eLife

Latest preprint reviews

1. Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses

   This article has 9 authors:

   1. Shweta Chaudhary
   2. Mothe Sravya
   3. Falak Pahwa
   4. Sureshkumar V
   5. Prateek Singh
   6. Shivam Chaturvedi
   7. Debasisa Mohanty
   8. Debasis Dash
   9. Ranjan Kumar Nanda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the intersection between tuberculosis and diabetes and the impact on immune responses, notably T cell and myeloid cell responses. The single-cell data collected and analyzed are convincing and provide a rich dataset to develop a more detailed understanding of cellular responses during Mtb infection of diabetic mice. Some of the mechanistic claims are incomplete, as there are no experiments performed to clearly define a role for IL-16 or IL-17 in disease. Inclusion of analysis of human samples would have strengthened the conclusions in the paper for translational impact, as well as the inclusion of a DM group alone in addition to DM-TB vs TB in some of the experiments.

   Reviewed by eLife

2. Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16

   This article has 18 authors:

   1. Ying Ru
   2. Meng Ma
   3. Xianxiao Zhou
   4. Divya Kriti
   5. Ninette Cohen
   6. Sunita D’Souza
   7. Christoph Schaniel
   8. Susan M Motch Perrine
   9. Sharon Kuo
   10. Oksana Pichurin
   11. Dalila Pinto
   12. Genevieve Housman
   13. Greg Holmes
   14. Eric Schadt
   15. Harm van Bakel
   16. Bin Zhang
   17. Ethylin Wang Jabs
   18. Meng Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors investigated KLF Transcription Factor 16 (KLF16) as an inhibitor of osteogenic differentiation, which plays a critical role in bone development, metabolism and repair. The results of the study are valuable as they could help to facilitate future research on the regulation of osteogenesis in vitro and in vivo. However, the evidence overall is incomplete, as validation by knockout mouse models would help to strengthen the conclusions.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2025.01.20.25320623

4. We couldn't get details of this article at this time:
   10.1101/2025.02.28.640838

5. We couldn't get details of this article at this time:
   10.1101/2025.01.16.633477

6. We couldn't get details of this article at this time:
   10.1101/2024.12.10.627807

7. Five-Year Survival Outcomes for Breast Cancer Patients Across Continental Africa: A Contemporary Review of Literature with Meta Analysis

   This article has 9 authors:

   1. Augustina Badu-Peprah
   2. Ernest Kissi Kontor
   3. Adu-Gyamfi Benjamin
   4. Jessica Kumah
   5. Akosua Aya Essuman
   6. Bossoh Selorm
   7. Issahak Nurudeen
   8. Bismark Osei Owusu
   9. Nityanand Jain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable meta-analysis that highlights low and highly variable breast cancer survival rates across Africa, emphasizing the pressing need for public health in Africa. The evidence supporting the claims of the authors is solid, although a clarification of the crude 5-year survival rates would have strengthened the study. The work will be of interest to scientists working in the field of public health and breast cancer.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2024.09.17.24312688

9. We couldn't get details of this article at this time:
   10.1101/2025.02.21.639560

10. We couldn't get details of this article at this time:
    10.1101/2025.02.19.638939