathing rhythms and place in freely behaving mice

   This article has 11 authors:

   1. Scott C Sterrett
   2. Teresa M Findley
   3. Sidney E Rafilson
   4. Morgan A Brown
   5. Aldis P Weible
   6. Rebecca Marsden
   7. Takisha Tarvin
   8. Michael Wehr
   9. James M Murray
   10. Adrienne L Fairhall
   11. Matthew C Smear

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study linking olfactory bulb activity not only to sniffing parameters but also to movement and place. The evidence for odor sampling is mostly solid, but the analysis supporting the potentially exciting result on the encoding of place is currently incomplete.

   Reviewed by eLife

8. Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

   This article has 27 authors:

   1. Inbal Avraham-Davidi
   2. Simon Mages
   3. Johanna Klughammer
   4. Noa Moriel
   5. Shinya Imada
   6. Matan Hofree
   7. Evan Murray
   8. Jonathan Chen
   9. Karin Pelka
   10. Arnav Mehta
   11. Genevieve M Boland
   12. Toni Delorey
   13. Leah Caplan
   14. Danielle Dionne
   15. Robert Strasser
   16. Jana Lalakova
   17. Anezka Niesnerova
   18. Hao Xu
   19. Morgane Rouault
   20. Itay Tirosh
   21. Hacohen Nir
   22. Fei Chen
   23. Omer Yilmaz
   24. Jatin Roper
   25. Orit Rozenblatt-Rosen
   26. Mor Nitzan
   27. Aviv Regev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents a valuable resource combining scRNA-seq and spatial transcriptomics studies to map mouse pre-clinical models of colorectal cancer, identifying distinct cellular programs and microenvironments that could enhance patient stratification and therapeutic approaches in colorectal cancer. While the evidence provided in the manuscript are not fully validated, these solid data were collected and analyzed using a validated methodology that will be of interest to the community in future studies.

   Reviewed by eLife

9. Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

   This article has 11 authors:

   1. Alina Xiaoyu Yang
   2. Lisa Ramos-Rodriguez
   3. Parand Sorkhdini
   4. Dongqin Yang
   5. Carmelissa Norbrun
   6. Sonoor Majid
   7. Sanghyun Lee
   8. Yong Zhang
   9. Michael Holtzman
   10. David F Boyd
   11. Yang Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript presents a potentially novel mechanism by which the phospholipid scramblase, PLSCR1, defends against influenza A virus infection. The strength of the paper rests on solid findings involving knockout and lung specific over-expressing Plscr1 mice, airway tissue expression and mechanistic studies to show Plscr1 enhances type III interferon-mediated viral clearance.

   Reviewed by eLife

10. Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    This article has 9 authors:

    1. Rémy Torro
    2. Beatriz Díaz-Bello
    3. Dalia El Arawi
    4. Ksenija Dervanova
    5. Lorna Ammer
    6. Florian Dupuy
    7. Patrick Chames
    8. Kheya Sengupta
    9. Laurent Limozin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      CellDetective is an important software package for segmentation, tracking, and analysis of time-lapse microscopy datasets, specifically designed to be accessible to researchers without coding expertise. The authors provide convincing evidence of its capabilities through comprehensive validations and well-executed comparisons across immunological assays, and the latest version adds support for defining and visualizing multiple cell subsets. The current implementation remains limited to 2D widefield imaging, though the authors provide a sound rationale for this scope, and one interface issue (a fixed main-window size on some systems) still affects usability. Overall, this work will be of significant interest to the bioimaging community, especially those in immunology and cell biology, and has applicability extending well beyond immune profiling.

    Reviewed by eLife